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Volumn 270, Issue 5, 2003, Pages 791-798

The subtle side to hypoxia inducible factor (HIFα) regulation

Author keywords

Growth factor; HIF ; MAPK; Oncogene; PI3K

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ANGIOTENSIN; ASPARAGINE; CARBON MONOXIDE; ENDOTHELIAL CELL GROWTH FACTOR; GROWTH FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; OXYGENASE; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROLINE DERIVATIVE; PROTEIN KINASE B; SERINE DERIVATIVE; SOMATOMEDIN B; SOMATOMEDIN C; THREONINE; TUMOR NECROSIS FACTOR ALPHA;

EID: 0037337061     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2003.03446.x     Document Type: Review
Times cited : (145)

References (69)
  • 1
    • 0036216692 scopus 로고    scopus 로고
    • HIF-1 and tumor progression: Pathophysiology and therapeutics
    • Semenza, G.L. (2002) HIF-1 and tumor progression: pathophysiology and therapeutics. Trends Mol. Med. 8, S62-S67.
    • (2002) Trends Mol. Med. , vol.8
    • Semenza, G.L.1
  • 2
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    • Wang, G.L., Jiang, B.H., Rue, E.A. & Semenza, G.L. (1995) Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl Acad. Sci. USA 92, 5510-5514.
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 5510-5514
    • Wang, G.L.1    Jiang, B.H.2    Rue, E.A.3    Semenza, G.L.4
  • 3
    • 0034901463 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1: Oxygen homeostasis and disease pathophysiology
    • Semenza, G.L. (2001) Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology. Trends Mol. Med. 7, 345-350.
    • (2001) Trends Mol. Med. , vol.7 , pp. 345-350
    • Semenza, G.L.1
  • 6
    • 0036469038 scopus 로고    scopus 로고
    • Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
    • Lando, D., Peer, D.J., Whelan, D.A., Gorman, J.J. & Whitelaw, M.L. (2002) Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. Science. 295, 858-861.
    • (2002) Science , vol.295 , pp. 858-861
    • Lando, D.1    Peer, D.J.2    Whelan, D.A.3    Gorman, J.J.4    Whitelaw, M.L.5
  • 7
    • 0035812772 scopus 로고    scopus 로고
    • 2), and the 3 phds: How animal cells signal hypoxia to the nucleus
    • 2), and the 3 phds: how animal cells signal hypoxia to the nucleus. Cell. 107, 1-3.
    • (2001) Cell , vol.107 , pp. 1-3
    • Semenza, G.L.1
  • 8
    • 0037337763 scopus 로고    scopus 로고
    • Oxygen-dependent regulation of the hypoxia-inducible factors by prolyl and asparaginyl hydroxylation
    • Lando, D., Gorman, J.J., Whitelaw, M.L. & Peet, D.J. (2003) Oxygen-dependent regulation of the hypoxia-inducible factors by prolyl and asparaginyl hydroxylation. Eur. J. Biochem. 270, 781-790.
    • (2003) Eur. J. Biochem. , vol.270 , pp. 781-790
    • Lando, D.1    Gorman, J.J.2    Whitelaw, M.L.3    Peet, D.J.4
  • 9
    • 0032169214 scopus 로고    scopus 로고
    • Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1α/ARNT
    • Zelzer, E., Levy, Y., Kahana, C., Shilo, B.Z., Rubinstein, M. & Cohen, B. (1998) Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1α/ARNT. EMBO J. 17, 5085-5094.
    • (1998) EMBO J. , vol.17 , pp. 5085-5094
    • Zelzer, E.1    Levy, Y.2    Kahana, C.3    Shilo, B.Z.4    Rubinstein, M.5    Cohen, B.6
  • 10
    • 0034654174 scopus 로고    scopus 로고
    • Modulation of hypoxia-inducible factor lalpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
    • Zhong, H., Chiles, K., Feldser, D., Laughner, E., Hanrahan, C., Georgescu, M.M., Simons, J.W. & Semenza, G.L. (2000) Modulation of hypoxia-inducible factor lalpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res. 60, 1541-1545.
