The importance of recombinant allergens for diagnosis and therapy of IgE-mediated allergies

International Archives of Allergy and Immunology

Volumn 118, Issue 2-4, 1999, Pages 171-176

  Kraft, Dietrich ^c   Ferreira, F ^a   Vrtala, S ^d   Breiteneder, H ^d   Ebner, C ^d   Valenta, R ^d   Susani, M ^b   Breitenbach, M ^a   Scheiner, O ^d  

^a UNIVERSITY OF SALZBURG   (Austria)

^b ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^c UNIVERSITY OF VIENNA   (Austria)

^d NONE

Author keywords

cDNA cloning; IgE; Immunotherapy specific; Recombinant allergens

Indexed keywords

ALLERGEN; COMPLEMENTARY DNA; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E ANTIBODY; ISOPROTEIN; POLLEN ANTIGEN; RECOMBINANT PROTEIN;

ALLERGY; ANTIGEN BINDING; BASOPHIL; CELL ACTIVATION; CONFERENCE PAPER; HUMAN; IMMUNOTHERAPY; MAST CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN VARIANT; T LYMPHOCYTE ACTIVATION;

EID: 0032964218     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000024058     Document Type: Conference Paper

References (36)

1. Coombs RRA: The First Carl Prausnitz Memorial Lecture. Int Arch Allergy Appl Immunol 1973;45:1-22.
2. Prausnitz C, Küstner H: Studien über die Überempflindlichkeit. Zentralbl Bakteriol 1921;86:160-169.
3. Scheiner O, Kraft D: Basic and practical aspects of recombinant allergens. Allergy 1995; 50:384-391.
4. Valenta R, Kraft D: Recombinant allergens for diagnosis and therapy of allergic diseases. Curr Opin Immunol 1995;7:751-756.
5. Valenta R, Vrtala S, Laffer S, Spitzauer S, Kraft D: Recombinant allergens. Allergy 1998; 53:552-561.
6. Thomas WR, Smith W, Hales BJ: House dust mite allergen characterization: Implications for T cell responses and immunotherapy. Int Arch Allergy Immunol 1998;115:9-14.
7. Crameri R: Recombinant Aspergillus fumigatus allergens: From the nucleotide sequences to clinical applications. Int Arch Allergy Immunol 1998;115:99-114.
8. Ipsen K, Loewenstein: Isolation and characterization of the major allergen of birch pollen (Betula verrucosa). J Allergy Clin Immunol 1983;72:150-159.
9. Breiteneder H, Pettenburger K, Bito A, Kraft D, Rumpold H, Scheiner O, Breitenhach M: The gene coding for the major birch allergen, Bet v I, is highly homologous to a pea disease resistance response gene. EMBO J 1989;8: 1935-1938.
10. Chua KY, Stewart GA, Thomas WR, Simpson RJ, Dilworth RJ, Plozza TM, Turner KJ: Sequence analysis of cDNA coding for a major house dust mite allergen, Der p 1. Homology with cysteine proteases. J Exp Med 1988;167: 175-182.
11. Swoboda I, Hoffmann-Sommergruber K, O'Riordain G, Scheiner O, Heberle-Bors E, Vicente O: Bet v 1, the major birch pollen allergen and members of a family of conserved pathogenesis-related proteins, show ribonuclease activity in vitro. Physiol Plant 1996;96: 433-438.
12. Bufe A, Spangfort MD, Kahlert H, Schlaak M, Becker WM: The major birch pollen allergen Bet v 1 shows ribonuclease activity. Planta 1996;199:413-415.
13. Gajhede M, Osmark P, Poulsen FM, Ipsen H, Larsen JN, van Neerven RJJ, Schou C, Loewenstein H, Spangfort MD: X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy. Nature Struct Biol 1996;3: 1040-1045.
14. Valenta R, Duchene M, Pettenburger K, Sillaber C, Valent P, Bettelheim P, Breitenbach M, Rumpold H, Kraft D, Scheiner O: Identification of profilin as a novel pollen allergen; IgE autoreactivity in sensitized individuals. Science 1991;253:557-560.
15. Valenta R, Duchene M, Ebner C, Valent P, Sillaber C, Deviller P, Ferreira F, Tejkl M, Edelmann H, Kraft D, Scheiner O: Profilins constitute a novel family of functional plant pan-allergens. J Exp Med 1992;175:377-385.
16. Vallier P, Dechamp C, Vial O, Deviller P: A study of allergens in celery with cross-sensitivity to mugwort and birch pollens. Clin Allergy 1988;18:491-500.
17. Valuer P, Dechamp C, Valenta R, Vial O, Deviller P: Purification and characterization of an allergen from celery with extended cross-reactivity in other plant species. Identification as profilin. Clin Exp Allergy 1992;22:774-782.
18. Stewart GA, Lake FR, Bird CH, Thompson PJ: Mite allergens as digestive enzymes; in Sehon AH, Kraft D, Kunkel G (eds): Epitopes of Atopic Allergens. Brussels, UCB, 1989, pp 83-86.
19. Ebner C, Birkner T, Valenta R, Rumpold H, Breitenbach M, Scheiner O, Kraft D: Common epitopes of birch pollen and apples - Studies by Western and Northern blot. J Allergy Clin Immunol 1991;88:588-594.
