Predicting inductive drug-drug interactions

Pharmacogenomics

Volumn 4, Issue 2, 2003, Pages 141-152

  Liddle, Christopher ^a   Robertson, Graham R ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Constitutive androstane receptor; Cytochrome P450; Drug development; Drug interactions; Drug metabolism; Pregnane X receptor

Indexed keywords

16ALPHA CYANOPREGNENOLONE; ALDEHYDE DEHYDROGENASE; BILE ACID; CELL NUCLEUS RECEPTOR; CLOTRIMAZOLE; CYCLOSPORIN; CYTOCHROME P450; CYTOCHROME P450 2A6; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; DEXAMETHASONE; DIGOXIN; ESTERASE; GLUTATHIONE TRANSFERASE; LITHOCHOLIC ACID; METYRAPONE; MIFEPRISTONE; MULTIDRUG RESISTANCE PROTEIN 1; OKADAIC ACID; ORAL CONTRACEPTIVE AGENT; PHENOBARBITAL; PHENYTOIN; PREGNANETRIOL; PROTEINASE INHIBITOR; RIFABUTIN; RIFAMPICIN; TAUROCHENODEOXYCHOLIC ACID; TRANSCRIPTION FACTOR; UNINDEXED DRUG; XENOBIOTIC AGENT;

ANTIVIRAL ACTIVITY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG EXCRETION; DRUG METABOLISM; ENZYME ACTIVITY; GENE FUNCTION; GENE INDUCTION; GRAFT REJECTION; HUMAN; HYPERICUM PERFORATUM; NONHUMAN; POSTMARKETING SURVEILLANCE; REVIEW; TRANSACTIVATION;

ANIMALS; CELL LINE; CELL-FREE SYSTEM; CYTOCHROME P-450 ENZYME SYSTEM; DRUG INTERACTIONS; HUMANS; MICE; MICE, TRANSGENIC; MODELS, ANIMAL; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; RESPONSE ELEMENTS; TRANSCRIPTION FACTORS; XENOBIOTICS;

HYPERICUM; HYPERICUM PERFORATUM;

EID: 0037340809     PISSN: 14622416     EISSN: None     Source Type: Journal    
DOI: 10.1517/phgs.4.2.141.22639     Document Type: Review

References (62)

