메뉴 건너뛰기




Volumn 6, Issue 2, 2002, Pages 217-233

Mechanisms of tumour invasion and metastasis: Emerging targets for therapy

Author keywords

Adhesion; Cadherins; Focal adhesion kinase; Growth factors; Integrins; Invasion; Matrix metalloproteinases; Metastasis; Migration; Phosphatidylinositol 3 kinase; Phospholipase C; Proteases; u PAR

Indexed keywords

ALPHA5 INTEGRIN; ALPHA6 INTEGRIN; ANTINEOPLASTIC AGENT; CADHERIN; CELL ADHESION MOLECULE; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; FOCAL ADHESION KINASE; GELATINASE A; GELATINASE B; GUANOSINE TRIPHOSPHATASE; INTERSTITIAL COLLAGENASE; JANUS KINASE; MATRIX METALLOPROTEINASE 14; MITOGEN ACTIVATED PROTEIN KINASE; NERVE CELL ADHESION MOLECULE; PHOSPHOLIPASE C; PLASMINOGEN ACTIVATOR; PROTEIN CDC42; PROTEIN TYROSINE KINASE; RAC PROTEIN; RAS PROTEIN; RHO FACTOR; SCATTER FACTOR; SOMATOMEDIN; TRANSFORMING GROWTH FACTOR BETA1; TYROSINE KINASE RECEPTOR; UROKINASE;

EID: 0036244198     PISSN: 14728222     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728222.6.2.217     Document Type: Review
Times cited : (116)