20. Hirschwehr R, Valenta R, Ebner C, Ferreira F, Sperr WR, Valent P, Rohac M, Rumpold H, Scheiner O, Kraft D: Identification of common allergenic structures in hazel pollen and hazelnuts: A possible explanation for sensitivity to hazel nuts in patients allergic to tree pollen. J Allergy Clin Immunol 1992;90:927-936.
21. Ebner C, Hirschwehr R, Bauer L, Breiteneder H, Valenta R, Ebner H, Kraft D, Scheiner O: Identification of allergens in fruits and vegetables: IgE cross-reactivities with the important birch pollen allergens Bet v 1 and Bet v 2 (birch profilin). J Allergy Clin Immunol 1995; 95:962-969.
22. Bauer L, Ebner C, Hirschwehr R, Wüthrich B, Pichler R, Fritsch R, Scheiner O, Kraft D: IgE cross-reactivity between birch pollen, mugwort pollen and celery is due to at least three distinct cross-reading allergens: Immunoblot investigation of the birch-mugwort-cellery syndrome. Clin Exp Allergy 1996;26:1161-1170.
23. Jensen-Jarolim E, Santner B, Leitner A, Grimm R, Scheiner O, Ebner C, Breiteneder H: Bell peppers (Capsicum annuum) express allergens (profilin, pathogenesis related protein P23 and Bet v 1) depending on the horticultural strain. Int Arch Allergy Immunol 1998;116:103-109.
24. Swoboda I, Jilek A, Ferreira F, Engel E, Hoffmann-Sommergruber K, Scheiner O, Kraft D, Breiteneder H, Pitteneauer E, Schmid E, Vicente O, Heberle-Bors E, Ahorn H, Breitenbach M: Isoforms of Bet v 1, the major birch pollen allergen, analyzed by liquid chromatography, mass spectrometry, and cDNA cloning. J Biol Chem 1995;270:2607-2613.
25. Ferreira F, Hirtenlehner K, Jilek A, Godnick-Cvar J, Breiteneder H, Grimm R, Hoffmann-Sommergruber K, Scheiner O, Kraft D, Breitenbach M, Rheinberger HJ, Ebner C: Dissection of immunoglobulin E and T lymphocyte reactivity of isoforms of the major birch pollen allergen Bet v 1: Potential use of hypoallergenic isoforms for immunotherapy. J Exp Med 1996;183:599-609.
26. Breiteneder H, Ferreira F, Hoffmann-Sommergruber K, Ebner C, Breitenbach M, Rumpold H, Kraft D, Scheiner O: Four recombinant isoforms of Cor a I, the major allergen of hazel pollen, show different IgE-binding properties. Eur J Biochem 1993;212:355-362.
27. Schenk S, Hoffmann-Sommergruber K, Breiteneder H, Ferreira F, Fischer F, Scheiner O, Kraft D, Ebner C: Four recombinant isoforms of Cor a 1, the major allergen of hazel pollen, show different reactivity with allergen-specific T-lymphocyte clones. Eur J Biochem 1994; 224:717-722.
28. Casari G, Sander C, Valencia A: A method to predict functional residues in proteins. Nature Struct Biol 1995;2:171-178.
29. Breiteneder H, Ferreira F, Reikerstorfer A, Duchene M, Valenta R, Hoffmann-Sommergruber K, Ebner C, Breitenbach M, Kraft D, Scheiner O: Complementary DNA cloning and expression in Escherichia coli of Aln g I, the major allergen in pollen of alder (Alnus glutinosa). J Allergy Clin Immunol 1992;90:909-917.
30. Ferreira F, Ebner C, Kramer B, Casari G, Briza P, Kungl A, Grimm R, Jahn-Schmid B, Breiteneder H, Kraft D, Breitenbach M. Rheinberger HJ, Scheiner O: Modulation of IgE reactivity of allergens by site-directed mutagenesis: Potential use of hypoallergenic variants for immunotherapy. FASEB J 1998;12:231-242.
31. Ebner C, Szépfalusi Z, Ferreira F, Jilek A, Valenta R, Parronchi P, Maggi E, Romagnani S, Scheiner O, Kraft D: Identification of multiple T cell epitopes on Bet v I, the major birch pollen allergen, using specific T cell clones and overlapping peptides. J Immunol 1993; 150:1047-1054.
32. Vrtala S, Hirtenlehner K, Vangelista L, Pastore A, Eichler HG, Sperr WR, Valent P, Ebner C, Kraft D, Valenta R: Conversion of the major birch pollen allergen, Bet v I, into two non-anaphylactic T-cell epitope-containing fragments; candidates for a novel form of specific immunotherapy. J Clin Invest 1997;99:1673-1681.
33. Carballido JM, Carballido-Perrig N, Terres G, Heusser CH, Blaser K: Bee venom phospholipase A2-specific T cell clones from human allergic and non-allergic individuals: Cytokine patterns change in response to the antigen concentration. Eur J Immunol 1992;22:1357-1363.
34. Jutel M, Pichler PJ, Skrbic D, Urwyler A, Dahinden C, Müller UR: Bee venom immunotherapy results in decrease of IL-4 and IL-5 and increase of IFN-gamma secretion in specific allergen-stimulated T cell cultures. J Immunol 1995;154:4187-4194.
35. Secrist H, Chelen CJ, When Y, Marshall JD, Umetsu DT: Allergen immunotherapy decreases interleukin 4 production in CD4+ T cells from allergic individuals. J Exp Med 1993; 178:2123-2130.
36. Secrist H, DeKruyff RH, Umetsu DT: Interleukin 4 production by CD4+ T cells from allergic individuals is modulated by antigen concentration and antigen-presenting cell type. J Exp Med 1995;181:1081-1089.