Lipopolysaccharide recognition: CD14, TLRs and the LPS-activation cluster

Trends in Immunology

Volumn 23, Issue 6, 2002, Pages 301-304

  Triantafilou, Martha ^a   Triantafilou, Kathy ^a  

^a UNIVERSITY OF PORTSMOUTH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CD11 ANTIGEN; CD14 ANTIGEN; CD18 ANTIGEN; CHEMOKINE RECEPTOR CCR4; DECAY ACCELERATING FACTOR; GROWTH DIFFERENTIATION FACTOR 5; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; LIPOPOLYSACCHARIDE BINDING PROTEIN; TOLL LIKE RECEPTOR;

ANTIGEN BINDING; ANTIGEN RECOGNITION; B LYMPHOCYTE; CELL ACTIVATION; EPITHELIUM CELL; HUMAN; MACROPHAGE; MAST CELL; MOLECULAR DYNAMICS; MOLECULAR MODEL; MONOCYTE; NEUTROPHIL; NONHUMAN; PROTEIN FUNCTION; PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, CD14; BONE MORPHOGENETIC PROTEINS; DROSOPHILA PROTEINS; GLYCOSYLPHOSPHATIDYLINOSITOLS; GROWTH SUBSTANCES; HEAT-SHOCK PROTEINS; IMMUNITY, NATURAL; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; MACROMOLECULAR SUBSTANCES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, IMMUNOLOGICAL; RECEPTORS, CELL SURFACE; RECEPTORS, CXCR4; TOLL-LIKE RECEPTORS;

EID: 0036606913     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4906(02)02233-0     Document Type: Review

References (30)

1. Structure and function of lipopolysaccharide-binding protein
2. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding-protein
3. Neither CD14 nor serum is absolutely necessary for activation of mononuclear phagocytes by bacterial lipopolysaccharide
4. Lipopolysaccharide complexed with soluble CD14 binds to normal human monocytes
5. Saturable CD14-dependent binding of fluorescein-labelled lipopolysaccharide to human monocytes
6. Rough and smooth forms of fluorescein-labelled bacterial endotoxin exhibit CD14/LBP dependent and independent binding that is influenced by endotoxin concentration
7. Specific endotoxin lipopolysaccharide binding protein on murine splenocytes
8. Peptidoglycan and lipopolysaccharide bind to the same binding site on lymphocytes
9. Identification of lipopolysaccharide binding proteins in 70Z/3 cells by photoaffinity crosslinking
10. Detection of lipopolysaccharide (LPS)-binding membrane proteins by immuno-coprecipitation with LPS and anti-LPS antibodies
11. Interactions of bacterial lipopolysaccharide and peptidoglycan with a 70kDa and an 80kDa protein on the cell surface of CD14 positive and CD14 negative cells
12. Defective LPS signaling in C3H/Hej and C57BL/10ScCr mice: Mutations in TLR4 gene
13. Endotoxin-tolerant mice have mutations in toll-like receptor 4 (TLR4)
14. Cutting edge: Toll-like receptor 4 (TLR4) deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the LPS gene product
15. The role of TLR4 in endotoxin responsiveness in humans
16. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
17. Fluorescence recovery after photobleaching reveals that lipopolysaccharide rapidly transfers from CD14 to heat shock proteins 70 and 90 on the cell membrane
18. Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. Transfer from CD14 to TLR4 and MD-2
19. A CD14-independent LPS receptor cluster
20. Lipopolysaccharide and ceramide docking to CD14 provokes ligand-specific receptor clustering in rafts
21. The Toll-like receptor protein RP105 regulates lipopolysaccharide signalling in B cells
22. TREM-1 amplifies inflammation and is crucial mediator of septic shock
23. Toll-like receptor 4-mediated activation of murine mast cells
24. Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells
25. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors
26. Novel engagement of CD14 and multiple Toll-like receptors by Group B Streptococci
27. Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products and cytokines
28. Biological activities of lipopolysaccharides are determined by the shape of their lipid A portion
29. + channel is involved in LPS signaling
30. A differential role for the mitogen-activated protein kinases in LPS signaling: the MEK/ERK pathway is not essential for nitric oxide and interleukin 1β production