c-Myb regulates the proliferation of immature thymocytes following β-selection

EMBO Journal

Volumn 19, Issue 22, 2000, Pages 6112-6120

  Pearson, R ^a   Weston, K ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

c Myb; Cell cycle; Pim1; T cell; selection

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GENE PRODUCT; ONCOPROTEIN; PROTEIN KINASE PIM 1; PROTEIN MENT; PROTEIN SERINE THREONINE KINASE; T LYMPHOCYTE RECEPTOR BETA CHAIN; UNCLASSIFIED DRUG;

ALLELE; ANIMAL CELL; ARTICLE; CELL CYCLE; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CELL SELECTION; CONTROLLED STUDY; MOUSE; NONHUMAN; ONCOGENE C MYB; PRIORITY JOURNAL; T LYMPHOCYTE; THYMOCYTE; TRANSGENIC MOUSE;

ALLELES; ANIMALS; ANTIGENS, CD4; ANTIGENS, CD8; BASE SEQUENCE; CELL CYCLE; CELL DIFFERENTIATION; CELL DIVISION; DNA PRIMERS; GENE REARRANGEMENT, BETA-CHAIN T-CELL ANTIGEN RECEPTOR; GENES, MYB; HEMATOPOIESIS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MYB; PROTO-ONCOGENE PROTEINS C-PIM-1; T-LYMPHOCYTES;

ANIMALIA; MUS MUSCULUS;

EID: 0034669164     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (71)

1. Delayed thymocyte development induced by augmented expression of p56lck
2. c-Myb is essential for early T cell development
3. Dominant interfering alleles define a role for c-Myb in T cell development
4. A novel role for HEB downstream or parallel to the pre-TCR signaling pathway during αβ thymopoiesis
5. Baxα perturbs T cell development and affects cell cycle entry of T cells
6. The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling
7. Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development
8. The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte
9. Specific requirement for CD3epsilon in T cell development
10. Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor γ chain
11. The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early α/β T cell development
12. Analysis of Pim1 function in mutant mice
13. Early αβ T cell development in the thymus of normal and genetically altered mice
14. Crucial role of the pre-T cell receptor α gene in development of αβ but not of γδ cells
15. Restoration of thymopoiesis in pTα(-/-) mice by anti-CD3ε antibody treatment or with transgenes encoding activated Lck or tailless pTα
16. v-Myb of E26 leukemia virus up-regulates bcl-2 and suppresses apoptosis in myeloid cells
17. Phenotypic and functional characterization of c-kit expression during intrathymic T cell development
18. Resistance to apoptosis in CTLL-2 cells overexpressing B-Myb is associated with B-Myb-dependent bcl-2 induction
19. 1 arrest induced by interleukin-2 withdrawal
20. Fyn can partially substitute for Lck in T-lymphocyte development
21. The CD3γ chain is essential for development of both the TCRαβ and TCRTγδ lineages
22. Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells
23. Productive T-cell receptor β-chain gene rearrangement: Coincident regulation of cell cycle and clonality during development in vivo
24. Inactivation of a c-Myb/estrogen receptor fusion protein in transformed primary cells leads to granulocyte/macrophage differentiation and down regulation of c-kit but not c-myc or cdc2
25. Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice
26. PIM1 reconstitutes thymus cellularity in inteleukin 7- and common γ chain-mutant mice and permits thymocyte maturation in Rag- but not CD3γ-deficient mice
27. Mitosis in transition
28. Receptors and signals in early thymic selection
29. Pim1 kinase and p100 cooperate to enhance c-Myb activity
30. T cell development in mice that lack the ζ chain of the T cell antigen receptor complex
31. 1 arrest
32. Functions of TCR and pre-TCR subunits: Lessons from gene ablation
33. T cell development in mice lacking the CD3-ζ/η gene
34. Altered T cell development in mice with a targeted mutation of the CD3-ε gene
35. Myb and Ets related transcription factors are required for activity of the human lck type I promoter
36. Extracellular signal-regulated kinase (ERK) activation by the pre-T cell receptor in developing thymocytes in vivo
37. + distinguished in the early growth response (Egr)-1 transgenic mice with a recombinase-activating gene-deficient background
38. Profound block in thymocyte development in mice lacking p56lck
39. Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages
40. RAG-1 deficient mice have no mature B and T lymphocytes
41. An activated lck transgene promotes thymocyte development in RAG-1 mutant mice
42. A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis
43. c-myb transactivates the human cyclin A1 promoter and induces cyclin A1 gene expression
44. V(D)J recombination is not required for the development of lymphoma in p53-deficient mice
45. Developmental and functional impairment of T cells in mice lacking CD3 ζ chains
46. Redundant regulation of T cell differentiation and TCRα gene expression by the transcription factors LEF-1 and TCF-1
47. The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry
48. +) thymocytes in normal and genetically modified mice
49. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice
50. Intrathymically expressed c-kit ligand (stem cell factor) is a major factor driving expansion of very immature thymocytes in vivo
51. Pro-thymocyte expansion by c-kit and the common cytokine receptor γ chain is essential for repertoire formation
52. Zinc finger protein GFI-1 has low oncogenic potential but cooperates strongly with pim and myc genes in T-cell lymphomagenesis
53. Evidence implicating Gfi-1 and Pim1 in pre-T-cell differentiation steps associated with β-selection
54. 1 cyclins
55. RAG-2 deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
56. Early T lymphocyte progenitors
57. Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice
58. pp59(fyn) mutant mice display differential signalling in thymocytes and peripheral T cells
59. 1 progression and c-myb progression
60. Abnormalities of the immune system induced by dysregulated bcl-2 expression in transgenic mice
61. − thymocyte development by kinase-inactive ZAP-70
62. A dominant interfering Myb mutant causes apoptosis in T cells
63. Expression of the c-myb proto-oncogene during cellular proliferation
64. The bHLH gene Hes1 is essential for expansion of early T cell precursors
65. Predisposition to lymphomagenesis in pim1 transgenic mice: Cooperation with c-myc and N-myc in murine leukemia virus-induced tumors
66. αβ T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases
67. Essential and partially overlapping role of CD3γ and CD3δ for development of αβ and γδ T lymphocytes
68. Myb proteins in life, death and differentiation
69. Myb is required for self-renewal in a model system of early hematopoiesis
70. Pre-T cell receptor (TCR) and TCR-controlled checkpoints in T cell differentiation are set by Ikaros
71. Gfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor