Targeting peptide nucleic acid (PNA) oligomers to mitochondria within cells by conjugation to lipophilic cations: Implications for mitochondrial DNA replication, expression and disease

Nucleic Acids Research

Volumn 29, Issue 9, 2001, Pages 1852-1863

  Muratovska, Aleksandra ^a   Lightowlers, Robert N ^b   Taylor, Robert W ^b   Turnbull, Douglass M ^b   Smith, Robin A J ^a   Wilce, Jacqueline A ^c   Martin, Stephen W ^d   Murphy, Michael P ^e  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^d AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^e WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CATION; COMPLEMENTARY DNA; MATRIX PROTEIN; MITOCHONDRIAL DNA; OLIGOMER; PEPTIDE NUCLEIC ACID; PHOSPHONIUM DERIVATIVE; (4 IODOBUTYL)TRIPHENYLPHOSPHONIUM; (4-IODOBUTYL)TRIPHENYLPHOSPHONIUM; LIPID; MITOCHONDRIAL PROTEIN; ORGANOPHOSPHORUS COMPOUND;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL FRACTIONATION; CELL MEMBRANE POTENTIAL; CONFOCAL MICROSCOPY; CONJUGATION; CONTROLLED STUDY; CROSS LINKING; DNA REPLICATION; DNA SEQUENCE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOELECTRON MICROSCOPY; IN VITRO STUDY; INCUBATION TIME; ION SELECTIVE ELECTRODE; LIPID BILAYER; LIPOPHILICITY; MAMMAL CELL; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MYOCLONUS EPILEPSY; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; PREVENTION; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; RNA REPLICATION; RNA SEQUENCE; RNA TRANSLATION; BINDING SITE; BIOSYNTHESIS; CELL LINE; CHEMISTRY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG DELIVERY SYSTEM; DRUG EFFECT; FIBROBLAST; GENETICS; METABOLISM; SKELETAL MUSCLE; TRANSPORT AT THE CELLULAR LEVEL; ULTRASTRUCTURE;

ANIMALIA; MAMMALIA;

BINDING SITES; BIOLOGICAL TRANSPORT; CATIONS; CELL CULTURE; CELL LINE; DNA REPLICATION; DNA, MITOCHONDRIAL; DRUG DELIVERY SYSTEMS; FIBROBLASTS; HUMAN; LIPIDS; MITOCHONDRIA; MITOCHONDRIAL DISEASES; MITOCHONDRIAL PROTEINS; MUSCLE, SKELETAL; ORGANOPHOSPHORUS COMPOUNDS; PEPTIDE NUCLEIC ACIDS; SUPPORT, NON-U.S. GOV'T;

EID: 0035339611     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/29.9.1852     Document Type: Article

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