The E-cadherin/catenin complex in invasion and metastasis

Current Topics in Microbiology and Immunology

Volumn 213 I, Issue , 1996, Pages 123-161

  Bracke, M E ^a   Van Roy, F M ^b   Mareel, M M ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CADHERIN; CATENIN; CELL MEMBRANE PROTEIN; RETINOIC ACID; TAMOXIFEN; TANGERETIN;

BREAST CARCINOMA; CANCER INVASION; CYTOSKELETON; EPITHELIUM CELL; GENE EXPRESSION REGULATION; HUMAN; METASTASIS; PRIORITY JOURNAL; REVIEW;

EID: 0029889851     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-61107-0_9     Document Type: Review

References (341)

1. Aberle H, Butz S, Stappert J, Weissig H, Kemler R, Hoschuetzky H (1994) Assembly of the cadherin-catenin complex in vitro with recombinant proteins J Cell Sci 107. 3655-3663
2. Akiyama T, Ishida J, Nakagawa S, Ogawara H, Watanabe S, Itoh N, Shibuya M, Fukami Y (1987) Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem 262. 5592-5595
3. Albrechtsen R, Nielsen M, Wewer U, Engvall E, Ruoslahti E (1981) Basement membrane changes in breast cancer detected by immunohistochemical staining for laminin Cancer Res 41: 5076-5081
4. Amagai M (1995) Adhesion molecules. I: Keratinocyte-keratinocyte interactions: cadherins and pemphigus. J Invest Dermatol 104: 146-152
5. Amagai M, Fujimori T, Masunaga T, Shimizu H, Nishikawa T, Shimizu N, Takeichi M, Hashimoto T (1995) Delayed assembly of desmosomes in keratinocytes with disrupted classic-cadherin-mediated cell adhesion by a dominant negative mutant. J Invest Dermatol 104: 27-34
6. Anzano MA, Byers SW, Smith JM, Peer CW, Mullen LT, Brown CC, Roberts AB, Sporn MB (1994) Prevention of breast cancer in the rat with 9-cis-retinoic acid as a single agent and in combination with tamoxifen. Cancer Res 54: 4614-4617
7. Ao A, Erickson RP (1992) Injection of antisense RNA specific for E-cadherin demonstrates that E-cadherin facilitates compaction, the first differentiative step of the mammalian embryo. Antisense Res Dev 2: 153-163
8. Babich M, Foti LR (1994) E-cadherins identified in osteoblastic cells: effects of parathyroid hormone and extracellular calcium on localization. Life Sci 54: PL201-208
9. Bae SN, Arand G, Azzam H, Pavasant P, Torri J, Frandsen TL, Thompson EW (1993) Molecular and cellular analysis of basement membrane invasion by human breast cancer cells in Matrigel-based in vitro assays. Breast Cancer Res Treat 24: 241-255
10. Balda MS, Gonzalez-Mariscal L, Matter K, Cereijido M, Anderson JM (1993) Assembly of the tight junction the role of diacylglycerol J Cell Biol 123: 293-302
11. Baltensperger K, Kozma LM, Cherniack AD, Klarlund JK, Chawla A, Banerjee U, Czech MP (1993) Binding of the ras activator son of sevenless to insulin receptor substrate-1 signaling complexes. Science 260: 1950-1952
12. Becker JW, Erickson HP, Hoffman S, Cunningham BA, Edelman GM (1989) Topology of cell adhesion molecules. Proc Natl Acad Sci USA 86: 1088-1092
13. Becker KF, Atkinson MJ, Reich U, Huang HH, Nekarda H, Siewert JR, Höfler H (1993) Exon skipping in the E-cadherin gene transcript in metastatic human gastric carcinomas Hum Mol Genet 2 803-804
14. Becker KF, Atkinson MJ, Reich U, Becker I, Nekarda H, Siewert JR, Höfler H (1994) E-cadherin gene mutations provide clues to diffuse type gastric carcinomas Cancer Res 54. 3845-3852
15. Behrens J, Birchmeier W, Goodman SL, Imhof BA (1985) Dissociation of Madin-Darby canine kidney epithelial cells by the monoclonal antibody anti-arc-1. mechanistic aspects and identification of the antigen as a component related to uvomorulin J Cell Biol 101: 1307-1315
16. Behrens J, Löwrick O, Klein-Hitpass L, Birchmeier W (1991a) The E-cadherin promoter-functional analysis of a G C-rich region and an epithelial cell-specific palindromic regulatory element. Proc Natl Acad Sci USA 88: 11495-11499
17. Behrens J, Weidner KM, Frixen UH, Schipper JH, Sachs M, Arakaki N, Daikuhara Y, Birchmeier W (1991b) The role of E-cadherin and scatter factor in tumor invasion and cell motility. EXS 59: 109-126
18. Behrens J, Vakaet L, Friis R, Winterhager E, Van Roy F, Mareel MM, Birchmeier W (1993) Loss of epithelial morphotype and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/β-catenin complex in cells transformed with a temperature-sensitive v-src gene. J Cell Biol 120 757-766
19. 2+-dependent cell adhesion molecule expressed in liver and intestine. J Cell Biol 125: 1353-1369
20. Berx G, Staes K, van Hengel J, Molemans F, Bussemakers MJG, van Bokhoven A, Van Roy F (1995) Cloning and characterization of the human invasion suppressor gene E-cadherin (CDH1) Genomics 26: 281-289
21. Birchmeier W, Behrens J (1994) Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim Biophys Acta 1198 11-26
22. Böhm M, Totzeck B, Wieland I (1994a) Differences of E-cadherin expression levels and patterns in human lung cancer. Ann Hematol 68: 81-83
23. Böhm M, Totzeck B, Birchmeier W, Wietand I (1994b) Differences of E-cadherin expression levels and patterns in primary and metastatic human lung cancer. Clin Exp Metastasis 12: 55-62
24. Bortier H, De Bruyne G, Espeel M, Vakaet L (1989) Immunohistochemistry of laminin in early chicken and quail blastoderms. Anat Embryol 180: 65-69
25. Boukamp P, Fusenig NE (1993) "Trans-differentiation" from epidermal to mesenchymal/myogenic phenotype is associated with a drastic change in cell-cell and cell-matrix adhesion molecules. J Cell Biol 120: 981-993
26. Bowie GL, Caslin AW, Roland NJ, Field JK, Jones AS, Kinsella A (1993) Expression of the cell-cell adhesion molecule E-cadherin in squamous cell carcinoma of the head and neck. Clin Otolaryngol 18: 196-201
27. Boyer B, Dufour S, Thiery JP (1992) E-cadherin expression during the acidic FGF-induced dispersion of a rat bladder carcinoma cell line Exp Cell Res 201. 347-357
28. Boyer B, Valles AM, Tucker GC, Delouvee A, Thiery JP (1993) Involvement of cell motility in tumor progression. Symp Soc Exp Biol 47: 183-195
29. Brabant G, Hoang-Vu C, Cetin Y, Dralle H, Scheumann G, Mölne J, Hansson G, Jansson S, Ericson LE, Nilsson M (1993) E-cadherin a differentiation marker in thyroid malignancies. Cancer Res 53: 4987-4993
30. Bracke ME, Castronovo V, Van Cauwenberge RM-L, Vakaet L Jr, Strojny P, Foidart J-M, Mareel MM (1987) The anti-invasive flavonoid (+)-catechin binds to laminin and abrogates the effect of laminin on cell morphology and adhesion Exp Cell Res 173. 193-205
31. Bracke ME, Vyncke BM, Van Larebeke NA, Bruyneel EA, De Bruyne GH, De Pestel GH, De Coster WJ, Espeel MF, Mareel MM (1989) The flavonoid tangeretin inhibits invasion of MO4 mouse cells into embryonic chick heart in vitro Clin Exp Metatasis 7. 283-300
32. Bracke ME, Vyncke B, De Pestel G, Vakaet L Jr, Bourgois L, Van Larebeke N, Bortier H, Mareel MM (1990) Effect of flavonoids on cancer cell invasiveness. In Das NP (ed) Plant flavonoids in biology and medictne. III Current issues in flavonoid research. National University of Singapore Press, Singapore, pp 279-292
33. Bracke ME, Van Larebeke NA, Vyncke BM, Mareel MM (1991) Retinoic acid modulates both invasion and plasma membrane ruffling of MCF-7 human mammary carcinoma cells in vitro. Br J Cancer 63: 867-872
34. Bracke M, Romijn H, Vakaet L Jr, Vyncke B, De Mets M, Mareel M (1992) The use of spheroids in the study of invasion. In. Bjerkvig R (ed) Spheroid culture in cancer research. CRC Press, Boca Raton, pp 73-105