1. Whitlock JP, Jr, Chichester CH, Bedgood RM et al.: Induction of drug-metabolizing enzymes by dioxin. Drug Metab. Rev. 29(4), 1107-1127 (1997).
2. Watkins PB, Wrighton SA, Schuetz EG, Molowa DT, Guzelian PS: Identification of glucocorticoid-inducible cytochromes P450 in the intestinal mucosa of rats and man. J. Clin. Invest. 80(4), 1029-1036 (1987).
3. Thiebaut F, Tsuruo T, Hamada H, Gottesman MM, Pastan I, Willingham MC: Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proc. Natl. Acad. Sci. USA 84(21), 7735-7738 (1987).
4. Michalets EL: Update: clinically significant cytochrome P450 drug interactions. Pharmacotherapy 18(1), 84-112 (1998).
5. Maurel P: Cytochromes P450: Metabolic and Toxicological Aspects. Ioannides C (Ed.) CRC Press, Inc., Boca Raton, FL 241-270 (1996).
6. Shimada T, Yamazaki H, Mimura M, Inui Y, Guengerich FP: Interindividual variations in human liver cytochrome P450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J. Pharmacol. Exp. Ther. 270(1), 414-423 (1994).
7. Brian WR, Sari MA, Iwasaki M, Shimada T, Kaminsky LS, Guengerich FP: Catalytic activities of human liver cytochrome P450 IIIA4 expressed in Saccharomyces cerevisiae. Biochemistry 29(51), 11280-11292 (1990).
8. Araya Z and Wikvall K: 6α-Hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes. Biochim. Biophys. Acta. 1438(1), 47-54 (1999).
9. Nebert DW, Gonzalez FJ: P450 genes: structure, evolution, and regulation. Ann. Rev. Biochem. 56, 945-993 (1987).
10. White TJ, Arakelian A, Rho JP: Counting the costs of drug-related adverse events. Pharmacoeconomics 15(5), 445-458 (1999).
11. Campana C, Regazzi MB, Buggia I, Molinaro M: Clinically significant drug interactions with cyclosporin. An update. Clin. Pharmacokinet. 30(2), 141-179 (1996).
12. Finch CK, Chrisman CR, Baciewicz AM, Self TH: Rifampin and rifabutin drug interactions: an update. Arch. Intern. Med. 162(9), 985-992 (2002).
13. Ernst E: St John's Wort supplements endanger the success of organ transplantation. Arch. Surg. 137(3), 316-319 (2002).
14. Shenfield GM: Oral contraceptives. Are drug interactions of clinical significance? Drug Saf. 9(1), 21-37 (1993).
15. Anonymous: Clinical update: impact of HIV protease inhibitors on the treatment of HIV-infected tuberculosis patients with rifampin. MMWR Morb. Mortal. Wkly. Rep. 45(42), 921-925 (1996).
16. Greiner B, Eichelbaum M, Fritz P et al.: The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin. J. Clin. Invest. 104(2), 147-153 (1999).
17. Giguere V: Orphan nuclear receptors: from gene to function. Endocr. Rev. 20(5), 689-725 (1999).
18. Kliewer SA, Moore JT, Wade L et al.: An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell 92(1), 73-82 (1998).
19. Choi HS, Chung M, Tzameli I et al.: Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR. J. Biol. Chem. 272(38), 23565-23571 (1997).
20. Blumberg B, Sabbagh W, Jr, Juguilon H et al.: SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes Dev. 12(20), 3195-3205 (1998).
21. Lehmann JM, McKee DD, Watson MA, Willson TM, Moore JT, Kliewer SA: The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J. Clin. Invest. 102(5), 1016-1023 (1998).
22. Bertilsson G, Heidrich J, Svensson K et al.: Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc. Natl. Acad. Sci. USA 95(21), 12208-12213 (1998).
23. de Waziers I, Cugnenc PH, Yang CS, Leroux JP, Beaune PH: Cytochrome P450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues. J. Pharmacol. Exp. Ther. 253(1), 387-394 (1990).
24. Baes M, Gulick T, Choi HS, Martinoli MG, Simha D, Moore DD: A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements. Mol. Cell Biol. 14(3), 1544-1551 (1994).
25. Moore LB, Parks DJ, Jones SA et al.: Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. J. Biol. Chem. 275(20), 15122-15127 (2000).
26. Watkins RE, Wisely GB, Moore LB et al.: The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity. Science 292(5525), 2329-2333 (2001).
27. Zhang H, LeCulyse E, Liu L et al.: Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation. Arch. Biochem. Biophys. 368(1), 14-22 (1999).
28. Jones SA, Moore LB, Shenk JL et al.: The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution. Mol. Endocrinol. 14(1), 27-39 (2000).
29. Tzameli I, Pissios P, Schuetz EG, Moore DD: The xenobiotic compound 1, 4-bis[2-(3,5-dichloropyridyloxy)]benzene is as agonist ligand for the nuclear receptor CAR. Mol. Cell Biol. 20(9), 2951-2958 (2000).
30. Zelko I, Sueyoshi T, Kawamoto T, Moore R, Negishi M: The peptide near the C terminus regulates receptor CAR nuclear translocation induced by xenochemicals in mouse liver. Mol. Cell Biol. 21(8), 2838-2846 (2001).
31. Kawamoto T, Sueyoshi T, Zelko I, Moore R, Washburn K, Negishi M: Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene. Mol. Cell Biol. 19(9), 6318-6322 (1999).
32. Staudinger JL, Goodwin B, Jones SA et al.: The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc. Natl. Acad. Sci. USA 98(6), 3369-3374 (2001).
33. Xie W, Barwick JL, Downes M et al.: Humanized xenobiotic response in mice expressing nuclear receptor SXR. Nature 406(6794), 435-439 (2000).
34. Wei P, Zhang J, Egan-Hafley M, Liang S, Moore DD: The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism. Nature 407(6806), 920-923 (2000).
