A novel, myeloid transcription factor, C/EBPξ, is upregulated during granulocytic, but not monocytic, differentiation

Blood

Volumn 90, Issue 7, 1997, Pages 2591-2600

  Morosetti, Roberta ^b   Park, Dorothy J ^b   Chumakov, Alexey M ^b   Grillier, Isabelle ^b   Shiohara, Masaaki ^b   Gombart, Adrian F ^b   Nakamaki, Tsuyoshi ^b   Weinberg, Kenneth ^b   Koeffler, H Phillip ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

ARTICLE; CELL DIFFERENTIATION; GRANULOCYTE; GRANULOPOIESIS; GROWTH REGULATION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MONOCYTE; MYELOPOIESIS; PRIORITY JOURNAL;

EID: 0030865680     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v90.7.2591.2591_2591_2600     Document Type: Article

References (60)

1. Chumakov AM, Grillier I, Chumakov E, Chih D, Slater J, Koeffler HP: Cloning of the novel human myeloid-specific C/EBP transcription factor (C/EBP∈). Mol Cell Biol 17:1375, 1996
2. Antonson P, Stellan B, Yamanaka R, Xanthopoulos KG: A novel human CCAAT/enhancer binding protein gene, C/EBP∈, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor α/δ locus. Genomics 35:30, 1996
3. Akira S, Isshiki H, Suguita T, Tanabe S, Kinoshita S, Nishio Y, Hirano T, Kishimoto T: A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J 9:1897, 1990
4. Cao Z, Umek RM, McKnight SL: Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev 5:1538, 1991
5. Chang C-J, Chen TT, Lei HY, Lee SC: Molecular cloning of a transcription factor, AGP/EBP, that belongs to members of the C/ EBP family. Mol Cell Biol 10:6442, 1990
6. Descombes P, Chojkier M, Lichsteiner S, Falvey E, Schibler V: LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein. Genes Dev 4:1541, 1990
7. Zhang D-E, Hetherington J, Meyers S, Rhoades KL, Larson CJ, Chen H-M, Hiebert SW, Tenen DG: CCAAT enhancer-binding protein (C/EBP) and AML1 (CBFα2) synergistically activate the macrophage colony-stimulating factor receptor promoter. Mol Cell Biol 16:1231, 1996
8. Johnson PF, Landschultz WH, Graves BJ, McKnight SL: Identification of a rat liver nuclear protein that binds to the enhancer core element of three animal viruses. Genes Dev 1:133,1987
9. Roman C, Platero JS, Shuman JD, Calame K: Ig/EBP-1: A ubiquitously expressed immunoglobulin enhancer binding protein that is similar to C/EBP and heterodimerizes with C/EBP. Genes Dev 4:1404, 1990
10. Ron D, Habener JF: CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev 6:439, 1992
11. Williams SC, Cantwell CA, Johnson PF: A family of C/EBP related proteins capable of forming covalently linked leucine zipper dimers in vitro. Genes Dev 5:1553, 1991
12. Vinson CR, Sigler PB, McKnight SL: Scissors-grip model for DNA recognition by a family of leucine zipper proteins. Science 246:911, 1989
13. Birkenmeier EH, Gwynn B, Howard S, Jerry J, Gordon JL, Landschulz, WH, McKnight SL: Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein. Genes Dev 3:1146, 1989
14. Friedman AD, Landschulz WH, McKnight SL: CCAAT/enhancer binding protein activates the promotor of the serum albumin gene in cultured hepatoma cells. Genes Dev 3:1314, 1989
15. Alam T, An MR, Papaconstantinou J: Differential expression of three C/EBP isoforms in multiple tissues during the acute phase response. J Biol Chem 267:5021, 1992
16. Alam T, An MR, Mifflin RC, Hsieh CC, Ge X, Papaconstantinou J: Trans-activation of the alpha 1-acid glycoprotein gene acute phase responsive element by multiple isoforms of C/EBP and glucocorticoid receptor. J Biol Chem 268:15681, 1993
17. Papconstantinou J: Evidence for posttranscriptional regulation of C/EBPα and C/EBPβ isoform expression during the lipopolysaccharide-mediated acute-phase response. Mol Cell Biol 16:2295, 1996
18. Baumann H, Morella KK, Campos SP, Cao Z, Jahreis GP: Role of CAAT-enhancer binding protein isoforms in the cytokine regulation of acute-phase plasma protein genes. J Biol Chem 267:19744, 1992
19. Baumann H, Jahreis GP, Morella KK, Won KA, Pruitt SC, Jones VE, Prowse KR: Transcriptional regulation through cytokine and glucocorticoid response elements of rat acute phase plasma protein genes by C/EBP and JunB. J Biol Chem 266:20390, 1991
20. Carter KC, Bryan S, Gadson P, Papaconstantinou J: Deadenylation of alpha 1-acid glycoprotein mRNA in cultured hepatic cells during stimulation by dexamethasone. J Biol Chem 264:4112, 1989
21. Yiangou M, Ge X, Carter KC, Papaconstantinou J: Induction of several acute-phase protein genes by heavy metals: a new class of metal-responsive genes. Biochemistry 30:3798, 1991
22. Yiangou M, Papaconstantinou J: The differential induction of alpha 1-acid glycoprotein and serum amyloid A genes by heavy metals. Biochim Biophys Acta 1174:123, 1993
23. Scott LM, Civin CI, Rorth P, Friedman AD: A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells. Blood 80:1725, 1992
24. Burk O, Mink S, Tingwald M, Klempnauer KH: Synergistic activation of the chicken mim-1 gene by v-myb and C/EBP transcription factors. EMBO J 12:2027, 1993
25. Ness SA, Kowenz-Leutz E, Casini T, Graf T, Leutz A: Myb and NF-M: combinatorial activators of myeloid genes in heterologous cell types. Genes Dev 7:749, 1993
26. Koeffler HP, Golde DW: Acute myelogenous leukemia: A human cell line responsive to colony-stimulating activity. Science 200:1153, 1978
27. Ferrante A, Thong YH: Optimal conditions for simultaneous purification of mononuclear and polymorphonuclear leucocytes from human peripheral blood by the Ficoll-Hypaque method. J Immunol Methods 36:109, 1980
28. Böyum A: A one-stage procedure for isolation of granulocytes and lymphocytes from human blood. Scand J Clin Lab Invest 21:51, 1968 (suppl 97)
29. 3 analogs and 9-cis retinoic acid. J Clin Invest 99:349, 1996
30. Selsted ME, Miller CW, Novotny MJ, Morris WL, Koeffler HP: Molecular analysis of myeloperoxidase deficiency shows heterogenous patterns of the complete deficieincy state manifested at the genomic, mRNA, and protein levels. Blood 82:1317, 1993
31. Shivdasani RA, Orkin SH: The transcriptional control of hematopoiesis. Blood 87:4025, 1996
32. Miyoshi H, Ohira M, Shimizu K, Mitani K, Hiai H, Imai T, Yokoyama K, Soeda E, Ohki M: Alternative splicing and genomic structure of the AML-1 gene involved in acute myeloid leukemia. Nucleic Acids Res 23:2762, 1995
33. Takahashi A, Satake M, Yamaguchi-Iwai Y, Bai SC, Lu J, Manuyama M, Zhang YW, Oka H, Arai N, Arai K: Positive and negative regulation of granulocyte-macrophage colony-stimulating factor promoter activity by AML-1 related transcription factor PEBP2. Blood 86:607, 1995
34. Yanaka T, Tanaka K, Ogawa S, Kurokawa M, Mitani K, Nishica J, Shibata Y, Yazaki Y, Hirai H: An acute myeloid leukemia gene, AML1, regulates hematopoietic myeloid cell differentiation and transcriptional activation antagonistically by two alternative spliced forms. EMBO J 14:341, 1995
35. Clarke M, Kukowska-Latolla JF, Westin E, Smith M, Prochownik E: Constitutive expression of a c-myb cDNA blocks Friend murine erythroleukemia cell differentiation. Mol Cell Biol 8:884, 1998
36. Gerwitz AM, Calabretta B: A c-myb antisense oligodeoxynucleotide inhibits normal human hematopoiesis in vitro. Science 242:1303, 1998
37. Graf T: Myb: A transcriptional activator linking proliferation and differentiation in hematopoietic cells. Curr Opin Genet Dev 2:2249, 1992
38. Todokoro K, Watson RJ, Higo H, Amanuma H, Kuramochi S, Yanagisawa H, Ikawa Y: Down-regulation of c-myb gene expression is a prerequisite for erythropoietin-induced erythroid differentiation. Proc Natl Acad Sci USA 85:8900, 1988
39. Chen HM, Zhang MT, Yoso MT, Hohaus S, Gonzalex D, Glass CK, Zhang DE, Tenen DG: Neutrophils and monocytes express high levels of PU.1 (Spi-1) but not Spi-B. Blood 85:2918, 1995
