Transcriptional mechanisms regulating myeloid-specific genes

Gene

Volumn 284, Issue 1-2, 2002, Pages 1-21

  Skalnik, David G ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AML1; CCAAT enhancer binding protein; Eosinophil; Granulocyte; Macrophage; PU.1

Indexed keywords

BONE MARROW CELL; CELL DIFFERENTIATION; CELL MATURATION; HUMAN; LEUKEMIA; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; TRANSCRIPTION REGULATION;

ANIMALS; CELL LINEAGE; GENE EXPRESSION REGULATION; HUMANS; MYELOID CELLS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0037028506     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(02)00387-6     Document Type: Review

References (293)

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2. CCAAT displacement protein binds to and negatively regulates human papillomavirus type 6†E6, E7, and E1 promoters
3. A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family
4. The MAR binding protein SATB1 orchestrates temporal and spatial expression of multiple gene during T cell development
5. Repression of the mouse M-lysozyme gene involves both hindrance of enhancer factor binding to the methylated enhancer and histone deacetylation
6. Neutrophils deficient in PU.1 do not terminally differentiate or become functionally competent
7. Clox, a mammalian homeobox gene related to Drosophila cut, encodes DNA-binding regulatory proteins differentially expressed during development
8. An oligomer complementary to c-myb-encoded mRNA inhibits proliferation of human myeloid leukemia cell lines
9. Structural and functional characterization of the human CD36 gene promoter
10. Isolation of PEBP2αB cDNA representing the mouse homolog of human acute myeloid leukemia gene, AML1
11. Interaction of the nuclear matrix-associated region (MAR)-binding proteins, SATB1 and CDP/Cux, with a MAR element (L2a) in an upstream regulatory region of the mouse CD8a gene
12. A direct physical association between ETS and AP-1 transcription factors in normal human T cells
13. Definition of interferon gamma-response elements in a novel human Fc gamma receptor gene (Fc gamma RIb) and characterization of the gene structure
14. Granulocyte colony-stimulating factor induction of normal human bone marrow progenitors results in neutrophil-specific gene expression
15. Patterns of expression of Cut, a protein required for external sensory organ development in wild-type and cut mutant Drosophila embryos
16. Tissue specific and position independent expression of the complete gene domain for chicken lysozyme in transgenic mice
17. Increased DNa binding and transcriptional activity associated with transcription factor Sp1 in K562 cells transfected with the myeloid-specific c-fes tyrosine kinase gene
18. Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells
19. Granules of the human neutrophlic polymorphonuclear leukocyte
20. Biosynthesis of granule proteins in normal human bone marrow cells. Gelatinase is a marker of terminal neutrophil differentiation
21. The translocation t(8;16) (p11;13) of acute myeloid leukemia fuses a putative acetyltransferase to the CREB-binding protein
22. Core binding factor cannot synergistically activate the myeloperoxidase proximal enhancer in immature myeloid cells without c-myb
23. Dichotomy of AML1-ETO functions: Growth arrest versus block of differentiation
24. Phorbol ester-stimulated phosphorylation of PU.1: Association with leukemic cell growth inhibition
25. Overexpression of CCAAT displacement protein represses the promiscuously active proximal gp91(phox) promoter
26. Down regulation of myeloperoxidase gene associated with specific nuclease hypersensitive sites during TPA induced differentiation of HL-60
27. A nuclear matrix attachment region upstream of the T cell receptor beta †gene enhancer binds Cux/CDP and SATB1 and modulates enhancer-dependent reporter gene expression but not endogenous gene expression
28. The Sp1 transcription factor binds the CD11b promoter specifically in myeloid cells in vivo and is essential for myeloid-specific promoter activity
29. Neutrophils and monocytes express high levels of PU.1 (Spi-1) but not Spi-B
30. PU.1 (Spi-1) autoregulates its expression in myeloid cells
31. Temporal mapping of gene expression levels during the differentiationof individual primary hematopoietic cells
32. CCAAT/enhancer binding protein gene promoter: Binding of nuclear factors during differentiation of 3T3-L1 preadipocytes
33. Myeloid-specific gene expression
34. The human lysozyme promoter directs reporter gene expression to activated myelomonocytic cells in transgenic mice
35. Regulation of GM-CSF gene transcription by core-binding factor
36. DNA binding by cut homeodomain proteins is down-modulated by protein kinase C
