Probability in transcriptional regulation and its implications for leukocyte differentiation and inducible gene expression

Blood

Volumn 96, Issue 7, 2000, Pages 2323-2328

  Hume, David A ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; LYMPHOKINE;

ALLELE; CELL DIFFERENTIATION; CELL LINEAGE; CELL POPULATION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE INDUCTION; GENETIC HETEROGENEITY; GENETIC TRANSCRIPTION; HEMATOPOIESIS; HEMATOPOIETIC CELL; LEUKOCYTE; MAMMAL CELL; PHENOTYPE; PRIORITY JOURNAL; REVIEW; STEM CELL; STOCHASTIC MODEL; TRANSCRIPTION REGULATION;

EID: 0034307684     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.7.2323.h8002323_2323_2328     Document Type: Review

References (75)

1. Regulation of the plasminogen activator inhibitor type 2 gene in murine macrophages: Demonstration of a novel pattern of responsiveness to bacterial endotoxin
2. Assembly and disassembly of the Drosophila RNA polymerase II complex during transcription
3. RNA polymerase II transcription complex assembly in nuclear extracts
4. Active RNA polymerases are localized with discrete transcription 'factories' in human nuclei
5. Regional and temporal specialization in the nucleus; a transcriptionally active nuclear domain rich in PTF, Oct1 and PIKA antigenes associates with specific chromosomes early in the cell cycle
6. Regional specialization in human nuclei: Visualization of discrete sites of transcription by RNA polymerase III
7. Nuclear distribution of transcription factors in relation to sites of transcription and RNA polymerase II
8. Functional compartmentalization of the nucleus
9. Distribution of pre-mRNA splicing factors at sites of RNA polymerase II transcription
10. The dynamics of pre-mRNA splicing factor in living cells
11. Dynamic relocation of transcription and splicing factors dependent upon transcriptional activity
12. Visualization of single RNA transcripts in situ
13. p300 and estrogen receptor cooperatively activate transcription via differential enhancement of initiation and reinitiation
14. Dimeric ligands define a role for transcriptional activation domains in reinitiation
15. Heat shock factor increases the reinitiation rate from potentiated chromatin templates
16. The acidic transcriptional activator GAL-VP16 acts on preformed template-committed complexes
17. Transcription of individual genes in eukaryotic cells occurs randomly and infrequently
18. Single cell assay of a transcription factor reveals a threshold in transcription activated by signals emanating from the T-cell antigen receptor
19. The dose dependence of glucocodicoid-inducible gene expression results from changes in the number of transcriptionally active templates
20. Transcription occurs in pulses in muscle fibers
21. Real-time analysis of the transcriptional regulation of HIV and hCMV promoters in single mammalian cells
22. Dynamic changes in prolactin promoter activation in individual living lactotrophic cells
23. Chromatin and chromosomal controls in development
24. The vagaries of variegating transgenes
25. Position-dependent variegation of globin transgene expression in mice
26. A globin enhancer acts by increasing the proportion of erythrocytes expressing a linked transgene
27. Chromatin and transcription
28. Role of chromatin structure in the regulation of transcription by RNA polymerase II
29. The transcription of chromatin templates
30. Chromatin disruption and modification
31. A general mechanism for transcriptional synergy by eukaryotic activators
32. TFIID (TBP) stabilizes the binding of MyoD to its DNA site at the promoter and MyoD facilitates the association of TFIIB with the preinitiation complex
33. Contributions of the TATA box sequence to rate-limiting steps in transcription initiation by RNA polymerase II
34. Recruitment of TBP or TFIIB to a promotor proximal position leads to stimulation of RNA polymerase II transcription without activator proteins both in vivo and in vitro
35. Steroid receptor induction of gene transcription: A two-step model
36. Oct-1 protein promotes functional transcription complex assembly on the mouse mammary tumor virus promoter
37. Efficient recruitment of TFIIB and CBP-RNA polymerase II holoenzyme by an interferon-beta enhanceosome in vitro
38. Stimulation of RNA polymerase II transcription initiation by recruitment of TBP in vivo
39. Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Spl and SREBP-1 in vitro
40. Transcription activation via enhanced preinitiation complex assembly in a human cell-free system lacking TAFIIs
41. Intermediates in formation and activity of the RNA polymerase II preinitiation complex: Holoenzyme recruitment and a postrecruitment role for the TATA box and TFIIB
42. Enhancers increase the probability but not the level of gene expression
43. Distal enhancer regulation by promoter derepression in topologically constrained DNA in vitro
44. A dynamic assembly of diverse transcription factors integrates activation and cell-type information for interleukin 2 gene regulation
45. Binding of disparate transcriptional activators to nucleosomal DNA is inherently cooperative
46. Multiple layers of cooperativity regulate enhanceosome-responsive RNA polymerase II transcription complex assembly
47. Graded transcriptional response to different concentrations of a single transactivator
48. Differentiation and proliferation of hematopoietic stem cells
49. Hematopoiesis
50. Hematopoietic and lymphopoietic responses in human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor transgenic mice injected with human GM-CSF
51. Analysis of gene expression in a complex differentiation hierarchy by global amplification of cDNA from single cells
52. Multilineage gene expression precedes commitment in the hemopoietic system
53. Cytokine receptor expression on hematopoietic stem and progenitor cells
54. Selective expression of a stable cell surface molecule on type 2 but not type 1 helper T cells
55. Evidence for the stochastic acquisition of cytokine profile by CD4+ T cells activated in a T helper type 2-like response in vivo
56. Single-cell analysis by RT-PCR reveals differential expression of multiple type 1 and 2 cytokine genes among cells within polarized CD4+ T cell populations
57. Single celt analysis of cytokine gene expression coexpression during CD4+ T-cell phenotype development
58. Heterogeneity of intracellular cytokine synthesis at the single cell level in polarized T helper 1 and T helper 2 populations
59. Single-cell analyses of CD4+ T cells from alpha beta T cell receptor-transgenic mice: A distinct mucosal cytokine phenotype in the absence of transgene-specific antigen
60. Heterogeneity in the clonal T cell response: Implications for models of T cell activation and cytokine phenotype development
61. Visualization of antigen-specific T cell activation and cytokine expression in vivo
62. Heterogeneity of single cell cytokine gene expression in clonal T cell populations
63. Monoallelic expression of the interleukin-2 locus
64. Regulation of IL-4 expression by activation of individual alleles
65. Mice with a fluorescent marker for interleukin 2 gene activation
66. Independent and epigenetic regulation of the interleukin-4 alleles in CD4+ T cells
67. Modeling stochastic gene expression: Implications for haploin-sufficiency
68. Independent regulation of the two Pax5 alleles during B-cell development
69. It's a noisy business! Genetic regulation at the nanomolar scale
70. Endotoxin signal transduction in macrophages
71. Persistent activation of mitogen-activated protein kinases p42 and p44 and ets-2 phosphorylation in response to colony-stimulating factor 1/c-fms signaling
72. Regulation of urokinase-type plasminogen activator gene transcription by macrophage colony-stimulating factor
73. CpG DNA and LPS induce distinct patterns of activation in human monocytes
74. Immuno-stimulatory DNA down-modulates CSF-1 receptor surface expression on murine macrophages with concomitant growth arrest and factor-independent survival
75. Out of Eden: Stem cells and their niches