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Volumn 38, Issue 17, 2002, Pages 2222-2228

Mouse models to study the role of telomeres in cancer, aging and DNA repair

Author keywords

Aging; Cancer; DNA repair; Mouse models; Telomerase; Telomeres

Indexed keywords

BINDING PROTEIN; M PROTEIN; TANKYRASE; TELOMERASE; TELOMERASE INHIBITOR; TELOMERIC REPEAT BINDING FACTOR 1; TELOMERIC REPEAT BINDING FACTOR 2; UNCLASSIFIED DRUG;

EID: 0036849595     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(02)00450-1     Document Type: Article
Times cited : (20)

References (66)
  • 1
    • 0035929353 scopus 로고    scopus 로고
    • Switching and signaling at the telomere
    • Blackburn E.H. Switching and signaling at the telomere. Cell. 106:2001;661-673.
    • (2001) Cell , vol.106 , pp. 661-673
    • Blackburn, E.H.1
  • 2
    • 0037148270 scopus 로고    scopus 로고
    • New ways not to make ends meet: Telomerase, DNA damage proteins and heterochromatin
    • Chan S.W.-L., Blackburn E.H. New ways not to make ends meet. telomerase, DNA damage proteins and heterochromatin Oncogene. 21:2001;553-563.
    • (2001) Oncogene , vol.21 , pp. 553-563
    • Chan, S.W.-L.1    Blackburn, E.H.2
  • 3
    • 0037148277 scopus 로고    scopus 로고
    • Protection of mammalian telomeres
    • De Lange T. Protection of mammalian telomeres. Oncogene. 21:2002;532-540.
    • (2002) Oncogene , vol.21 , pp. 532-540
    • De Lange, T.1
  • 4
    • 0033553536 scopus 로고    scopus 로고
    • Mammalian telomeres end in a large duplex loop
    • Griffith J.D., Comeau L., Rosenfield S.et al. Mammalian telomeres end in a large duplex loop. Cell. 97:1999;503-514.
    • (1999) Cell , vol.97 , pp. 503-514
    • Griffith, J.D.1    Comeau, L.2    Rosenfield, S.3
  • 5
    • 0037148330 scopus 로고    scopus 로고
    • Many ways to telomere dysfunction: In vivo studies using mouse models
    • Goytisolo F.A., Blasco M.A. Many ways to telomere dysfunction. in vivo studies using mouse models Oncogene. 21:2002;584-591.
    • (2002) Oncogene , vol.21 , pp. 584-591
    • Goytisolo, F.A.1    Blasco, M.A.2
  • 6
    • 0030931491 scopus 로고    scopus 로고
    • Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
    • Blasco M.A., Lee H.W., Hande M.P.et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell. 91:1997;25-34.
    • (1997) Cell , vol.91 , pp. 25-34
    • Blasco, M.A.1    Lee, H.W.2    Hande, M.P.3
  • 7
    • 0036566036 scopus 로고    scopus 로고
    • Mammalian Ku86 mediates chromosomal fusions apoptosis caused by critically short telomeres
    • Espejelet al. Mammalian Ku86 mediates chromosomal fusions apoptosis caused by critically short telomeres. EMBO J. 21:2002;2207-2219.
    • (2002) EMBO J. , vol.21 , pp. 2207-2219
    • Espejel1
  • 9
    • 84984775429 scopus 로고    scopus 로고
    • Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2
    • Broccoli D., Smogorzewska A., Chong L., de Lange T. Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat Genet. 17:1997;231-235.
    • (1997) Nat Genet , vol.17 , pp. 231-235
    • Broccoli, D.1    Smogorzewska, A.2    Chong, L.3    De Lange, T.4
  • 11
    • 0033961281 scopus 로고    scopus 로고
    • Control of human telomere length by TRF1 and TRF2
    • Smogorzewska A., van Steensel B., Bianchi A.et al. Control of human telomere length by TRF1 and TRF2. Mol Cell Biol. 20:2000;1659-1668.
    • (2000) Mol Cell Biol. , vol.20 , pp. 1659-1668
    • Smogorzewska, A.1    Van Steensel, B.2    Bianchi, A.3
  • 12
    • 0032727616 scopus 로고    scopus 로고
    • TIN2, a new regulator of telomere length in human cells
    • Kim S.H., Kaminker P., Campisi J. TIN2, a new regulator of telomere length in human cells. Nat Genet. 23:1999;405-412.
    • (1999) Nat Genet , vol.23 , pp. 405-412
    • Kim, S.H.1    Kaminker, P.2    Campisi, J.3
  • 13
    • 0032553473 scopus 로고    scopus 로고
    • Tankyrase, a poly(ADP-ribose) polymerase at human telomeres
    • Smith S., Giriat I., Schmitt A., de Lange T. Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. Science. 282:1998;1484-1487.
    • (1998) Science , vol.282 , pp. 1484-1487
    • Smith, S.1    Giriat, I.2    Schmitt, A.3    De Lange, T.4
  • 14
    • 0035929591 scopus 로고    scopus 로고
    • TANK2, a new TRF1-associated PARP, causes rapid induction of cell death upon overexpression
    • Kaminker P.G., Kim S.H., Taylor R.D.et al. TANK2, a new TRF1-associated PARP, causes rapid induction of cell death upon overexpression. J. Biol. Chem. 276:2001;35891. (3589).
    • (2001) J. Biol. Chem. , vol.276 , pp. 35891
    • Kaminker, P.G.1    Kim, S.H.2    Taylor, R.D.3
  • 15
    • 0034687248 scopus 로고    scopus 로고
    • Tankyrase promotes telomere elongation in human cells
    • Smith S., de Lange T. Tankyrase promotes telomere elongation in human cells. Curr Biol. 10:2000;1299-1302.
    • (2000) Curr Biol. , vol.10 , pp. 1299-1302
    • Smith, S.1    De Lange, T.2
  • 16
    • 0002582383 scopus 로고    scopus 로고
    • Biological significance of poly(ADP-ribosyl)ation reactions: Molecular and genetic approaches
    • G. de Murcia, & S. Shall. Oxford: Oxford University Press
    • Bürkle A., Schreiber V., Dantzer F.et al. Biological significance of poly(ADP-ribosyl)ation reactions. molecular and genetic approaches de Murcia G., Shall S. From DNA Damage and Stress Signaling to Cell Death. Poly ADP-ribosylation Reactions. 2000;80-124 Oxford University Press, Oxford.
    • (2000) From DNA Damage and Stress Signaling to Cell Death. Poly ADP-ribosylation Reactions , pp. 80-124
    • Bürkle, A.1    Schreiber, V.2    Dantzer, F.3
  • 17
    • 0032489012 scopus 로고    scopus 로고
    • TRF2 protects human telomeres from end-to-end fusions
    • van Steensel B., Smogorzewska A., de Lange T. TRF2 protects human telomeres from end-to-end fusions. Cell. 92:1998;401-413.
    • (1998) Cell , vol.92 , pp. 401-413
    • Van Steensel, B.1    Smogorzewska, A.2    De Lange, T.3
  • 18
    • 0033605145 scopus 로고    scopus 로고
    • P53- and ATM-dependent apoptosis induced by telomeres lacking TRF2
    • Karlseder J., Broccoli D., Dai Y., Hardy S., de Lange T. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science. 283:1999;1321-1325.
    • (1999) Science , vol.283 , pp. 1321-1325
    • Karlseder, J.1    Broccoli, D.2    Dai, Y.3    Hardy, S.4    De Lange, T.5
  • 19
    • 0034716904 scopus 로고    scopus 로고
    • Identification of human Rap1: Implications for telomere evolution
    • Li B., Oestreich S., de Lange T. Identification of human Rap1. implications for telomere evolution Cell. 101:2000;471-483.
    • (2000) Cell , vol.101 , pp. 471-483
    • Li, B.1    Oestreich, S.2    De Lange, T.3
  • 20
    • 0342561644 scopus 로고    scopus 로고
    • Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
    • Zhu X.D., Kuster B., Mann M., Petrini J.H., Lange T. Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. Nat Genet. 25:2000;347-352.
