Telomeres: Has cancer's Achilles' heel been exposed?

Nature Medicine

Volumn 5, Issue 10, 1999, Pages 1129-1130

  Zumstein, Louis A ^a   Lundblad, Victoria ^b  

^a Introgen Therapeutics Inc   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TELOMERASE;

CANCER GROWTH; CANCER RESEARCH; CARCINOGENESIS; CELL IMMORTALIZATION; ENZYME ACTIVITY; ENZYME SUBUNIT; GENE EXPRESSION REGULATION; GROWTH REGULATION; GROWTH STIMULATION; HUMAN; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; SHORT SURVEY; TELOMERE;

CELL TRANSFORMATION, NEOPLASTIC; DNA REPLICATION; DRUG DESIGN; NEOPLASMS; TELOMERASE;

EID: 0032825217     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/13451     Document Type: Short Survey

References (10)

1. Shay, J.W. & Bacchetti, S. A survey of telomerase activity in human cancer. Eur. J. of Cancer 33, 787-791 (1997).
2. Δ2/3 cancer-prone mouse. Cell 97, 515-525.
3. Hahn, W.C. et al. Creation of human tumor cells with defined genetic elements. Nature 400, 464-472 (1999).
4. Hahn, W.C. et al. Inhibition of telomerase inhibits the growth of human cancer cells. Nature Med. 5, 1164-1170 (1999).
5. Lingner, J. et al. Reverse transcriptase motifs in the catalytic subunit of telomerase. Science 276, 561-567 (1997).
6. Chin, L. et al. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell 14, 527-538 (1999).
7. Karlseder, J., Broccoli, D., Dai, Y., Hardy, S. & de Lange, T. p53-and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 283, 1321-1325 (1999).
8. Lee, H.-W. et al. Essential role of mouse telomerase in highly proliferative organs. Nature 392, 569-574.
9. Rudolph, K.L. et al. Longevity, stress response, and cancer in aging telomerase deficient mice. Cell 96, 701-712.
10. Nugent, C., Hughes, T.R., Lue, N.F. & Lundblad, V. Cdc13 is a single-stranded telomere binding protein with a dual role in yeast telomere maintenance. Science 274, 249-252 (1996).