    • (2000) Cancer Res. , vol.60 , pp. 1541-1545
    • Zhong, H.1    Chiles, K.2    Feldser, D.3    Laughner, E.4    Hanrahan, C.5    Georgescu, M.M.6    Simons, J.W.7    Semenza, G.L.8
  • 11
    • 0033566693 scopus 로고    scopus 로고
    • Reciprocal positive regulation of hypoxia-inducible factor 1α and insulin-like growth factor 2
    • Feldser, D., Agani, F., Iyer, N.V., Pak, B., Ferreira, G. & Semenza, G.L. (1999) Reciprocal positive regulation of hypoxia-inducible factor 1α and insulin-like growth factor 2. Cancer Res. 59, 3915-3918.
    • (1999) Cancer Res. , vol.59 , pp. 3915-3918
    • Feldser, D.1    Agani, F.2    Iyer, N.V.3    Pak, B.4    Ferreira, G.5    Semenza, G.L.6
  • 12
    • 0033181324 scopus 로고    scopus 로고
    • Interleukin-1β and tumor necrosis factor-α stimulate DNA binding of hypoxia-inducible factor-1
    • Hellwig-Burgel, T., Rutkowski, K., Metzen, E., Fandrey, J. & Jelkmann, W. (1999) Interleukin-1β and tumor necrosis factor-α stimulate DNA binding of hypoxia-inducible factor-1. Blood. 94, 1561-1567.
    • (1999) Blood , vol.94 , pp. 1561-1567
    • Hellwig-Burgel, T.1    Rutkowski, K.2    Metzen, E.3    Fandrey, J.4    Jelkmann, W.5
  • 13
    • 0034282388 scopus 로고    scopus 로고
    • Nonhypoxic pathway mediates the induction of hypoxia-inducible factor lalpha in vascular smooth muscle cells
    • Richard, D.E., Berra, E. & Pouyssegur, J. (2000) Nonhypoxic pathway mediates the induction of hypoxia-inducible factor lalpha in vascular smooth muscle cells. J. Biol. Chem. 275, 26765-26771.
    • (2000) J. Biol. Chem. , vol.275 , pp. 26765-26771
    • Richard, D.E.1    Berra, E.2    Pouyssegur, J.3
  • 14
    • 0035816732 scopus 로고    scopus 로고
    • Thrombin activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells: Role of the p22 (phox)-containing NADPH oxidase
    • Gorlach, A., Diebold, I., Schini-Kerth, V.B., Berchner-Pfannschmidt, U., Roth, U., Brandes, R.P., Kietzmann, T. & Busse, R. (2001) Thrombin activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells: Role of the p22 (phox)-containing NADPH oxidase. Circ Res. 89, 47-54.
    • (2001) Circ. Res. , vol.89 , pp. 47-54
    • Gorlach, A.1    Diebold, I.2    Schini-Kerth, V.B.3    Berchner-Pfannschmidt, U.4    Roth, U.5    Brandes, R.P.6    Kietzmann, T.7    Busse, R.8
  • 15
    • 0034816327 scopus 로고    scopus 로고
    • Hepatocyte growth factor signalling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells
    • Tacchini, L., Dansi, P., Matteucci, E. & Desiderio, M.A. (2001) Hepatocyte growth factor signalling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells. Carcinogenesis. 22, 1363-1371.
    • (2001) Carcinogenesis , vol.22 , pp. 1363-1371
    • Tacchini, L.1    Dansi, P.2    Matteucci, E.3    Desiderio, M.A.4
  • 16
    • 0034663561 scopus 로고    scopus 로고
    • Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synovial fibroblasts
    • Thornton, R.D., Lane, P., Borghaei, R.C., Pease, E.A., Caro, J. & Mochan, E. (2000) Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synovial fibroblasts. Biochem. J. 350, 307-312.
    • (2000) Biochem. J. , vol.350 , pp. 307-312
    • Thornton, R.D.1    Lane, P.2    Borghaei, R.C.3    Pease, E.A.4    Caro, J.5    Mochan, E.6
  • 17
    • 0035012605 scopus 로고    scopus 로고
    • HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1α (HIF-1α) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
    • Laughner, E., Taghavi, P., Chiles, K., Mahon, P.C. & Semenza, G.L. (2001) HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1α (HIF-1α) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol. 21, 3995-4004.
    • (2001) Mol. Cell Biol. , vol.21 , pp. 3995-4004
    • Laughner, E.1    Taghavi, P.2    Chiles, K.3    Mahon, P.C.4    Semenza, G.L.5
  • 18
    • 0035937715 scopus 로고    scopus 로고
    • Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia
    • Chen, C., Pore, N., Behrooz, A., Ismail-Beigi, F. & Maity, A. (2001) Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia. J. Biol. Chem. 276, 9519-9525.
    • (2001) J. Biol. Chem. , vol.276 , pp. 9519-9525
    • Chen, C.1    Pore, N.2    Behrooz, A.3    Ismail-Beigi, F.4    Maity, A.5
  • 19
    • 0030659531 scopus 로고    scopus 로고
    • V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: Involvement of HIF-1 in tumor progression
    • Jiang, B.H., Agani, F., Passaniti, A. & Semenza, G.L. (1997) V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression. Can. Res. 57, 5328-5335.
    • (1997) Can. Res. , vol.57 , pp. 5328-5335
    • Jiang, B.H.1    Agani, F.2    Passaniti, A.3    Semenza, G.L.4
  • 21
    • 0034638623 scopus 로고    scopus 로고
    • Induction of hypoxia-inducible-factor 1 by nitric oxide is mediated via the PI 3K pathway
    • Sandau, K.B., Faus, H.G. & Brune, B. (2000) Induction of hypoxia-inducible-factor 1 by nitric oxide is mediated via the PI 3K pathway. Biochem. Biophys. Res. Commun. 278, 263-267.
    • (2000) Biochem. Biophys. Res. Commun. , vol.278 , pp. 263-267
    • Sandau, K.B.1    Faus, H.G.2    Brune, B.3
  • 22
    • 85047695603 scopus 로고    scopus 로고
    • Cell density mediated pericellular hypoxia leads to induction of HIF-1α via nitric oxide and Ras/MAP kinase mediated signaling pathways
    • Sheta, E.A., Trout, H., Gildea, J.J., Harding, M.A. & Theodorescu, D. (2001) Cell density mediated pericellular hypoxia leads to induction of HIF-1α via nitric oxide and Ras/MAP kinase mediated signaling pathways. Oncogene. 20, 7624-7634.
    • (2001) Oncogene , vol.20 , pp. 7624-7634
    • Sheta, E.A.1    Trout, H.2    Gildea, J.J.3    Harding, M.A.4    Theodorescu, D.5
  • 23
    • 0031901109 scopus 로고    scopus 로고
    • High cell density induces vascular endothelial growth factor expression via protein tyrosine phosphorylation
    • Mukhopadhyay, D., Tsiokas, L. & Sukhatme, V.P. (1998) High cell density induces vascular endothelial growth factor expression via protein tyrosine phosphorylation. Gene Expr. 7, 53-60.
    • (1998) Gene Expr. , vol.7 , pp. 53-60
    • Mukhopadhyay, D.1    Tsiokas, L.2    Sukhatme, V.P.3
  • 24
    • 0037008770 scopus 로고    scopus 로고
    • Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-Kinase/Target of rapamycin-dependent signaling pathway
    • Treins, C., Giorgetti-Peraldi, S., Murdaca, J., Semenza, G.L. & Van Obberghen, E. (2002) Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-Kinase/Target of rapamycin-dependent signaling pathway. J. Biol. Chem. 277, 27975-27981.