    • (2000) Nat Genet , vol.25 , pp. 347-352
    • Zhu, X.D.1    Kuster, B.2    Mann, M.3    Petrini, J.H.4    Lange, T.5
  • 21
    • 0033560796 scopus 로고    scopus 로고
    • The DNA-dependent protein kinase
    • Smith G.C., Jackson S.P. The DNA-dependent protein kinase. Genes Dev. 13:1999;916-934.
    • (1999) Genes Dev , vol.13 , pp. 916-934
    • Smith, G.C.1    Jackson, S.P.2
  • 22
    • 0033597820 scopus 로고    scopus 로고
    • Ku binds telomeric DNA in vitro
    • Bianchi A., de Lange T. Ku binds telomeric DNA in vitro. J Biol Chem. 274:1999;21223-21227.
    • (1999) J Biol Chem. , vol.274 , pp. 21223-21227
    • Bianchi, A.1    De Lange, T.2
  • 24
    • 0034669104 scopus 로고    scopus 로고
    • Ku acts in a unique way at the mammalian telomere to prevent end joining
    • Hsu H.L., Gilley D., Galande S.A.et al. Ku acts in a unique way at the mammalian telomere to prevent end joining. Genes Dev. 14:2000;2807-2812.
    • (2000) Genes Dev , vol.14 , pp. 2807-2812
    • Hsu, H.L.1    Gilley, D.2    Galande, S.A.3
  • 26
    • 0033592950 scopus 로고    scopus 로고
    • DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes
    • Bailey S.M., Meyne J., Chen D.J.et al. DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes. Proc Natl Acad Sci USA. 96:1999;14899-14904.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 14899-14904
    • Bailey, S.M.1    Meyne, J.2    Chen, D.J.3
  • 27
    • 0034280093 scopus 로고    scopus 로고
    • Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang
    • Samper E., Goytisolo F.A., Slijepcevic P., van Buul P.P., Blasco M.A. Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang. EMBO rep. 1:2000;244-252.
    • (2000) EMBO rep , vol.1 , pp. 244-252
    • Samper, E.1    Goytisolo, F.A.2    Slijepcevic, P.3    Van Buul, P.P.4    Blasco, M.A.5
  • 28
    • 0035023139 scopus 로고    scopus 로고
    • The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang
    • Goytisolo F.A., Samper E., Edmonson S., Taccioli G.E., Blasco M.A. The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang. Mol Cell Biol. 21:2001;3642-3651.
    • (2001) Mol Cell Biol. , vol.21 , pp. 3642-3651
    • Goytisolo, F.A.1    Samper, E.2    Edmonson, S.3    Taccioli, G.E.4    Blasco, M.A.5
  • 29
    • 0035964864 scopus 로고    scopus 로고
    • Strand-specific postreplicative processing of mammalian telomeres
    • Bailey S.M., Conforth M.N., Kurimasa A., Chen D.J., Goodwin E.H. Strand-specific postreplicative processing of mammalian telomeres. Science. 293:2001;2462-2465.
    • (2001) Science , vol.293 , pp. 2462-2465
    • Bailey, S.M.1    Conforth, M.N.2    Kurimasa, A.3    Chen, D.J.4    Goodwin, E.H.5
  • 30
    • 0035844082 scopus 로고    scopus 로고
    • Pot1, the putative telomere end-binding protein in fission yeast and humans
    • Baumann P., Cech T.R. Pot1, the putative telomere end-binding protein in fission yeast and humans. Science. 292:2001;1171-1175.
    • (2001) Science , vol.292 , pp. 1171-1175
    • Baumann, P.1    Cech, T.R.2
  • 31
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • Harley C.B., Futcher A.B., Greider C.W. Telomeres shorten during ageing of human fibroblasts. Nature. 345:1990;458-460.
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 32
    • 0037148271 scopus 로고    scopus 로고
    • Telomerase in the human organism
    • Collins K., Mitchell J.R. Telomerase in the human organism. Oncogene. 21:2002;564-579.
    • (2002) Oncogene , vol.21 , pp. 564-579
    • Collins, K.1    Mitchell, J.R.2
  • 33
    • 0034020630 scopus 로고    scopus 로고
    • Mammalian telomeres and telomerase
    • Collins K. Mammalian telomeres and telomerase. Curr. Opin. Cell Biol. 12:2000;378-383.
    • (2000) Curr. Opin. Cell Biol. , vol.12 , pp. 378-383
    • Collins, K.1
  • 35
    • 0033153424 scopus 로고    scopus 로고
    • Disease states associated with telomerase deficiency appear earlier in mice with short telomeres
    • Herrera E., Samper E., Martin-Caballero J., Flores J.M., Lee H.W., Blasco M.A. Disease states associated with telomerase deficiency appear earlier in mice with short telomeres. Embo J. 18:1999;2950-2960.
    • (1999) Embo J. , vol.18 , pp. 2950-2960
    • Herrera, E.1    Samper, E.2    Martin-Caballero, J.3    Flores, J.M.4    Lee, H.W.5    Blasco, M.A.6
  • 37
    • 0035812845 scopus 로고    scopus 로고
    • The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability
    • Hemann M.T., Strong M.A., Hao L.Y., Greider C.W. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell. 107:2001;67-77.
    • (2001) Cell , vol.107 , pp. 67-77
    • Hemann, M.T.1    Strong, M.A.2    Hao, L.Y.3    Greider, C.W.4
  • 38
    • 0010045614 scopus 로고    scopus 로고
    • Extension of life-span by introduction of telomerase into normal human cells
    • Bodnar A.G.et al. Extension of life-span by introduction of telomerase into normal human cells. Science. 279:1998;349-352.
    • (1998) Science , vol.279 , pp. 349-352
    • Bodnar, A.G.1
  • 39
    • 0037148326 scopus 로고    scopus 로고
    • Clinical utility of telomerase in cancer
    • Hiyama E., Hiyama K. Clinical utility of telomerase in cancer. Oncogene. 21:2002;643-649.
    • (2002) Oncogene , vol.21 , pp. 643-649
    • Hiyama, E.1    Hiyama, K.2
  • 40
    • 0032825217 scopus 로고    scopus 로고
    • Telomeres: Has cancer's Achilles' heel been exposed?
    • Zumstein L.A., Lundblad V. Telomeres. has cancer's Achilles' heel been exposed? Nature Med. 5:1999;1129-1130.
    • (1999) Nature Med. , vol.5 , pp. 1129-1130
    • Zumstein, L.A.1    Lundblad, V.2
  • 41
    • 0035978922 scopus 로고    scopus 로고
    • Emerging roles for telomerase in regulating cell differentiation and survival: A neuroscientist's perspective
    • Mattson M.P., Fu W., Zhang P. Emerging roles for telomerase in regulating cell differentiation and survival. a neuroscientist's perspective Mech. Aging and Dev. 122:2001;659-671.
    • (2001) Mech. Aging and Dev , vol.122 , pp. 659-671
    • Mattson, M.P.1    Fu, W.2    Zhang, P.3
  • 43
    • 0030697342 scopus 로고    scopus 로고
    • Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines
    • Bryan T.M., Englezou A., Dalla-Pozza L., Dunham M.A., Reddel R.R. Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines. Nat Med. 3:1997;1271-1274.
    • (1997) Nat Med. , vol.3 , pp. 1271-1274
    • Bryan, T.M.1    Englezou, A.2    Dalla-Pozza, L.3    Dunham, M.A.4    Reddel, R.R.5
  • 45
    • 0029154735 scopus 로고
    • Functional characterization and developmental regulation of mouse telomerase RNA
    • Blasco M.A., Funk W.D., Villeponteau B., Greider C.W. Functional characterization and developmental regulation of mouse telomerase RNA. Science. 269:1995;1267-1270.
    • (1995) Science , vol.269 , pp. 1267-1270
    • Blasco, M.A.1    Funk, W.D.2    Villeponteau, B.3    Greider, C.W.4
  • 46
    • 0033104511 scopus 로고    scopus 로고
    • Telomere shortening in mTR-/- embryos is associated with failure to close the neural tube
    • Herrera E., Samper E., Blasco M.A. Telomere shortening in mTR-/- embryos is associated with failure to close the neural tube. Embo J. 18:1999;1172-1181.
