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1
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Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow
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Hardy RR, Carmack CE, Shinton SA, Kemp JD, Hayakawa K. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J Exp Med. 173:1991;1213-1225.
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Hardy, R.R.1
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B lymphopoiesis in the mouse
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Rolink A, Melchers F. B lymphopoiesis in the mouse. Adv Immunol. 53:1993;123-156.
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Rolink, A.1
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Identification of the earliest B lineage stage in mouse bone marrow
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Li YS, Wasserman R, Hayakawa K, Hardy RR. Identification of the earliest B lineage stage in mouse bone marrow. Immunity. 5:1996;527-535.
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Li, Y.S.1
Wasserman, R.2
Hayakawa, K.3
Hardy, R.R.4
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4
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0027363528
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Hematopoietic lineage- And stage-restricted expression of the ETS oncogene family member PU.1
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Hromas R, Orazi A, Neiman R, Maki R, Van Beveran C, Moore J, Klemsz M. Hematopoietic lineage- and stage-restricted expression of the ETS oncogene family member PU.1. Blood. 82:1993;2998-3004.
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Hromas, R.1
Orazi, A.2
Neiman, R.3
Maki, R.4
Van Beveran, C.5
Moore, J.6
Klemsz, M.7
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5
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0028136726
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Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
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Scott EW, Simon MC, Anastasi J, Singh H. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science. 265:1994;1573-1577.
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Scott, E.W.1
Simon, M.C.2
Anastasi, J.3
Singh, H.4
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6
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0029550341
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PU.1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation
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Olson MC, Scott EW, Hack AA, Su GH, Tenen DG, Singh H, Simon MC. PU.1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation. Immunity. 3:1995;703-714.
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Olson, M.C.1
Scott, E.W.2
Hack, A.A.3
Su, G.H.4
Tenen, D.G.5
Singh, H.6
Simon, M.C.7
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7
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0030611964
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Pu.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors
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of outstanding interest. This paper provides valuable insight into the defects in the PU.1-deficent mice. It demonstrates the cell-autonomous nature of the requirement for PU.1 and defines defects in the stem cell compartment that suggest that the loss of myeloid and B cells in these mice is due to a problem with a putative common progenitor.
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of outstanding interest Scott EW, Fisher RC, Olson MC, Kehrli EW, Simon MC, Singh H. Pu.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors. Immunity. 6:1997;437-447 This paper provides valuable insight into the defects in the PU.1-deficent mice. It demonstrates the cell-autonomous nature of the requirement for PU.1 and defines defects in the stem cell compartment that suggest that the loss of myeloid and B cells in these mice is due to a problem with a putative common progenitor.
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Immunity
, vol.6
, pp. 437-447
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Scott, E.W.1
Fisher, R.C.2
Olson, M.C.3
Kehrli, E.W.4
Simon, M.C.5
Singh, H.6
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8
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0242549003
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Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities
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McKercher S, Torbett B, Anderson K, Henkel GW, Vestal DJ, Baribault H, Klemsz M, Feeney AJ, Wu GE, Paige CJ, Maki RA. Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J. 15:1996;5647-5658.
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EMBO J
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McKercher, S.1
Torbett, B.2
Anderson, K.3
Henkel, G.W.4
Vestal, D.J.5
Baribault, H.6
Klemsz, M.7
Feeney, A.J.8
Wu, G.E.9
Paige, C.J.10
Maki, R.A.11
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9
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-
0029073345
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Pip, a novel IRF family member, is a lymphoid-specific PU.1-dependent transcriptional activator
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Eisenbeis CF, Singh H, Storb U. Pip, a novel IRF family member, is a lymphoid-specific PU.1-dependent transcriptional activator. Genes Dev. 9:1995;1377-1387.
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Genes Dev
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Eisenbeis, C.F.1
Singh, H.2
Storb, U.3
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10
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0031034118
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PU.1 can participate in an active enhancer complex without its transcriptional activation domain
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Pongubala JMR, Atchison ML. PU.1 can participate in an active enhancer complex without its transcriptional activation domain. Biochemistry. 94:1997;127-132.
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Biochemistry
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, pp. 127-132
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Pongubala, J.M.R.1
Atchison, M.L.2
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11
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0029763203
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Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1
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Brass AL, Kehrli E, Eisenbeis CF, Storb U, Singh H. Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1. Genes Dev. 10:1996;2335-2347.
