The transcriptional repressor CDP (Cutl1) is essential for epithelial cell differentiation of the lung and the hair follicle

Genes and Development

Volumn 15, Issue 17, 2001, Pages 2307-2319

  Ellis, Tammy ^a   Gambardella, Laure ^b   Horcher, Markus ^a   Tschanz, Stefan ^c   Capol, Janine ^c   Bertram, Paula ^a   Jochum, Wolfram ^a,d   Barrandon, Yann ^b   Busslinger, Meinrad ^a  

^a RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

^b ECOLE NORMALE SUPÉRIEURE   (France)

^c UNIVERSITY OF BERN   (Switzerland)

^d UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

CCAAT displacement protein; Cutl1; Cux; Hair follicle development; Lung

Indexed keywords

TRANSCRIPTION FACTOR;

ARTICLE; CELL DIFFERENTIATION; DROSOPHILA; GENE MUTATION; HAIR FOLLICLE; LUNG ALVEOLUS EPITHELIUM; LUNG DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

ALLELES; ANIMALS; BETA-GALACTOSIDASE; CELL DIFFERENTIATION; CYTOPLASM; DNA, COMPLEMENTARY; DROSOPHILA; EPITHELIAL CELLS; EXONS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HAIR; HEDGEHOG PROTEINS; HOMEODOMAIN PROTEINS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LUNG; MICE; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; NUCLEAR PROTEINS; PROTEIN STRUCTURE, TERTIARY; REPRESSOR PROTEINS; TIME FACTORS; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

ERINACEIDAE; MAMMALIA;

EID: 0035449998     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.200101     Document Type: Article

References (42)

1. Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis
2. Interaction of the nuclear matrix-associated region (MAR)-binding proteins, SATB1 and CDP/Cux, with a MAR element (L2a) in an upstream regulatory region of the mouse CD8a gene
3. Mutually exclusive interaction of the CCAAT-binding factor and of a displacement protein with overlapping sequences of a histone gene promoter
4. Primary structure and expression of a product from cut, a locus involved in specifying sensory organ identity in Drosophila
5. Transformation of sensory organ identity by ectopic expression of Cut in Drosophila
6. Lung development and pulmonary angiogenesis
7. A nuclear matrix attachment region upstream of the T cell receptor β gene enhancer binds Cux/CDP and SATB1 and modulates enhancer-dependent reporter gene expression but not endogenous gene expression
8. Essential role of Sonic hedgehog during hair follicle morphogenesis
9. Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation
10. The mammalian Cut homeodomain protein functions as a cell-cycle-dependent transcriptional repressor which downmodulates p21WAF1/CIP1/SDI1 in S phase
11. Pattern of expression of the transcription factor Krox-20 in mouse hair follicle
12. De novo hair follicle morphogenesis and hair tumors in mice expressing a truncated β-catenin in skin
13. cut interacts with Notch and Protein kinase A to regulate egg chamber formation and to maintain germline cyst integrity during Drosophila oogenesis
14. Abnormal lung development and cleft palate in mice lacking TGF-β3 indicates defects of epithelial-mesenchymal interaction
15. Transcriptional repression of the cystic fibrosis transmembrane conductance regulator gene, mediated by CCAAT displacement protein/cut homolog, is associated with histone deacetylation
16. Repressor activity of CCAAT displacement protein in HL-60 myeloid leukemia cells
17. CASP, a novel, highly conserved alternative-splicing product of the CDP/cut/cux gene, lacks cut-repeat and homeo DNA-binding domains, and interacts with full-length CDP in vitro
18. Functional analysis of Drosophila and mammalian cut proteins in files
19. The human Cut homeodomain protein can repress gene expression by two distinct mechanisms: Active repression and competition for binding site occupancy
20. The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate
21. CCAAT displacement activity involves Cut repeats 1 and 2 and not the Cut homeodomain
22. Role of the multifunctional CDP/Cut/Cux homeodomain transcription factor in regulating differentiation, cell growth and development
23. Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut
24. Morphogenesis and renewal of hair follicles from adult multipotent stem cells
25. Principles of hair follicle morphogenesis
26. Primary structure, neural-specific expression, and chromosomal localization of Cux-2, a second murine homeobox gene related to Drosophila cut
27. Hair follicle companion layer: Reacquainting an old friend
28. Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog
29. Strain-dependent epithelial defects in mice lacking the EGF receptor
30. CCAAT displacement protein as a repressor of the myelomonocytic-specific gp91-phox gene promoter
31. Sonic hedgehog signaling is essential for hair development
32. The -117 mutation in Greek HPFH affects the binding of three nuclear factors to the CCAAT region of the γ-globin gene
33. Evidence that members of the Cut/Cux/CDP family may be involved in AER positioning and polarizing activity during chick limb development
34. Involvement of follicular stem cells in forming not only the follicle but also the epidermis
35. Hair defects and pup loss in mice with targeted deletion of the first cut repeat domain of the Cux/CDP homeoprotein gene
36. A unique variant of a homeobox gene related to Drosophila cut is expressed in mouse testis
37. 1/S phase cell cycle transition point independent of transcription factor E2F
38. Cux/CDP homeoprotein is a component of NF-μNR and represses the immunoglobulin heavy chain intronic enhancer by antagonizing the bright transcription activator
39. Conditional disruption of hedgehog signaling pathway defines its critical role in hair development and regeneration
40. Hair shaft defects
41. A novel human type II cytokeratin, K6hf, specifically expressed in the companion layer of the hair follicle
42. Exon/intron structure and alternative transcripts of the CUTL1 gene