40. Giese K, Kinsley D, Kirshner JR, Grosschedl R: Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA binding and multiple protein interactions. Genes Dev 9:995, 1995
41. Klemsz MJ, McKercher SR, Cellada A, Van Beveren C, Maki RA: The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene. Cell 61:113, 1990
42. Sun W, Graves BJ, Speck NA: The transactivation of the Moloney murine leukemia virus and T-cell receptor beta-chain enhancers by cbf and ets requires intact binding sites for both proteins. J Virol 69:4941, 1995
43. Wotton D, Ghysdale J, Wang S, Speck NA, Owen MJ: Cooperative binding of Ets-1 and core binding factor to DNA. Mol Cell Biol 14:840, 1994
44. Bavisotto L, Kaushansky K, Kin N, Hromas R: Antisense oligonucleotides from the stage-specific myeloid zinc finger gene MZF-1 inhibit granulopoiesis in vitro. J Exp Med 174:1097, 1991
45. Hromas R, Collins SJ, Hickstein D, Faskind W, Deaven LL, O'Hara P, Hagen FS, Kaushansky K: A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells. J Biol Chem 226:14183, 1991
46. Nguyen HQ, Hoffman-Liebermann B, Liebermann DA: The zinc finger transcription factor Egr-1 is essential for and restricts differentiation along the macrophage lineage. Cell 72:197, 1993
47. Dreider BL, Benezra G, Rovera G, Kadesch T: Inhibition of myeloid differentiation by the helix-loop helix protein Id. Science 255:1700, 1992
48. Screpanti T, Romani L, Musianai P, Modesti A, Fattori E, Lazzaro D, Sellitto C, Scarpa S, Bellavia D, Lattanzio G: Lympho-proliferative disorder and imbalanced T-helper response in C/EPB beta-deficient mice. EMBO J 14:1932, 1995
49. Tanaka T, Akira S, Yoshida K, Umemoto M, Yoneda Y, Shirafuji N, Fujiwara H, Suematsu S, Yoshida K, Kishimoto T: Targeted disruption of the NF-IL6 gene disclosed its essential role in bacteria killing and tumor cytotoxicity by macrophages. Cell 80:353, 1995
50. Zhang D, Zhang P, Wang N, Hetherington C, Darlington G, Tennen D: Absence of granulocyte colong-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein α-deficient mice. Proc Natl Acad Sci USA 94:569, 1996
51. Hohaus S, Petronick MS, Voso MT, Sun Z, Zhang DE, Tenen DG: PU.1 (Spi-1) and C/EBPα regulate the expression of the granulocyte-monocyte colony-stimulating factor receptor and gene. Mol Cell Biol 15:5830, 1995
52. Smith LT, Gonzalez D, Tenen DG: The myeloid specific G-CSF receptor promoter contains a functional site for the myeloid transcription factor PU.1. Blood 84:372a, 1994
53. Oelgeschlager M, Nuchpragoon I, Luscher B, Friedman A: C/ EBP, C-Myb, and PU.1 cooperate to regulate the neutrophil elastase promoter. Mol Cell Biol 16:4717, 1996
54. Natsuka S, Akira S, Nishio Y, Hashimoto S, Sugita T, Isshiki H, Kishimoto T: Macrophage differentiation-specific expression of NF-IL6, a transcription factor of interleukin-6. Blood 79:460, 1992
55. Freytag SO, Geddes JJ: Reciprocal regulation of adipogenesis by Myc and C/EBP alpha. Science 256:379, 1992
56. Umek RM, Friedman SD, McKnight SL: CCAAT-enhancer binding protein: A component of a differentiation switch. Science 251:288, 1991
57. Katz S, Kowenz-Leutz E, Muller C, Meese K, Ness SA, Leutz A: The NF-M transcription factor is related to C/EBP beta and plays a role in signal transduction, differentiation and leukemogenesis of avian myelomonocytic cells. EMBO J 12:1321, 1993
58. Gaynor R, Simon K, Koeffler HP: Expression of c-jun during macrophage differentiation of HL-60 cells. Blood 77:2618, 1991
59. Johnson RS, Spiegelman BM, Papaionannou V: Pleiotropic effects of a null mutation in the c-fos proto-oncogene. Cell 71:577, 1992
60. Wang Z-Q, Ovitt C, Grigoriadis AE, Mohle-Steinhein U, Ruther U, Wagner EF: Bone and hematopoietic defects in mice lacking c-fos. Nature, 360:741, 1992