    • (2002) J. Biol. Chem. , vol.277 , pp. 27975-27981
    • Treins, C.1    Giorgetti-Peraldi, S.2    Murdaca, J.3    Semenza, G.L.4    Van Obberghen, E.5
  • 25
    • 0035312747 scopus 로고    scopus 로고
    • Regulation of translation initiation by FRAP/mTOR
    • Gingras, A.C., Raught, B. & Sonenberg, N. (2001) Regulation of translation initiation by FRAP/mTOR. Genes Dev. 15, 807-826.
    • (2001) Genes Dev. , vol.15 , pp. 807-826
    • Gingras, A.C.1    Raught, B.2    Sonenberg, N.3
  • 26
    • 0037064010 scopus 로고    scopus 로고
    • IGF-1 induces HIF-1-mediated VEGF expression that is dependent on MAP kinase and PI-3-kinase signaling in colon cancer cells
    • Fukuda, R., Hirota, K., Fan, F., Jung, Y.D., Ellis, L.M. & Semenza, G.L. (2002) IGF-1 induces HIF-1-mediated VEGF expression that is dependent on MAP kinase and PI-3-kinase signaling in colon cancer cells. J. Biol. Chem. 277, 38205-38211.
    • (2002) J. Biol. Chem. , vol.277 , pp. 38205-38211
    • Fukuda, R.1    Hirota, K.2    Fan, F.3    Jung, Y.D.4    Ellis, L.M.5    Semenza, G.L.6
  • 28
    • 0030869787 scopus 로고    scopus 로고
    • Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras- transformed cells through a hypoxia inducible factor-1 transcriptional element
    • Mazure, N.M., Chen, E.Y., Laderoute, K.R. & Giaccia, A.J. (1997) Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras- transformed cells through a hypoxia inducible factor-1 transcriptional element. Blood 90, 3322-3331.
    • (1997) Blood , vol.90 , pp. 3322-3331
    • Mazure, N.M.1    Chen, E.Y.2    Laderoute, K.R.3    Giaccia, A.J.4
  • 30
    • 0029753008 scopus 로고    scopus 로고
    • Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit
    • Huang, L.E., Arany, Z., Livingston, D.M. & Bunn, H.F. (1996) Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J. Biol. Chem. 271, 32253-32259.
    • (1996) J. Biol. Chem. , vol.271 , pp. 32253-32259
    • Huang, L.E.1    Arany, Z.2    Livingston, D.M.3    Bunn, H.F.4
  • 31
    • 0035313697 scopus 로고    scopus 로고
    • HIF-1 and mechanisms of hypoxia sensing
    • Semenza, G.L. (2001) HIF-1 and mechanisms of hypoxia sensing. Curr. Opin. Cell Biol. 13, 167-171.
    • (2001) Curr. Opin. Cell Biol. , vol.13 , pp. 167-171
    • Semenza, G.L.1
  • 32
    • 0035991511 scopus 로고    scopus 로고
    • Recombinant human interleukin (IL)-1beta-mediated regulation of hypoxia-inducible factor-1alpha (HIF-1alpha) stabilization, nuclear translocation and activation requires an antioxidant/reactive oxygen species (ROS)-sensitive mechanism
    • Haddad, J.J. (2002) Recombinant human interleukin (IL)-1beta-mediated regulation of hypoxia-inducible factor-1alpha (HIF-1alpha) stabilization, nuclear translocation and activation requires an antioxidant/reactive oxygen species (ROS)-sensitive mechanism. Eur. Cytokine Netw. 13, 250-260.
    • (2002) Eur. Cytokine Netw. , vol.13 , pp. 250-260
    • Haddad, J.J.1
  • 33
    • 0029993503 scopus 로고    scopus 로고
    • UV activates growth factor receptors via reactive oxygen intermediates
    • Huang, R.P., Wu, J.X., Fan, Y. & Adamson, E.D. (1996) UV activates growth factor receptors via reactive oxygen intermediates. J. Cell Biol. 133, 211-220.
    • (1996) J. Cell Biol. , vol.133 , pp. 211-220
    • Huang, R.P.1    Wu, J.X.2    Fan, Y.3    Adamson, E.D.4
  • 34
    • 0035856949 scopus 로고    scopus 로고
    • Insulin signalling and the regulation of glucose and lipid metabolism
    • Saltiel, A.R. & Kahn, C.R. (2001) Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414, 799-806.
    • (2001) Nature , vol.414 , pp. 799-806
    • Saltiel, A.R.1    Kahn, C.R.2
  • 35
    • 0031754373 scopus 로고    scopus 로고
    • Mersalyl is a novel inducer of vascular endothelial growth factor gene expression and hypoxia-inducible factor 1 activity
    • Agani, F. & Semenza, G.L. (1998) Mersalyl is a novel inducer of vascular endothelial growth factor gene expression and hypoxia-inducible factor 1 activity. Mol. Pharmacol. 54, 749-754.
    • (1998) Mol. Pharmacol. , vol.54 , pp. 749-754
    • Agani, F.1    Semenza, G.L.2
  • 36
    • 0035651033 scopus 로고    scopus 로고
    • Dissecting hypoxia-dependent and hypoxia-independent steps in the HIF-1α activation cascade: Implications for HIF-1α gene therapy
    • Hofer, T., Desbaillets, I., Hopfl, G., Gassmann, M. & Wenger, R.H. (2001) Dissecting hypoxia-dependent and hypoxia-independent steps in the HIF-1α activation cascade: implications for HIF-1α gene therapy. FASEB J. 15, 2715-2717.
    • (2001) FASEB J. , vol.15 , pp. 2715-2717
    • Hofer, T.1    Desbaillets, I.2    Hopfl, G.3    Gassmann, M.4    Wenger, R.H.5
  • 37
    • 0028785860 scopus 로고
    • Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1
    • Wang, G.L., Jiang, B.H. & Semenza, G.L. (1995) Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1. Biochem. Biophys. Res. Commun. 216, 669-675.
    • (1995) Biochem. Biophys. Res. Commun. , vol.216 , pp. 669-675
    • Wang, G.L.1    Jiang, B.H.2    Semenza, G.L.3
  • 38
    • 0030937718 scopus 로고    scopus 로고
    • Activation of hypoxia-inducible factor-1; definition of regulatory domains within the α subunit
    • Pugh, C.W., O'Rourke, J.F., Nagao, M., Gleadle, J.M. & Ratcliffe, P.J. (1997) Activation of hypoxia-inducible factor-1; definition of regulatory domains within the α subunit. J. Biol. Chem. 272, 11205-11214.
    • (1997) J. Biol. Chem. , vol.272 , pp. 11205-11214
    • Pugh, C.W.1    O'Rourke, J.F.2    Nagao, M.3    Gleadle, J.M.4    Ratcliffe, P.J.5
  • 39
    • 0037189565 scopus 로고    scopus 로고
    • The transcriptional activation function of the HIF-like factor requires phosphorylation at a conserved threonine
    • Gradin, K., Takasaki, C., Fujii-Kuriyama, Y. & Sogawa, K. (2002) The transcriptional activation function of the HIF-like factor requires phosphorylation at a conserved threonine. J. Biol. Chem. 277, 23508-23514.
    • (2002) J. Biol. Chem. , vol.277 , pp. 23508-23514
    • Gradin, K.1    Takasaki, C.2    Fujii-Kuriyama, Y.3    Sogawa, K.4
  • 41
    • 0032725554 scopus 로고    scopus 로고
    • p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1
    • Richard, D.E., Berra, E., Gothie, E., Roux, D. & Pouyssegur, J. (1999) p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1. J. Biol. Chem. 274, 32631-32637.
    • (1999) J. Biol. Chem. , vol.274 , pp. 32631-32637
    • Richard, D.E.1    Berra, E.2    Gothie, E.3    Roux, D.4    Pouyssegur, J.5
  • 42
    • 0034282553 scopus 로고    scopus 로고
    • The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1α
    • Sodhi, A., Montaner, S., Patel, V., Zohar, M., Bais, C., Mesri, E.A. & Gutkind, J.S. (2000) The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1α. Cancer Res. 60, 4873-4880.
    • (2000) Cancer Res. , vol.60 , pp. 4873-4880
    • Sodhi, A.1    Montaner, S.2    Patel, V.3    Zohar, M.4    Bais, C.5    Mesri, E.A.6    Gutkind, J.S.7
  • 43
    • 0033593219 scopus 로고    scopus 로고
    • Oxygen-regulated and transactivating domains in endothelial PAS protein 1: Comparison with hypoxia-inducible factor-1α
    • O'Rourke, J.F., Tian, Y.M., Ratcliffe, P.J. & Pugh, C.W. (1999) Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1α. J. Biol. Chem. 274, 2060-2071.
    • (1999) J. Biol. Chem. , vol.274 , pp. 2060-2071
    • O'Rourke, J.F.1    Tian, Y.M.2    Ratcliffe, P.J.3    Pugh, C.W.4
  • 44
    • 0035887011 scopus 로고    scopus 로고
    • FIH-1: A novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
    • Mahon, P.C., Hirota, K. & Semenza, G.L. (2001) FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev. 15, 2675-2686.
    • (2001) Genes Dev. , vol.15 , pp. 2675-2686
    • Mahon, P.C.1    Hirota, K.2    Semenza, G.L.3
  • 45
    • 0037097861 scopus 로고    scopus 로고
    • FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
    • Lando, D., Peet, D.J., Gorman, J.J., Whelan, D.A., Whitelaw, M.L. & Bruick, R.K. (2002) FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev. 16, 1466-1471.
    • (2002) Genes Dev. , vol.16 , pp. 1466-1471
    • Lando, D.1    Peet, D.J.2    Gorman, J.J.3    Whelan, D.A.4    Whitelaw, M.L.5    Bruick, R.K.6
  • 46
    • 0037070223 scopus 로고    scopus 로고
    • Normoxic induction of the hypoxia-inducible factor 1α by insulin and interleukin-1β involves the phosphatidylinositol 3-kinase pathway
    • Stiehl, D.P., Jelkmann, W., Wenger, R.H. & Hellwig-Burgel, T. (2002) Normoxic induction of the hypoxia-inducible factor 1α by insulin and interleukin-1β involves the phosphatidylinositol 3-kinase pathway. FEBS Lett. 512, 157-162.
    • (2002) FEBS Lett. , vol.512 , pp. 157-162
    • Stiehl, D.P.1    Jelkmann, W.2    Wenger, R.H.3    Hellwig-Burgel, T.4
  • 47
    • 0033854863 scopus 로고    scopus 로고
    • Translational control of malignancy: The mRNA cap-binding protein, eIF-4E, as a central regulator of tumor formation, growth, invasion and metastasis
    • Zimmer, S.G., DeBenedetti, A. & Graft, J.R. (2000) Translational control of malignancy: the mRNA cap-binding protein, eIF-4E, as a central regulator of tumor formation, growth, invasion and metastasis. Anticancer Res. 20, 1343-1351.
    • (2000) Anticancer Res , vol.20 , pp. 1343-1351
    • Zimmer, S.G.1    DeBenedetti, A.2    Graft, J.R.3
  • 48
    • 0030583293 scopus 로고    scopus 로고
    • In vivo expression of mRNAs encoding hypoxia-inducible factor 1
    • Wiener, C.M., Booth, G. & Semenza, G.L. (1996) In vivo expression of mRNAs encoding hypoxia-inducible factor 1. Biochem. Biophys. Res. Commun. 225, 485-488.
    • (1996) Biochem. Biophys. Res. Commun. , vol.225 , pp. 485-488
    • Wiener, C.M.1    Booth, G.2    Semenza, G.L.3
  • 50
    • 0033525830 scopus 로고    scopus 로고
    • Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway
    • Kallio, P.J., Wilson, W.J., O'Brien, S., Makino, Y. & Poellinger, L. (1999) Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway. J. Biol. Chem. 274, 6519-6525.
    • (1999) J. Biol. Chem. , vol.274 , pp. 6519-6525
    • Kallio, P.J.1    Wilson, W.J.2    O'Brien, S.3    Makino, Y.4    Poellinger, L.5
  • 51
    • 0037131271 scopus 로고    scopus 로고
    • Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha
    • Chan, D.A., Sutphin, P.D., Denko, N.C. & Giaccia, A.J. (2002) Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha. J. Biol. Chem 277, 40112-40117.
    • (2002) J. Biol. Chem. , vol.277 , pp. 40112-40117
    • Chan, D.A.1    Sutphin, P.D.2    Denko, N.C.3    Giaccia, A.J.4
  • 52
    • 0033673457 scopus 로고    scopus 로고
    • Normoxic stabilization of hypoxia-inducible factor-1 expression and activity: Redox-dependent effect of nitrogen oxides
    • Palmer, L.A., Gaston, B. & Johns, R.A. (2000) Normoxic stabilization of hypoxia-inducible factor-1 expression and activity: redox-dependent effect of nitrogen oxides. Mol. Pharmacol. 58, 1197-1203.
    • (2000) Mol. Pharmacol. , vol.58 , pp. 1197-1203
    • Palmer, L.A.1    Gaston, B.2    Johns, R.A.3
  • 53
    • 0027260899 scopus 로고
    • Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia
    • Kourembanas, S., McQuillan, L.P., Leung, G.K. & Faller, D.V. (1993) Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia. J. Clin. Invest. 92, 99-104.
    • (1993) J. Clin. Invest. , vol.92 , pp. 99-104
    • Kourembanas, S.1    McQuillan, L.P.2    Leung, G.K.3    Faller, D.V.4
  • 54
    • 0032511014 scopus 로고    scopus 로고
    • Carbon monoxide and nitric oxide suppress the hypoxic induction of vascular endothelial growth factor gene via the 5′ enhancer
    • Liu, Y., Christou, H., Morita, T., Laughner, E., Semenza, G.L. & Kourembanas, S. (1998) Carbon monoxide and nitric oxide suppress the hypoxic induction of vascular endothelial growth factor gene via the 5′ enhancer. J. Biol. Chem. 273, 15257-15262.
    • (1998) J. Biol. Chem. , vol.273 , pp. 15257-15262
    • Liu, Y.1    Christou, H.2    Morita, T.3    Laughner, E.4    Semenza, G.L.5    Kourembanas, S.6
  • 55
    • 0033605676 scopus 로고    scopus 로고
    • Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Implications for oxygen sensing and signaling
    • Huang, L.E., Willmore, W.G., Gu, J., Goldberg, M.A. & Bunn, H.F. (1999) Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Implications for oxygen sensing and signaling. J. Biol. Chem. 274, 9038-9044.
    • (1999) J. Biol. Chem. , vol.274 , pp. 9038-9044
    • Huang, L.E.1    Willmore, W.G.2    Gu, J.3    Goldberg, M.A.4    Bunn, H.F.5
  • 56
    • 0028786601 scopus 로고
    • A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter
    • Melillo, G., Musso, T., Sica, A., Taylor, L.S., Cox, G.W. & Varesio, L. (1995) A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter. J. Exp Med. 182, 1683-1693.
