Microbial compounds selectively induce Th1 cell-promoting or Th2 cell-promoting dendritic cells in vitro with diverse th cell-polarizing signals

Journal of Immunology

Volumn 168, Issue 4, 2002, Pages 1704-1709

  De Jong, Esther C ^a   Vieira, Pedro L ^a   Kalinski, Pawel ^a   Schuitemaker, Joost H N ^a   Tanaka, Yuetsu ^a   Wierenga, Eddy A ^a   Yazdanbakhsh, Maria ^a   Kapsenberg, Martien L ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; BACTERIAL TOXIN; DOUBLE STRANDED RNA; INTERLEUKIN 12; LIGAND; POLYINOSINIC POLYCYTIDYLIC ACID;

ARTICLE; BORDETELLA PERTUSSIS; CELL ACTIVATION; CELL MATURATION; CELL POLARITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; EFFECTOR CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCHISTOSOMA MANSONI; SIGNAL TRANSDUCTION; TH1 CELL; TH2 CELL; VIBRIO CHOLERAE;

EID: 0037083298     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.4.1704     Document Type: Article

References (31)

1. Maturation, activation, and protection of dendritic cells induced by double-stranded RNA
2. Dendritic cells discriminate between yeasts and hyphae of the fungus Candida albicans: Implications for initiation of T helper cell immunity in vitro and in vivo
3. A filarial nematode-secreted product signals dendritic cells to acquire a phenotype that drives development of Th2 cells
4. Cholera toxin induces maturation of human dendritic cells and licenses them for Th2 priming
5. Immunobiology of dendritic cells
6. T-cell priming by type-1 and type-2 polarized dendritic cells: The concept of a third signal
7. Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
8. Interferon-γ-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: Synergism with interleukin-12 for interferon-γ production
9. Influenza A virus-induced IFN-α/β and IL-18 synergistically enhance IFN-γ gene expression in human T cells
10. CD4 T cell cytokine differentiation: The B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1
11. + dendritic cells: The levels of IL-12 are determined during the final dendritic cell maturation and are resistant to further modulation
12. Development of Th1-inducing capacity in myeloid dendritic cells requires environmental instruction
13. Leukocytes of patients with Schistosoma mansoni respond with a Th2 pattern of cytokine production to mitogen or egg antigens but with a Th0 pattern to worm antigens
14. Helper T cell subsets for immunoglobulin A responses: Oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues
15. Cell-mediated immunity and antibody responses to Bordetella pertussis antigens in children with a history of pertussis infection and in recipients of an acellular pertussis vaccine
16. Antigen-specific proliferation and interferon-γ and interleukin-5 production are down-regulated during Schistosoma haematobium infection
17. The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells
18. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: Downregulation by cytokines and bacterial products
19. Final maturation of dendritic cells is associated with impaired responsiveness to IFN-γ and to bacterial IL-12 inducers: Decreased ability of mature dendritic cells to produce IL-12 during the interaction with Th cells
20. Kinetics of dendritic cell activation: Impact on priming of Th1, Th2 and nonpolarized T cells
21. The antigen dose determines T helper subset development by regulation of CD40 ligand
22. Human monocyte-derived dendritic cells induce naive T cell differentiation into T helper cell type 2 (Th2) or Th1/Th2 effectors: Role of stimulator/responder ratio
23. Freshly isolated Peyer's patch, but not spleen, dendritic cells produce interleukin 10 and induce the differentiation of T helper type 2 cells
24. Mice lacking IL-12 develop polarized Th1 cells during viral infection
25. Residual type 1 immunity in patients genetically deficient for interleukin 12 receptor b1 (IL-12Rbl): Evidence for an IL-12Rbl-independent pathway of 1L-12 responsiveness in human T cells
26. Natural interferon α/β-producing cells link innate and adaptive immunity
27. 2 is a potent inhibitor of human interleukin 12 production
28. Primary role for Gi protein signaling in the regulation of interleukin 12 production and the induction of T helper cell type 1 responses
29. The effects of pertussis toxin and cholera toxin on mitogen-induced interleukin-2 production: Evidence for G protein involvement in signal transduction
30. A Toll-like receptor recognizes bacterial DNA
31. Paralysis of dendritic cell IL-12 production by microbial products prevents infection-induced immunopathology