Elements of transcription factor network design for T-lineage specification

Developmental Biology

Volumn 246, Issue 1, 2002, Pages 29-44

  Rothenberg, Ellen V ^a   Anderson, Michele K ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Combinatorial regulation; Dose dependent regulation; GATA 3; Hematopoiesis; Lineage choice; PU.1; T cell development; Transcriptional network

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR PU 1;

CELL DIFFERENTIATION; CELL FATE; CELL LINEAGE; CELL MATURATION; CELL SURVIVAL; COMBINATORIAL LIBRARY; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; MOLECULAR MODEL; NONHUMAN; PLASTICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; REGULATORY MECHANISM; REVIEW; T LYMPHOCYTE;

MAMMALIA; MURINAE;

EID: 0036607584     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.2002.0667     Document Type: Review

References (108)

1. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
2. c-Myb is essential for early T cell development
3. Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells
4. Transcription factor PU.1 is necessary for development of thymic and myeloid progenitor-derived dendritic cells
5. Precise developmental regulation of Ets family transcription factors during specification and commitment to the T cell lineage
6. Definition of regulatory network elements for T-cell development by perturbation analysis with PU.1 and GATA-3
7. Constitutive expression of PU.1 in fetal hematopoietic progenitors blocks T-cell development at the pro-T stage
8. Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade
9. The role of E-proteins in B- and T-lymphocyte development
10. A novel role for HEB downstream or parallel to the pre-TCR signaling pathway during αβ thymopoiesis
11. The SCL gene: From case report to critical hematopoietic regulator
12. 2-terminal kinase-independent coactivator of the PU.1 transcription factor
13. Granulocytic differentiation of normal hematopoietic precursor cells induced by transcription factor PU.1 correlates with negative regulation of the c-myb promoter
14. Lineage commitment in lymphopoiesis
15. Signals transduced by CD3ε, but not by surface pre-TCR complexes, are able to induce maturation of an early thymic lymphoma in vitro
16. Enforced expression of the GATA-3 transcription factor affects cell fate decisions in hematopoiesis
17. Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: Parallels with E2A-deficient mice
18. BSAP/Pax5A expression blocks survival and expansion of early myeloid cells implicating its involvement in maintaining commitment to the B-lymphocyte lineage
19. Differential requirement for the transcription factor PU.1 in the generation of natural killer cells versus B and T cells
20. Control of lymphocyte development by the Ikaros gene family
21. The lineage commitment of haemopoietic progenitor cells
22. Regulation of B lymphocyte and macrophage development by graded expression of PU.1
23. Qualitative and quantitative aspects of haematopoietic cell development in the mammalian embryo
24. Early thymocyte development is regulated by modulation of E2A protein activity
25. The function of E- and Id proteins in lymphocyte development
26. A critical role for PU.1 in homing and long-term engraftment by hematopoietic stem cells in the bone marrow
27. Role of PU.1 in hematopoiesis
28. Transcription factors required for lymphoid lineage commitment
29. Transcription factors that induce commitment of multipotent hematopoietic progenitors: Lessons from the MEP system
30. T-cell expression of the human GATA-3 gene is regulated by a non-lineage specific silencer
31. Cell-fate decisions in early T cell development: Regulation by cytokine receptors and the pre-TCR
32. Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix loop helix factor Id3
33. Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus
34. SCL and LMO1 alter thymocyte differentiation: Inhibition of E2A-HEB function and pre-Tα chain expression
35. Cooperation among multiple transcription factors is required for access to minimal T-cell receptor α-enhancer chromatin in vivo
36. Opposing effects of the basic helix-loop-helix transcription factor SCL on erythroid and monocytic differentiation
37. Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis
38. PU.1/Spi-B regulation of c-rel Is essential for mature B cell survival
39. Multilineage gene expression precedes commitment in the hemopoietic system
40. Commitment of common T/natural killer (NK) progenitors to unipotent T and NK progenitors in the murine fetal thymus revealed by a single progenitor assay
41. Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation
42. Stromal expression of Jagged 1 promotes colony formation by fetal hematopoietic progenitor cells
43. A role for Pref-1 and HES-1 in thymocyte development
44. Induction of Early B Cell Factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12
45. Subversion of the T/B lineage decision in the thymus by lunatic fringe-mediated inhibition of Notch-1
46. Lymphocyte development from hematopoietic stem cells
47. Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines
48. Identification of clonogenic common lymphoid progenitors in mouse bone marrow
49. Transcription factor SCL is required for c-kit expression and c-Kit function in hemopoietic cells
50. Branching out to gain control: How the pre-TCR is linked to multiple functions
51. Suppression of erythroid but not megakaryocytic differentiation of human K562 erythroleukemic cells by Notch-1
52. Generation of macrophages from early T progenitors in vitro
53. BSAP can repress enhancer activity by targeting PU.1 function
54. Biologic significance of GATA-1 activities in Ras-mediated megakaryocytic differentiation of hematopoietic cell lines
55. The transcription factor PU.1 does not regulate lineage commitment but has lineage-specific effects
56. Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities
57. Clonal characterization of a bipotent T cell and NK cell progenitor in the mouse fetal thymus
58. Overexpression of the helix-loop-helix protein Id2 blocks T cell development at multiple stages
59. The AML1 transcription factor functions to develop and maintain hematogenic precursor cells in the embryonic aorta-gonad-mesonephros region
60. PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors
61. GATA-1 interacts with the myeloid PU.1 transcription factor and represses PU.1-dependent transcription
62. Vintage reds and whites: Combinatorial transcription factor utilization in hematopoietic differentiation
63. Defects in hemopoietic stem cell activity in Ikaros mutant mice
64. E-box sequence and context-dependent TAL1/SCL modulation of basic helix-loop-helix protein-mediated transcriptional activation
65. Cbfa2 is required for the formation of intra-aortic hematopoietic clusters
66. Commitment to the B-lymphoid lineage depends on the transcription factor Pax5
67. Essential functions of Pax5 (BSAP) in pro-B cell development: Difference between fetal and adult B lymphopoiesis and reduced V- to-DJ recombination at the IgH locus
68. The Notch ligand Delta-1, inhibits the differentiation of monocytes into macrophages but permits their differentiation into dendritic cells
69. Notch inhibition of E47 supports the existence of a novel signaling pathway
70. Transcriptional control during erythroid and megakaryocytic development
71. c-Myb regulates the proliferation of immature thymocytes following β-selection
72. Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1
73. Notch1 expression in early lymphopoiesis influences B versus T lineage determination
74. Cooperation of Spi-1/PU.1 with an activated erythropoietin receptor inhibits apoptosis and Epo-dependent differentiation in primary erythroblasts and induces their Kit ligand-dependent proliferation
75. Notch1 deficiency dissociates the intrathymic development of dendritic cells and T cells
76. Deficient T cell fate specification in mice with an induced inactivation of Notch1
77. Myb and Ets proteins are candidate regulators of c-kit expression in human hematopoietic cells
78. Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: Functional antagonism in erythroid cells
79. Transcriptional regulation of B-cell differentiation
80. Developmental dissociation of thymic dendritic cell and thymocyte lineages revealed in growth factor receptor mutant mice
81. Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors
82. Constitutive c-myb expression in K562 cells inhibits induced erythroid differentiation but not tetradecanoyl phorbol acetate-induced megakaryocytic differentiation
83. Transcriptional regulation of lymphocyte lineage commitment
84. A dynamic assembly of diverse transcription factors integrates activation and cell-type information for interleukin-2 gene regulation
85. PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors
86. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
87. B-cell-specific DNA binding by an E47 homodimer
88. The transcriptional control of hematopoiesis
89. The linkage between T-cell and dendritic cell development in the mouse thymus
90. A transcription factor party during blood cell differentiation
91. T cell development in PU.1-deficient mice
92. + stem cells into predendritic cell (Pre-DC)2 but not into Pre-DC1: Evidence for a lymphoid origin of Pre-DC2
93. Transcription factors, normal myeloid development, and leukemia
94. Transcription factor GATA-3 is required for development of the T-cell lineage
95. The bHLH gene Hes1 is essential for expansion of early T cell precursors
96. Enforced TAL-1 expression stimulates primitive, erythroid and megakaryocytic progenitors but blocks the granulopoietic differentiation program
97. Complex regulation of human c-kit transcription by promoter repressors, activators, and specific myb elements
98. Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling
99. Pleiotropic changes controlled by the pre-T-cell receptor
100. Dependence of BSAP repressor and activator functions on BSAP concentration
101. Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation
102. Novel insights into erythroid development revealed through in vitro differentiation of GATA-1-embryonic stem cells
103. Notch1 -deficient common lymphoid precursors adopt a B cell fate in the thymus
104. Overexpression of PU.1 induces growth and differentiation inhibition and apoptotic cell death in murine erythroleukemia cells
105. Acetylation of GATA-3 affects T-cell survival and homing to secondary lymphoid organs
106. Human granulocyte-macrophage colony-stimulating factor (hGM-CSF) induces inhibition of intrathymic T-cell development in hGM-CSF receptor transgenic mice
107. Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2
108. Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1