    • (1999) Embo J. , vol.18 , pp. 1172-1181
    • Herrera, E.1    Samper, E.2    Blasco, M.A.3
  • 47
    • 0033525558 scopus 로고    scopus 로고
    • Longevity, stress response, and cancer in aging telomerase-deficient mice
    • Rudolph K.L., Chang S., Lee H.W.et al. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell. 96:1999;701-712.
    • (1999) Cell , vol.96 , pp. 701-712
    • Rudolph, K.L.1    Chang, S.2    Lee, H.W.3
  • 48
    • 0343750697 scopus 로고    scopus 로고
    • Impaired germinal center reaction in mice with short telomeres
    • Herrera E., Martinez A.C., Blasco M.A. Impaired germinal center reaction in mice with short telomeres. Embo J. 19:2000;472-481.
    • (2000) Embo J. , vol.19 , pp. 472-481
    • Herrera, E.1    Martinez, A.C.2    Blasco, M.A.3
  • 49
    • 0037081078 scopus 로고    scopus 로고
    • Telomere length is a key molecular determinant of angiogenic potential in vivo: Implications for cancer and aging
    • Franco S., Segura I., Riese H., Blasco M.A. Telomere length is a key molecular determinant of angiogenic potential in vivo. implications for cancer and aging Cancer Research. 62:2002;552-559.
    • (2002) Cancer Research , vol.62 , pp. 552-559
    • Franco, S.1    Segura, I.2    Riese, H.3    Blasco, M.A.4
  • 50
    • 0037089438 scopus 로고    scopus 로고
    • Long-term repopulating ability of telomerase-deficient murine hematopoietic stem cells
    • Samper E., Fernández P., Martín-Rivera L., Bernad A., Blasco M.A., Aracil M. Long-term repopulating ability of telomerase-deficient murine hematopoietic stem cells. Blood. 99:2002;2767-2775.
    • (2002) Blood , vol.99 , pp. 2767-2775
    • Samper, E.1    Fernández, P.2    Martín-Rivera, L.3    Bernad, A.4    Blasco, M.A.5    Aracil, M.6
  • 51
    • 0031010342 scopus 로고    scopus 로고
    • A survey of telomerase activity in human cancer
    • Shay J.W., Bacchetti S. A survey of telomerase activity in human cancer. Eur. J. Cancer. 33:1997;787-791.
    • (1997) Eur. J. Cancer , vol.33 , pp. 787-791
    • Shay, J.W.1    Bacchetti, S.2
  • 52
    • 0343228751 scopus 로고    scopus 로고
    • Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis
    • Gonzalez-Suarez E., Samper E., Flores J.M., Blasco M.A. Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis. Nat Genet. 26:2000;114-117.
    • (2000) Nat Genet , vol.26 , pp. 114-117
    • Gonzalez-Suarez, E.1    Samper, E.2    Flores, J.M.3    Blasco, M.A.4
  • 53
    • 0033553516 scopus 로고    scopus 로고
    • P53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
    • Chin L., Artandi S.E., Shen Q.et al. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell. 97:1999;527-538.
    • (1999) Cell , vol.97 , pp. 527-538
    • Chin, L.1    Artandi, S.E.2    Shen, Q.3
  • 54
    • 0034632717 scopus 로고    scopus 로고
    • Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
    • Artandi S.E., Chang S., Lee S.L.et al. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature. 406:2000;641-645.
    • (2000) Nature , vol.406 , pp. 641-645
    • Artandi, S.E.1    Chang, S.2    Lee, S.L.3
  • 55
    • 0034978564 scopus 로고    scopus 로고
    • Telomere dysfunction and evolution of intestinal carcinoma in mice and humans
    • Rudolph K.L., Millard M., Bosenberg M.W., DePinho R.A. Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nat Genet. 28:2001;155-159.
    • (2001) Nat Genet , vol.28 , pp. 155-159
    • Rudolph, K.L.1    Millard, M.2    Bosenberg, M.W.3    DePinho, R.A.4
  • 56
    • 0000146723 scopus 로고    scopus 로고
    • Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse
    • Greenberg R.A., Chin L., Femino A.et al. Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse. Cell. 97:1999;515-525.
