Emerging roles for telomerase in regulating cell differentiation and survival: A neuroscientist's perspective

Mechanisms of Ageing and Development

Volumn 122, Issue 7, 2001, Pages 659-671

  Mattson, Mark P ^a,b   Fu, Weiming ^a   Zhang, Peisu ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Cancer; Differentiation; Mitochondria; Neurons

Indexed keywords

CYTOKINE; ESTROGEN; NEUROTROPHIC FACTOR; TELOMERASE;

APOPTOSIS; ARTICLE; BRAIN NERVE CELL; CELL DEATH; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; DEGENERATIVE DISEASE; DNA SEQUENCE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME MECHANISM; HUMAN; NERVOUS SYSTEM DEVELOPMENT; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

ANIMALS; CELL DEATH; CELL DIFFERENTIATION; CELL SURVIVAL; HUMANS; NEOPLASMS; NERVOUS SYSTEM; NEURONS; NEUROSCIENCES; TELOMERASE;

EID: 0035978922     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(01)00221-4     Document Type: Review

References (54)

1. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
2. Extension of life-span by introduction of telomerase into normal human cells
3. Control of cell proliferation by Myc
4. Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2
5. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
6. Differentiation-related mechanisms which suppress DNA replication
7. Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability
8. Telomerase, Ku, and telomeric silencing in Saccharomyces cerevisiae
9. Anti-apoptotic role of telomerase in pheochromocytoma cells
10. The catalytic subunit of telomerase is expressed in developing brain neurons and serves a cell survival-promoting function
11. The MYC dualism in growth and death
12. Identification and characterization of negative regulatory elements of the human telomerase catalytic subunit (hTERT) gene promoter: Possible role of MZF-2 in transcriptional repression of hTERT
13. Mammalian neural stem cells
14. Cell birth, cell death, cell diversity and DNA breaks: How do they all fit together?
15. Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation
16. Expression of the hTERT gene is regulated at the level of transcriptional initiation and repressed by Mad1
17. Fibroblast growth factor 2 up regulates telomerase activity in neural precursor cells
18. The hallmarks of cancer
19. Human telomerase contains evolutionarily conserved catalytic and structural subunits
20. Impaired germinal center reaction in mice with short telomeres
21. Telomere shortening in mTR -/- embryos is associated with failure to close the neural tube
22. Resistance to apoptosis in human cells conferred by telomerase function and telomere stability
23. Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit
24. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2
25. Specific association of human telomerase activity with immortal cells and cancer
26. Telomerase biology in human aging and aging syndromes
27. Telomerase activity in immortal fish
28. Longevity of lobsters is linked to ubiquitous telomerase expression
29. Differential regulation of telomerase activity and TERT expression during brain development in mice
30. Inhibition of telomerase increases the susceptibility of human malignant glioblastoma cells to cisplatin-induced apoptosis
31. Antisense telomerase treatment: Induction of two distinct pathways, apoptosis and differentiation
32. Treatment of prostate cancer in vitro and in vivo with 2-5A-anti-telomerase RNA component
33. Telomere reduction and telomerase inactivation during neuronal cell differentiation
34. hTERT
35. Inhibition of mitogen-activated protein kinase blocks proliferation of neural progenitor cells
36. p53: The cellular gatekeeper for growth and division
37. Studies of the molecular mechanisms in the regulation of telomerase activity
38. Bcl-2 modulates telomerase activity
39. Neurotrophic factor and cytokine signaling in the aging brain
40. Apoptosis in neurodegenerative disorders
41. Roles of NF-κB in neuronal survival and plasticity
42. Induction of hTERT expression and telomerase activity by estrogens in human overy epithelium cells
43. Presence of telomeric G-strand tails in the telomerase catalytic subunit TERT knockout mice
44. Human neural precursor cells express low levels of telomerase in vitro and show diminishing cell proliferation with extensive axonal outgrowth following transplantation
45. Influence of ATM function on interactions between telomeres and nuclear matrix
46. Telomeres, telomerase and immortality
47. Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery
48. Restoration of wild-type PTEN expression leads to apoptosis, induces differentiation, and reduces telomerase activity in human glioma cells
49. Control of telomere length by the human telomeric protein TRF1
50. Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cell
51. Anti-telomerase therapy suppressed glioma proliferation
52. NF-κB regulates transcription of the mouse telomerase catalytic subunit
53. The catalytic subunit of telomerase protects neurons against amyloid β-peptide-induced apoptosis
54. Telomerase extends the lifespan of virsu-transformed human cells without net telomere lengthening