37. The mammalian Cut homeodomain protein functions as a cell-cycle-dependent transcriptional repressor which down modulates p21WAF1/CIP1/SDI1 in S phase
38. DNA binding by cut homeodomain proteins is down-modulated by casein kinase II
39. Lineage- and stage-specific expression of runt box polypeptides in primitive and definitive hematopoiesis
40. Localization of human neutrophil peptide (HNP) and its messenger RNA in neutrophil series
41. Regulation of B lymphocyte and macrophage development by graded expression of PU.1
42. PU.1 regulates both cytokine dependent proliferation and differentiation of granulocyte/macrophage progenitors
43. Role of gelatinase B and elastase in human polymorphonucloear neutrophil migration across basement membrane
44. Immunocytichemical and flow cytometric detection of proteinase 3 (myeloblastin) in normal and leukaemic myeloid cells
45. A tissue-specific MAR/SAR DNA-binding protein with unusual binding site recognition
46. An atypical homeodomain in SATB1 promotes specific recognition of the key structural element in a matrix attachment region
47. Molecular genetics of chronic granulomatous disease
48. Requirement for nuclear factor (NF)-kappa B p65 and NF-interleukin-6 binding elements in the tumor necrosis factor response region of the granulocyte colony-stimulating factor promoter
49. The CD11b promoter directs high-level expression of reporter genes in macrophages in transgenic mice
50. Mice transgenic for the human CGM6 gene express its product, the granulocyte marker CD66b, exclusively in granulocytes
51. Restriction of interferon gamma responsiveness and basal expression of the myeloid human Fc gamma R1b gene is mediated by a functional PU.1 site and a transcription initiator consensus
52. Recruitment of CREB-binding protein by PU.1, IFN-regulatory factor-1, and the IFN consensus sequence-binding protein is necessary for IFN-γ-induced p67phox and gp91phox expression
53. PU.1, interferon regulatory factor 1, and interferon consensus sequence-binding protein cooperate to increase gp91phox expression
54. Tyrosine phosphorylation of HoxA10 decreases DNA binding and transcriptional repression during interferon gamma-induced differentiation of myeloid leukemia cell lines
55. The transcriptional repressor CDP (Cutl1) is essential for epithelial cell differentiation of the lung and the hair follicle
56. Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt
57. PU.1 and an HLH family member contribute to the myeloid-specific transcription of the FcgRIIIA promoter
58. Reversible tumorigenesis by MYC in hematopoietic lineages
59. Double knockout of the ALL-1 gene blocks hematopoietic differentiation in vitro
60. To be or not to be active: The stochastic nature of enhancer action
61. Regulation of the myeloperoxidase enhancer binding proteins PU.1, C-EBPα, -β, and -δ during granulocyte-lineage specification
62. The murine myeloperoxidase gene contains a bipartite distal enhancer, including a novel region regulated by PEBP2/CBF
63. Macrophage foam cells from experimental atheroma constitutively produce matrix-degrading proteinases
64. Expression of c-jun during macrophage differentiation of HL-60 cells
65. A c-myb antisense oligodeoxy-nucleotide inhibits normal human hematopoiesis in vitro
66. The far upstream chicken lysozyme enhancer at -6.1 kb, by interacting with NF-M, mediates lipopolysaccharide-induced expression of the chicken lysozyme gene in chicken myelomonocytic cells
67. Combinatorial activation of the eosinophil major basic protein gene requires transcription factors C/EBPε, PU.1 and GATA-1
68. Neutrophil-specific granule deficiency: Homozygous recessive inheritance of a frameshift mutation in the gene encoding transcription factor CCAAT/enhancer binding protein-epsilon
69. Human eosinophil Charcot-Leyden crystal protein: Cloning and characterization of a lysophospholipase gene promoter
70. Myeloid expression of the human c-fps/fes proto-oncogene in transgenic mice
71. Early myeloid cell-specific expression of the human cathepsin G gene in transgenic mice
72. C/EBP, NF-κB, and c-Ets family members and transcriptional regulation of the cell-specific and inducible macrophage inflammatory protein 1α immediate-early gene
73. The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB
74. Developmental regulation of the human cathepsin G gene in myelomonocytic cells
75. Undermethylaion and DNase I hypersensitivity of myeloperoxidase gene in HL-60 cells before and after differentiation
76. The transcription factor Sp1 regulates the myeloid-specific expression of the human hematopoietic cell kinase (HCK) gene through binding to two adjacent GC boxes within the HCK promoter-proximal region
77. The matrix attachment region-binding protein SATB1 interacts with multiple elements within the gp91-phox promoter and is down regulated during myeloid differentiation
78. c-Maf interacts with c-myb to regulate transcription of an early myeloid gene during differentiation
79. PU.1 but not Ets-2 is essential for macrophage development from embryonic stem cells
80. Commitment of the monocytic lineage occurs in the absence of the transcription factor PU.1
81. Distinct temporal patterns of defensin mRNA regulation during drug-induced differentiation of human myeloid leukemia cells
82. Characterization of human endotoxin lipopolysaccharide receptor CD14 expression in transgenic mice
83. The myeloid-cell-specific c-fes promoter is regulated by Sp1, PU.1, and a novel transcription factor
84. A minimal c-fes cassette directs myeloid-specific expression in transgenic mice
85. Expression of granule protein mRNA in acute promyelocytic leukemia
86. c-Jun as a co-activator of the myeloid transcription factor PU.1: Combinatorial interaction with C/EBPβ
87. Suppression of c-myc and -myb is tightly linked to terminal differentiation induced by IL6 or LIF and not growth inhibition in myeloid leukemia cells
88. PU.1 (Spi-1) and C/EBPα regulate the expression of the granulocyte-macrophage colony-stimulating factor receptor α gene
89. An oligomer complementary to c-myc mRNA inhibits proliferation of HL-60 promyelocytic cells and induces differentiation
90. Inhibition of GATA-1 acetylation by the Ets-family oncoprotein PU.1
91. Myeloperoxidase: Expression and modulation in a large panel of human leukemia-lymphoma cell lines
92. Recruitment of CD11b/CD18 to the neutrophil surface and adherence-dependent cell locomotion
93. Probability in transcriptional regulation and its implications for leukocyte differentiation and inducible gene expression
94. Adenovirus E1A-associated protein p300 is involved in acute myeloid leukemia with t(11;22) (q23;q13)
95. CDP/cut and C/EBP are essential in regulating the activity of the human neutrophil collagenase promoter in late myeloid differentiation
96. Regulation of the CD13/aminopeptidase N gene by DMP1, a transcription factor antagonized by D-type cyclins
97. Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBPα
98. YY1 binds five cis-elements and trans-activates the myeloid cell-restricted gp91-phox promoter
99. Role of positive and negative cis-regulatory elements in the transcriptional activation of the lysozyme locus in developing macrophages of transgenic mice
100. c-Myc is a critical target for C/EBPα in granulopoiesis
101. Chromatin structural analysis of the 5′ end and contiguous flanking region of the myeloperoxidase gene
102. SHP1 protein tyrosine phosphatase inhibits gp91phox and p67phox expression by inhibiting interaction of PU.1, IRF1, ICSBP and CBP with homologous cis elements in the CYBB and NCF2 genes
103. CCAAT displacement protein (CDP/cut) recognizes a silencer element within the lactoferrin gene promoter
104. Sp1 and C/EBP are necessary to activate the lactoferrin gene promoter during myeloid differentiation
105. C/EBP-ε mediates myeloid differentiation and is regulated by the CCAAT displacement protein (CDP-cut)
106. Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloic cell differentiation
107. The involvement of demethylation in the myeloid-specific function of the mouse M lysozyme gene downstream enhancer
108. A thymocyte factor SATB1 suppresses transcription of stably integrated matrix-attachment region-linked reporter genes
109. Monocyte expression of the human prointerleukin 1 beta gene (IL1B) is dependent on promoter sequences which bind the hematopoietic transcription factor Spi-1/PU.1
110. Chromatin fine structure profiles for a developmentally regulated gene: Reorganization of the lysozyme locus before trans-activator binding and gene expression
111. The -3.9 kb DNaseI hypersensitive site of the chicken lysozyme locus harbours an enhancer with unusual chromatin reorganzing activity
112. Representational difference analysis using myeloid cells from C/EBPε deletional mice
113. Human peripheral eosinophils have a specific mechanism to express gp91-phox, the large subunit of cytochrome b558
114. The DNA binding domain of the rat liver nuclear protein C/EBP is bipartite
115. Isolation and characterization of the cDNA for mouse neutrophil collagenase: Demonstration of shared negative regulatory pathways for neutrophil secondary granule protein gene expression
116. Targeting of proteins to granule subsets is determined by timing and not by sorting: The specific granule protein NGAL is localized to azurophil granules when expressed in HL-60 cells
117. The p50 subunit of NF-κB associates with the NF-IL6 transcription factor
118. Neutrophil-mediated tissue injury
119. Defensins: Endogenous antibiotic peptides of animal cells
120. CCAAT/enhancer binding protein ε is critical for effective neutrophil-mediated response to inflammatory challenge
