Hyperphosphorylation and association with RBP of the intracellular domain of Notch1

Biochemical and Biophysical Research Communications

Volumn 286, Issue 3, 2001, Pages 484-492

  Foltz, Daniel R ^a   Nye, Jeffrey S ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Alzheimer's disease; Lateral inhibition; Neuronal differentiation; Notch; Phosphorylation

Indexed keywords

NOTCH RECEPTOR; PHOSPHATE; PHOSPHORUS 32;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; DEGENERATIVE DISEASE; IMMUNOPRECIPITATION; MOUSE; NERVE CELL DIFFERENTIATION; NEUROLOGIC DISEASE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

EID: 0034801779     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.5421     Document Type: Article

References (24)

1. Notch signaling: Cell fate control and signal integration in development
2. Notch signaling: From the outside in
3. The suppressor of hairless protein participates in notch receptor signaling
4. Suppressor of Hairless is required for signal reception during lateral inhibition in the Drosophila pupal notum
5. Signaling downstream of activated mammalian Notch
6. Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives
7. Structure and distribution of the Notch protein in developing Drosophila
8. Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos
9. Binding of Delta1 Jagged1, and Jagged2 to N0tch2 rapidly induces cleavage, nuclear translocation, and hyperphospherylation of Notch2
10. Nuclear Notch1 signaling and the regulation of dendritic development
11. SEL-5, a serine/threonine kinase that facilitates lin-12 activity in Caenorhabditis elegans
12. Numb-associated kinase interacts with the phosphotyrosine binding domain of Numb and antagonizes the function of Numb in vivo
13. GAK: A cyclin G associated kinase contains a tensin/ auxilin-like domain
14. Drosophila shaggy kinase and rat glycogen synthase kinase-3 have conserved activities and act downstream of Notch
15. An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells
16. Signal transduction by activated mNotch: Importance of proteolytic processing and its regulation by the extracellular domain
17. Notch-1 signaling requires ligand-induced proteolytic release of intracellular domain
18. The intracellular domain of mouse Notch: A constitutively activated represser of myogenesis directed at the basic helix-loop-helix region of MyoD
19. Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane
20. The Notch1 receptor is cleaved constitutively by a furin-like convertase
21. Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription
22. The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity
23. The regulation of protein transport to the nucleus by phosphorylation
24. Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins