The human lysozyme gene undergoes stepwise demethylation during phagocyte maturation

Leukemia

Volumn 11, Issue 7, 1997, Pages 990-997

  Lubbert M ^a   Henschler, R ^a   Kreutz, M ^b   Andreesen, R ^b   Mertelsmann, R ^a   Herrmann, F ^c  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^c UNIVERSITY HOSPITAL ULM   (Germany)

Author keywords

Alu repetitive elements; Differentiation; Hematopoiesis; Methylation; Myelopoiesis; Transcription

Indexed keywords

DNA; LYSOZYME;

ALU SEQUENCE; ARTICLE; CELL MATURATION; CONTROLLED STUDY; CPG ISLAND; DEMETHYLATION; DNA FLANKING REGION; DNA METHYLATION; GENE ACTIVATION; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; MYELOPOIESIS; PHAGOCYTE; PRIORITY JOURNAL; PROMYELOCYTE;

EID: 0030795839     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2400693     Document Type: Article

References (12)

1. Blau HM. Differentiation requires continuous active control. Annu Rev Biochem 1992; 61: 1213-1230.
2. Metcalf D. The molecular control of cell division, differentiation, commitment, and maturation in hematopoietic cells. Nature 1989; 339: 27-29.
3. Gordon S, Todd T, Cohn ZA. In vitro synthesis and secretion of lysozyme by mononuclear phagocytes. J Exp Med 1974; 139: 1228-1248.
4. Jollés P, Jolĺes J. What's new in lysozyme research? Mol Cell Biochem 1984; 63: 165-189.
5. Peters CWB, Kruse U, Pollwein R, Grzeschik KH, Sippel AE. The human lysozyme gene: sequence, organization and chromosomal localization. Eur J Biochem 1989; 182: 507-516.
6. Clarke S, Greaves DR, Chung LP, Tree P, Gordon S. The human lysozyme promoter directs reporter gene expression to activated myelomonocytic cells in transgenic mice. Proc Natl Acad Sci USA 1996; 93: 1434-1438.
7. Bird A. The essentials of DNA methylation. Cell 1992; 70: 5-8.
8. Clark SJ, Harrison J, Frommer M. CpNpG methylation in mammalian cells. Nat Genet 1995; 10: 20-27.
9. Hellmann-Blumberg U, Hintz MF, Gatewood JM, Schmidt CW. Developmental differences in methylation of human Alu repeats. Mol Cell Biol 1993; 13: 4523-1530.
10. Li E, Bestor TH, Jaenisch R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 1992; 69: 915-926.
11. Tate P, Skarnes W, Bird A. The methyl-CpG binding protein MeCP2 is essential for embryonic development in the mouse. Nat Genet 1996; 12: 205-208.
12. Chu C, Shen CKJ. DNA methylation: its possible functional roles in developmental regulation of human globin gene families. In: Jost JP, Saluz HP (eds). DNA Methylation: Molecular Biology and Biological Significance. Birkhäuser Verlag: Basel, 1993, pp385-403.