The murine myeloperoxidase gene contains a bipartite distal enhancer, including a novel region regulated by PEBP2/CBF

Leukemia Research

Volumn 20, Issue 10, 1996, Pages 809-815

  Friedman, Alan D ^a   Britos Bray, Martin ^a   Suzow, Joseph ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Differentiation; Enhancer; Leukemia; Myeloperoxidase; Myelopoiesis; PEBP2 CB F

Indexed keywords

MYELOPEROXIDASE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; BINDING SITE; BONE MARROW CELL; CONSENSUS SEQUENCE; CONTROLLED STUDY; DNA SEQUENCE; DNA TRANSFECTION; ENHANCER REGION; GENE DELETION; GENE EXPRESSION REGULATION; GENE SEQUENCE; MOLECULAR CLONING; MOUSE; MYELOPOIESIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; TRANSCRIPTION REGULATION;

EID: 0030271491     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(96)00035-5     Document Type: Article

References (23)

1. 1. Klebanoff S. J. (1975) Antimicrobial mechanisms in neutrophilic polymorphonuclear leukocytes. Semin. Hematol. 12, 117.
2. 2. Nauseef W. M., Metcalf J. A. & Root R. K. (1983) Role of myeloperoxidase in the respiratory burst of human neutrophils. Blood 61, 483.
3. 3. Tobler A., Miller C. W., Johnson K. R., Selsted M. E., Rovera G. & Koeffler P. (1988) Regulation of gene expression of myeloperoxidase during myeloid differentiation. J. Cell Physiol. 136, 215.
4. 4. Sagoh T. & Yamada M. (1988) Transcriptional regulation of myeloperoxidase gene expression in myeloid leukemia HL-60 cells during differentiation into granulocytes and macrophages. Arch. Biochem. Biophys. 262, 599.
5. 5. Friedman A. D., Krieder B. L., Venturelli D. & Rovera G. (1991) Transcriptional regulation of two myeloid-specific genes, myeloperoxidase and lactoferrin, during differentiation of the murine cell line 32D C13. Blood 78, 2426.
6. 6. Pryzwansky K. B., Martin L. E. & Spitznagel J. K. (1978) Immunocytochemical localization of myeloperoxidase, lactoferrin, lysozyme, and neutral proteases in human monocytes and neutrophilic granulocytes. J. Reticuloendothel. Soc. 24, 295.
7. 7. Fouret P., duBois R. M., Bernaudin J.-F., Takahashi H., Ferrans V. J. & Crystal R. G. (1989) Expression of the neutrophil elastase gene during human bone marrow cell differentiation. J. exp. Med. 169, 183.
8. 8. Stroble H., Takimoto M., Majdic O., Fritsch G., Scheinecker C., Hocker P. & Knapp W. (1993) Myeloperoxidase expression in CD34+ normal hematopoietic cells. Blood 82, 2069.
9. 9. Valtieri M., Tweardy D. J., Caracciolo D., Johnson K., Mavilio F., Altman S., Snatoli D. & Rovera G. (1987) Regulation of proliferative and differentiative responses in a murine progenitor cell line. J. Immunol. 138, 3829.
10. 10. Suzow J. & Friedman A. D. (1993) The murine myeloperoxidase promoter contains several functional elements, one of which binds a cell type-restricted transcription factor, myeloid nuclear factor 1 (MyNF1). Molec. Cell. Biol. 13, 2141.
11. 11. Venturelli D., Bittenbender S. & Rovera G. (1989) Sequence of the murine myeloperoxidase (MPO) gene. Nucleic Acids Res. 17, 7987.
12. 12. Johnson K. R., Nauseef W. M., Care A., Wheelock M. J., Shane S., Hudson S., Koeffler H. P., Selsted M., Miller C. & Rovera G. (1987) Characterization of cDNA clones for human myeloperoxidase: predicted amino acid sequence and evidence for multiple mRNA species. Nucleic Acids Res. 15, 2013.
13. 13. Jorgenson K. F., Antoun G. R. & Zipf I. F. (1991) Chromatin structural analysis of the 5′ end and contiguous flanking region of the myeloperoxidase gene. Blood 77, 159.
14. 14. Lubbert M., Miller C. W. & Koeffler H. P. (1991) Changes of DNA methylation and chromatin structure in the human myeloperoxidase gene during myeloid differentiation. Blood 78, 345.
15. 15. Nuchprayoon I., Meyers S., Scott L. M., Suzow L., Hiebert S. & Friedman A. D. (1994) PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2β/CBFβ oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells. Molec. Cell. Biol. 14, 5558.
16. 16. Zhu L., Bennett C. A., MacGregor A. D., Greaves M. F., Goodwin G. H. & Ford A. M. (1994) A myeloid-lineage-specific enhancer upstream of the mouse myeloperoxidase (MPO) gene. Leukemia 8, 717.
17. 17. Sambrook J., Fritsch E. F. & Maniatis T. (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
18. 18. Sanger F. & Coulson A. R. (1975) A rapid method for determining sequences in DNA by primed synthesis with DNA polymerase. J. Molec. Biol. 94, 441.
19. 19. Friedman A. D. (1996) Regulation of immature myeloid cell differentiation by PEBP2/CBF, Myb, C/EBP, and Ets family members. Current Topics Microb. Immunol, 211, 149.
20. 20. Antoniou M., deBoer E., Habets G. & Grosveld F. (1988) The human β-globin gene contains multiple regulatory regions: identification of one promoter and two downstream enhancers. EMBO J. 7, 377.
21. 21. Liu J.-K., Bergman Y. & Zaret K. S. (1988) The mouse albumin promoter and a distal upstream site are simultaneously DNase I hypersensitive in liver chromatin and bind similar liver-abundant factors in vitro. Genes Dev. 2, 528.
22. 22. Kamachi Y., Ogawa E., Asano M., Ishida S., Murakami Y., Satake M., Ito Y. & Shigesada K. (1990) Purification of a mouse nuclear factor that binds to both the A and B cores of the polyomavirus enhancer. J. Virol. 64, 4808.
23. 23. Meyers S., Downing J. R. & Hiebert S. W. (1993) Identification of AML-1 and the t(8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions. Molec. Cell. Biol. 13, 6336.