Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain

EMBO Journal

Volumn 21, Issue 3, 2002, Pages 294-302

  Shimizu, Kiyoshi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Extracellular cleavage; Intracellular cleavage; Multimerization; Notch; Notch ligand

Indexed keywords

GENE PRODUCT; NOTCH RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FAMILY; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; CROSS-LINKING REAGENTS; DIMERIZATION; HUMANS; MEMBRANE PROTEINS; MICE; PROTEIN BINDING; RECEPTOR, NOTCH2; RECEPTORS, CELL SURFACE; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0036469994     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/21.3.294     Document Type: Article

References (43)

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5. Roles for proteolysis and trafficking in notch maturation and signal transduction
6. Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta
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11. Dimerization of cell surface receptors in signal transduction
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15. The Notch ligand, X-Delta-2, mediates segmentation of the paraxial mesoderm in Xenopus embryos
16. The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells
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21. Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1
22. The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1
23. The Notch1 receptor is cleaved constitutively by a furin-like convertase
24. RBP-L, a transcription factor related to RBP-Jkappa
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27. Mutations in the human Jagged1 gene are responsible for Alagille syndrome
28. Ligand endocytosis drives receptor dissociation and activation in the Notch pathway
29. Processing of the notch ligand delta by the metalloprotease Kuzbanian
30. Calcium depletion dissociates and activates heterodimeric notch receptors
31. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
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33. Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2
34. Nuclear access and action of notch in vivo
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37. Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila
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39. Immobilization of Notch ligand, Delta-1, is required for induction of notch signaling
40. The ins and outs of notch signaling
41. A homolog of Drosophila Notch expressed during mammalian development
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43. Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants