Novel MLL-CBP fusion transcript in therapy-related chronic myelomonocytic leukemia with a t(11;16) (q23;p13) chromosome translocation

Genes Chromosomes and Cancer

Volumn 20, Issue 1, 1997, Pages 60-63

  Satake, Noriko ^a   Ishida, Yasushi ^b   Otoh, Yoshiko ^b   Hinohara, Shin Ichi ^a   Kobayashi, Hirofumi ^a   Sakashita, Akiko ^a   Maseki, Nobuo ^a   Kaneko, Yasuhiko ^a  

^a SAITAMA CANCER CENTER   (Japan)

^b EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GYRASE INHIBITOR; PIRARUBICIN;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CASE REPORT; CHILD; CHROMOSOME 11Q; CHROMOSOME 16P; CHROMOSOME TRANSLOCATION 11; CHROMOSOME TRANSLOCATION 16; CHRONIC MYELOMONOCYTIC LEUKEMIA; GENE FUSION; GENE REARRANGEMENT; HUMAN; MALE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHOOL CHILD;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BLOTTING, SOUTHERN; CHILD; CHROMOSOME BANDING; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 16; CREB-BINDING PROTEIN; DNA PRIMERS; DNA, NEOPLASM; DNA-BINDING PROTEINS; GENE REARRANGEMENT; HUMANS; LEUKEMIA, LYMPHOCYTIC, ACUTE, L1; LEUKEMIA, MYELOMONOCYTIC, CHRONIC; MALE; MYELOID-LYMPHOID LEUKEMIA PROTEIN; NEOPLASMS, SECOND PRIMARY; NUCLEAR PROTEINS; POLYMERASE CHAIN REACTION; PROTO-ONCOGENES; RECOMBINATION, GENETIC; REMISSION INDUCTION; RNA-DIRECTED DNA POLYMERASE; SEQUENCE ANALYSIS, DNA; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC;

EID: 0030885075     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2264(199709)20:1<60::AID-GCC9>3.0.CO;2-7     Document Type: Article

References (23)

1. Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, Sultan C (1976) Proposals for the classification of the acute leukaemias. Br J Haematol 33:451-458.
2. Bernard OA, Berger R (1995) Molecular basis of 11q23 rearrangements in hematopoietic malignant proliferations. Genes Chromosom Cancer 13:75-85.
3. Borrow J, Stanton JVP, Andresen JM, Becher R, Behm FG, Chaganti RSK, Civin CI, Disteche C, Dubé I, Frischauf AM, Horsman D, Mitelman F, Volinia S, Watmore AE, Housman DE (1996) The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein. Nat Genet 14:33-41.
4. Chrivia JC, Kwok RPS, Lamb N, Hagiwara M, Montminy MR, Goodman RH (1993) Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365:855-859.
5. Corral J, Forster A, Thompson S, Lampert F, Kaneko Y, Slater R, Kroes WG, van der Schoot CE, Ludwig W-D, Karpas A, Pocock C, Cotter F, Rabbitts TH (1993) Acute leukemias of different lineages have similar MLL gene fusions encoding related chimeric proteins resulting from chromosomal translocation. Proc Natl Acad Sci USA 90:8538-8543.
6. Felix CA, Hosler MR, Winick NJ, Masterson M, Wilson AE, Lange BJ (1995) ALL-1 gene rearrangements in DNA topoisomerase II inhibitor-related leukemia in children. Blood 85:3250-3256.
7. Gill Super HJ, McCabe NR, Thirman MJ, Larson RA, Le Beau MM, Pedersen-Bjergaard J, Philip P, Diaz MO, Rowley JD (1993) Rearrangements of the MLL gene in therapy-related acute myeloid leukemia in patients previously treated with agents targeting DNA-topoisomerase II. Blood 82:3705-3711.
8. Gu Y, Nakamura T, Alder H, Prasad R, Canaani O, Cimino G, Croce CM, Canaani E (1992) The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene. Cell 71:701-708.
9. Hunger S, Tkachuk DC, Amylon MD, Link MP, Carroll AJ, Welborn JL, Willman CL, Cleary ML (1993) HRX involvement in de novo and secondary leukemias with diverse chromosome 11q23 abnormalities. Blood 81:3197-3203.
10. Kamei Y, Xu L, Heinzel T, Torchia J, Kurokawa R, Gloss B, Lin S, Heyman RA, Rose DW, Glass CK, Rosenfeld MG (1996) A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85:403-414.
11. Koizumi S, Fujimoto T, Oka T, Watanabe S, Kikuta A, Tsuchiya T, Matsushita T, Asami K, Yanase T, Miyata J, Ohta S, Miyake M, Nishikawa K, Furuyama T, Yamamura Y, Takaue Y, Ninomiya T, Shimokaua T, Iwai A, Ishida Y, Ariyoshi N, Kimura K, Kawakami K, Gushiken T, Sekine I (1996) Overview of clinical studies of childhood acute lymphoblastic leukemia for more than ten years by the Japanese Children's Cancer and Leukemia Study Group. Pediatr Hematol Oncol 14:17-28.
12. Kwok RPS, Lundblad JR, Chrivia JC, Richards JP, Bächinger HP, Brennan RG, Roberts SGE, Green MR, Goodman RH (1994) Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature 370:223-226.
13. Petrij F, Giles RH, Dauwerse HG, Saris JJ, Hennekam RCM, Masuno M, Tommerup N, van Ommen G-JB, Goodman RH, Peters DJM, Breuning MH (1995) Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP. Nature 376:348-351.
14. Quesnel B, Kantarjian H, Bjergaard JP, Brault P, Estey E, Lai JL, Tilly H, Stoppa AM, Archimbaud E, Harousseau JL, Bauters F, Fenaux P (1993) Therapy-related acute myeloid leukemia with t(8:21). inv(16), and t(8:16): A report on 25 cases and review of the literature. J Clin Oncol 11:2370-2379.
15. Roulston D, Anastasi J, Rudinsky R, Nucifora G, Zeleznik-Le N, Rowley JD, McGavran L, Tsuchida M, Hayashi Y (1995) Therapy-related acute leukemia associated with t(11q23) after primary acute myeloid leukemia with t(8;21): A report of two cases. Blood 86:3613-3614.
16. Rowley JD, Vignon C, Gollin SM, Rosenberg CL, Wyandt HE, Milunsky A (1996) Chromosomal translocations in secondary acute myeloid leukemia. N Engl J Med 334:601-603.
17. Saha V, Chaplin T, Gregorini A, Ayton P, Young BD (1995) The leukemia-associated-protein (LAP) domain, a cysteine-rich motif, is present in a wide range of proteins, including MLL, AF10, and MLLT6 proteins. Proc Natl Acad Sci USA 92:9737-9741.
18. Satake N, Maseki N, Kozu T, Sakashita A, Kobayashi H, Sakurai M, Ohki M, Kaneko Y (1995) Disappearance of AML1-MTG8(ETO) fusion transcript in acute myeloid leukaemia patients with t(8:21) in long-term remission. Br J Haematol 91:892-898.
19. Satake N, Sakashita A, Kobayashi H, Maseki N, Sakurai M, Kaneko Y (1997) Minimal residual disease in acute monocytic leukemia patient with trisomy 11 and partial tandem duplication of MLL. Cancer Genet Cytogenet (in press).
20. Schichman SA, Caligiuri MA, Gu Y, Strout MP, Canaani E, Bloomfield CD, Croce CM (1994): ALL-1 partial duplication in acute leukemia. Proc Natl Acad Sci USA 91:6236-6239.
21. Thirman MJ, Gill HJ, Burnett RC, Mbangkollo D, McCabe NR, Kobayashi H, Ziemin-van der Poel S, Kaneko Y, Morgan R, Sandberg AA, Chaganti RSK, Larson RA, Le Beau MM, Diaz MO, Rowley JD (1993) Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations. N Engl J Med 324:909-914.
22. Tkachuk DC, Kohler S, Cleary ML (1992) Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. Cell 71:691-700.
23. Yamamoto K, Seto M, Akao Y, Iida S, Komatsu H, Kamada N, Kojima S, Kodera Y, Nakazawa S, Saito H, Takahashi T, Ueda R (1994) A reverse transcriptase-polymerase chain reaction detects heterogeneous chimeric mRNAs in leukemias with 11q23 abnormalities. Blood 83:2912-2921.