Carbohydrate epitopes and their relevance for the diagnosis and treatment of allergic diseases

International Archives of Allergy and Immunology

Volumn 129, Issue 3, 2002, Pages 189-197

  Van Ree, Ronald ^a  

^a SANQUIN RESEARCH   (Netherlands)

Author keywords

Carbohydrate epitopes; Diagnostic tests; IgE; Immunotherapy; Recombinant allergens

Indexed keywords

CARBOHYDRATE; EPITOPE; FUCOSE; IMMUNOGLOBULIN E ANTIBODY; MANNOSE; N ACETYLGLUCOSAMINE; XYLOSE;

ALLERGENICITY; ALLERGIC DISEASE; ANTIBODY AFFINITY; CARBOHYDRATE ANALYSIS; CROSS REACTION; DIAGNOSTIC TEST; EXPOSURE; FOOD ALLERGY; GLYCOSYLATION; IMMUNOTHERAPY; INSECT STING; INVERTEBRATE; LABORATORY DIAGNOSIS; NONHUMAN; PLANT; POLLEN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; REVIEW; SENSITIZATION;

ANTIBODIES; ANTIBODY SPECIFICITY; CARBOHYDRATES; EPITOPES; HUMANS; HYPERSENSITIVITY, IMMEDIATE; IMMUNOGLOBULIN E; IMMUNOTHERAPY;

EID: 0036436846     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000066770     Document Type: Review

References (157)

1. Aalberse RC, Koshte V, Clemens JG: Immunoglobulin E antibodies that crossreact with vegetable foods, pollen, and Hymenoptera venom. J Allergy Clin Immunol 1981;68:356-364.
2. Shibasaki M, Sumazaki R, Isoyama S, Takita H: Interaction of lectins with human IgE: IgE-binding property and histamine-releasing activity of twelve plant lectins. Int Arch Allergy Immunol 1992;98:18-25.
3. 2. Allergy 1987;42:464-470.
4. Ohta M, Shigeta S, Ono K, Takao T, Shimonishi Y, Oka S: Sugar sequences of allergenically active oligosaccharide alcohols isolated from a large-molecular-size sea squirt antigen termed H-antigen. Arch Biochem Biophys 1989;275:151-165.
5. Savolainen J, Viander M, Koivikko A: IgE-, IgA- and IgG-antibody responses to carbohydrate and protein antigens of Candida albicans in asthmatic children. Allergy 1990;45:54-63.
6. Mucci N, Liberatore P, Federico R, Forlani F, Di Felice G, Afferni C, et al: Role of carbohydrate moieties in cross-reactivity between different components of Parietaria judaica pollen extract. Allergy 1992;47:424-430.
7. Tretter V, Altmann F, Kubelka V, März L, Becker WM: Fucose alpha 1,3-linked to the core region of glycoprotein N-glycans creates an important epitope for IgE from honeybee venom allergic individuals. Int Arch Allergy Immunol 1993;102:259-266.
8. Hansen MY, Wold JK, Smestad PB, Cohen EH, Karlsson-Borga A: Allergens in Aspergillus fumigatus. I. Characterization of two different allergen extracts and evaluation of their stability and the importance of carbohydrate for IgE binding. Allergy 1994;49:235-241.
9. van Ree R, Fernandez-Rivas M, Cuevas M, van Wijngaarden M, Aalberse RC: Pollen-related allergy to peach and apple: An important role for profilin. J Allergy Clin Immunol 1995;95:726-734.
10. Petersen A, Vieths S, Aulepp H, Schlaak M, Becker WM: Ubiquitous structures responsible for IgE cross-reactivity between tomato fruit and grass pollen allergens. J Allergy Clin Immunol 1996;98:805-815.
11. Jankiewicz A, Aulepp H, Baltes W, Bogl KW, Dehne LI, Zuberbier T, et al: Allergic sensitization to native and heated celery root in pollen-sensitive patients investigated by skin test and IgE binding. Int Arch Allergy Immunol 1996;111:268-278.
12. Fahlbusch B, Rudeschko O, Schumann C, Steurich F, Henzgen M, Schlenvoigt G, et al: Further characterization of IgE-binding antigens in kiwi, with particular emphasis on glycoprotein allergens. J Investig Allergol Clin Immunol 1998;8:325-332.
13. Afferni C, Iacovacci P, Barletta B, Di Felice G, Tinghino R, Mari A, et al: Role of carbohydrate moieties in IgE binding to allergenic components of Cupressus arizonica pollen extract. Clin Exp Allergy 1999;29:1087-1094.