121. Neutrophil-specific granule deficiency results from a novel mutation with loss of function of the transcription factor CCAAT/enhancer binding protein ε
122. phox promoter activity in myeloid cells
123. Transcriptional repression of the cystic fibrosis transmembrane conductance regulator gene, mediated by CCAAT displacement protein/cut homolog, is associated with histone deacetylation
124. Critical flanking sequences of PU.1 binding sites in myeloid-specific promoters
125. Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein (CBP)-associated factor and CBP
126. Regulation of the PU.1 gene by distal elements
127. Regulation of the myeloid-cell-expressed human gp91-phox gene as studied by transfer of yeast artificial chromosome clones into embryonic stem cells: Suppression of a variegated cellular pattern of expression requires a full complement of distant cis elements
128. Repressor activity of CCAAT displacement protein in HL60 myeloid leukemia cells
129. Expression of the leukemic fusion protein, PML/RARα, inhibits C/EBPα DNA binding and blocks granulocytic differentiation
130. Oncogenic role of 'master' transcription factors in human leukemias and sarcomas: A developmental model
131. CCAAT-enhancer-binding proteins (C/EBP) regulate the tissue specific activity of the CD11c integrin gene promoter through functional interactions with Sp1 proteins
132. Proto-oncogenes of the fos-jun family of transcription factors are positive regulators of myeloid differentiation
133. Macrophage nitric oxide synthase gene: Two upstream regions mediate induction by interferon γ and lipopolysaccharide
134. Changes of DNA methylation and chromatin structure in the human myeloperoxidase gene during myeloid differentiation
135. A switch toward demethylation is associated with the expression of myeloperoxidase in acute myeloblastic and promyelocytic leukemias
136. The human lysozyme gene undergoes stepwise demethylation during phagocyte maturation
137. Cytosine demethylation of the proteinase-3/myeloblastin primary granule protease gene during phagocyte development
138. CCAAT displacement protein competes with multiple transcriptional activators for binding to four sites in the proximal gp91-phox promoter
139. Interferon regulatory factor-2 directs transcription from the gp91-phox promoter
140. Myeloblastin is a granulocyte colony-stimulating factor-responsive gene conferring factor-independent growth to hematopoietic cells
141. Myeloblastin is an Myb target gene: Mechanisms of regulation in myeloid leukemia cells growth-arrested by retinoic acid
142. The deletion of the distal CCAAT box region of the Aγ-globin gene in black HPFH abolishes the binding of the erythroid specific protein NFE3 and of the CCAAT displacement protein
143. Differential phosphorylations of Spi-B and Spi-1 transcription factors
144. Localization of an abundant myeloid mRNA to individual leukocytes in mixed cell populations
145. Transcription factors NF-IL6 and NF-κB synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8
146. cAMP stimulates the C/EBP-related transcription factor rNFIL-6 to trans-locate to the nucleus and induce c-fos transcription
147. Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: The runt homology domain is required for DNA binding and protein-protein interactions
148. The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript
149. The mouse M-lysozyme gene domain: Identification of myeloid and differentiation specific DNaseI hypersensitive sites and of a 3′-cis acting regulatory element
150. Differences in expression of transcription factor AP-1 in human promyelocytic HL-60 cells during differentiation towards macrophages versus granulocytes
151. S phase-specific proteolytic cleavage is required to activate stable DNA binding by the CDP/Cut homeodomain protein
152. A novel, myeloid transcription factor, C/EBP epsilon, is upregulated during granulocytic, but not monocytic, differentiation
153. Cell-specific expression of the macrophage scavenger receptor gene is dependent on PU.1 and a composite AP-1/ets motif
154. A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis
155. Evaluation of the expression of the cationic peptide gene in various types of leukocytes
156. Granulocyte colony-stimulating factor regulates myeloid differentiation through CCAAT/enhancer-binding protein ε
157. Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6
158. Role of the multifunctional CDP/Cut/Cux homeodomain transcription factor in regulating differentiation, cell growth and development
159. Distinct C/EBP functions are required for eosinophil lineage commitment and maturation
160. GATA-1 interacts with the myeloid PU.1 transcription factor and represses PU.1-dependent transcription