35. Bracke ME, Vyncke BM, Bruyneel EA, Vermeulen SJ, De Bruyne GK, Van Larebeke NA, Vleminckx K, Van Roy FM, Mareel MM (1993) Insulin-like growth factor I activates the invasion suppressor function of E-cadherin in MCF-7 human mammary carcinoma ceils in vitro Br J Cancer 68: 282-289
36. Bracke ME, Bruyneel EA, Vermeulen SJ, Vennekens K, Van Marck V, Mareel MM (1994a) Citrus flavonoid effect on tumor invasion and metastasis Food Technol 48 121-124
37. Bracke ME, Charlier C, Bruyneel EA, Labit C, Mareel MM, Castronovo V (1994b) Tamoxifen restores the E-cadherin function in human breast cancer MCF-7/6 cells and suppresses their invasive phenotype. Cancer Res 54: 4607-4609
38. Bracke ME, Vermeulen SJ, Bruyneel EA, Vennekens KM, De Bruyne GK, Van Roy FM, Mareel MM (1994c) The invasion suppressor function of E-cadherin in mammary epitheloid cells. In: Schmitt M, Graeff H, Kindermann G (eds) Prospects in diagnosis and treatment of breast cancer. Elsevier Science, Amsterdam, pp 107-115 (Excerpta Medica international congress series no 1050)
39. Bradley RS, Cowin P, Brown AM (1993) Expression of Wnt-1 in PC12 cells results in modulation of plakoglobin and E-cadherin and increased cellular adhesion. J Cell Biol 123: 1857-1865
40. Brady-Kalnay SM, Boghaert ER, Zimmer S, Brackenbury R (1993) Increasing N-CAM-mediated cell-cell adhesion does not reduce invasion of RSV-transformed WC5 rat cerebellar cells. Clin Exp Metastasis 11. 313-324
41. 2+- dependent cell-cell adhesion Cell Adhesion Commun 1. 239-250
42. Brieher WM, Gumbiner BM (1994) Regulation of C-cadherin function during activin induced morphogenesis of Xenopus animal caps J Cell Biol 126: 519-527
43. Bringuier PP, Umbas R, Schaafsnna HE, Karthaus HFM, Debruyne FMJ, Schalken JA (1993) Decreased E-cadherin immunoreactivity correlates with poor survival in patients with bladder tumors. Cancer Res 53. 3241-3245
44. Burge SM, Schomberg KH (1992) Adhesion molecules and related proteins in Darier's disease and Hailey-hailey disease Br J Dermatol 127: 335-343
45. Bussemakers MJG, van Moorselaar RJA, Giroldi LA, Ichikawa T, Isaacs JT, Takeichi M, Debruyne FMJ, Schalken JA (1992) Decreased expression of E-cadherin in the progression of rat prostatic cancer. Cancer Res 52: 2916-2922
46. Bussemakers MJ, Giroldi LA, van Bokhoven A, Schalken JA (1994a) Transcriptional regulation of the human E-cadherin gene in human prostate cancer cell lines: characterization of the human E-cadherin gene promoter. Biochem Biophys Res Commun 203: 1284-1290
47. Bussemakers MJ, van Bokhoven A, Voller M, Smit FP, Schalken JA (1994b) The genes for the calcium-dependent cell adhesion molecules P- and E-cadherin are tandemly arranged in the human genome. Biochem Biophys Res Commun 203: 1291-1294
48. Butz S, Kemler R (1994) Distinct cadherin-catenin complexes in CA (2+)- dependent cell-cell adhesion FEBS Lett 355 195-200
49. Byers S, Amaya E, Munro S, Blaschuk O (1992) Fibroblast growth factor receptors contain a conserved HAV region common to cadherins and influenza strain A hemagglutinins: a role in protein-protein interactions? Dev Biol 152: 411-414
50. Byers SW, Sujarit S, Jegou B, Butz S, Hoschutzky H, Herrenknecht K, MacCalman C, Blaschuk OW (1994) Cadherins and cadherin-associated molecules in the developing and maturing rat testis. Endocrinology 134: 630-639
51. Cai JC, Jiang SJ, Chen ZP (1994) Relationship between E-cadherin and growth pattern of gastric cancer and degree of cell differentiation Chung Hua Ping Li Hsueh Tsa Chih 23: 132-134
52. Castronovo V (1993) Laminin receptors and laminin-binding proteins during tumor invasion and metastasis. Invasion Metastasis 13. 1-30
53. Cepek KL, Shaw SK, Parker CM, Russell GJ, Morrow JS, Rimm DL, Brenner MB (1994) Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alphaEbeta 7 integrin n Nature 372: 190-193
54. Chastre E, Empereur S, Di Gioia Y, El Mahdani N, Mareel M, Vleminckx K, Van Roy F, Bex V, Emami S, Spandidos DA, Gespach C (1993) Neoplastic progression of human and rat intestinal cell lines after transfer of the ras and polyoma middle T oncogenes Gastroenterology 105. 1776-1789
55. Chen W, Öbrink B (1991) Cell-cell contacts mediated by E-cadherin (Uvomorulin) restrict invasive behavior of L-cells. J Cell Biol 114 319-327
56. Ching LM, Baguley BC (1987) Induction of natural killer cell activity by the antitumor compound flavone acetic acid (NSC 347512). Eur J Cancer Clin Oncol 23: 1047-1050
57. Chowdhury K, Dietrich S, Balling R, Guenet JL, Gruss P (1989) Structure, expression and chromosomal localization of zfp-1, a murine zinc finger protein gene. Nucleic Acids Res 17: 10427-10438
58. Clayton L, Stinchcombe SV, Johnson MH (1993) Cell surface localisation and stability of uvomorulin during early mouse development. Zygote 1: 333-344
59. Coopman PJ, Bracke ME, Lissitzky JC, De Bruyne GK, Van Roy FM, Foidart J-M, Mareel MM (1991) Influence of basement membrane molecules on directional migration of human breast cell lines in vitro. J Cell Sci 98: 395-401
60. Correct P, Fondanëche M-C, Bracke M, Burtin P (1990) The presence of plasmin receptors on three mammary carcinoma MCF-7 sublines. Int J Cancer 46. 745-750
61. Correc P, Zhang S, Komano O, Laurent M, Burtin P (1992) Visualization of the plasmin receptor on carcinoma cells. Int J Cancer 50: 767-771
62. Coutifaris C, Kao L-C, Sehdev HM, Chin U, Babalola GO, Blaschuk OW, Strauss JF III (1991) E-cadherin expression during the differentiation of human trophoblasts. Development 113: 767-777
63. Cowley GP, Smith MEF (1995) Modulation of E-cadherin expression and morphological phenotype in the intravascular component of adenocarcinomas. Int J Cancer 60: 325-329
64. Crepaldi T, Pollack AL, Prat M, Zborek A, Mostov K, Comoglio PM (1994) Targeting of the SF/HGF receptor to the basolateral domain of polarized epithelial cells. J Cell Biol 125: 313-320
65. Crossin KL, Chuong CM, Edelman GM (1985) Expression sequences of cell adhesion molecules. Proc Natl Acad Sci USA 82: 6942-6946
66. Cullen KJ, Smith HS, Hill S, Rosen N, Lippman ME (1991) Growth factor messenger RNA expression by human breast fibroblasts from benign and malignant lesions Cancer Res 51: 4978-4985
67. Cunningham BA, Leutzinger Y, Gallin WJ, Sorkin BC, Edelman GM (1984) Linear organization of the liver cell adhesion molecule L-CAM. Proc Natl Acad Sci USA 81: 5787-5791
68. Czech W, Krutmann J, Herrenknecht K, Schopf E, Kapp A (1993) Human cell adhesion molecule uvomorulin is differentially expressed in various skin tumors J Cutan Pathol 20. 168-172
69. Danø K, Andreasen PA, Grondahl-Hansen G, Kristensen P, Nielsen LS, Skriver L (1985) Plasminogen activators, tissue degradation and cancer. Adv Cancer Res 44 139-266
70. Daughaday WH (1992) The historical evolution of concepts of the role of the insulin-like growth factors. In: Schofield PN (ed) The insulin-like growth factors Oxford University Press, Oxford, pp 5-11
71. De Leon DD , Bakker B, Wilson DM, Hintz RL, Rosenfeld RG (1988) Demonstration of insulin-like growth factor (IGF-I and -II) receptors and binding protein in human breast cancer cell lines. Biochem Biophys Res Commun 152: 390-405
72. Dimanche-Boitrel MT, Genne P, Duchamp O, Chauffert B (1994a) Confluence dependent resistance (CDR) to doxorubicin and E-cadherin expression in murine mammary cells. Cancer Lett 85. 171-176
73. Dimanche-Boitrel MT, Vakaet LJr, Pujuguet P, Chauffert B, Martin MS, Hammann A, Van Roy F, Mareel M, Martin F (1994b) In vivo and in vitro invasiveness of a rat colon cancer cell line maintaining E-cadherin expression. An enhancing role of tumor-associated myofibroblasts. Int J Cancer 56: 512-521
74. Doki Y, Shiozaki H, Tahara H, Inoue M, Oka H, Iihara K, Kadowaki T, Takeichi M, Mori T (1993) Correlation between E-cadherin expression and invasiveness in vitro in a human esophageal cancer cell line. Cancer Res 53: 3421-3426
75. Dorudi S, Sheffield JP, Poulsom R, Northover JMA, Hart I (1992) E-cadherin expression in colorectal cancer. Clin Exp Metastasis 10 [Suppl 1]: 39
76. Dorudi S, Sheffield JP, Poulsom R, Northover JMA, Hart IR (1993) E-cadherin expression in colorectal cancer. Am J Pathol 142 981-986
77. D'Souza B, Taylor-Papadimitriou J (1994) Overexpression of ERBB2 in human mammary epithelial cells signals inhibition of transcription of the E-cadherin gene Proc Natl Acad Sci USA 91. 7202-7206
78. Duband JL, Thiery JP (1990) Spatio-temporal distribution of the adherens junction-associated molecules vinculin and talin in the early avian embryo. Cell Differ Dev 30. 55-76
79. Dustin ML, Springer TA (1991) Role of lymphocyte adhesion receptors in transient interctions and cell locomotion Annu Rev Immunol 9: 27-66
80. Edelman GM (1987) Epigenetic rules for expression of cell adhesion molecules during morphogenesis Ciba Found Symp 125: 192-216
81. Edelman GM, Crossin KL (1991) Cell adhesion molecules: implications for a molecular histology. Annu Rev Biochem 60: 155-190
82. Edelman GM, Gallin WJ, Delouvee A, Cunningham BA, Thiery J-P (1983) Early epochal maps of two different cell adhesion molecules Proc Natl Acad Sci USA 80: 4384-4388
83. Eichele G (1993) Retinoids in embryonic development Ann NY Acad Sci 678 22-36
84. Eistetter HR, Adolph S, Ringwald M, Simon-Chazottes D, Schuh R, Guenet JL, Kemler R (1988) Chromosomal mapping of the structural gene coding for the mouse cell adhesion molecule uvomorulin. Proc Natl Acad Sci USA 85: 3489-3493
85. Eskelinen S, Huotan V, Sormunen R, Palovuori R, Kok JW, Lehto VP (1992) Low intracellular pH induces redistribution of fodrin and instabalization of lateral walls in MDCK cells J Cell Physiol 150: 122-133
86. Estreicher A, Mühlhauser J, Carpentier J-L, Orci L, Vassalli J-D (1990) The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes J Cell Biol 111 783-792
87. Fabre M, Garcia de Herreros A (1993) Phorbol ester-induced scattering of HT-29 human intestinal cancer cells is associated with down-modulation of E-cadherin. J Cell Sci 106: 513-522
88. Fahraeus R, Chen W, Trivedi P, Klein G, Öbrink B (1992) Decreased expression of E-cadherin and increased invasive capacity in EBV-LMP-transfected human epithelial and murine adenocarcinoma cells Int J Cancer 52 834-838
89. Fearon ER, Vogelstein B (1990) A genetic model for colorectal tumongenesis. Cell 61: 759-767
90. Fenyves AM, Behrens J, Spanel-Borowski K (1993) Cultured microvascular endothelial cells (MVEC) differ in cytoskeleton, expression of cadherins and fibronectin matrix. A study under the influence of interferon-gamma. J Cell Sci 106: 879-890
91. Fidler I, Hart I (1982) Biological diversity in metastatic neoplasms: origins and implications. Science 217 998-1003
92. Field JK (1992) Oncogenes and tumour-suppressor genes in squamous cell carcinoma of the head and neck Eur J Cancer 28B: 67-76
93. Figueroa JA, Yee D (1992) The insulin-like growth factor binding proteins (IGFBPs) in human breast cancer Breast Cancer Res Treat 22: 81-90
94. Fligiel SEG, Rodriguez AF, Knibbs RN, McCoy JP Jr, Varani J (1985) Characterization of laminin-stimulated adherence and motility in tumor cells Oncology 42: 265-271
95. Friedlander DR, Mège RM, Cunningham BA, Edelman GM (1989) Cell sorting-out is modulated by both the specificity and amount of different cell adhesion molecules (CAMs) expressed on cell surfaces Proc Natl Acad Sci USA 86: 7043-7047
96. Frixen UH, Nagamine Y (1993) Stimulation of urokinase-type plasminogen activator expression by blockage of E-cadherin-dependent cell-cell adhesion. Cancer Res 53: 3618-3623
97. Frixen UH, Behrens J, Sachs M, Eberle G, Voss B, Warda A, Lochner D, Birchmeier W (1991) E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol 113: 173-185
98. Furukawa Y, Nakatsuru S, Nagafuchi A, Tsukita S, Muto T, Nakamura Y, Horii A (1994) Structure, expression and chromosome assignment of the human catenin (cadherin-associated protein) alpha 1 gene (CTNNA 1). Cytogenet Cell Genet 65: 74-78
99. Gallin WJ, Prediger EA, Edelman GM, Cunningham BA (1985) Isolation of a cDNA clone for the liver cell adhesion molecule (L-CAM). Proc Natl Acad Sci USA 82: 2809-2813
100. Gallin WJ, Sorkin BC, Edelman GM, Cunningham BA (1987) Sequence analysis of a cDNA clone encoding the liver cell adhesion molecule, L-CAM Proc Natl Acad Sci USA 84. 2808-2812
101. Gao Y (1993) Downregulation of E-cadherin during experimental tumor formation in syngeneic mice and in human colorectal tumors. PhD thesis, Universiteit Gent
102. Geiger B, Ayalon O (1992) Cadherins. Annu Rev Cell Biol 8. 307-332
103. Giavazzi R, Garofalo A, Damia G, Garattini S, D'Incalci M (1989) Response to flavone acetic acid (NSC 347512) of primary and metastatic human colorectal carcinoma xenografts. Br J Cancer 57: 277-280
104. Giguere V, Ong ES, Segui P, Evans RM (1987) Identification of a receptor for the morphogen retinoic acid Nature 330 624-629
105. Ginsberg D, DeSimone D, Geiger B (1991) Expression of a novel cadherin (EP-cadherin) in unfertilized eggs and early Xenopus embryos. Development 111: 315-325
106. Giroldi LA, Schalken JA (1993) Decreased expression of the intercellular adhesion molecule E-cadherin in prostate cancer: biological significance and clinical implications. Cancer Metastasis Rev 12: 29-37
107. Gluck U, Rodriguez-Fernandez JL, Pankov R, Ben-Ze'ev A (1992) Regulation of adherens junction protein expression in growth-activated 3T3 cells and in regenerating liver. Exp Cell Res 202: 477-486
108. V-Src kinase activities. In Cody V, Middleton E Jr, Harborne JB (eds) Plant flavonoids in biology and medicine: biochemical, pharmacological and structure-activity relationships. Liss, New York, pp 301-313
109. Grundy PE, Telzerow PE, Breslow N, Moksness J, Huff V, Paterson MC (1994) Loss of heterozygosity for chromosomes 16q and 1p in Wilms' tumors predicts an adverse outcome. Cancer Res 54: 2331-2333
110. Gumbiner BM (1993) Proteins associated with the cytoplasmic surface of adhesion molecules Neuron 11. 551-564
111. Gumbiner B, Simons K (1986) A functional assay for proteins involved in establishing an epithelial occluding barrier identification of a Uvomorulin-like polypeptide J Cell Biol 102: 457-468
112. Gumbiner B, Stevenson B, Grimaldi A (1988) The role of the cell adhesion molecule uvomorulin in the formation and the maintenance of the epithelial junctional complex. J Cell Biol 107 1575-1587
113. Hashimoto M, Niwa O, Nitta Y, Takeichi M, Yokoro K (1989) Unstable expression of E-cadherin adhesion molecules in metastatic ovarian tumor cells. Jpn J Cancer Res 80: 459-463
114. Hatta K, Takeichi M (1986) Expression of N-Cadherin adhesion molecules associated with early morphogenetic events in chick development. Nature 320: 447-449
115. Hatta M, Miyatani S, Copeland NG, Gilbert DJ, Jenkins NA, Takeichi M (1991) Genomic organization and chromosomal mapping of the mouse P-cadherin gene. Nucleic Acids Res 19: 4437-4441
116. Hauck W, Stanners CP (1991) Control of carcmoembryonic antigen gene family expression in a differentiating colon carcinoma cell line, Caco-2. Cancer Res 51: 3526-3533