14. Jensen-Jarolim E, Gerstmayer G, Kraft D, Scheiner O, Ebner H, Ebner C: Serological characterization of allergens in poppy seeds. Clin Exp Allergy 1999;29:1075-1079.
15. Mari A, Iacovacci P, Afferni C, Barletta B, Tinghino R, Di Felice G, et al: Specific IgE to cross-reactive carbohydrate determinants strongly affect the in vitro diagnosis of allergic diseases. J Allergy Clin Immunol 1999;103:1005-1011.
16. Batanero E, Crespo JF, Monsalve RI, Martin-Esteban M, Villalba M, Rodriguez R: IgE-binding and histamine-release capabilities of the main carbohydrate component isolated from the major allergen of olive tree pollen, Ole e 1. J Allergy Clin Immunol 1999;103:147-153.
17. Fötisch K, Altmann F, Haustein D, Vieths S: Involvement of carbohydrate epitopes in the IgE response of celery-allergic patients. Int Arch Allergy Immunol 1999;120:30-42.
18. van Die I, Gomord V, Kooyman FN, van den Berg TK, Cummings RD, Vervelde L: Core alpha 1,3-fucose is a common modification of N-glycans in parasitic helminths and constitutes an important epitope for IgE from Haemonchus contortus infected sheep. FEBS Lett 1999;463:189-193.
19. Hiemori M, Bando N, Ogawa T, Shimada H, Tsuji H, Yamanishi R, et al: Occurrence of IgE antibody-recognizing N-linked glycan moiety of a soybean allergen, Gly m Bd 28K. Int Arch Allergy Immunol 2000;122:238-245.
20. Reindl J, Anliker MD, Karamloo F, Vieths S, Wuthrich B: Allergy caused by ingestion of zucchini (Cucurbita pepo): Characterization of allergens and cross-reactivity to pollen and other foods. J Allergy Clin Immunol 2000;106:379-385.
21. Lorenzo S, Romaris F, Iglesias R, Audicana MT, Alonso JM, Leiro J, et al: O-glycans as a source of cross-reactivity in determinations of human serum antibodies to Anisakis simplex antigens. Clin Exp Allergy 2000;30:551-559.
22. Jensen-Jarolim E, Schmid B, Bernier F, Berna A, Kinaciyan T, Focke M, et al: Allergologic exploration of germins and germin-like proteins, a new class of plant allergens. Allergy 2002;57:805-810.
23. Vieths S, Luttkopf D, Reindl J, Anliker MD, Wuthrich B, Ballmer-Weber BK: Allergens in celery and zucchini. Allergy 2002;57(suppl 72):100-105.
24. Kwaasi AA, Harfi HA, Parhar RS, Saleh S, Collison KS, Panzani RC, et al: Cross-reactivities between date palm (Phoenix dactylifera L.) polypeptides and foods implicated in the oral allergy syndrome. Allergy 2002;57:508-518.
25. Sten E, Stahl SP, Andersen SB, Torp AM, Olesen A, Bindslev-Jensen U, et al: Allergenic components of a novel food, Micronesian nut nangai (Canarium indicum), shows IgE cross-reactivity in pollen allergic patients. Allergy 2002;57:398-404.
26. Ballmer-Weber BK, Wüthrich B, Wangorsch A, Fötisch K, Altmann F, Vieths S: Carrot allergy: Double-blinded, placebo-controlled food challenge and identification of allergens. J Allergy Clin Immunol 2001;108:301-307.
27. Ballmer-Weber BK, Hoffmann A, Wüthrich B, Lüttkopf D, Pompei C, Wangorsch A, et al: Influence of food processing on the allergenicity of celery: DBPCFC with celery spice and cooked celery in patients with celery allergy. Allergy 2002;57:228-235.
28. Berger EG, Buddecke E, Kamerling JP, Kobata A, Paulson JC, Vliegenthart JF: Structure, biosynthesis and functions of glycoprotein glycans. Experientia 1982;38:1129-1162.
29. Hounsell EF, Davies MJ, Renouf DV: O-linked protein glycosylation structure and function. Glycoconj J 1996;13:19-26.
30. Lerouge P, Cabanes-Macheteau M, Rayon C, Fischette-Laine AC, Gomord V, Faye L: N-glycoprotein biosynthesis in plants: Recent developments and future trends. Plant Mol Biol 1998;38:31-48.
31. Apweiler R, Hermjakob H, Sharon N: On the frequency of protein glycosylation, as deduced from analysis of the SWISS-PROT database. Biochim Biophys Acta 1999;1473:4-8.
32. Carraway KL, Hull SR: O-glycosylation pathway for mucin-type glycoproteins. Bioessays 1989;10:117-121.
33. Kieliszewski MJ, Lamport DT: Extensin: Repetitive motifs, functional sites, post-translational codes, and phylogeny. Plant J 1994;5:157-172.