161. Regulatory interactions between transcription factors and their role in hematopoietic lineage determination
162. Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut
163. Mutations in the promoter region of the gene for gp91-phox in X-linked chronic granulomatous disease with decreased expression of cytochrome b558
164. Methylation of the mouse M-lysozyme downstream enhancer inhibits heterotetrameric GABP binding
165. The role of CDP in the negative regulation of CXCL1 gene expression
166. Sp1 binds two sites in the CD11c promoter in vivo specifically in myeloid cells and cooperates with AP1 to activate transcription
167. Structural and functional characterization of the leukocyte integrin gene CD11d. Essential role of Sp1 and Sp3
168. PEB2/CBF, the murine homolog of the human myeloid AML1 and PEB2β/CBFβ proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells
169. GABP cooperates with c-myb and C/EBP to activate the neutrophil elastase promoter
170. An enhancer located between the neutrophil elastase and proteinase 3 promoters is activated by Sp1 and an Ets factor
171. The differentiation-specific factor CDP/Cut represses transcription and replication of human papillomaviruses through a conserved silencing element
172. C/EBP, c-myb, and PU.1 cooperate to regulate the neutrophil elastase promoter
173. Molecular cloning and characterizaion of PEBP2β, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2α
174. PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the Human hML1 gene
175. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis
176. PU.1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation
177. Transcription factors and hematopoietic development
178. Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia
179. AML1-ETO down regulates the granulocytic differentiation factor C/EBPα in t(8;21) myeloid leukemia
180. Characterization of the myeloid-specific CD11b promoter
181. The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter
182. Phagocytic NADPH oxidase and its role in chronic granulomatous disease
183. CCAAT/enhancer-binding protein activates the CD14 promoter and mediates transforming growth factor beta signaling in monocyte development
184. CCAAT/enhancer binding protein epsilon is a potential retinoid target gene in acute promyelocytic leukemia treatment
185. Macrophages in cardiovascular disease
186. CCAAT displacement protein, a regulator of differentiation-specific gene expression, binds a negative regulatory element within the 5′ end of the human papillomavirus type 6 long control region
187. The Sfp-1 proviral integration site of friend erythroleukemia encodes the ets-related transcription factor PU.1
188. Activation of the endogenous metalloproteinase, gelatinase, by triggered human neutrophils
189. Two cis-DNA elements involved in myeloid-cell-specific expression and gamma interferon (IFNγ) activation of the human high-affinity Fcγ receptor gene: A novel IFN regulatory mechanism
190. An Alu element in the myeloperoxidase promoter contains a composite SP1-thyroid hormone-retinoic acid response element
191. C/EBPβ regulation of the tumor necrosis factor α gene
192. Antagonism between C/EBPbeta and FOG in eosinophil lineage commitment of multipotent hematopoietic progenitors
193. Lactoferrin biosynthesis during granulocytopoiesis
194. Isolation of lactoferrin cDNA from a human myeloid library and expression of mRNA during normal and leukemic myelopoisis
195. CCAAT/enhancer binding protein α is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors
196. C/EBP alpha downregulates c-jun expression: Significance in AML and granulopoiesis
197. Opposing actions of c-ets/PU.1 and c-myb protooncogene products in regulating the macrophage-specific promoters of the human and mouse colony-stimulating factor-1 receptor (c-fms) genes
198. Analysis of the role of AML1-ETO in leukemogenesis, using an inducible transgenic mouse model
199. The human leukocyte integrin CD11a promoter directs expression in leukocytes of transgenic mice
200. Modulation of transcription factor Sp1 by cAMP-dependent protein kinase
201. Differential expression of CD11b/CD18 (MO1) and myeloperoxidse genes during myeloid differentiation
202. CD18 (b2 leukocyte integrin) promoter requires PU.1 transcription factor for myeloid activity
203. Sp1 cooperates with the ets transcription factor, GABP, to activate the CD18 (beta 2 leukocyte integrin) promoter
204. The pathogenesis of atherosclerosis: A perspective for the 1990s
205. All patients with the t(11;16) (q23;p13.3) that involves MLL and CBP have treatment-related hematologic disorders
206. Developmental expression of Sp1 in the mouse
207. Differential expression of subspecies of polyomavirus and mjurine leukemia virus enhancer core binding protein, PEBP2, in various hematopoietic cells