    • (1999) Cell , vol.97 , pp. 515-525
    • Greenberg, R.A.1    Chin, L.2    Femino, A.3
  • 57
    • 0034606226 scopus 로고    scopus 로고
    • Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals
    • Goytisolo F.A., Samper E., Martin-Caballero J.et al. Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals. J Exp Med. 192:2000;1625-1636.
    • (2000) J Exp Med. , vol.192 , pp. 1625-1636
    • Goytisolo, F.A.1    Samper, E.2    Martin-Caballero, J.3
  • 58
    • 0033822365 scopus 로고    scopus 로고
    • Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation
    • Wong K.K., Chang S., Weiler S.R.et al. Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation. Nat Genet. 26:2000;85-88.
    • (2000) Nat Genet , vol.26 , pp. 85-88
    • Wong, K.K.1    Chang, S.2    Weiler, S.R.3
  • 59
    • 0030070054 scopus 로고    scopus 로고
    • Differential regulation of telomerase activity and its RNA component during multistage tumorigenesis
    • Blasco M.A., Rizen M., Greider C.W., Hanahan D. Differential regulation of telomerase activity and its RNA component during multistage tumorigenesis. Nat Genet. 12:1996;200-204.
    • (1996) Nat Genet , vol.12 , pp. 200-204
    • Blasco, M.A.1    Rizen, M.2    Greider, C.W.3    Hanahan, D.4
  • 60
    • 0029941676 scopus 로고    scopus 로고
    • Telomerase activation in mouse mammary tumors: Lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation
    • Broccoli D., Godley L.A., Donehower L.A., Varmus H.E., de Lange T. Telomerase activation in mouse mammary tumors. lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation Mol Cell Biol. 16:1996;3765-3772.
    • (1996) Mol Cell Biol. , vol.16 , pp. 3765-3772
    • Broccoli, D.1    Godley, L.A.2    Donehower, L.A.3    Varmus, H.E.4    De Lange, T.5
  • 61
    • 0035355340 scopus 로고    scopus 로고
    • Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes
    • Gonzalez-Suarez E., Samper E., Ramirez A.et al. Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes. Embo J. 20:2001;2619-2630.
    • (2001) Embo J. , vol.20 , pp. 2619-2630
    • Gonzalez-Suarez, E.1    Samper, E.2    Ramirez, A.3
  • 62
    • 0036787840 scopus 로고    scopus 로고
    • Coorperation between p53 mutation and high telomerase transgenic expression in spontaneous cancer development
    • in press
    • González-Suárez E, Flores JM, Blasco MA. Coorperation between p53 mutation and high telomerase transgenic expression in spontaneous cancer development. Mol Cell Biol, in press.
    • Mol Cell Biol
    • González-Suárez, E.1    Flores, J.M.2    Blasco, M.A.3
  • 63
    • 0037062454 scopus 로고    scopus 로고
    • Constitutive telomerase expression promotes mammary carcinomas in aging mice
    • Artandiet al. Constitutive telomerase expression promotes mammary carcinomas in aging mice. Proc Natl Acad Sci USA. 99:2002;8191-8196.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 8191-8196
    • Artandi1
  • 64
    • 0029778191 scopus 로고    scopus 로고
    • Requirement for Ku80 in growth and immunoglobulin V(D)J recombination
    • Nussenzweig A., Chen C., da Costa Soares V.et al. Requirement for Ku80 in growth and immunoglobulin V(D)J recombination. Nature. 382:1996;551-555.
    • (1996) Nature , vol.382 , pp. 551-555
    • Nussenzweig, A.1    Chen, C.2    Da Costa Soares, V.3
  • 66
    • 0034732239 scopus 로고    scopus 로고
    • DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation
    • Difilippantonio M.J., Zhu J., Chen H.T.et al. DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation. Nature. 404:2000;510-514.
    • (2000) Nature , vol.404 , pp. 510-514
    • Difilippantonio, M.J.1    Zhu, J.2    Chen, H.T.3


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