34. Yoshida A, Suzuki M, Ikenaga H, Takeuchi M: Discovery of the shortest sequence motif for high level mucin-type O-glycosylation. J Biol Chem 1997;272:16884-16888.
35. Shpak E, Leykam JF, Kieliszewski MJ: Synthetic genes for glycoprotein design and the elucidation of hydroxyproline-O-glycosylation codes. Proc Natl Acad Sci USA 1999;96:14736-14741.
36. Kieliszewski MJ: The latest hype on Hyp-O-glycosylation codes. Phytochemistry 2001;57:319-323.
37. 2. Evidence for the presence of terminal N-acetylglucosamine and fucose in an insect glycoprotein. Comp Biochem Physiol B 1986;83:321-324.
38. Schachter H: The joys of HexNAc. The synthesis and function of N- and O-glycan branches. Glycoconj J 2000;17:465-483.
39. 2. The role of alpha 1,3-fucosylation of the asparagine-bound N-acetylglucosamine. Biochem J 1992;284(pt 2):377-380.
40. Kaladas PM, Goldberg R, Poretz RD: Rabbit anti-carbohydrate antibody elicited by the lymphocyte mitogenic glycoprotein from Wistaria floribunda seeds. Mol Immunol 1983;20:727-735.
41. Faye L, Chrispeels MJ: Common antigenic determinants in the glycoproteins of plants molluscs and insects. Glycoconj J 1988;5:245-256.
42. Laine AC, Faye L: Significant immunological cross-reactivity of plant glycoproteins. Electrophoresis 1988;9:841-844.
43. Faye L, Gomord V, Fitchette-Laine AC, Chrispeels MJ: Affinity purification of antibodies specific for Asn-linked glycans containing alpha 1,3 fucose or beta 1,2 xylose. Anal Biochem 1993;209:104-108.
44. Wan L, van Huystee RB: Immunogenicity of the N-glycans of peanut peroxidase. Phytochemistry 1994;37:933-940
45. van Ree R, Cabanes-Macheteau M, Akkerdaas J, Milazzo JP, Loutelier-Bourhis C, Rayon C, et al: Beta(1,2)-xylose and alpha(1,3)-fucose residues have a strong contribution in IgE binding to plant glycoallergens. J Biol Chem 2000;275:11451-11458.
46. Yasuda Y, Takahashi N, Murachi T: The composition and structure of carbohydrate moiety of stem bromelain. Biochemistry 1970;9:25-32.
47. Ishihara H, Takahashi N, Oguri S, Tejima S: Complete structure of the carbohydrate moiety of stem bromelain. An application of the almond glycopeptidase for structural studies of glycopeptides. J Biol Chem 1979;254:10715-10719.
48. Hayashi M, Tsuru A, Mitsui T, Takahashi N, Hanzawa H, Arata Y, et al: Structure and biosynthesis of the xylose-containing carbohydrate moiety of rice alpha-amylase. Eur J Biochem 1990;191:287-295.
49. Ohsuga H, Su SN, Takahashi N, Yang SY, Nakagawa H, Shimada I, et al: The carbohydrate moiety of the bermuda grass antigen BG60. New oligosaccharides of plant origin. J Biol Chem 1996;271:26653-26658.
50. Ogawa H, Hijikata A, Amano M, Kojima K, Fukushima H, Ishizuka I, et al: Structures and contribution to the antigenicity of oligosaccharides of Japanese cedar (Cryptomeria japonica) pollen allergen Cryj I: Relationship between the structures and antigenic epitopes of plant N-linked complex-type glycans. Glycoconj J 1996;13:555-566.
51. Altmann F: Structures of the N-linked carbohydrate of ascorbic acid oxidase from zucchini. Glycoconj J 1998;15:79-82.
52. Lommerse JP, Kroon-Batenburg LM, Kamerling JP, Vliegenthart JF: Conformational analysis of the xylose-containing N-glycan of pineapple stem bromelain as part of the intact glycoprotein. Biochemistry 1995;34:8196-8206.
53. Calkhoven PG, Aalbers M, Koshte VL, Pos O, Oei HD, Aalberse RC: Cross-reactivity among birch pollen, vegetables and fruits as detected by IgE antibodies is due to at least three distinct cross-reactive structures. Allergy 1987;42:382-390.
54. van Ree R, Aalberse RC: Pollen-vegetable food crossreactivity: Serological and clinical relevance of crossreactive IgE. J Clin Immunoassay 1993;16:124-130.