117. Herrenknecht K, Ozawa M, Eckerskorn C, Lottspeich F, Lenter M, Kemler R (1991) The uvomorulin-anchorage protein alpha catenin is a vinculin homologue Proc Natl Acad Sci USA 88: 9156-9160
118. Herzberg F, Wildermuth V, Wedlich D (1991) Expression of XBcad, a novel cadherin, during oogenesis and early development of Xenopus. Mech Dev 35: 33-42
119. Hinck L, Näthke IS, Papkoff J, Nelson WJ (1994a) Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly. J Cell Biol 125: 1327-1340
120. Hinck L, Nelson WJ, Papkoff J (1994b) Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing β-catenin binding to the cell adhesion protein cadherin. J Cell Biol 124: 729-741
121. Hirano S, Kimoto N, Shimoyama y, Hirohashi S, Takeichi M (1992) Identification of a Neural alpha-catenin as a key regulator of cadherin function and multicellular organisation. Cell 70: 293-301
122. Hodivala KJ, Watt FM (1994) Evidence that cadherins play a role in the down-regulation of integrin expression that occurs during keratinocyte terminal differentiation J Cell Biol 124: 589-600
123. Hoffman AG, Burghardt RC, Tilley R, Auersperg N (1993) An in vitro model of ovarian epithelial carcinogenesis: changes in cell-cell communication and adhesion occurring during neoplastic progression. Int J Cancer 54: 828-838
124. Honda S (1992) Immunohistochemical study on the expression of E-cadherin in normal tissues and squamous cell carcinomas of the uterine cervix Nippon Sanka Fujinka Gakkai Zasshi 44: 517-523
125. Hoschuetzky H, Aberle H, Kemler R (1994) β-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor J Cell Biol 127: 1375-1380
126. Hülsken J, Birchmeier W, Behrens J (1994) E-cadherin and APC compete for the interaction with β-catenin and the cytoskeleton. J Cell Biol 127. 2061-2069
127. Hyafil F, Babinet C, Jacob F (1981) Cell-cell interactions in early embryogenesis: a molecular approach to the role of calcium. Cell 26 447-454
128. Hynes RO, Lander AD (1992) Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons. Cell 68: 303-322
129. Inoue M, Ogawa H, Miyata M, Shiozaki H, Tanizawa O (1992) Expression of E-cadherin in normal, benign, and malignant tissues of female genital organs Am J Clin Pathol 98. 76-80
130. Ishisaki A, Oida S, Momose F, Amagasa T, Rikimaru K, Ichijo H, Sasaki S (1994) Identification and characterization of autocrine-motility-factor-like activity in oral squamous-cell-carcinoma cells. Int J Cancer 59. 783-788
131. Jacobs J, Kull FC Jr, Earp HS, Svoboda ME, Van Wyck JJ, Cuatrecasas P (1983) Somatomedine-C stimulates the phosphorylation of the β subunit of its own receptor. J Biol Chem 258: 9581-9584
132. Jaffe SH, Friedlander DR, Matsuzaki F, Crossin KL, Cunningham BA, Edelman GM (1990) Differential effects of the cytoplasmic domains of cell adhesion molecules on cell aggregation and sorting-out Proc Natl Acad Sci USA 87: 3589-3593
133. Jennische E, Isgaard J, Isaksson OGP (1992) Local expression of insulin-like growth factors during tissue growth and regeneration In: Schofiefd PN (ed) The insulin-like growth factors. Oxford University Press, Oxford, pp 221-239
134. Jensen PJ, Wheelock MJ (1992) Regulation of urokinase plasminogen activator localization in keratinocytes by calcium ion and E-cadherin Exp Cell Res 202. 190-198
135. Johnson JP (1991) Cell adhesion molecules of the immunoglobulin supergene family and their role in malignant transformation and progression to metastatic disease. Cancer Metastasis Rev 10: 11-22
136. Johnston SRD, Haynes BP, Smith IE, Jarman M, Sacks NPM, Ebbs SR, Dowsett M (1993) Acquired tamoxifen resistance in human breast cancer and reduced intra-tumoral drug concentration. Lancet 342 1521-1522
137. Jongen WMF, Fitzgerald DJ, Asamoto M, Piccoli C, Slaga TJ, Gros D, Takeichi M, Yamasaki H (1991) Regulation of connexin 43-mediated gap junctional intercellular communication by CA2+ in mouse epidermal cells is controlled by E-cadherin J Cell Biol 114: 545-555
138. Kadmon G, Korvitz A, Altevogt P, Schachner M (1990) The neural cell adhesion molecule N-CAM enhances Li-dependent cell-cell interactions J Cell Biol 110. 193-208
139. Kadowaki T, Koyasu S, Nishida E, Tobe K, Izumi T, Takaku F, Sakai H, Yahara J, Kasuga M (1987) Tyrosine phosphorylation of common and specific sets of cellular proteins rapidly induced by insulin, insulin-like growth factor I, and epidermal growth factor in an intact cell J Biol Chem 262: 7342-7350
140. Kadowaki T, Shiozaki H, Inoue M, Tamura S, Oka H, Doki Y, Iihara K, Matsui S, Iwazawa T, Nagafuchi A, Tsukita S, Mori T (1994) E-cadherin and a-catenin expression in human esophageal cancer. Cancer Res 54: 291-296
141. Kanai Y, Oda T, Tsuda H, Ochiai A, Hirohashi S (1994) Point mutation of the E-cadherin gene in invasive lobular carcinoma of the breast. Jpn J Cancer Res 85 1035-1039
142. 2+ ion medium. J Cell Biol 113: 881-892
143. Katagin A, Watanabe R, Tomita Y (1995) E-cadherin expression in renal cancer and its significance in metastasis and survival Br J Cancer 71: 376-379
144. Katayama M, Hirai S, Kamihagi K, Nakagawa K, Yasumoto M, Kato I (1994) Soluble E-cadherin fragments increased in circulation of cancer patients. Br J Cancer 69: 580-585
145. Kaupmann K, Becker-Follmann J, Scherer G, Jockusch H, Starzinski-Powitz A (1992) The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16p24.1-qter and is near the E-cadherin (uvomorulin) locus in both species. Genomics 14: 488-490
146. Kawanishi J, Kato J, Sasaki K, Fujii S, Watanabe N, Niitsu Y (1995) Loss of E-cadherin-dependent cell-cell adhesion due to mutation of the β-catenin gene in a human cancer cell line, HSC-39. Mol Cell Biol 15: 1175-1181
147. 2+-dependent cell adhesion molecule Bioessays 11: 88-91
148. Khokha R, Waterhouse P, Yagel S, Lala PK, Overall CM, Norton G, Denhardt DT (1989) Antisense RNA induced reduction in murine TIMP levels confers oncogenicity on Swiss 3T3 cells. Science 243: 947-950
149. Kinsella AR, Green B, Lepts GC, Hill CL, Bowie G, Taylor BA (1993) The role of the cell-cell adhesion molecule E-cadherin in large bowel tumour cell invasion and metastasis Br J Cancer 67: 904-999
150. Kinsella AR, Lepts GC, Hill CL, Jones M (1994) Reduced E-cadherin expression correlates with increased invasiveness in colorectal carcinoma cell lines. Clin Exp Metastasis 12: 335-342
151. Knabbe C, Lippman ME, Wakefield LM, Flanders KC, Kasid A, Derynck R, Dickson RB (1987) Evidence that transforming growth factor-β is a hormonally regulated negative growth factor in human breast cancer cells. Cell 48. 417-428
152. Knudsen AK, Wheelock MJ (1992) Plakoglobin, or an 83-kD homologue distinct from beta-catenin, interacts with E-cadherin and N-cadherin. J Cell Biol 118 671-679
153. Koga M, Sutherland RL (1987) Epidermal growth factor partially reverses the inhibitory effects of antiestrogens on T47D human breast cancer cell growth. Biochem Biophys Res Commun 146: 739-745
154. Kopper L, Van Hahn T, Lapis K (1982) Experimental model for liver metastasis formating using Lewis lung tumor J Cancer Res Clin Oncol 103: 31-38
155. Kraus C, Liehr T, Hulsken J, Behrens J, Birchmeier W, Grzeschik KH, Ballhausen WG (1994) Localization of the human β-catenin gene (CTNNB1) to 3p21: a region implicated in tumor development. Genomics 23: 272-274
156. Kuzu I, Bicknell R, Fletcher CD, Gatter KC (1993) Expression of adhesion molecules on the endothelium of normal tissue vessels and vascular tumors Lab Invest 69. 322-328
157. Larue L, Ohsugi M, Hirchenhain J, Kemler R (1994) E-cadherin null mutant embryos fail to form a trophectoderm epithelium. Proc Natl Acad Sci USA 91: 8263-8267
158. Le Bivic A, Sambuy Y, Mostov K, Rodriguez-Boulan E (1990) Vectonal targeting of an endogenous apical membrane sialoglycoprotein and uvomorulin in MDCK cells J Cell Biol 110: 1533-1539
159. Lee MG, Sharrow SO, Farr AG, Singer A, Udey MC (1994) Expression of the homotypic adhesion molecule E-cadherin by immature murine thymocytes and thymic epithelial cells. J Immunol 152: 5653-5659
160. Lewis JE, Jensen PJ, Wheelock MJ (1994) Cadherin function is required for human keratinocytes to assemble desmosomes and stratify in response to calcium J Invest Dermatol 102: 870-877
161. Liotta LA (1986) Tumor invasion and metastases-role of the extracellular matrix: Rhoads memorial award lecture. Cancer Res 46. 1-7
162. Liotta LA, Mandler R, Murano G, Katz DA, Gordon RK, Chiang PK, Schiffmann E (1986) Tumor cell autocrine motility factor. Proc Natl Acad Sci USA 83: 3302-3306
163. Lipponen P, Saarelainen E, Ji H, Aaltomaa S, Syqanen K (1994) Expression of E-cadherin (E-CD) as related to other prognostic factors and survival in breast cancer J Pathol 174: 101-109
164. Lombardo CR, Rimm DL, Koslov E, Morrow JS (1994) Human recombinant alpha-catenin binds to spectrin Mol Biol Cell 5 [Suppl]. 47a
165. MacCalman CD, Brodt P, Doublet JD, Jednak R, Elhilali MM, Bazinet M, Blaschuk OW (1994a) The loss of E-cadherin mRNA transcripts in rat prostatic tumors is accompanied by increased expression of mRNA transcripts encoding fibronectin and its receptor Clin Exp Metastasis 12: 101-107
166. MacCalman CD, Farookht R, Blaschuk OW (1994b) Estradiol regulates E-cadherin mRNA levels in the surface epithelium of the mouse ovary Clin Exp Metastasis 12. 276-282
167. Mader S, Leroy P, Chen JY, Chambon P (1993) Multiple parameters control the selectivity of nuclear receptors ior their response elements. Selectivity and promiscuity in response element recognition by retmoic acid receptors and retinoic X receptors J Biol Chem 268: 591-600
168. Maillet L, Buc-Caron MH (1985) Modulation of specific protein expression in teratocarcinoma cell aggregates by antibodies affecting cell-cell interactions. Dev Biol 111: 1-7
169. Mandeville R, Ghali SS, Chausseau JP (1984) In vitro stimulation of human NK activity by an estrogen antagonist (tamoxifen). Eur J Cancer Clin Oncol 20. 983-985
170. Mansouri A, Spurr N, Goodfellow PN, Kemler R (1988) Characterization and chromosomal localization of the gene encoding the human cell adhesion molecule uvomorulin. Differentiation 38. 67-71
171. Mareel M, Kint J, Meyvisch C (1979) Methods of study of the invasion of malignant C3H mouse fibroblasts into embryonic chick heart in vitro. Virchows Arch [B] Cell Pathol 30: 95-111
172. Mareel MM, Behrens J, Birchmeter W, De Bruyne GK, Vleminckx K, Hoogewijs A, Fiers WC Van Roy FM (1991) Down-regulation of E-cadherin expression in Madin Darby canine kidney (MDCK) cells inside nude mice tumors Int J Cancer 47 922-928
173. Mareel MM, Van Roy FM, Bracke ME (1993) How and when do tumor cells metastasize? Crit Rev Oncogenesis 4. 559-594
174. Martin PM, Horwitz KB, Ryan DS, McGuire WL (1978) Phytoestrogen interaction with estrogen receptors in human breast cancer cells. Endocrinology 103: 1860-1867
175. Matsui S, Shiozaki H, Inoue M, Tamura S, Doki Y, Kadowaki T, Iwazawa T, Shimaya K, Nagafuchi A, Tsukita S et al. (1994) Immunohistochemical evaluation of alpha-catenin expression in human gastric cancer. Virchows Arch 424. 375-381
176. Matsunami H, Miyatsni S, Inoue T, Copeland NG, Gilbert DJ, Jenkins NA, Takeichi M (1993) Cell binding specificity of mouse R-cadherin and chromosomal mapping of the gene J Cell Sci 106. 401-409
177. Matsuura K, Kawanishi J, Fujii S, Imamura M, Hirano S, Takeichi M, Niitsu Y (1992) Altered expression of E-cadherin in gastric cancer tissues and carcinomatous fluid. Br J Cancer 66: 1122-1130
178. Matsuyoshi N, Hemaguchi M, Tanigushi S, Nagafuchi A, Tsukita S, Taketchi M (1992) Cadherin-mediated cell-cell adhesion is perturbed by v-src tyrosine phosphorytation in metastatic fibroblasts J Cell Biol 118: 703-714
179. Matsuzaki F, Mège RM, Jaffe SH, Friedlander DR, Gallin WJ, Goldberg JI, Cunningham BA, Edelman GM (1990) cDNAs of cell adhesion molecules of different specificity induce changes in cell shape and border formation in cultured S180 cells. J Cell Biol 110: 1239-1252
180. Mattijssen V, Peters HM, Schalkwijk L, Manni JJ, van't Hof Grootenboer B, de Mulder PH, Ruiter DJ (1993) E-cadherin expression in head and neck squamous cell carcinoma is associated with clinical outcome. Int J Cancer 55: 580-585
181. Mayer B, Johnson JP, Leitl F, Jauch KW, Heiss MM, Schildberg FW, Birchmeier W, Funke I (1993) E-cadherin expression in primary and metastatic gastric cancer, down-regulation correlates with cellular dedifferentiatton and glandular disintegration Cancer Res 53: 1690-1695
182. McCrea PD, Gumbiner BM (1991) Purification of a 92-kDa cytoplasmic protein tightly associated with the cell-cell adhesion molecule E-cadherin (uvornorulin) Characterization and extractability of the protein complex from the cell cytostructure J Biol Chem 266: 4514-4520
183. McCrea PD, Turck CW, Gumbiner B (1991) A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin. Science 254 1359-1361
184. McNeill H, Ozawa M, Kemler R, Nelson WJ (1990) Novel function of the cell adhesion molecule uvomorulin as an inducer of cell surface polarity. Cell 62. 309-316
185. McNeill H, Ryan TA, Smith SJ, Nelson WJ (1993) Spatial and temporal dissection of immediate and early events following cadherin-mediated epithelial cell adhesion. J Cell Biol 120: 1217-1226
186. Mecham RP (1991) Laminin receptors. Annu Rev Cell Biol 7. 71-91
187. Millon R, Nicora F, Muller D, Eber M, Klem-Soyer C, Abecassis J (1989) Modulation of human breast cancer cell adhesion by estrogens and antiestrogens. Clin Exp Metastasis 7: 405-415
188. Miyata M, Shiozaki H, Kobayashi K, Yano H, Tamura S, Tahara H, Mori T (1990) Correlation between expression of E-cadherin and metastases in human esophageal cancer: preliminary report Nippon Geka Gakkai Zasshi 91: 1761
189. Miyatani S, Copeland NG, Gilbert DJ, Jenkins NA, Takeichi M (1992) Genomic structure and chromosomal mapping of the mouse N-cadherin gene. Proc Natl Acad Sci USA 89: 8443-8447
190. Moll R, Mitze M, Frixen UH, Brichmeier W (1993) Differential loss of E-cadherin expression in infiltrating ductal and lobular breast carcinomas. Am J Pathol 143: 1731-1742
191. Moller CJ, Christgau S, Williamson MR, Madsen OD, Niu ZP, Bock E, Baekkeskov S (1992) Differential expression of neural cell adhesion molecule and cadherins in pancreatic islets, glucagonomas, and insulinomas. Mol Endocrinol 6. 1332-1342
192. Moon RT, DeMarais A, Olson DJ (1993) Responses to Wnt signals in vertebrate embroys may involve changes in cell adhesion and cell movement. J Cell Sci [Suppl] 17: 183-188
193. Mori Y, Mizuuchi H, Sato K, Okamura N, Kudo R (1994) The factors involved in invasive ability of endometrial carcinoma cells. Nippon Sanka Fujinka Gakkai Zasshi 46. 509-516
194. Morton RA, Ewing CM, Nagafuchi A, Tsukita S, Isaacs WB (1993) Reduction of E-cadherin levels and deletion of the alpha-catenin gene in human prostate cancer cells Cancer Res 53: 3585-3590
195. Mottonen J, Strand A, Symersky J, Sweet RM, Danley DE, Geoghegan KF, Gerard RD, Goldsmith EJ (1992) Structural basis of latency in plasminogen activator inhibitor-1. Nature 355: 270-273
196. Mountjoy KG, Finlay GJ, Holdaway IM (1987) Abnormal insulin-receptor down regulation and dissociation of down regulation from insulin biological action in cultured human tumor cells Cancer Res 47: 6500-6504
197. Moxham CP, Duronio V, Jacob S (1989) Insulin-like growth factor I receptor beta-subunit heterogeneity. Evidence for hybrid tetramers composed of insuisn-like growth factor I and insulin receptor heterodimers. J Biol Chem 264 13238-13244
198. Murphy G, Reynolds JJ, Hembry RM (1989) Metalloproteinases and cancer invasion and metastasis. Int J Cancer 44. 757-760
199. Musil LS, Cunningham BA, Edelman GM, Goodenough DA (1990) Differential phosphorylation of the gap junction protein connexin43 in junctional communication-competent and -deficient cell lines. J Cell Biol 111: 2077-2088
200. Nagafuchi A, Takeichi M (1988) Cell binding function of E-cadherin is regulated by the cytoplasmic domain. EMBO J 7: 3679-3684
201. Nagafuchi A, Takeichi M (1990) Transmembrane control of cadherin-mediated cell adhesion. a94 kDa protein functionally associated with a specific region of the cytoplasmic region of E-cadherin Cell Regul 1 37-44
202. Nagafuchi A, Tsukita S (1994) The loss of the expression of alpha catenin, the 102 kD cadherin associated protein, in central nervous tissues during development Dev Growth Differ 36: 59-71
203. Naldmi L, Weidner KM, Vigna E, Gaudino G, Bardelli A, Ponzetta C, Narsimhan RP, Hartmann G, Zarnegar R, Michalopoulos GK, Birchmeier W, Comogho PM (1991) Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor. EMBO J 10. 2867-2878
204. Napolitano EW, Venstrom K, Wheeler EF, Reichardt LF (1991) Molecular cloning and characterization of B-cadherin, a novel chick cadherin. J Cell Biol 113: 893-905
205. Näthke IS, Hinck L, Swedlow JR, Papkoff J, Nelson WJ (1994) Defining interactions and distributions of cadherin and catenin complexes in polarized epithelial cells. J Cell Biol 125: 1341-1352
206. Natt E, Magenis RE, Zimmer J, Mansouri A, Scherer G (1989) Regional assignment of the human loci for uvomorulin (UVO) and chymotrypsinogen B (CTRB) with the help of two overlapping deletions on the long arm of chromosome 16. Cytogenet Cell Genet 50 145-148
207. Navarro P, Lozano E, Cano A (1993) Expression of E- or P-cadherin is not sufficient to modify the morphology and the tumongenic behavior of murine spindle carcinoma cells. Possible involvement of plakoglobin J Cell Sci 105: 923-934
208. Nelson WJ, Shore EM, Wang AZ, Hammerton RW (1990) Identification of a membrane-cytoskeletal complex containing the cell adhesion molecule uvomorulin (E-cadherin), ankynn, and fodrin in Madin-Darby Canine Kidney epithelial cells. J Cell Biol 110: 349-357
209. Nelson WJ, Hammerton RW, McNeill H (1991) Role of the membrane-cytoskeleton in the spatial organization of the Na, K-ATPase in polarized epithelial cells Soc Gen Physiol Ser 46 77-87
210. Nicolson GL, Birdweil CR, Brunson KW, Robbins JC, Beattie G, Fidler IJ (1977) Cell interactions in the metastatic process some cell surface properties associated with successful blood-borne tumor spread. In Lash JW, Burger MM (eds) Cell and tissue interactions Raven, New York, pp 225-241
211. Nicholson LJ, Pei XF, Watt FM (1991) Expression of E-cadherin, P-cadherin and involucrin by normal and neoplastic keratinocytes in culture Carcinogenesis 12. 1345-1349
212. Nieto MA, Sargent MG, Wilkinson DG, Cooke J (1994) control of cell behavior during vertebrate development by Slug, a zinc finger gene Science 264: 835-839
213. Nigam AK, Savage FJ, Boulos PB, Stamp GW, Liu D, Pignatelli M (1993) Loss of cell-cell and cell-matrix adhesion molecules in colorectal cancer. Br J Cancer 68 507-514
214. Nollet F, Van Hengel J, Berx G, Molemans F, Van Roy F (1995) Isolation and characterization of a human pseudogene (CTNNAP1) for alphaE-catenin (CTNNA1): assignment of the pseudogene to 5q22 and the alphaE-catenin gene to 5q31. Genomics 26 410-413
215. Nose A, Takeichi M (1986) A novel cadherin cell adhesion molecule: its expression patterns associated with implantation and organogenesis of mouse embroys. J Cell Biol 103: 2649-2658
216. Nose A, Nagafuchi A, Takeichi M (1988) Expressed recombinant cadherins mediate cell sorting in model systems Cell 54: 993-1001
217. Öbrink B (1991) C-CAM (Cell-CAM 105) - a member of the growing immunoglobulin superfamily of cell adhesion proteins Bioessays 13: 227-234
218. Ochiai A, Akimoto S, Kanai Y, Shibata T, Oyama T, Hirohashi S (1994a) c-erbB-2 gene product associates with catenins in human cancer cells Biochem Biophys Res Commun 205: 73-78
219. Ochiai A, Akimoto S, Shimoyama Y, Nagafuchi A, Shoichiro T, Hirohashi S (1994b) Frequent loss of alpha catenin expression in scirrhous carcinomas with scattered cell growth. Jpn J Cancer Res 85: 266-273
220. Oda T, Kanai Y, Shimoyama Y, Nagafuchi A, Tsukita S, Hirohashi S (1993) Cloning of the human alpha-catenin cDNA and its aberrant mRNA in a human cancer cell line Biochem Biophys Res Commu 193: 897-904
221. Oda T, Kanai Y, Oyama T, Yoshiura K, Shimoyama Y, Birchmeier W, Sugimura T, Hirohashi S (1994) E-cadherin gene mutations in human gastric carcinoma cell lines Proc Natl Acad Sci USA 91: 1858-1862
222. Ogasawara M, Karey KP, Sirbasku DA (1988) Insulin-like growth factor I: relationship between plasma and tissue sources, biological potency and N-alpha truncation. Proc AACR 29. A207
223. Oka H, Shiozoaki H, Kobayashi K, Tahara H, Tamura S, Yamazaki K, Mori T (1990) Immunoreactive expression of E-cadherin in human gastric cancer: preliminary report Nippon Geka Gakkai Zasshi 91: 1814
224. Oka H, Shiozaki H, Kobayashi K, Tahara H, Kobayashi t, Takatsuka Y, Mori T (1992a) Correlation between E-cadherin expression and metastasis in human breast cancer: preliminary report. Nippon Geka Gakkai Zasshi 93. 105
225. Oka H, Shiozaki H, Kobayashi K, Tahara H, Tamura S, Miyata M, Doki Y, Iihara K, Matsuyoshi N, Hirano S, Takeichi M, Mori T (1992b) Immunohistochemical evaluation of E-cadherin adhesion molecule expression in human gastric cancer. Virchows Arch [A] Pathol Anat 421: 149-156
226. Okazaki M, Takeshita S, Kawai S, Kikuno R, Tsujimura A, Kudo A, Amann E (1994) Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts J Biol Chem 269 12092-12098
227. Olson DJ, Christian JL, Moon RT (1991) Effect of Wnt-1 and related proteins in gap junctional communication in Xenopus embroys Science 252: 1173-1176
228. Otto T, Rembrink K, Goepel M, Meyer-Schwickerath M, Rubben H (1993) E-cadherin: a marker for differentiation and invasiveness in prostatic carcinoma Urol Res 21. 359-362
229. Otto T, Birchmeier W, Schmidt U, Hinke A, Schipper J, Rübben H, Raz A (1994) Inverse relation of E-cadherin and autocrine motility factor receptor expression as a prognostic factor in patients with bladder carcinomas Cancer Res 54. 3120-3123
230. Overduin M, Harvey TS, Bagby S, Tong KI, Yau P, Takeichi M, Ikura M (1995) Solution structure of the epithelial cadherin domain responsible for selective cell adhesion. Science 267. 386-389
231. Oyama T, Kanai Y, Ochiai A, Akimoto S, Oda T, Yanagihara K, Nagafuchi A, Tsukita S, Shibamoto S, Ito F, Takeichi M, Matsuda H, Hirohashi S (1994) A truncated beta-catenin disrupts the interaction between E-cadherin and alpha-catenin: a cause of loss of intercellular adhesiveness in human cancer cell lines. Cancer Res 54: 6282-6287