208. Novel MLL-CBP fusion transcript in therapy-related chronic myelomonocytic leukemia with a t(11;16) (q23;p13) chromosome translocation
209. Regional localization of the CCAAT displacement protein gene (CUTL1) to 7q22 by analysis of somatic cell hybrids
210. A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells
211. The transcription factor PU.1 is required for the development of multiple hematpoietic lineages
212. Lymphoproliferative disorder and imbalanced T-helper response in C/EBP beta-deficient mice
213. Myeloblastic leukemia cells conditionally blocked by Myc-estrogen receptor chimeric transgenes for terminal differentiation coupled to growth arrest and apoptosis
214. Myb and Ets proteins cooperate to transactivate an early myeloid gene
215. Separate promoters control transcription of the human aminopeptidase N gene in myeloid and intestinal epithelial cells
216. AML1-MTG8 leukemic protein induces the expression of granulocyte colony-stimulating factor (G-CSF) receptor through the up-regulation of CCAAT/enhancer binding protein epsilon
217. The human prointerleukin 1 beta gene requires DNA sequences both proximal and distal to the transcription start site for tissue-specific induction
218. The transcriptional control of hematopoiesis
219. Lymphoid apoptosis and myeloid hyperplasia in CCAAT displacement protein (cux/CDP) mutant mice
220. Targeting of trangene expression to monocyte/macrophages by the gp91-phox promoter and consequent histiocytic malignancies
221. Restriction of neuroblastoma to the prostate gland in transgenic mice
222. CCAAT displacement protein as a repressor of the myelomonocytic-specific gp91-phox promoter
223. PU.1 (Spi-1) and C/EBP alpha regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells
224. MLL is fused to CBP, a histone acetyletransferase, in therapy-related acute myeloid leukemia with a t(aa;16) (q23;p13.3)
225. Control of hematopoietic differentiation: Lack of specificity in signaling by cytokine receptors
226. A 30-base pair element is responsible for the myeloid-specific activity of the human neutrophil elastase promoter
227. Distinct mechanisms for regulation of the interleukin-8 gene involve synergism and cooperativity between C/EBP and NF-κB
228. Functional and physical associations between NF-kappa B and C/EBP family members: A Rel domain-bZIP interaction
229. Human proteinase-3 expression is regulated by PU.1 in conjunction with a cytidine-rich element
230. The protein CDP, but not CP1, footprints on the CCAAT region of the γ-globin gene in unfractionated B-cell extracts
231. The murine myeloperoxidase promoter contains several functional elements, one of which binds a cell type-restricted transcription factor, myeloid nuclear factor 1 (MyNF1)
232. PU.1 as an essential activator for the expression of gp91phox gene in human peripheral neutrophils, monocytes, and B lymphocytes
233. Positive and negative regulation of granulocyte-macrophage colony-stimulating factor promoter activity by AML1-related transcription factor
234. The t(11;16) (q23;p13) translocation in myelodyspastic syndrome fuses the MLL gene to the CBP gene
235. Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages
236. The extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product, and potentially regulates its transactivation ability
237. Cooperation between core binding factor and adjacent promoter elements contributes to the tissue-specific expression of interleukin-3
238. CCAAT displacement protein (CDP/Cut) binds a negative regulatory element in the human tryptophan hydroxylase gene
239. Myeloid transcription factors and development
240. Transcription factors, normal myeloid development, and leukemia
241. Analysis of the rat JE gene promoter identifies an AP-1 binding site essential for basal expression but not for TPA induction
242. Effects of myeloid cell growth factors on alkaline phosphatase, myeloperoxidase, defensin, and granulocyte colony-stimulating factor receptor mRNA expression in haemopoietic cells of normal individual and myeloid disorders
243. Role of CCAAT-enhancer-binding proteinsite in transcription of human neutrophil peptide-1 and -3 defensin genes
244. AML1A and AML1B can transactivate the human IL-3 promoter
245. The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype
246. The role of transcription factor PU.1 in the activity of the intronic enhancer of the eosinophil-derived neurotoxin (RNS2) gene
247. The CCAAT displacement protein/cut homeodomain protein represses osteocalcin gene transcription and forms complexes with the retinoblastoma protein-related protein p107 and cyclin A
248. Expression of a cut-related homeobox gene in developing and polycystic mouse kidney