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Genes Dev
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, pp. 2335-2347
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Brass, A.L.1
Kehrli, E.2
Eisenbeis, C.F.3
Storb, U.4
Singh, H.5
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12
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0029928685
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A novel interferon regulatory factor family transcription factor, ICSAT/Pip/LSIRF, that negatively regulates the activity of interferon regulated genes
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Yamagata T, Nishida J, Tanaka T, Sakai R, Mitani K, Yoshida M, Taniguchi T, Yazaki Y, Hirai H. A novel interferon regulatory factor family transcription factor, ICSAT/Pip/LSIRF, that negatively regulates the activity of interferon regulated genes. Mol Cell Biol. 16:1996;1283-1294.
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Mol Cell Biol
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Yamagata, T.1
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Tanaka, T.3
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Mitani, K.5
Yoshida, M.6
Taniguchi, T.7
Yazaki, Y.8
Hirai, H.9
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13
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15444346834
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Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function
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Mittrucker H-W, Matsuyama T, Grossman A, Kundig TM, Potter J, Shahinian A, Wakeham A, Patterson B, Ohashi PS, Mak TW. Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function. Science. 275:1997;540-543.
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Science
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Mittrucker H-W1
Matsuyama, T.2
Grossman, A.3
Kundig, T.M.4
Potter, J.5
Shahinian, A.6
Wakeham, A.7
Patterson, B.8
Ohashi, P.S.9
Mak, T.W.10
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14
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0030933151
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The role of the Ikaros gene in lymphocyte development and homeostasis
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Georgopoulos K, Winandy S, Avitahl N. The role of the Ikaros gene in lymphocyte development and homeostasis. Annu Rev Immunol. 15:1997;155-176.
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Georgopoulos, K.1
Winandy, S.2
Avitahl, N.3
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15
-
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15144358621
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Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin
-
of outstanding interest. This paper describes a novel member of the Ikaros family, Helios. Its specific expression on T cells provides a basis for postulating that the severe defects observed in the dominant-negative ikaros mutation may be due to blocking Helios' function. The paper also describes Helios' function as a repressor.
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of outstanding interest Hahm K, Cobb BS, McCarty AS, Brown KE, Klug CA, Lee R, Akashi K, Weissman I, Fisher AG, Smale ST. Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin. Genes Dev. 12:1998;782-796 This paper describes a novel member of the Ikaros family, Helios. Its specific expression on T cells provides a basis for postulating that the severe defects observed in the dominant-negative ikaros mutation may be due to blocking Helios' function. The paper also describes Helios' function as a repressor.
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(1998)
Genes Dev
, vol.12
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Hahm, K.1
Cobb, B.S.2
McCarty, A.S.3
Brown, K.E.4
Klug, C.A.5
Lee, R.6
Akashi, K.7
Weissman, I.8
Fisher, A.G.9
Smale, S.T.10
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16
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-
0031907815
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Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytes
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Klug CA, Morrison SJ, Masek M, Hahm K, Smale ST, Weissman IL. Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytes. Proc Natl Acad Sci USA. 95:1998;657-662.
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Proc Natl Acad Sci USA
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Klug, C.A.1
Morrison, S.J.2
Masek, M.3
Hahm, K.4
Smale, S.T.5
Weissman, I.L.6
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17
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0030972497
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Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation
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Morgan B, Sun L, Avitahl N, Andrikopoulos K, Ikeda T, Gonzales E, Wu P, Neben S, Georgopoulos K. Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. EMBO J. 16:1997;2004-2013.
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EMBO J
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Morgan, B.1
Sun, L.2
Avitahl, N.3
Andrikopoulos, K.4
Ikeda, T.5
Gonzales, E.6
Wu, P.7
Neben, S.8
Georgopoulos, K.9
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18
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0025943384
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LyF-1, a transcriptional regulator that interacts with a novel class of promoters for lymphocyte-specific genes
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Lo K, Landau NR, Smale ST. LyF-1, a transcriptional regulator that interacts with a novel class of promoters for lymphocyte-specific genes. Mol Cell Biol. 11:1991;5229-5243.
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Mol Cell Biol
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Lo, K.1
Landau, N.R.2
Smale, S.T.3
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19
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0029831978
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Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development
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Sun L, Liu A, Georgopoulos K. Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development. EMBO J. 15:1996;5358-5369.
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(1996)
EMBO J
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Sun, L.1
Liu, A.2
Georgopoulos, K.3
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20
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0030498975
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Selective defects in the development of the fetal, adult lymphoid system in mice with an Ikaros null mutation
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of outstanding interest. This paper describes the phenotype due to a null mutation of Ikaros (generated by disrupting the carboxyl terminus dimerization domain) and highlights the differences between this and the dominant negative mutation of Ikaros. It also provides interesting evidence for a very marked differential requirement for Ikaros between T cell development in the fetus and adult.
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of outstanding interest Wang J-H, Nichogiannopoulou A, Wu L, Sun L, Sharpe AH, Bigby M, Georgopoulos K. Selective defects in the development of the fetal, adult lymphoid system in mice with an Ikaros null mutation. Immunity. 6:1996;537-549 This paper describes the phenotype due to a null mutation of Ikaros (generated by disrupting the carboxyl terminus dimerization domain) and highlights the differences between this and the dominant negative mutation of Ikaros. It also provides interesting evidence for a very marked differential requirement for Ikaros between T cell development in the fetus and adult.
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(1996)
Immunity
, vol.6
, pp. 537-549
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-
Wang J-H1
Nichogiannopoulou, A.2
Wu, L.3
Sun, L.4
Sharpe, A.H.5
Bigby, M.6
Georgopoulos, K.7
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21
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0028001362
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The Ikaros gene is required for the development of all lymphoid lineages
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Georgopoulos K, Bigby M, Wang J-H, Molnar A, Wu P, Winandy S, Sharpe A. The Ikaros gene is required for the development of all lymphoid lineages. Cell. 79:1994;143-156.
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Cell
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Georgopoulos, K.1
Bigby, M.2
Wang J-H3
Molnar, A.4
Wu, P.5
Winandy, S.6
Sharpe, A.7
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22
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0031437119
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Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin
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of outstanding interest. This paper is the first to describe the localization of the Ikaros gene within the nucleus and reports that Ikaros is associated with heterochromatin and transcriptionally silent loci. These findings suggest that these proteins may be involved in repression of gene expression.
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of outstanding interest Brown KE, Guest SS, Smale ST, Hahm K, Merkenschlager M, Fisher AG. Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin. Cell. 91:1997;845-854 This paper is the first to describe the localization of the Ikaros gene within the nucleus and reports that Ikaros is associated with heterochromatin and transcriptionally silent loci. These findings suggest that these proteins may be involved in repression of gene expression.
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Cell
, vol.91
, pp. 845-854
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Brown, K.E.1
Guest, S.S.2
Smale, S.T.3
Hahm, K.4
Merkenschlager, M.5
Fisher, A.G.6
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23
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0028971289
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Rel/NF-κB/IκB family: Intimate tales of association and dissociation
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Verma IM, Stevenson JK, Schwarz EM, van Antwerp D, Miyamoto S. Rel/NF-κB/IκB family: intimate tales of association and dissociation. Genes Dev. 9:1995;2723-2735.
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Verma, I.M.1
Stevenson, J.K.2
Schwarz, E.M.3
Van Antwerp, D.4
Miyamoto, S.5
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24
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0029874138
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The NF-kappa B, I kappa B proteins: New discoveries and insights
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Baldwin AS. The NF-kappa B, I kappa B proteins: new discoveries and insights. Annu Rev Immunol. 14:1996;649-683.
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Baldwin, A.S.1
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25
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0030999057
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NF-κB RelA-deficient lymphocytes: Normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses
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Doi TS, Takahashi T, Taguchi O, Azuma T, Obata Y. NF-κB RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses. J Exp Med. 185:1997;953-961.
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J Exp Med
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Doi, T.S.1
Takahashi, T.2
Taguchi, O.3
Azuma, T.4
Obata, Y.5
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26
-
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0030837598
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Failure of lymphopoiesis after adoptive transfer of NF-κB-deficient fetal liver cells
-
+ cells, while mice lacking either one alone have relatively normal B-cell development. This paper is additionally interesting because it suggests that the loss of secreted, or cell bound signals from wild-type hematopoietic cells may be the basis for this defect.
-
+ cells, while mice lacking either one alone have relatively normal B-cell development. This paper is additionally interesting because it suggests that the loss of secreted, or cell bound signals from wild-type hematopoietic cells may be the basis for this defect.
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(1997)
Immunity
, vol.6
, pp. 765-772
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-
Horwitz, B.H.1
Scott, M.L.2
Cherry, S.R.3
Bronson, R.T.4
Baltimore, D.5
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27
-
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0028804551
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Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune response
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Sha WC, Liou H-C, Tuomanen EI, Baltimore D. Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune response. Cell. 80:1995;321-330.
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Cell
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Sha, W.C.1
Liou H-C2
Tuomanen, E.I.3
Baltimore, D.4
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28
-
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0030048332
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B cells from p50/NF-κB knockout mice have selective defects in proliferation, differentiation, germ line CH transcription, and Ig class switching
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Snapper CM, Zelazowski P, Rosas FR, Kehry MR, Tian M, Baltimore D, Sha WR. B cells from p50/NF-κB knockout mice have selective defects in proliferation, differentiation, germ line CH transcription, and Ig class switching. J Immunol. 156:1996;183-191.
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Snapper, C.M.1
Zelazowski, P.2
Rosas, F.R.3
Kehry, M.R.4
Tian, M.5
Baltimore, D.6
Sha, W.R.7
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29
-
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0028817585
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Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family
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Weih F, Carrasco D, Durham SK, Barton DS, Rizzo CA, Ryseck R-P, Lira SA, Bravo R. Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family. Cell. 80:1995;331-340.
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Cell
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Weih, F.1
Carrasco, D.2
Durham, S.K.3
Barton, D.S.4
Rizzo, C.A.5
Ryseck R-P6
Lira, S.A.7
Bravo, R.8
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30
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0029903486
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B cells lacking relB are defective in proliferative responses, but undergo normal B cell maturation to Ig secretion and Ig class switching
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Snapper CM, Rosas FR, Zelazowski P, Moorman MA, Kehry MR, Bravo R, Weih F. B cells lacking relB are defective in proliferative responses, but undergo normal B cell maturation to Ig secretion and Ig class switching. J Exp Med. 184:1996;1537-1541.
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Snapper, C.M.1
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Zelazowski, P.3
Moorman, M.A.4
Kehry, M.R.5
Bravo, R.6
Weih, F.7
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0030292678
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Both multiorgan inflammation and myeloid hyperplasia in relB-deficient mice are T cell dependent
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Weih F, Durham SK, Barton DS, Sha WC, Baltimore D, Bravo R. Both multiorgan inflammation and myeloid hyperplasia in relB-deficient mice are T cell dependent. J Immunol. 157:1996;3974-3979.
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Weih, F.1
Durham, S.K.2
Barton, D.S.3
Sha, W.C.4
Baltimore, D.5
Bravo, R.6
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33
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Requirement of NF-κB in osteoclast and B-cell development
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+ cells in the periphery.
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+ cells in the periphery.
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Franzoso, G.1
Carlson, L.2
Xing, L.3
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Shores, E.W.5
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Leonardi, A.7
Tran, T.8
Boyce, B.9
Siebenlist, U.10
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Helix-loop-helix proteins in the regulation of the immunoglobulin gene transcription
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Kadesch, T.1
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B cell specific DNA binding by an E47 homodimer
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Shen CP, Kadesch T. B cell specific DNA binding by an E47 homodimer. Mol Cell Biol. 15:1995;4518-4524.
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Shen, C.P.1
Kadesch, T.2
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37
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0026045243
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Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre T-cell line
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Schlissel MS, Voronova A, Baltimore D. Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre T-cell line. Genes Dev. 5:1991;1367-1376.
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Schlissel, M.S.1
Voronova, A.2
Baltimore, D.3
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38
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E47 activates the Ig-heavy chain and TdT loci in non-B cells
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Choi JK, Shen CP, Radomska HS, Eckhardt LA, Kadesch T. E47 activates the Ig-heavy chain and TdT loci in non-B cells. EMBO J. 15:1996;5014-5021*.
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Choi, J.K.1
Shen, C.P.2
Radomska, H.S.3
Eckhardt, L.A.4
Kadesch, T.5
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39
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-
0027992622
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E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements
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Bain G, Robanus Maandag EC, Izon DJ, Amsen D, Kruisbeek AM, Weintraub BC, Krop I, Schlissel MS, Feeney AJ, van Roon M, et al. E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Cell. 79:1994;885-892.
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Cell
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Bain, G.1
Robanus Maandag, E.C.2
Izon, D.J.3
Amsen, D.4
Kruisbeek, A.M.5
Weintraub, B.C.6
Krop, I.7
Schlissel, M.S.8
Feeney, A.J.9
Van Roon, M.10
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40
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0028148938
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The helix-loop-helix gene E2A is required for B cell formation
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Zhuang Y, Soriano P, Weintraub H. The helix-loop-helix gene E2A is required for B cell formation. Cell. 79:1994;875-884.
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Cell
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Zhuang, Y.1
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41
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0031003914
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Both E12 and E47 allow commitment to the B cell lineage
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Bain G, Robanus Maandag EC, te Riele HPJ, Feeney AJ, Sheehy A, Schlissel MS, Shinton SA, Hardy RR, Murre C. Both E12 and E47 allow commitment to the B cell lineage. Immunity. 6:1997;145-154.
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Immunity
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Bain, G.1
Robanus Maandag, E.C.2
Te Riele, H.P.J.3
Feeney, A.J.4
Sheehy, A.5
Schlissel, M.S.6
Shinton, S.A.7
Hardy, R.R.8
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42
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0029825698
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Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle, B-cell differentiation
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of special interest
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of special interest Eckner R, Yao TP, Oldread E, Livingston DM. Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle, B-cell differentiation. Genes Dev. 10:1996;2478-2490.
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Eckner, R.1
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Livingston, D.M.4
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43
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