55. Batanero E, Villalba M, Monsalve RI, Rodriguez R: Cross-reactivity between the major allergen from olive pollen and unrelated glycoproteins: Evidence of an epitope in the glycan moiety of the allergen. J Allergy Clin Immunol 1996;97:1264-1271.
56. Aalberse RC, van Ree R: Cross-reactive carbohydrate determinants. Monogr Allergy 1996;32:78-83.
57. Garcia-Casado G, Sanchez-Monge R, Chrispeels MJ, Armentia A, Salcedo G, Gomez L: Role of complex asparagine-linked glycans in the allergenicity of plant glycoproteins. Glycobiology 1996;6:471-477.
58. Petersen A, Vieths S, Aulepp H, Schlaak M, Becker WM: Ubiquitous structures responsible for IgE cross-reactivity between tomato fruit and grass pollen allergens. J Allergy Clin Immunol 1996;98:805-815.
59. van der Veen MJ, van Ree R, Aalberse RC, Akkerdaas J, Koppelman SJ, Jansen HM, et al: Poor biologic activity of cross-reactive IgE directed to carbohydrate determinants of glycoproteins. J Allergy Clin Immunol 1997;100:327-334.
60. Aalberse RC, van Ree R: Crossreactive carbohydrate determinants. Clin Rev Allergy Immunol 1997;15:375-387.
61. Vieths S: Allergenic cross-reactivity, food allergy and pollen. Evironm Toxicol Pharmacol 1997;4:61-70.
62. Aalberse RC, Akkerdaas J, van Ree R: Cross-reactivity of IgE antibodies to allergens. Allergy 2001;56:478-490.
63. Vieths S, Scheurer S, Ballmer-Weber B: Current understanding of cross-reactivity of food allergens and pollen. Ann NY Acad Sci 2002;964:47-68.
64. Valenta R, Kraft D: Type 1 allergic reactions to plant-derived food: A consequence of primary sensitization to pollen allergens. J Allergy Clin Immunol 1996;97:893-895.
65. Bauer L, Ebner C, Hirschwehr R, Wüthrich B, Pichler C, Fritsch R, et al: IgE cross-reactivity between birch pollen, mugwort pollen and celery is due to at least three distinct cross-reacting allergens: Immunoblot investigation of the birch-mugwort-celery syndrome. Clin Exp Allergy 1996;26:1161-1170.
66. Astwood JD, Leach JN, Fuchs RL: Stability of food allergens to digestion in vitro. Nat Biotechnol 1996;14:1269-1273.
67. Asero R, Mistrello G, Roncarolo D, de Vries SC, Gautier MF, Ciurana CL, et al: Lipid transfer protein: A pan-allergen in plant-derived foods that is highly resistant to pepsin digestion. Int Arch Allergy Immunol 2000;122:20-32.
68. van Ree R, Akkerdaas J, van Leeuwen A, et al: New perspectives for the diagnosis of food allergy. Allergy Clin Immunol Int 2000;12:7-12.
69. van Ree R, Aalberse RC: Specific IgE without clinical allergy. J Allergy Clin Immunol 1999;103:1000-1001.
70. van Ree R: Factors modulating allergen-induced histamine release: in Bousquet J, Yssel H (eds): Immunotherapy in Asthma. New York, Marcel Dekker, 1999, pp 399-409.
71. Pierson-Mullany LK, Jackola DR, Blumenthal MN, Rosenberg A: Evidence of an affinity threshold for IgE-allergen binding in the percutaneous skin test reaction. Clin Exp Allergy 2002;32:107-116.
72. Lynch NR, Lopez RI, Prisco-Fuenmayor MC, Hagel I, Medouze L, Viana G, et al: Allergic reactivity and socio-economic level in a tropical environment. Clin Allergy 1987;17:199-207.
73. Aalberse RC, Van Milligen F, Tan KY, Stapel SO: Allergen-specific IgG4 in atopic disease. Allergy 1993;48:559-569.
74. van Ree R, Aalberse RC: Demonstration of carbohydrate-specific immunoglobulin G4 antibodies in sera of patients receiving grass pollen immunotherapy. Int Arch Allergy Immunol 1995;106:146-148.
75. Wensing M, Akkerdaas JH, van Leeuwen WA, Stapel SO, Bruijnzeel-Koomen C, Aalberse RC, et al: IgE to Bet v 1 and profilin: Cross-reactivity patterns and clinical relevance. J Allergy Clin Immunol 2002;110:435-442.
76. Ebner C, Birkner T, Valenta R, Rumpold H, Breitenbach M, Scheiner O, et al: Common epitopes of birch pollen and apples - Studies by western and northern blot. J Allergy Clin Immunol 1991;88:588-594.
77. Du Buske LM: Introduction: Basophil histamine release and the diagnosis of food allergy. Allergy Proc 1993;14:243-249.
78. Nolte H: The clinical utility of basophil histamine release. Allergy Proc 1993;14:251-254.
79. Fureder W, Agis H, Sperr WR, Lechner K, Valent P: The surface membrane antigen phenotype of human blood basophils. Allergy 1994;49:861-865.
80. Ebo DG, Lechkar B, Schuerwegh AJ, Bridts CH, De Clerck LS, Stevens WJ: Validation of a two-color flow cytometric assay detecting in vitro basophil activation for the diagnosis of IgE-mediated natural rubber latex allergy. Allergy 2002;57:706-712.
81. Valenta R, Vrtala S, Laffer S, Spitzauer S, Kraft D: Recombinant allergens. Allergy 1998; 53:552-561.
82. Kraft D, Ferreira F, Ebner C, Valenta R, Breiteneder H, Susani M, et al: Recombinant allergens: The future of the diagnosis and treatment of atopic allergy. Allergy 1998;53:62-66.
83. Kraft D, Ferreira F, Vrtala S, Breiteneder H, Ebner C, Valenta R, et al: The importance of recombinant allergens for diagnosis and therapy of IgE-mediated allergies. Int Arch Allergy Immunol 1999;118:171-176.
84. Valenta R, Lidholm J, Niederberger V, Hayek B, Kraft D, Gronlund H: The recombinant allergen-based concept of component-resolved diagnostics and immunotherapy (CRD and CRIT). Clin Exp Allergy 1999;29:896-904.
85. Kazemi-Shirazi L, Niederberger V, Linhart B, Lidholm J, Kraft D, Valenta R: Recombinant marker allergens: Diagnostic gatekeepers for the treatment of allergy. Int Arch Allergy Immunol 2002;127:259-268.
86. Cramer CL, Weissenborn DL, Oishi KK, Grabau EA, Bennett S, Ponce E, et al: Bioproduction of human enzymes in transgenic tobacco. Ann NY Acad Sci 1996;792:62-71.
87. Jung E, Williams KL: The production of recombinant glycoproteins with special reference to simple eukaryotes including Dictyostelium discoideum. Biotechnol Appl Biochem 1997;25(pt 1):3-8.
88. Altmann F, Staudacher E, Wilson IB, Marz L: Insect cells as hosts for the expression of recombinant glycoproteins. Glycoconj J 1999;16:109-123.
89. Baneyx F: Recombinant protein expression in Escherichia coli. Curr Opin Biotechnol 1999;10:411-421.
90. Bretthauer RK, Castellino FJ: Glycosylation of Pichia pastoris-derived proteins. Biotechnol Appl Biochem 1999;30(pt 3):193-200.
91. Grabenhorst E, Schlenke P, Pohl S, Nimtz M, Conradt HS: Genetic engineering of recombinant glycoproteins and the glycosylation pathway in mammalian host cells. Glycoconj J 1999;16:81-97.
92. Maras M, van D, I, Contreras R, van den Hondel CA: Filamentous fungi as production organisms for glycoproteins of biomedical interest. Glycoconj J 1999;16:99-107.
93. Lerouge P, Bardor M, Pagny S, Gomord V, Faye L: N-glycosylation of recombinant pharmaceutical glycoproteins produced in transgenic plants: Towards an humanisation of plant N-glycans. Curr Pharm Biotechnol 2000;1:347-354.
94. Cereghino JL, Cregg JM: Heterologous protein expression in the methylotrophic yeast Pichia pastoris. FEMS Microbiol Rev 2000;24:45-66.
95. Balbas P: Understanding the art of producing protein and nonprotein molecules in Escherichia coli. Mol Biotechnol 2001;19:251-267.
96. Breiteneder H, Pettenburger K, Bito A, Valenta R, Kraft D, Rumpold H, Scheiner O, Breitenbach M: The gene coding for the major allergen Betv1, is highly homologous to a pea disease resistance response gene. EMBO J 1989;8:1935-1938.
97. Chua KY, Dilworth RJ, Thomas WR: Expression of Dermatophagoides pteronyssinus allergen, Der p II, in Escherichia coliand the binding studies with human IgE. Int Arch Allergy Appl Immunol 1990;91:124-129.
98. Yuuki T, Okumura Y, Ando T, Yamakawa H, Suko M, Haida M, et al: Cloning and expression of cDNA coding for the major house dust mite allergen Der f II in Escherichia coli. Agric Biol Chem 1991;55:1233-1238.