249. Myeloid transcription factor C/EBPepsilon is involved in the positive regulation of lactoferrin gene expression in neutrophils
250. C/EBPε -/- mice: Increased rate of myeloid proliferation and apoptosis
251. GATA-1 but not SCL induces megakaryocytic differentiation in an early myeloid cell line
252. Two-step model of leukocyte endothelial cell interaction in inflammation: Distinct roles for LECAM-1 and the leukocyte β2 integrins in vivo
253. Elf-1 and PU.1 induce expression of gp91phox via a promoter element mutated in a subset of chronic granulomatous disease patients
254. Inhibition of hematopoiesis by competitive binding of transcription factor PU.1
255. Purification of core-binding factor, a protein that binds the conserved core site in murine leukemia virus enhancers
256. Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor
257. C/EBPα bypasses granulocyte colony-stimulating factor signals to rapidly induce PU.1 gene expression, stimulate granulocytic differentiation, and limit proliferation in 32Dc13 myeloblasts
258. Cux-CDP homeoprotein is a component of NF-uNR and represses the immunoglobulin heavy chain intronic enhancer by antagonizing the bright transcription activator
259. Regulation of granulopoiesis by transcription factors and cytokine signals
260. The induction of uterine leiomyomas and mammary tumors in transgenic mice expressing polyomavirus (PyV) large T (LT) antigen is associated with the ability of PyV LT antigen to form specific complexes with retinoblastoma and CUTL1 family members
261. Chlorination of taurine by human nuetrophils: Evidence for hypochlorous acid generation
262. Oxidative autoactivation of latent collagenase by human neutrophils
263. Rheumatoid arthritis: The role of neutrophil activation
264. The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-α, inhibits C/EBP-α-dependent transcription, and blocks granulocytic differentiation
265. PU.1 regulates the CXCR1 promoter
266. Stem cell model of hematopoiesis
267. C/EBPε is a myeloid-specific activator of cytokine, chemokine, and macrophage-colony-stimulating factor receptor genes
268. Changes in chromatin organization at the neutrophil elastase locus associated with myeloid cell differentiation
269. A new X-linked variant of chronic granulomatous disease characterized by the existence of a normal clone of respiratory burst-competent phagocytic cells
270. C/EBPβ and GATA-1 synergistically regulate activity of the eosinophil granule major basic protein promoter: Implication for C/EBPβ activity in eosinophil gene expression
271. Impaired granulopoiesis, myelodysplasia and early lethality in CCAAT/enhancer binding protein ε-deficient mice
272. CCAAT-enhancer binding protein is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing
273. Eosinophil-specific regulation of gp91phox gene expression by transcription factors GATA-1 and GATA-2
274. NF-IL6 (C/EBPbeta) vigorously activates il1b gene expression via a Spi-1 (PU.1) protein-protein tether
275. Isolation of two E-box binding factors that interact with the rat tyrosine hydroxylase enhancer
276. Altered Hox expression and segmental identify in Mll-mutant mice
277. AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations
278. Loss of heterozygosity and reduced expression of the CUTL1 gene in uterine leiomyomas
279. Refined mapping of the region of loss of heterozygosity on the long arm of chromosome 7 in human breast cancer defines the location of a second tumor suppressor gene at 7q22 in the region of the CUTL1 gene
280. Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1)
281. The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor
282. Sp1 is a critical factor for the monocytic specific expression of human CD14
283. Activation of the interleukin 6 gene by mycobacterium tuberculosis or lipopolysaccharide is mediated by nuclear factors NF-IL6 and NF-κB
284. CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter
285. Function of PU.1 (Spi-1), C/EBP, and AML1 in early myelopoiesis: Regulation of multiple myeloid CSF receptor promoters
286. Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein α-deficient mice
287. Up regulation of interleukin 6† and granulocyte colony-stimulating factor receptors by transcription factor CCAAT enhancer binding protein alpha †(C/EBPalpha) is critical for granulopoiesis
288. C/EBPα physically interacts with and recruits the chromatin remodeling complex (SWI/SNF) to myeloid promoters
289. PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding
290. A myeloid-lineage-specific enhancer upstream of the mouse myeloperoxidase (MPO) gene
291. AML1 is expressed in skeletal muscle and is regulated by innervation
292. Three human elastase-like genes coordinately expressed in the myelomonocytic lineage are organized as a single genetic locus on 19pter