    • (1995) J. Exp. Med. , vol.182 , pp. 1683-1693
    • Melillo, G.1    Musso, T.2    Sica, A.3    Taylor, L.S.4    Cox, G.W.5    Varesio, L.6
  • 57
    • 0031041377 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia
    • Lee, P.J., Jiang, B.H., Chin, B.Y., Iyer, N.V., Alam, J., Semenza, G.L. & Choi, A.M. (1997) Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia. J. Biol. Chem. 272, 5375-5381.
    • (1997) J. Biol. Chem. , vol.272 , pp. 5375-5381
    • Lee, P.J.1    Jiang, B.H.2    Chin, B.Y.3    Iyer, N.V.4    Alam, J.5    Semenza, G.L.6    Choi, A.M.7
  • 58
    • 0029789432 scopus 로고    scopus 로고
    • Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells
    • Zeng, G. & Quon, M.J. (1996) Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells. J. Clin. Invest. 98, 894-898.
    • (1996) J. Clin. Invest. , vol.98 , pp. 894-898
    • Zeng, G.1    Quon, M.J.2
  • 62
    • 0032891180 scopus 로고    scopus 로고
    • Endothelial cell responses to hypoxic stress
    • Faller, D.V. (1999) Endothelial cell responses to hypoxic stress. Clin. Exp Pharmacol. Physiol. 26, 74-84.
    • (1999) Clin. Exp. Pharmacol. Physiol. , vol.26 , pp. 74-84
    • Faller, D.V.1
  • 63
    • 0029070920 scopus 로고
    • Hypoxia-mediated induction of acidic/basic fibroblast growth factor and platelet-derived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial cells
    • Kuwabara, K., Ogawa, S., Matsumoto, M., Koga, S., Clauss, M., Pinsky, D.J., Lyn, P., Leavy, J., Witte, L., Joseph-Silverstein, J. et al. (1995) Hypoxia-mediated induction of acidic/basic fibroblast growth factor and platelet-derived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial cells. Proc. Natl Acad. Sci. USA 92, 4606-4610.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 4606-4610
    • Kuwabara, K.1    Ogawa, S.2    Matsumoto, M.3    Koga, S.4    Clauss, M.5    Pinsky, D.J.6    Lyn, P.7    Leavy, J.8    Witte, L.9    Joseph-Silverstein, J.10
  • 64
    • 0028843411 scopus 로고
    • Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents
    • Gleadle, J.M., Ebert, B.L., Firth, J.D. & Ratcliffe, P.J. (1995) Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents. Am. J. Physiol. 268, C1362-C1368.
    • (1995) Am. J. Physiol. , vol.268
    • Gleadle, J.M.1    Ebert, B.L.2    Firth, J.D.3    Ratcliffe, P.J.4
  • 65
    • 0033582315 scopus 로고    scopus 로고
    • Identification of inducible genes at the early stage of adipocyte differentiation of 3T3-L1 cells
    • Imagawa, M., Tsuchiya, T. & Nishihara, T. (1999) Identification of inducible genes at the early stage of adipocyte differentiation of 3T3-L1 cells. Biochem. Biophys. Res. Commun. 254, 299-305.
    • (1999) Biochem. Biophys. Res. Commun. , vol.254 , pp. 299-305
    • Imagawa, M.1    Tsuchiya, T.2    Nishihara, T.3
  • 68
    • 0035900767 scopus 로고    scopus 로고
    • Glucose catabolism in cancer cells: Identification and characterization of a marked activation response of the type II hexokinase gene to hypoxic conditions
    • Mathupala, S.P., Rempel, A. & Pedersen, P.L. (2001) Glucose catabolism in cancer cells: identification and characterization of a marked activation response of the type II hexokinase gene to hypoxic conditions. J. Biol. Chem. 276, 43407-43412.
    • (2001) J. Biol. Chem. , vol.276 , pp. 43407-43412
    • Mathupala, S.P.1    Rempel, A.2    Pedersen, P.L.3


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