35. Jover R, Bort R, Gomez-Lechon MJ, Castell JV: Cytochrome P450 regulation by hepatocyte nuclear factor 4 in human hepatocytes: a study using adenovirus-mediated antisense targeting. Hepatology 33(3), 668-675 (2001).
36. Wisely GB, Miller AB, Davis RG et al.: Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids. Structure (Camb) 10(9), 1225-1234 (2002).
37. Dhe-Paganon S, Duda K, Iwamoto M, Chi YI, Shoelson SE: Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand. J. Biol. Chem. 277(41), 37973-37976 (2002).
38. Xie W, Radominska-Pandya A, Shi Y et al.: An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Proc. Natl. Acad. Sci. USA 98(6), 3375-3380 (2001).
39. Goodwin B, Hodgson E, Liddle C: The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module. Mol. Pharmacol. 56(6), 1329-1339 (1999).
40. Bertilsson G, Berkenstam A, Blomquist P: Functionally conserved xenobiotic responsive enhancer in cytochrome P450 3A7. Biochem. Biophys. Res. Commun. 280(1), 139-144 (2001).
41. Goodwin B, Hodgson E, D'Costa DJ, Robertson GR, Liddle C: Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor. Mol. Pharmacol. 62(2), 359-365 (2002).
42. Sueyoshi T, Kawamoto T, Zelko I, Honkakoski P, Negishi M: The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene. J. Biol. Chem. 274(10), 6043-6046 (1999).
43. Goodwin B, Moore LB, Stoltz CM, McKee DD, Kliewer SA. Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor. Mol. Pharmacol. 60(3), 427-431 (2001).
44. Makinen J, Frank C, Jyrkkarinne J, Gynther J, Carlberg C, Honkakoski P: Modulation of mouse and human phenobarbital-responsive enhancer module by nuclear receptors. Mol. Pharmacol. 62(2), 366-378 (2002).
45. Geick A, Eichelbaum M, Burk O: Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J. Biol. Chem. 276(18), 14581-14587 (2001).
46. Rae JM, Johnson MD, Lippman ME, Flockhart DA: Rifampin is a selective, pleiotropic inducer of drug metabolism genes in human hepatocytes: studies with cDNA and oligonucleotide expression arrays. J. Pharmacol. Exp. Ther. 299(3), 849-857 (2001).
47. Maglich JM, Stoltz CM, Goodwin B, Hawkins-Brown D, Moore JT, Kliewer SA: Nuclear pregnane X receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification. Mol. Pharmacol. 62(3), 638-646 (2002).
48. Ueda A, Hamadeh HK, Webb HK et al.: Diverse roles of the nuclear receptor orphan CAR in regulating hepatic genes in response to Phenobarbital. Mol. Pharmacol. 61(1), 1-6 (2002).
49. Mode A, Tollet P, Strom A, Legraverend C, Liddle C, Gustafsson JA: Growth hormone regulation of hepatic cytochrome P450 expression in the rat. Adv. Enzyme Regul. 32, 255-263 (1992).
50. Pichard L, Fabre I, Fabre G et al.: Cyclosporin A drug interactions. Screening for inducers and inhibitors of cytochrome P450 (cyclosporin A oxidase) in primary cultures of human hepatocytes and in liver microsomes. Drug Metab. Dispos. 18 (5), 595-606 (1990).
51. LeCluyse EL: Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation. Eur. J. Pharm. Sci. 13(4),343-368 (2001).
52. Dussault I, Lin M, Hollister K, Wang EH, Synold TW, Forman BM: Peptide mimetic HIV protease inhibitors are ligands for the orphan receptor SXR. J. Biol. Chem. 276(36), 33309-33312 (2001).
53. Luo G, Cunningham M, Kim S et al.: CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in primary human hepatocytes. Drug Metab. Dispos. 30(7), 795-804 (2002).
54. Weltman M, Farrell GC, Hall P, Ingelman-Sundberg M, Liddle C: Hepatic CYP2E1 is increased in patients with non-alcoholic steatohepatitis. Hepatology 27(1), 128-133 (1998).
55. Jones SA, Moore LB, Wisely GB, Kliewer SA: Use of in vitro pregnane X receptor assays to assess CYP3A4 induction potential of drug candidates. Methods Enzymol. 357, 161-170 (2002).
56. Raucy J, Warfe L, Yueh M-F, Allen SW: A cell-based reporter gene assay for determining induction of CYP3A4 in a high-volume system. J. Pharmacol. Exp. Ther. 303(1), 412-423 (2002).
57. Desai PB, Nallani SC, Sane RS et al.: Induction of cytochrome P450 3A4 in primary human hepatocytes and activation of the human pregnane X receptor by tamoxifen and 4-hydroxytamoxifen. Drug Metab. Dispos. 30(5),608-612 (2002).
58. Zhou G, Cummings R, Li Y et al.: Nuclear receptors have distinct affinities for coactivators: characterization by fluorescence resonance energy transfer. Mol. Endocrinol. 12(10), 1594-1604 (1998).
59. Parks DJ, Blanchard SG, Bledsoe RK et al.: Bile acids: natural ligands for an orphan nuclear receptor. Science 284(5418), 1365-1368 (1999).
60. Zhang J, Huang W, Chua SS, Wei P, Moore DD: Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR. Science 298(5592), 422-424 (2002).
61. Guidance for Industry: In vivo Drug Metabolism/Drug Interaction Studies - Study Design, Data Analysis, and Recommendations for Dosing and Labeling. US Department of Health and Human Services' Food and Drug Administration, Center for Drug Evaluation and Research, November 1999. http://www.fda.gov/cber/gdlns/metabol.htm
62. Schuetz E, Lan L, Yasuda K et al.: Development of a real-time in vivo transcription assay: application reveals pregnane X receptor-mediated induction of CYP3A4 by cancer chemotherapeutic agents. Mol. Pharmacol. 62(3), 439-445 (2002).