232. Ozawa M, Kemler R (1990) Correct proteolytic cleavage is required for the cell adhesive function of uvomorulin J Cell Biol 111: 1645-1650
233. Ozawa M, Baribault H, Kemler R (1989) The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J8: 1711-1717
234. 2+ binding site of uvomorulin abolish the adhesive function Cell 63: 1033-1038
235. Ozawa M, Hoschutzky H, Herrenknecht K, Kemler R (1990b) A possible new adhesive site in the cell-adhesion molecule uvomorulin Mech Dev 33: 49-56
236. Ozawa M, Ringwald M, Kemler R (1990c) Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule. Proc Natl Acad Sci USA 87. 4246-4250
237. Paik S (1992) Expression of IGF-I and IGF-II mRNA in breast tissue. Breast Cancer Res Treat 22 31-38
238. Palka J, Peterkofsky B (1988) Salt stimulation of serum insulin-like growth factor binding protein activity. Anal Biochem 175: 442-449
239. Pandolfi F, Trentin L, Boyle LA, Stamenkovic I, Byers HR, Colvin RB, Kurnick JT (1992) Expression of cell adhesion molecules in human melanoma cell lines and their role in cytotoxicity mediated by tumor-infiltrating lymphocytes. Cancer 69: 1165-1173
240. Papa V, Ghozzo B, Clark GM, McGuire WL, Moore D, Fujita-Yamaguchi Y, Vigneri R, Goldfine ID, Pezzino V (1993) Insulin-like growth factor-I factors are overexpressed and predict a low risk in human breast cancer. Cancer Res 53: 3736-3740
241. Parmer VS, Jain R, Sharma SK, Vardhan A, Taeja P, Singh S, Vyncke BM, Bracke ME, Mareel MM (1994) Anti-invasive activity of 3,7-dimethoxyflavone in vitro. J Pharm Sci 83. 1217-1221
242. Pasdar M, Li Z (1993) Disorganization of microfilaments and intermediate filaments interfere with the assembly and stability of desmosomes in MDCK epithelial cells. Cell Motil Cytoskeleton 26 163-180
243. Peifer M, McCrea PD, Green KJ, Wieschaus E, Gumbiner B (1992) The vertebrate adhesive junction proteins β-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties. J Cell Biol 118: 681-691
244. Peifer M, Sweeton D, Casey M, Wieschaus E (1994) Wingless signal and Zeste-white 3 kinase trigger opposing changes tn the intracellular distribution of Armadillo Development 120: 369-380
245. Peyrat JP, Bonneterre J (1992) Type 1 IGF receptor in human breast diseases Breast Cancer Res Treat 22: 59-67
246. Piepenhagen PA, Nelson WJ (1993) Defining E-cadherin-associated protein complexes in epithelial cells. plakoglobin, beta- and gamma-catenin are distinct components J Cell Sci 104: 751-762
247. Pignatelli M, Liu D, Nasim MM, Stamp GWH, Hirano S, Takeichi M (1992) Morphoregulatory activities of E-cadherin and beta-1 integrins in colorectal tumour cells. Br J Cancer 66: 629-634
248. Pizarro A, Benito N, Navarro P, Palacios J, Cano A, Quintanilla M, Contreras F, Gamallo C (1994) E-cadherin expression in basal cell carcinoma Br J Cancer 69 157-162
249. Plessers L, Bosmans E, Cox A, Op de Beek L, Vandepitte J, Vanvuchelen J, Raus J (1990) Production of immunohistochemical reacticity of mouse anti-epithelial monoclonal antibodies raised against human breast cancer cells. Anticancer Res 10: 271-277
250. Ploug M, Rønne ER, Behrendt N, Jensen AL, Blasi F, Danø K (1991) Cellular receptor for urokinase plasminogen activator Carboxyl-terminal processing and membrane anchoring by glycosylphosphatidylinositol J Biol Chem 266 1926-1933
251. Pokutta S, Herrenknecht K, Kemler R, Engel J (1994) Conformational changes of the recombinant extracellular domain of E-cadherin upon calcium binding. Eur J Biochem 223. 1019-1026
252. Rasbridge SA, Gillett CE, Sampson SA, Walsh FS, Millis RR (1993) Epithelial (E-) and placental (P-) cadherin adhesion molecule expression in breast carcinoma. J Pathol 169: 245-250
253. c-src activity and cellular localization during differentiation of human trophoblast cells in culture J Cell Sci 105: 629-636
254. Reeders ST, Breuning MH, Davies KE, Nicholls RD, Jarman AP, Higgs DR, Pearson PL, Weatherall DJ (1985) a highly polymorphic DNA marker linked to adult polycystic kidney disease on chromosome 16. Nature 317. 542-544
255. Reima I, Lehtonen E, Virtanen I, Flechon JE (1993) The cytoskeleton and associated proteins during cleavage, compaction and blastocyst differentiation in the pig Differentiation 54. 35-45
256. Reinsch S, Karsenti E (1994) Orientation of spindle axis and distribution of plasma membrane proteins during cell division in polarized MDCKII cells J Cell Biol 126: 1509-1526
257. Reynolds AB, Daniel J, McCrea PD, Wheelock MJ, Wu J, Zhang Z (1994) Identification of a new catenin, the tyrosine kinase substrate p120cas associates with E-cadherin complexes. Mol Cell Biol 14: 8333-8342
258. Riethmacher D, Brinkmann V, Birchmeier C (1995) A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development Proc Natl Acad Sci USA 92. 855-859
259. Rimm DL, Morrow JS (1994) Molecular cloning of human E-cadherin suggests a novel subdivision of the cadherin superfamily. Biochem Biophys Res Commun 200. 1754-1761
260. Ringwald M, Schuh R, Vestweber D, Eistetter H, Lottspeich F, Engel J, Dolz R, Jahnig F, Epplen J, Mayer S et al. (1987) The structure of cell adhesion molecule uvomorulin. Insights into the molecular mechanism of ca2+-dependent cell adhesion. EMBO J 6: 3647-3653
261. Ringwald M, Baribault H, Schmidt C, Kemler R (1991) The structure of the gene coding for the mouse cell adhesion molecule uvomorulin. Nucleic Acids Res 19: 6533-6539
262. Risinger JI, Berchuck A, Kohler MF, Boyd J (1994) Mutations of the E-cadherin gene in human gynecologic cancers. Nature Genet 7: 98-102
263. Rocco MV, Neltson EG, Hoyer JR, Ziyadeh FH (1992) Attenuated expression of epithelial cell adhesion molecules in murine polycystic kidney disease Am J Physiol 262. F679-F686
264. Rochefort H, Augereau P, Briozzo P, Capony F, Cavailles V, Freiss G, Garcia M, Maudelonde T, Morisset M, Vignon F (1988) Structure, function, regulation and clinical significance of the 52K pro-cathepsin D secreted by breast cancer cells. Biochimie 70: 943-949
265. Rubinfeld B, Souza B, Albert I, Muller O, Chamberlain SH, Masiarz FR, Munemitsu S, Polakis P (1993) Association of the APC gene product with beta-catenin. Science 262. 1731-1734
266. Sacchi TB, Bani D, Brandi ML, Faichetti A, Bigazzi M (1994) Relaxin influences growth, differentiation and cell-cell adhesion of human breast-cancer cells in culture. Int J Cancer 57: 129-134
267. Sakuragi N, Nishiya M, Ikeda K, Ohkouch T, Furth EE, Hareyama H, Satoh C, Fujimoto S (1994) Decreased E-cadherin expression in endometrial carcinoma is associated with tumor dedifferentiation and deep myometrial invasion. Gynecol Oncol 53. 183-189
268. Sara VR (1992) The role of the insulin-like growth factors in the nervous system. In: Schofield PN (ed) The insulin-like growth factors. Oxford University Press, Oxford, pp 258-279
269. Sara VR, Carlsson-Skwirut C, Andersson C, Hall E, Sjogren B, Holmgren A, Jornvall H (1986) Characterization of somatomedins from human fetal brain: identification of a variant form of insulin-like growth factor I Proc Natl Acad Sci USA 83: 4904-4907
270. Sato H, Takino T, Okada Y, Cao J, Shingawa A, Yamamoto E, Seiki M (1994) A matrix metallo-proteinase expressed on the surface of invasive tumor cells. Nature 370: 61-65
271. Scherer G, Bausch E, Gaa A, von Deimling O (1989) Gene mapping on mouse chromosome 8 by interspecific crosses new data on a linkage group conserved on human chromosome 16q. Genomics 5: 275-282
272. Schipper JH, Frixen UH, Behrens J, Unger A, Jahnke K, Birchmeier W (1991) E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis. Cancer Res 51: 6328-6337
