Development of DNA-based radiopharmaceuticals carrying Auger-electron emitters for antigene radiotherapy

International Journal of Radiation Oncology Biology Physics

Volumn 49, Issue 2, 2001, Pages 391-396

  Sedelnikova, Olga A ^a   Luu, Andrew N ^a   Karamychev, Valeri N ^a   Panyutin, Igor G ^a   Neumann, Ronald D ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Antigene radiotherapy; Iodine 125; MDR1 gene; Triplex forming oligonucleotides

Indexed keywords

IODINE 125; OLIGONUCLEOTIDE; RADIOPHARMACEUTICAL AGENT;

CANCER RADIOTHERAPY; CARCINOMA CELL; CONFERENCE PAPER; CONTROLLED STUDY; DNA STRAND BREAKAGE; GENE; GENOME; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; RADIOTHERAPY;

DNA; DNA DAMAGE; DNA PRIMERS; DNA, NEOPLASM; ELECTROPHORESIS, AGAR GEL; GENES, MDR; HUMANS; IODINE RADIOISOTOPES; NUCLEIC ACID HYBRIDIZATION; OLIGONUCLEOTIDES; PLASMIDS; RADIOBIOLOGY; RADIOPHARMACEUTICALS; RADIOTHERAPY; TUMOR CELLS, CULTURED;

EID: 0035253828     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(00)01486-3     Document Type: Conference Paper

References (19)

1. Biological damage from the Auger effects, possible benefits
2. Range of radiochemical damage to DNA with decay of iodine-125
3. 125I labeled oligonucleotides
4. Sequence-specific DNA breaks produced by triplex-directed decay of iodine-125
5. Gene radiotherapy; gene targeted versus targeted by gene product [letter; comment]
6. The anti-gene strategy; Control of gene expression by triplex-forming-oligonucleotides
7. Triplex DNA structure
8. Triplex targeting of a native gene in permeabilized intact cells; Covalent modification of the gene for the chemokine receptor CCR5
9. Gene delivery; A single nuclear localization signal peptide is sufficient to carry DNA to cell nucleus
10. Biochemistry of multidrug resistance mediated by the multidrug transporter
11. Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells
12. The human mdr1 (multidrug-resistance) gene harbours a long homopyrymidine[circf]homopurine sequence next to a cluster of Alu repeated sequences in intron 14*
13. Nuclear transport of adenovirus DNA polymerase is facilitated by interaction with preterminal protein
14. Accessibility of nuclear DNA to triplex-forming oligonucleotides; The integrated HIV-1 provirus as a target
15. Triplex-forming oligonucleotides can modulate Aquaporine-5 gene expression in epithelial cells
16. Radiotoxicity of iodine-125 labeled oligodeoxyribonucleotides in mammalian cells
17. The stability of DNA triplexes inside cells as studied by iodine-125 radioprinting
18. 111In-labeled ologodeoxyribonucleotides
19. Triplex DNA; Fundamentals, advances, and potential applications for gene therapy