Notch signaling as a therapeutic target

Current Opinion in Chemical Biology

Volumn 6, Issue 4, 2002, Pages 501-509

  Nam, Yunsun ^a   Aster, Jon C ^a   Blacklow, Stephen C ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NOTCH RECEPTOR;

CELL DIFFERENTIATION; CELL PROLIFERATION; CELL TYPE; GENE TARGETING; HUMAN; NONHUMAN; PROTEIN DEGRADATION; REVIEW; SIGNAL TRANSDUCTION; STEM CELL;

EID: 0036679649     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1367-5931(02)00346-0     Document Type: Review

References (120)

1. The LIN-12/Notch signaling pathway and its regulation
2. Notch signaling: Cell fate control and signal integration in development
3. TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
4. Deficient T cell fate specification in mice with an induced inactivation of Notch1
5. Notch1 expression in early lymphopoiesis influences B versus T lineage determination
6. Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by Notch1
7. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles
8. Strong clustering and stereotyped nature of Notch3 mutations in CADASIL patients
9. The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients
10. Mutations in the human Jagged1 gene are responsible for Alagille syndrome
11. Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1
12. Fifteen novel mutations in the JAGGED1 gene of patients with Alagille syndrome
13. Mutation analysis of Jagged1 (JAG1) in Alagille syndrome patients
14. Mutations in the human delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis
15. The Notch1 receptor is cleaved constitutively by a furin-like convertase
16. Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane
17. Specific EGF repeats of Notch mediate interactions with Delta and Serrate: Implications for Notch as a multifunctional receptor
18. Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei
19. Analysis of gain-of-function mutations of the lin-12 gene of Caenorhabditis elegans
20. Further evidence for function of the Drosophila Notch protein as a transmembrane receptor
21. The folding and structural integrity of the first LIN-12 module of human Notch1 are calcium-dependent
22. Calcium depletion dissociates and activates heterodimeric Notch receptors
23. Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H)
24. Studies of the ankyrin repeats of the Drosophila melanogaster Notch receptor. 1. Solution conformational and hydrodynamic properties
25. Studies of the ankyrin repeats of the Drosophila melanogaster Notch receptor. 2. Solution stability and cooperativity of unfolding
26. Dynamic expression patterns of the pudgy/spondylocostal dysostosis gene Dll3 in the developing nervous system
27. Isolation and characterization of the Notch ligand delta4
28. Dll4, a novel Notch ligand expressed in arterial endothelium
29. Molecular cloning of delta-4, a new mouse and human Notch ligand
30. Shibire, a neurogenic mutant of Drosophila
31. Requirement for dynamin during Notch signaling in Drosophila neurogenesis
32. Ligand endocytosis drives receptor dissociation and activation in the Notch pathway
33. Neuralized functions as an E3 ubiquitin ligase during Drosophila development
34. Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta
35. Neuralized encodes a peripheral membrane protein involved in delta signaling and endocytosis
36. Neuralized functions cell-autonomously to regulate a subset of Notch- dependent processes during adult Drosophila development
37. Neuralized is essential for a subset of Notch pathway-dependent cell fate decisions during Drosophila eye development
38. Neuralized functions cell autonomously to regulate Drosophila sense organ development
39. Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans
40. A novel proteolytic cleavage involved in Notch signaling: The role of the disintegrin-metalloprotease TACE
41. A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1
42. Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis
43. The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs
44. Kuzbanian-mediated cleavage of Drosophila Notch
45. Presenilin is required for activity and nuclear access of Notch in Drosophila
46. Neurogenic phenotypes and altered Notch processing in Drosophila presenilin mutants
47. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
48. Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations
49. Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1
50. Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state
51. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1
52. Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing
53. Aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling
54. APH-2/nicastrin functions in LIN-12/Notch signaling in the Caenorhabditis elegans somatic gonad
55. Nicastrin is required for presenilin-mediated transmembrane cleavage in Drosophila
56. Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor
57. Nicastrin binds to membrane-tethered Notch
58. Nuclear access and action of notch in vivo
59. Indirect evidence for Delta-dependent intracellular processing of notch in Drosophila embryos
60. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
61. Signalling downstream of activated mammalian Notch
62. Structure, chromosomal locus, and promoter of mouse Hes2 gene, a homologue of Drosophila hairy and Enhancer of split
63. Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes
64. The suppressor of hairless protein participates in Notch receptor signaling
65. Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2
66. MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors
67. Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5
68. Mammalian Notch1 is modified with two unusual forms of O-linked glycosylation found on epidermal growth factor-like modules
69. Fringe is a glycosyltransferase that modifies Notch
70. Glycosyltransferase activity of Fringe modulates Notch-Delta interactions
71. Fringe modulates Notch-ligand interactions
72. A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway
73. Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila
74. Fringe forms a complex with Notch
75. The Abruptex domain of Notch regulates negative interactions between Notch, its ligands and Fringe
76. Manic Fringe and Lunatic Fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation
77. Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2
78. The notch intracellular domain is ubiquitinated and negatively regulated by the mammalian sel-10 homolog
79. SEL-10 is an inhibitor of Notch signaling that targets notch for ubiquitin-mediated protein degradation
80. Structure and distribution of the Notch protein in developing Drosophila
81. Nuclear Notch1 signaling and the regulation of dendritic development
82. Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2
83. Hyperphosphorylation and association with rbp of the intracellular domain of Notch1
84. Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor
85. Phosphorylation of Ser2078 modulates the Notch2 function in 32D cell differentiation
86. Ligand-induced signaling in the absence of furin processing of Notch1
87. Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats
88. Numb antagonizes Notch signaling to specify sibling neuron cell fates
89. Control of daughter cell fates during asymmetric division: Interaction of Numb and Notch
90. T cell leukemia-associated human Notch/translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells
91. Human notch-1 inhibits NF-κB activity in the nucleus through a direct interaction involving a novel domain
92. Alterations in Notch signaling in neoplastic lesions of the human cervix
93. Novel association of a diverse range of genes with renal cell carcinoma as identified by differential display
94. Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice
95. The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4)
96. Two distinct Notch1 mutant alleles are involved in the induction of T- cell leukemia in c-myc transgenic mice
97. A carboxy-terminal deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic mice
98. A novel Notch ligand, Dll4, induces T-cell leukemia/lymphoma when overexpressed in mice by retroviral-mediated gene transfer
99. Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2
100. Epstein-Barr virus genes and cancer cells
101. EBNA2 and Notch signalling in Epstein-Barr virus mediated immortalization of B lymphocytes
102. Notch-1 controls the expression of fatty acid-activated transcription factors and is required for adipogenesis
103. Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch
104. Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch
105. New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage
106. A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a csl protein to build a transcriptional activator complex on target promoters
107. Activated Notch2 signaling inhibits differentiation of cerebellar granule neuron precursors by maintaining proliferation
108. The Notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells
109. Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain
110. Immobilization of Notch ligand, Delta-1, is required for induction of notch signaling
111. Soluble Jagged 1 represses the function of its transmembrane form to induce the formation of the Src-dependent chord-like phenotype
112. Dual role of the Fringe connection gene in both heparan sulphate and Fringe-dependent signalling events
113. Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase
114. Fringe modulation of Jagged1-induced Notch signaling requires the action of beta 4galactosyltransferase-1
115. Enhanced proliferation and differentiation of rat hepatocytes cultured with bone marrow stromal cells
116. The Notch/Jagged pathway inhibits proliferation of human hematopoietic progenitors in vitro
117. Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling
118. Characterization of a high-molecular-weight Notch complex in the nucleus of Notch(ic)-transformed RKE cells and in a human T-cell leukemia cell line
119. Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex
120. Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma