Isolation and characterization of the notch ligand Delta4

Experimental Cell Research

Volumn 260, Issue 2, 2000, Pages 379-386

  Rao, Prakash K ^a   Dorsch, Marion ^b   Chickering, Troy ^b   Zheng, Gang ^b   Jiang, Chiang ^b   Goodearl, Andrew ^b   Kadesch, Tom ^a   McCarthy, Sean ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; LIGAND; MEMBRANE PROTEIN; MEMBRANE RECEPTOR; NOTCH LIGAND DELTA4; PROTEIN CSL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA BINDING; EMBRYO; EMBRYO DEVELOPMENT; EYE; HEART; KIDNEY; LIVER; LUNG; MOUSE; MUSCLE DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION;

EID: 0034329423     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2000.5034     Document Type: Article

References (51)

1. Notch signaling: Cell fate control and signal integration in development
2. Notch signalling controls pancreatic cell differentiation
3. Notch1 is required for the coordinate segmentation of somites
4. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
5. Notch2: A second mammalian Notch gene
6. The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium
7. Notch signaling in vertebrate development and disease
8. Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta
9. Mouse Dll3: A novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo
10. Jagged: A mammalian ligand that activates Notch1
11. Jagged2: A serrate-like gene expressed during rat embryogenesis
12. Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor
13. Functional domains of LAG-2, a putative signaling ligand for LIN-12 and GLP-1 receptors in Caenorhabditis elegans
14. Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods
15. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
16. Nuclear access and action of notch in vivo
17. A ligand-induced extracellular cleavage regulates g-secretase-like proteolytic activation of Notch1
18. A novel proteolytic cleavage involved in Notch signaling: The role of the disintegrin-metalloprotease TACE
19. Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2
20. Signalling downstream of activated mammalian Notch
21. Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H)
22. A histone deacetylase corepressor complex regulates the Notch signal transduction pathway
23. CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex
24. Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5
25. Activated notch inhibits myogenic activity of the MADS-Box transcription factor myocyte enhancer factor 2C
26. Protective effects of notch-1 on TCR-induced apoptosis
27. T cell leukemia-associated human Notch/translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells
28. Notch signaling: A dance of proteins changing partners
29. Maintenance of somite borders in mice requires the Delta homologue Dll1
30. Expression of the mouse Delta1 gene during organogenesis and fetal development
31. Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice
32. Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1
33. Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1
34. Mutations in the human Jagged1 gene are responsible for Alagille syndrome
35. Dll4, a novel Notch ligand expressed in arterial endothelium
36. Characterization of a neuregulin-related gene. Don-1, that is highly expressed in restricted regions of the cerebellum and hippocampus
37. Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow
38. Phylogenetic analysis of vertebrate and invertebrate Delta/Serrate/LAG- 2 (DSL) proteins
39. Sequence of C. elegans lag-2 reveals a cell-signalling domain shared with Delta and Serrate of Drosophila
40. Single amino acid substitutions in EGF-like elements of Notch and Delta modify Drosophila development and affect cell adhesion in vitro
41. Vertebrate retinal ganglion cells are selected from competent progenitors by the action of Notch
42. Expression patterns of Jagged, Delta1, Notch1, Notch2, and Notch3 genes identify ligand-receptor pairs that may function in neural development
43. Notch receptor activation inhibits oligodendrocyte differentiation
44. The Notch pathway helps to pattern the tips of the Drosophila tracheal branches by selecting cell fates
45. Interplay of Notch and FGF signaling restricts cell fate and MAPK activation in the Drosophila trachea
46. Notch signaling is essential for vascular morphogenesis in mice
47. Notch signaling imposes two distinct blocks in the differentiation of C2C12 myoblasts
48. Delta-1 activation of notch-1 signaling results in HES-1 trans-activation
49. Delta-induced Notch signaling mediated by RBP-J inhibits MyoD expression and myogenesis
50. Contact-dependent inhibition of cortical neurite growth mediated by notch signaling
51. Delta and Serrate are redundant Notch ligands required for asymmetric cell divisions within the Drosophila sensory organ lineage