99. Rogers BL, Morgenstern JP, Griffith IJ, Yu XB, Counsell CM, Brauer AW, et al: Complete sequence of the allergen Amb alpha II. Recombinant expression and reactivity with T cells from ragweed allergic patients. J Immunol 1991;147:2547-2552.
100. Valenta R, Duchene M, Vrtala S, Birkner T, Ebner C, Hirschwehr R, et al: Recombinant allergens for immunoblot diagnosis of tree-pollen allergy. J Allergy Clin Immunol 1991;88:889-894.
101. Moser M, Crameri R, Menz G, Schneider T, Dudler T, Virchow C, et al: Cloning and expression of recombinant Aspergillus fumigatus allergen I/a (rAsp f I/a) with IgE binding and type I skin test activity. J Immunol 1992;149:454-460.
102. Rafnar T, Ghosh B, Metzler WJ, Huang SK, Perry MP, Mueller L, et al: Expression and analysis of recombinant Amb a V and Amb t V allergens. Comparison with native proteins by immunological assays and NMR spectroscopy. J Biol Chem 1992;267:21119-21123.
103. Lüttkopf D, Muller U, Skov PS, Ballmer-Weber BK, Wüthrich B, Skamstrup HK, et al: Comparison of four variants of a major allergen in hazelnut (Corylus avellana) Cor a 1.04 with the major hazel pollen allergen Cor a 1.01. Mol Immunol 2002;38:515-525.
104. Pomes A, Vailes LD, Helm RM, Chapman MD: IgE reactivity of tandem repeats derived from cockroach allergen, Bla g 1. Eur J Biochem 2002;269:3086-3092.
105. Derewenda U, Li J, Derewenda Z, Dauter Z, Mueller GA, Rule GS, et al: The crystal structure of a major dust mite allergen Der p 2, and its biological implications. J Mol Biol 2002;318:189-197.
106. Swoboda I, Bugajska-Schretter A, Verdino P, Keller W, Sperr WR, Valent P, et al: Recombinant carp parvalbumin, the major cross-reactive fish allergen: A tool for diagnosis and therapy of fish allergy. J Immunol 2002;168:4576-4584.
107. O'Riordain G, Radauer C, Hoffmann-Sommergruber K, Adhami F, Peterbauer CK, Blanco C, et al: Cloning and molecular characterization of the Hevea brasiliensis allergen Hev b 11, a class I chitinase. Clin Exp Allergy 2002;32:455-462.
108. Ramos JD, Cheong N, Lee BW, Chua KY, Nge C, Wah LB, et al: cDNA cloning and expression of Blo t 11, the Blomia tropicalis allergen homologous to paramyosin. Int Arch Allergy Immunol 2001;126:286-293.
109. Smith PM, Suphioglu C, Griffith IJ, Theriault K, Knox RB, Singh MB: Cloning and expression in yeast Pichia pastoris of a biologically active form of Cyn d 1, the major allergen of Bermuda grass pollen. J Allergy Clin Immunol 1996;98:331-343.
110. Sowka S, Hsieh LS, Krebitz M, Akasawa A, Martin BM, Starrett D, et al: Identification and cloning of prs a 1, a 32-kDa endochitinase and major allergen of avocado, and its expression in the yeast Pichia pastoris. J Biol Chem 1998;273:28091-28097.
111. Sowka S, Wagner S, Krebitz M, Arija-Mad-Arif S, Yusof F, Kinaciyan T, et al: cDNA cloning of the 43-kDa latex allergen Hev b 7 with sequence similarity to patatins and its expression in the yeast Pichia pastoris. Eur J Biochem 1998;255:213-219.
112. Rautiainen J, Auriola S, Rouvinen J, Kauppinen J, Zeiler T, Novikov D, et al: Molecular and crystal properties of Bos d 2, an allergenic protein of the lipocalin family. Biochem Biophys Res Commun 1998;247:746-750.
113. Vailes LD, Kinter MT, Arruda LK, Chapman MD: High-level expression of cockroach allergen, Bla g 4, in Pichia pastoris. J Allergy Clin Immunol 1998;101:274-280.
114. Monsalve RI, Lu G, King TP: Expression of yellow jacket and wasp venom Ag5 allergens in bacteria and in yeast. Arb Paul Ehrlich Inst Bundesamt Sera Impfstoffe Frankf A M. 1999;181-188.
115. van Ree R, van Leeuwen WA, Bulder I, Bond J, Aalberse RC: Purified natural and recombinant Fel d 1 and cat albumin in in vitro diagnostics for cat allergy. J Allergy Clin Immunol 1999;104:1223-1230.
116. Breiteneder H, Sowka S, Wagner S, Krebitz M, Hafner C, Kinaciyan T, et al: Cloning of the patatin-like latex allergen Hev b 7, its expression in the yeast Pichia pastoris and its immunological characterization. Int Arch Allergy Immunol 1999;118:309-310.
117. Huecas S, Villalba M, Gonzalez E, Martinez-Ruiz A, Rodriguez R: Production and detailed characterization of biologically active olive pollen allergen Ole e 1 secreted by the yeast Pichia pastoris. Eur J Biochem 1999;261:539-546.
118. Best EA, Stedman KE, Bozic CM, Hunter SW, Vailes L, Chapman MD, et al: A recombinant group 1 house dust mite allergen, rDer f 1, with biological activities similar to those of the native allergen. Protein Expr Purif 2000;20:462-471.
119. McDermott MJ, Weber E, Hunter S, Stedman KE, Best E, Frank GR, et al: Identification, cloning, and characterization of a major cat flea salivary allergen (Cte f 1). Mol Immunol 2000;37:361-375.
120. van Oort E, de Heer PG, Lerouge P, Faye L, Aalberse RC, van Ree R: Immunochemical characterization of two Pichia pastoris-derived recombinant group 5 Dactylis glomerata isoallergens. Int Arch Allergy Immunol 2001;126:196-205.
121. Yasuhara T, Takai T, Yuuki T, Okudaira H, Okumura Y: Cloning and expression of cDNA encoding the complete preproform of an isoform of Der f 1, the major group 1 allergen from house dust mite Dermatophagoides farinae. Biosci Biotechnol Biochem 2001;65:563-569.
122. Gonzalez E, Villalba M, Rodriguez R: Immunological and molecular characterization of the major allergens from lilac and privet pollens overproduced in Pichia pastoris. Clin Exp Allergy 2001;31:313-321.
123. Jacquet A, Magi M, Petry H, Bollen A: High-level expression of recombinant house dust mite allergen Der p 1 in Pichia pastoris. Clin Exp Allergy 2002;32:1048-1053.
124. Pomes A, Vailes LD, Helm RM, Chapman MD: IgE reactivity of tandem repeats derived from cockroach allergen, Bla g 1. Eur J Biochem 2002;269:3086-3092.
125. Palomares O, Monsalve RI, Rodriguez R, Villalba M: Recombinant pronapin precursor produced in Pichia pastoris displays structural and immunologic equivalent properties to its mature product isolated from rapeseed. Eur J Biochem 2002;269:2538-2545.
126. Diaz-Perales A, Sanchez-Monge R, Blanco C, Lombardero M, Carillo T, Salcedo G: What is the role of the hevein-like domain of fruit class I chitinases in their allergenic capacity? Clin Exp Allergy 2002;32:448-454.
127. van Oort E, de Heer PG, van Leeuwen WA, Derksen NI, Muller M, Huveneers S, et al: Maturation of Pichia pastoris-derived recombinant pro-Der p 1 induced by deglycosylation and by the natural cysteine protease Der p 1 from house dust mite. Eur J Biochem 2002;269:671-679.
128. Tomalski MD, King TP, Miller LK: Expression of hornet genes encoding venom allergen antigen 5 in insects. Arch Insect Biochem Physiol 1993;22:303-313.
129. Schmidt M, McConnell TJ, Hoffman DR: Production of a recombinant imported fire ant venom allergen, Sol i 2, in native and immunoreactive form. J Allergy Clin Immunol 1996;98:82-88.
130. Shoji H, Hanawa M, Shibuya I, Hirai M, Yas-uhara T, Okumura Y, et al: Production of recombinant mite allergen Der fI in insect cells and characterization of products - Removal of pro-sequence is essential to IgE-binding activity. Biosci Biotechnol Biochem 1996;60:621-625.
131. Xu W, Simons FE, Peng Z: Expression and rapid purification of an Aedes aegypti salivary allergen by a baculovirus system. Int Arch Allergy Immunol 1998;115:245-251.
132. Soldatova LN: Biological activity of recombinant bee venom allergens expressed in baculovirus-infected cells. Arb Paul Ehrlich Inst Bundesamt Sera Impfstoffe Frankf A M. 1999;189-193.
133. Soldatova LN, Crameri R, Gmachl M, Kemeny DM, Schmidt M, Weber M, et al: Superior biologic activity of the recombinant bee venom allergen hyaluronidase expressed in baculovirus-infected insect cells as compared with Escherichia coli. J Allergy Clin Immunol 1998;101:691-698.
134. McDermott MJ, Weber E, Hunter S, Stedman KE, Best E, Frank GR, et al: Identification, cloning, and characterization of a major cat flea salivary allergen (Cte f 1). Mol Immunol 2000;37:361-375.
135. Peng Z, Xu W, James AA, Lam H, Sun D, Cheng L, et al: Expression, purification, characterization and clinical relevance of rAed a 1 - A 68-kDa recombinant mosquito Aedes aegypti salivary allergen. Int Immunol 2001;13:1445-1452.
136. King TP, Jim SY, Monsalve RI, Kagey-Sobotka A, Lichtenstein LM, Spangfort MD: Recombinant allergens with reduced allergenicity but retaining immunogenicity of the natural allergens: Hybrids of yellow jacket and paper wasp venom allergen antigen 5s. J Immunol 2001;166:6057-6065.
137. Krebitz M, Wiedermann U, Essl D, Steinkellner H, Wagner B, Turpen TH, et al: Rapid production of the major birch pollen allergen Bet v 1 in Nicotiana benthamiana plants and its immunological in vitro and in vivo characterization. FASEB J 2000;14:1279-1288.
138. Breiteneder H, Krebitz M, Wiedermann U, Wagner B, Essl D, Steinkellner H, et al: Rapid production of recombinant allergens in Nicotiana benthamiana and their impact on diagnosis and therapy. Int Arch Allergy Immunol 2001;124:48-50.
139. Durham SR: New insights into the mechanisms of immunotherapy. Eur Arch Otorhinolaryngol 1995;252(suppl 1):S64-S67.
140. Durham SR, Till SJ: Immunologic changes associated with allergen immunotherapy. J Allergy Clin Immunol 1998;102:157-164.
141. Maggi E: The TH1/TH2 paradigm in allergy. Immunotechnology 1998;3:233-244.
142. Akdis CA, Blaser K: Mechanisms of allergen-specific immunotherapy. Allergy 2000;55:522-530.
143. Akdis CA, Joss A, Akdis M, Blaser K: Mechanism of IL-10-induced T cell inactivation in allergic inflammation and normal response to allergens. Int Arch Allergy Immunol 2001;124:180-182.
144. Hilkens CM, Kalinski P, de Boer M, Kapsenberg ML: Human dendritic cells require exogenous interleukin-12-inducing factors to direct the development of naive T-helper cells toward the Th1 phenotype. Blood 1997;90:1920-1926.
145. 2, promote Th2 responses. Adv Exp Med Biol 1997;417:363-367.
146. Kapsenberg ML, Hilkens CM, Wierenga EA, Kalinski P: The paradigm of type 1 and type 2 antigen-presenting cells. Implications for atopic allergy. Clin Exp Allergy 1999;29(suppl 2):33-36.
147. Liu YJ, Kadowaki N, Rissoan MC, Soumelis V: T cell activation and polarization by DC1 and DC2. Curr Top Microbiol Immunol 2000;251:149-159.
148. Vieira PL, de Jong EC, Wierenga EA, Kapsenberg ML, Kalinski P: Development of Th1-inducing capacity in myeloid dendritic cells requires environmental instruction. J Immunol 2000;164:4507-4512.
149. Maldonado-Lopez R, Maliszewski C, Urbain J, Moser M: Cytokines regulate the capacity of CD8alpha(+) and CD8alpha(-) dendritic cells to prime Th1/Th2 cells in vivo. J Immunol 2001;167:4345-4350.
150. de Jong EC, Vieira PL, Kalinski P, Schuitemaker JH, Tanaka Y, Wierenga EA, et al: Microbial compounds selectively induce Th1 cell-promoting or Th2 cell-promoting dendritic cells in vitro with diverse th cell-polarizing signals. J Immunol 2002;168:1704-1709.
151. Shortman K, Liu YJ: Mouse and human dendritic cell subtypes. Nat Rev Immunol 2002;2:151-161.
152. Yazdanbakhsh M, Kremsner PG, van Ree R: Allergy, parasites and the hygiene hypothesis. Science 2002;296:490-494.
153. Medzhitov R: Toll-like receptors and innate immunity. Nat Rev Immunol 2001;1:135-145.
154. Janeway CA, Jr., Medzhitov R: Innate immune recognition. Annu Rev Immunol 2002;20:197-216.
155. Almeida IC, Gazzinelli RT: Proinflammatory activity of glycosylphosphatidylinositol anchors derived from Trypanosoma cruzi: Structural and functional analyses. J Leukoc Biol 2001;70:467-477.
156. Bendelac A, Medzhitov R: Adjuvants of immunity: Harnessing innate immunity to promote adaptive immunity. J Exp Med 2002;195:F19-F23.
157. Triantafilou M, Triantafilou K: Lipopolysaccharide recognition: CD14, TLRs and the LPS-activation cluster. Trends Immunol 2002;23:301-304.