Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis

Immunity

Volumn 14, Issue 6, 2001, Pages 779-790

  Horcher, Markus ^a   Souabni, Abdallah ^a   Busslinger, Meinrad ^a  

^a RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

B LINEAGE COMMITMENT FACTOR PAX5; B LYMPHOCYTE ANTIGEN; CD19 ANTIGEN; CRE RECOMBINASE; IMMUNOGLOBULIN D; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CELL MATURATION; CELL SURFACE; CONTROLLED STUDY; DOWN REGULATION; GENE DELETION; GENE EXPRESSION; GENE INACTIVATION; GENE LOCUS; GENETIC TRANSCRIPTION; IMMUNOGLOBULIN BLOOD LEVEL; LYMPHOBLAST; LYMPHOPOIESIS; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

EID: 0034959755     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(01)00153-4     Document Type: Article

References (47)

1. Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis
2. Bypass of lethality with mosaic mice generated by Cre-loxP-mediated recombination
3. Role of the transcription factor BSAP (Pax-5) in B-cell development
4. Deregulation of PAX-5 by translocation of the Eμ enhancer of the IgH locus adjacent to two alternative PAX-5 promoters in a diffuse large-cell lymphoma
5. Structure of genes for membrane and secreted murine IgD heavy chains
6. DNA sequence recognition by Pax proteins: Bipartite structure of the paired domain and its binding site
7. Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family
8. Blnk: A central linker protein in B cell activation
9. The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells
10. B cell differentiation and isotype switching is related to division cycle number
11. Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65
12. Inducible gene targeting in mice
13. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death
14. Identification of the earliest B lineage stage in mouse bone marrow
15. The transcription factor BSAP (NF-HB) is essential for immunoglobulin germ-line ε transcription
16. Impairment of T and B cell development by treatment with a type I interferon
17. Cell cycle regulation of immunoglobulin class switch recombination and germ-line transcription: Potential role of Ets family members
18. Survival of long-lived plasma cells is independent of antigen
19. Mode of regulation of immunoglobulin μ- and δ-chain expression varies during B-lymphocyte maturation
20. - memory B cell compartment
21. B lymphocyte activation: Entry into cell cycle is accompanied by decreased expression of IgD but not IgM
22. The murine Ig 3′α enhancer is a target site with repressor function for the B cell lineage-specific transcription factor BSAP (NF-HB, Sα-BP)
23. Essential functions of Pax5 (BSAP) in pro-B cell development: Difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus
24. Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments
25. Commitment to the B-lymphoid lineage depends on the transcription factor Pax5
26. Independent regulation of the two Pax5 alleles during B-cell development
27. Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses
28. Mouse CD38 is down-regulated on germinal center B cells and mature plasma cells
29. The molecular characterization of the fetal stem cell marker AA4
30. Overexpression of BSAP/Pax-5 inhibits switching to IgA and enhances switching to IgE in the I.29μ B cell line
31. Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice
32. B lymphocyte-specific, Cre-mediated mutagenesis in mice
33. An interleukin-2 signal relieves BSAP (Pax5)-mediated repression of the immunoglobulin J chain gene
34. Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity
35. Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors
36. A developmentally modulated chromatin structure at the mouse immunoglobulin κ 3′ enhancer
37. B lymphocytes express and lose syndecan at specific stages of differentiation
38. Generation of Cre recombinase-specific monoclonal antibodies, able to characterize the pattern of Cre expression in cre-transgenic mouse strains
39. NF-HB (BSAP) is a repressor of the murine immunoglobulin heavy-chain 3′α enhancer at early stages of B cell differentiation
40. Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)
41. Aberrant B cell development and immune response in mice with a compromised BCR complex
42. Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells
43. Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP
44. Overexpression of B cell-specific activator protein (BSAP/Pax-5) in a late B cell is sufficient to suppress differentiation to an Ig high producer cell with plasma cell phenotype
45. The B cell-specific transcription factor BSAP regulates B cell proliferation
46. SLP-65: A new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation
47. Regulation of mouse CD72 expression during B lymphocyte development