The transcription factor PU.1 does not regulate lineage commitment but has lineage-specific effects

Journal of Leukocyte Biology

Volumn 66, Issue 5, 1999, Pages 727-732

  McKercher, Scott R ^a   Henkel, Gregory W ^a   Maki, Richard A ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

Hematopoiesis; Macrophage; Myeloid; Oncogene; Spi 1

Indexed keywords

TRANSCRIPTION FACTOR;

ANIMAL CELL; B LYMPHOCYTE; BONE MARROW CELL; CELL MATURATION; CONFERENCE PAPER; ERYTHROCYTE; GENE EXPRESSION REGULATION; HEMATOPOIETIC SYSTEM; MACROPHAGE; MEGAKARYOCYTE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALIA;

EID: 0032710581     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.66.5.727     Document Type: Conference Paper

References (38)

1. Klemsz, M. J., McKercher, S. R., Celada, A., Van Beveren, C., Maki, R. A. (1990) The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene [see comments]. Cell 61, 113-124.
2. Moreau-Gachelin, F., Tavitan, A., Tambourin, P. (1988) Spi-1 is a putative oncogene in virally induced murine erythroleukaemias. Nature 331, 277-280.
3. Klemsz, M. J., Maki, R. A. (1996) Activation of transcription by PU.1 requires both acidic and glutamine domains. Mol. Cell Biol. 16, 390-397.
4. Rodgers, S., Wells, R., Rechsteiner, M. (1986) Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis. Science 234, 364-368.
5. Lodie, T. A., Savedra, R., Jr., Golenbock, D. T., Van Beveren, C. P., Maki, R. A., Fenton, M. J. (1997) Stimulation of macrophages by lipopolysaccharide alters the phosphorylation state, conformation, and function of PU.1 via activation of casein kinase II. J. Immunol. 158, 1848-1856.
6. Pongubala, J. M., Nagulapalli, S., Klemsz, M. J., McKercher, S. R., Maki, R. A., Atchison, M. L. (1992) PU.1 recruits a second nuclear factor to a site important for immunoglobulin kappa 3′ enhancer activity. Mol. Cell Biol. 12, 368-378.
7. Pongubala, J. M., Van Beveren, C., Nagulapalli, S., Klemsz, M. J., McKercher, S. R., Maki, R. A., Atchison, M. L. (1993) Effect of PU.1 phosphorylation on interaction with NF-EM5 and transcriptional activation. Science 259, 1622-1625.
8. Eisenbeis, C. F., Singh, H., Storb, U. (1995) Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator. Genes Dev. 9, 1377-1387.
9. Rosmarin, A. G., Caprio, D. G., Kirsch, D. G., Handa, H., Simkevich, C. P. (1995) GABP and PU.1 compete for binding, yet cooperate to increase CD18 (beta 2 leukocyte integrin) transcription. J. Biol. Chem. 270, 23627-23333.
10. Pahl, H. L., Scheibe, R. J., Zhang, D. E., Chen, H. M., Galson, D. L., Maki, R. A., Tenen, D. G. (1993) The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter. J. Biol. Chem. 268, 5014-5020.
11. Zhang, D. E., Hetherington, C. J., Chen, H. M., Tenen, D. G. (1994) The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor. Mol. Cell Biol. 14, 373-381.
12. Hohaus, S., Petrovick, M. S., Voso, M. T., Sun, Z., Zhang, D. E., Tenen, D. G. (1995) PU.1 (Sp-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene. Mol. Cell Biol. 15, 5830-5845.
13. Smith, L. T., Hohaus, S., Gonzalez, D. A., Dziennis, S. E., Tenen, D. G. (1996) PU.1 (Spi-1) and C/EBP alpha regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells. Blood 88, 1234-1247.
14. Eichbaum, Q., Heney, D., Raveh, D., Chung, M., Davidson, M., Epstein, J., Ezekowitz, R. A. (1997) Murine macrophage mannose receptor promoter is regulated by the transcription factors PU.1 and SP1. Blood 90, 4135-4143.
15. Li, A. C., Guidez, F. R., Collier, J. G., Glass, C. K. (1998) The macrosialin promoter directs high levels of transcriptional activity in macrophages dependent on combinatorial interactions between PU.1 and c-Jun. J. Biol. Chem. 273, 5389-5399.
16. Moulton, K. S., Semple, K., Wu, H., Glass, C. K. (1994) Cell-specific expression of the macrophage scavenger receptor gene is dependent on PU.1 and a composite AP-1/ets motif. Mol. Cell Biol. 14, 4408-4418.
17. Shin, M. K., Koshland, M. E. (1993) Ets-related protein PU.1 regulates expression of the immunoglobulin J-chain gene through a novel Ets-binding element. Genes Dev. 7, 2006-2015.
18. Henkel, G., Brown, M. A. (1994) PU.1 and GATA: components of a mast cell-specific interleukin 4 intronic enhancer. Proc. Natl. Acad. Sci. USA 91, 7737-7741.
19. Chen, H., Ray-Gallet, D., Zhang, P., Hetherington, C. J., Gonzalez, D. A., Zhang, D. E., Moreau-Gachelin, F., Tenen, D. G. (1995) PU.1 (Spi-1) autoregulates its expression in myeloid cells. Oncogene 11, 1549-1560.
20. Pio, F., Ni, C. Z., Mitchell, R. S., Knight, J., McKercher, S., Klemsz, M., Lombardo, A., Maki, R. A., Ely, K. R. (1995) Co-crystallization of an ETS domain (PU.1) in complex with DNA. Engineering the length of both protein and oligonucleotide. J. Biol. Chem. 270, 24258-24263.
21. Kodandapani, R., Pio, F., Ni, C. Z., Piccialli, G., Klemsz, M., McKercher, S., Maki, R. A., Ely, K. R. (1996) A new pattern for helix-turn-helix recognition revealed by the PU.1 ETS-domain-DNA complex. Nature 380, 456-460.
22. Pio, F., Kodandapani, R., Ni, C. Z., Shepard, W., Klemsz, M., McKercher, S. R., Maki, R. A., Ely, K. R. (1996) New insights on DNA recognition by ets proteins from the crystal structure of the PU.1 ETS domain-DNA complex. J. Biol. Chem. 271, 23329-23337 [published erratum appears in J. Biol. Chem. (1996) 271, 33156].
23. McKercher, S. R., Torbett, B. E., Anderson, K. L., Henkel, G. W., Vestal, D. J., Baribault, H., Klemsz, M., Feeney, A. J., Wu, G. E., Paige, C. J., Maki, R. A. (1996) Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J. 15, 5647-5658.
24. Tondravi, M. M., McKercher, S. R., Anderson, K., Erdmann, J. M., Quiroz, M., Maki, R., Teitelbaum, S. L. (1997) Osteopetrosis in mice lacking haematopoietic transcription factor PU.1. Nature 386, 81-84.
25. Galson, D. L., Hensold, J. O., Bishop, T. R., Schalling, M., D'Andrea, A. D., Jones, C., Auron, P. E., Housman, D. E. (1993) Mouse beta-globin DNA-binding protein B1 is identical to a proto-oncogene, the transcription factor Spi-1/PU.1, and is restricted in expression to hematopoietic cells and the testis. Mol. Cell Biol. 13, 2929-2941.
26. Rao, G., Rekhtman, N., Cheng, G., Krasikov, T., Skoultchi, A. I. (1997) Deregulated expression of the PU.1 transcription factor blocks murine erythroleukemia cell terminal differentiation. Oncogene 14, 123-131.
27. Hromas, R., Orazi, A., Neiman, R. S., Maki, R., Van Beveran, C., Moore, J., Klemsz, M. (1993) Hematopoietic lineage-and stage-restricted expression of the ETS oncogene family member PU.1. Blood 82, 2998-3004.
28. Anderson, K. L., Smith, K. A., Conners, K., McKercher, S. R., Maki, R. A., Torbett, B. E. (1998) Myeloid development is selectively disrupted in PU.1 null mice [in process citation]. Blood 91, 3702-3710.
29. Anderson, K. L., Smith, K. A., Pio, F, Torbett, B. E., Maki, R. A. (1998) Neutrophils deficient in PU.1 do not terminally differentiate or become functionally competent. Blood 92, 1576-1585.
30. Du, J., Savage, M., DeKoter, R., McKercher, S., Maki, R., Singh, H., Ackerman, S. (1998) Impaired eosinophilopoiesis in PU.1 deficient mice. Blood 92, 191a [Abstract 776].
31. Henkel, G. W., McKercher, S. R., Leenen, P. J. M., Maki, R. A. (1999) Commitment to the monocytic lineage occurs in the absence of the transcription factor PU.1. Blood 93, 2849-2858.
32. Kraal, G., Rep, M., Janse, M. (1987) Macrophages in T and B cell compartments and other tissue macrophages recognized by monoclonal antibody Moma-2. Scand. J. Immunol. 26, 653-661.
33. Leenen, P., Melis, M., Slicker, W., Van Ewijk, W. (1990) Murine macrophage precursor characterization II. Monoclonal antibodies against macropage precursor antigens. Eur. J. Immunol. 20, 27-34.
34. de Bruijn, M., Slieker, W., Voerman, J., Campbell, P., van Ewijk, W. (1994) Distinct mouse bone marrow macrophage precursors identified by differential expressin of ER-MP12 and ER-MP20 antigens. Eur. J. Immunol. 24, 2279-2284.
35. Scott, E. W., Simon, M. C., Anastasi, J., Singh, H. (1994) Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science 265, 1573-1577.
36. Olson, M. C., Scott, E. W., Hack, A. A., Su, G. H., Tenen, D. G., Singh, H., Simon, M. C. (1995) PU. 1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation. Immunity 3, 703-714.
37. DeKoter, R., Walsh, J., Singh, H. (1998) PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors. EMBO J. 17, 4456-4468.
38. Anderson, K. L., Smith, K. A., Perkin, H., Hermanson, G., Anderson, C. G., Jolly, D. J., Maki, R. A., Torbett, B. E. (1999) PU.1 and the granulocyte-and macrophage-colony stimulating factor receptors play distinct roles in late-stage myeloid cell differentiation. Blood 94, 2310-2318.