References (173)
  • 1
    • 0021941053 scopus 로고
    • Cancer metastasis: Experimental approaches, theoretical concepts, and impacts for treatment strategies
    • (1985) Adv. Cancer Res , vol.43 , pp. 1-73
    • Schirrmacher, V.1
  • 17
    • 0026770377 scopus 로고
    • Integrins: Versatility, modulation, and signaling in cell adhesion
    • (1992) Cell , vol.69 , pp. 11-25
    • Hynes, R.O.1
  • 37
    • 0027212509 scopus 로고
    • Laminin regulates a tumor cell chemotaxis receptor through the laminin-binding integrin subunit alpha 6
    • (1993) Cancer Res , vol.53 , pp. 2661-2666
    • Blood, C.H.1    Zetter, B.R.2
  • 41
    • 0031283128 scopus 로고    scopus 로고
    • The integrin alpha6beta4 functions in carcinoma cell migration on laminin-1 by mediating the formation and stabilization of actin-containing motility structures
    • (1997) J. Cell Biol , vol.139 , pp. 1873-1884
    • Rabinovitz, I.1    Mercurio, A.M.2
  • 42
    • 0034951677 scopus 로고    scopus 로고
    • Identification of insulin receptor substrate 1 (IRS-1) and IRS-2 as signaling intermediates in the alpha6beta4 integrin-dependent activation of phosphoinositide 3-OH kinase and promotion of invasion
    • (2001) Mol. Cell. Biol , vol.21 , pp. 5082-5093
    • Shaw, L.M.1
  • 47
    • 0033524949 scopus 로고    scopus 로고
    • The integrin alpha v beta 6 binds and activates latent TGF beta 1: A mechanism for regulating pulmonary inflammation and fibrosis
    • (1999) Cell , vol.96 , pp. 319-328
    • Munger, J.S.1    Huang, X.2    Kawakatsu, H.3
  • 54
  • 58
    • 0031770035 scopus 로고    scopus 로고
    • Adenoviral gene transfer of beta3 integrin subunit induces conversion from radial to vertical growth phase in primary human melanoma
    • (1998) Am. J. Pathol , vol.153 , pp. 1435-1442
    • Hsu, M.Y.1    Shih, D.T.2    Meier, F.E.3
  • 86
    • 0035042153 scopus 로고    scopus 로고
    • Differential expression of p16/p21/p27 and cyclin D1/D3, and their relationships to cell proliferation, apoptosis, and tumour progression in invasive ductal carcinoma of the breast
    • (2001) J. Pathol , vol.194 , pp. 35-42
    • Wong, S.C.1    Chan, J.K.2    Lee, K.C.3    Hsiao, W.L.4
  • 104
    • 2142784516 scopus 로고    scopus 로고
    • MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover
    • (1999) Cell , vol.99 , pp. 81-92
    • Holmbeck, K.1    Biancop, A.2    Caterina, J.3
  • 108
    • 0035110730 scopus 로고    scopus 로고
    • Overexpression of membrane-type matrix metalloproteinase-1 gene induces mammary gland abnormalities and adenocarcinoma in transgenic mice
    • (2001) Cancer Res , vol.61 , pp. 984-990
    • Ha, H.Y.1    Moon, H.B.2    Nam, M.S.3
  • 109
    • 0030966970 scopus 로고    scopus 로고
    • MT1-MMP correlates with MMP-2 activation potential seen after epithelial to mesenchymal transition in human breast carcinoma cells
    • [published erratum appears in Clin. Exp. Metastasis (1997) 15(3):338]
    • (1997) Clin. Exp. Metastasis , vol.15 , pp. 111-120
    • Pulyaeva, H.1    Bueno, J.2    Polette, M.3
  • 112
    • 0030475119 scopus 로고    scopus 로고
    • Recent advances in the field of matrix metalloproteinase inhibitors
    • (1996) , vol.6 , pp. 1305-1315
    • Beckett, R.P.1
  • 117
    • 0035127868 scopus 로고    scopus 로고
    • The role and regulation of urokinase-type plasminogen activator receptor gene expression in cancer invasion and metastasis
    • (2001) Med. Res. Rev , vol.21 , pp. 146-170
    • Wang, Y.1
  • 120
  • 121
    • 0027077443 scopus 로고
    • Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor
    • (1992) EMBO J , vol.11 , pp. 4825-4833
    • Naldini, L.1    Tamagnone, L.2    Vigna, E.3
  • 126
    • 0033549558 scopus 로고    scopus 로고
    • Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner
    • (1999) J. Cell Biol , vol.146 , pp. 149-164
    • Nguyen, D.H.1    Catling, A.D.2    Webb, D.J.3
  • 128
    • 0034906667 scopus 로고    scopus 로고
    • Adenovirus-mediated antisense urokinase-type plasminogen activator receptor gene transfer reduces tumor cell invasion and metastasis in non-small cell lung cancer cell lines
    • (2001) Clin. Cancer Res , vol.7 , pp. 1087-1093
    • Lakka, S.S.1    Rajagopal, R.2    Rajan, M.K.3
  • 130
    • 0035833983 scopus 로고    scopus 로고
    • Peptide-derived antagonists of the urokinase receptor affinity maturation by combinatorial chemistry, identification of functional epitopes, and inhibitory effect on cancer cell intravasation
    • (2001) Biochemistry , vol.40 , pp. 12157-12168
    • Ploug, M.1    Ostergaard, S.2    Gardsvoll, H.3
  • 131
    • 0034601499 scopus 로고    scopus 로고
    • Molecular switches in metastasis
    • (2000) Nature , vol.406 , pp. 466-467
    • Ridley, A.1
  • 134
    • 0034638917 scopus 로고    scopus 로고
    • Overexpression of ErbB2 in cancer and ErbB2-targeting strategies
    • (2000) Oncogene , vol.19 , pp. 6115-6121
    • Yu, D.1    Hung, M.C.2
  • 138
    • 0034060505 scopus 로고    scopus 로고
    • Docetaxel (Taxotere) in HER-2-positive patients and in combination with trastuzumab (Herceptin)
    • (2000) Semin. Oncol , vol.27 , pp. 19-23
    • Burris H.A. III1
  • 145
    • 0032145417 scopus 로고    scopus 로고
    • Platelet-derived growth factor-BB, insulin-like growth factor-I, and phorbol ester activate different signaling pathways for stimulation of vascular smooth muscle cell migration
    • (1998) Exp. Cell Res , vol.242 , pp. 548-560
    • Pukac, L.1    Huangpu, J.2    Karnovsky, M.J.3
  • 149
    • 0034635434 scopus 로고    scopus 로고
    • Specific requirement for the p85-p110alpha phosphatidylinositol 3-kinase during epidermal growth factor-stimulated actin nucleation in breast cancer cells
    • (2000) J. Biol. Chem , vol.275 , pp. 3741-3744
    • Hill, K.1    Welti, S.2    Yu, J.3
  • 164
    • 85047697264 scopus 로고    scopus 로고
    • Inhibition of the EGF-induced activation of phospholipase C-gammal by a single chain antibody fragment
    • (2001) Oncogene , vol.20 , pp. 7954-7964
    • Yi, K.S.1    Chung, J.H.2    Lee, Y.H.3
  • 168
  • 169
    • 0031657454 scopus 로고    scopus 로고
    • Focal adhesion kinase and its potential involvement in tumor invasion and metastasis
    • (1998) Head Neck , vol.20 , pp. 745-752
    • Kornberg, L.J.1
  • 170
    • 0035476836 scopus 로고    scopus 로고
    • Inhibition of focal adhesion kinase expression or activity disrupts epidermal growth factor-stimulated signaling promoting the migration of invasive human carcinoma cells
    • (2001) Cancer Res , vol.61 , pp. 7079-7090
    • Hauck, C.R.1    Sieg, D.J.2    Hsia, D.A.3
  • 173
    • 0033002997 scopus 로고    scopus 로고
    • Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2
    • (1999) Mol. Cell. Biol , vol.19 , pp. 4806-4818
    • Owen, J.D.1    Ruest, P.J.2    Fry, D.W.3    Hanks, S.K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.