Peptide nucleic acids targeted to the neurotensin receptor and administered i.p. cross the blood-brain barrier and specifically reduce gene expression

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 12, 1999, Pages 7053-7058

  Tyler, Beth M ^a   Jansen, Karen ^a   Mccormick, Daniel J ^b   Douglas, Christopher L ^a   Boules, Mona ^a   Stewart, Jennifer A ^a   Zhao, Lihong ^a   Lacy, Benjamin ^a   Cusack, Bernadette ^a   Fauq, Abdul ^a   Richelson, Elliott ^a  

^a MAYO CLINIC   (United States)

^b MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; MORPHINE; MU OPIATE RECEPTOR; NEUROTENSIN; NEUROTENSIN RECEPTOR; PEPTIDE NUCLEIC ACID;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE TARGETING; HYPOTHERMIA; INJECTION; MALE; MICROINJECTION; NEUROCHEMISTRY; NONHUMAN; PERITONEUM; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; PROTEIN TARGETING; RAT; RECEPTOR DENSITY; SMALL INTESTINE;

ANIMALS; ANTISENSE ELEMENTS (GENETICS); BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; DRUG DELIVERY SYSTEMS; GENE EXPRESSION REGULATION; INJECTIONS, INTRAPERITONEAL; MALE; PEPTIDE NUCLEIC ACIDS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NEUROTENSIN;

ANIMALIA;

EID: 13044266375     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.12.7053     Document Type: Article

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