273. Shapiro L, Fannon AM, Kwong PD, Thompson A, Lehmann MS, Grubel G, Legrand JF, Als-Nielsen J, Colman DR, Hendrickson WA (1995) Structural basis of cell-cell adhesion by cadherins. Nature 374. 327-337
274. Shibamoto S, Hayakawa M, Takeuchi K, Hori T, Oku N, Miyazawa K, Kitamura N, Takeichi M, I to F (1994) Tyrosine phosphorylation of β-catenin and plakoglobin enhanced by hepatocyte growth factor and epidermal growth factor in human carcinoma cells. Cell Adhesion Commun 1 295-305
275. Shibata T, Gotoh M, Ochiai A, Hirohashi S (1994) Association of plakoglobin with APC, a tumor suppressor gene product, and its regulation by tyrosine phosphorylation. Biochem Biophys Res Commun 203: 519-522
276. Shimamura K, Takeichi M (1992) Local and transient expression of E-cadherin involved in mouse embryonic brain morphogenesis. Development 116: 1011-1019
277. Shimamura K, Takahashi T, Takeichi M (1992) E-cadherin expression in a particular subset of sensory neurons. Dev Biol 152: 242-254
278. Shimoyama Y, Hirohashi S (1991a) Cadherin intercellular adhesion molecule in hepatocellular carcinomas loss of E-cadherin expression in an undifferentiated carcinoma Cancer Lett 57: 131-135
279. Shimoyama Y, Hirohashi S (1991b) Expression of E- and P-cadherin in gastric carcinomas. Cancer Res 51: 2185-2192
280. Shimoyama Y, Hirohashi S, Hirano S, Nogushi M, Shimosato Y, Takeichi M, Abe O (1989) Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas Cancer Res 49. 2128-2133
281. Shimoyama Y, Nagafuchi A, Fujita S, Gotoh M, Takeichi M, Tsukita S, Hirohashi S (1992) Cadherin dysfunction in a human cancer cell line: possible involvement of loss of alpha-catenin expression in reduced cell-cell adhesiveness Cancer Res 52: 5770-5774
282. Shino Y, Nakatani K, Watanabe A, Sawada H, Okumura T, Yamada Y, Nakano H (1992) Expression of E-cadherin in human gastric carcinomas. Gastroenterol Jpn 26: 231
283. Shino Y, Nakatani K, Watanabe A, Okumura T, Yamada Y, Yamada Y, Yano T, Nakano H (1991) Expression of E-cadherin in poorly differentiated carcinomas of human stomach: preliminary report. Nippon Geka Gakkai Zasshi 93: 217
284. Shiozaki H, Tahara H, Oka H, Miyata M, Kobayashi K, Tamura S, Iihara K, Doki Y, Hirano S, Takeichi M, Mori T (1991) Expression of immunoreactive E-cadherin adhesion molecules in human cancers. Am J Pathol 139. 17-23
285. Shiozaki H, Doki Y, Oka H, Iihara K, Miyata M, Kadowaki T, Matsui S, Tamura S, Inoue M, Mori T (1993) E-cadherin expression and cancer invasion and metastasis. Hum Cell 6: 94-99
286. Shiozaki H, Iihara K, Oka H, Kadowaki T, Matsui S, Gofuku J, Inoue M, Nagafuchi A, Tsukita S, Mori T (1994) Immunohistochemical detection of alpha-catenin expression in human cancers. Am J Pathol 144 667-674
287. Shiozaki H, Kadowaki T, Doki Y, Inoue M, Tamura S, Oka H, Iwazawa T, Matsui S, Shimaya K, Takeichi M, Mori T (1995) Effect of epidermal growth factor on cadherin-mediated adhesion in a human oesophageal cancer cell line. Br J Cancer 71: 250-258
288. Shirayoshi Y, Nose A, Iwasaki K, Takeichi M (1986) N-linked oligosaccharides are not involved in the function of a cell-cell binding glycoprotein E-cadherin Cell Struct Funct 11: 245-252
289. Shore EM, Nelson WJ (1991) Biosynthesis of the cell adhesion molecule uvomorulin (E-cadherin) in Madin-Darby Canine Kidney epithelial cells. J Bioi Chem 266: 19672-19680
290. Skolnik EY, Batzer A, Li N, Lee C-H, Lowenstein E, Mohammadi M, Margolis B, Schlessinger J (1993) The function of GRB2 in linking the insulin receptor to ras signaling pathways. Science 260: 1953-1955
291. Sloane BF, Honn KV (1984) Cysteine proteinases and metastasis. Cancer Metastasis Rev 3: 249-263
292. Sommers CL, Thompson EW, Torri JA, Kemler R, Gelmann EP, Beyers SW (1991) Cell adhesion molecule uvomorulin expression in human breast cancer cell lines: relationship to morphology and invasive capacities Cell Growth Differ 2: 365-372
293. Sommers CL, Gelmann EP, Kemler R, Cowin P, Byers SW (1994) Alterations in β-catenin phosphorylation and plakoglobin expression in human breast cancer cells. Cancer Res 54: 3544-3552
294. Sorkin BC, Hemperly JJ, Edelman GM, Cunningham BA (1988) Structure of the gene for the liver cell adhesion molecule, L-CAM. Proc Natl Acad Sci USA 85: 7617-7621
295. Sorkin BC, Jones FS, Cunningham BA, Edelman GM (1993) Identification of the promoter and a transcriptional enhancer of the gene encoding L-CAM, a calcium-dependent cell adhesion molecule Proc Natl Acad Sci USA 90 11356-11360
296. Sorscher SM, Russack V, Cagle M, Faramisco JR, Green MR (1995) Immunolocalization of E-cadherin in human head and neck cancer. Arch Pathol Lab Med 119: 82-84
297. Soule HD, Vazquez J, Long A, Albert S, Brennan M (1973) A human cell line from a pleural effusion derived from a breast carcinoma J Natl Cancer Inst 51 1409-1416
298. Stappert J, Kemler R (1994) A short core region of E-cadherin is essential for catenin binding and is highly phosphorylated. Cell Adhesion Commun (in press)
299. Stoker M, Gherardi E (1991) Regulation of cell movement the motogenic cytokines. Biochim Biophys Acta 1072. 81-102
300. Stoker M, Gherardi E, Ferryman M, Gray J (1987) Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature 327. 239-242
301. Su L-K, Vogelstein B, Kinzler KW (1993) Association of the APC tumor suppressor protein with catenins. Science 262. 1734-1737
302. Suarez-Quian CA, Byers SW (1993) Redistribution of epidermal growth factor receptor as a function of cell density, cell-cell adhesion and calcium in human (A-431) cells. Tissue Cell 25: 1-17
303. Suzuki S, Sano K, Tanihara H (1991) Diversity of the cadherin family evidence for eight new cadherins in nervous tissue. Cell Regul 2. 261-270
304. Takeichi M (1977) Functional correlation between cell adhesive properties and some cell surface proteins. J Cell Biol 75 464-474
305. Tang A, Amagai M, Granger LG, Stanley JR, Udey MC (1993) Adhesion of epidermal Langerhans cell to keratinocytes mediated by E-cadherin Nature 361: 82-85
306. Tang A, Eller MS, Hara M, Yaar M, Hirohashi S, Gilchrest BA (1994) E-cadherin is the major mediator of human melanocyte adhesion to keratinocytes in vitro J Cell Sci 107. 983-992
307. Tanihara H, Kido M, Obata S, Heimark RL, Davidson M, St John T, Suzuki S (1994) Characterization of cadherin-4 and cadherin-5 reveals new aspects of cadherins. J Cell Sci 107: 1697-1704
308. Terpe HJ, Tajrobehkar K, Gunthert U, Almannsberger M (1993) Expression of cell adhesion molecules alpha-2, alpha-5 and alpha-6 integrin, E-cadherin, N-CAM and CD-44 in renal cell carcinomas. An immunohistochemical study Virchows Arch [A] Pathol Anat Histopathol 422: 219-224
309. Thiery P, Delouvee A, Gallin WJ, Cunningham BA, Edelman GM (1984) Ontogenetic expression of cell adhesion molecules: L-CAM is found in epithelia derived from the three primary germ layers. Dev Biol 102. 61-78
310. Thompson EW, Reich R, Shima TB, Albini A, Graf J, Martin GR, Dickson RB, Lippman ME (1988) Differential regulation of growth and invasiveness of MCF-7 breast cancer cells by antiestrogens. Cancer Res 48: 6764-6768
311. Thompson EW, Torri J, Sabol M, Sommers CL, Byers S, Valvenus EM, Martin GR, Lippman ME, Stampfer MR, Dickson RB (1994) Oncogene-induced basement membrane invasiveness in human mammary epithelial cells. Clin Exp Metastasis 12: 181-194
312. Tohma Y, Yamashima T, Yamashita J (1992) Immunohistochemical localization of cell adhesion molecule epithelial cadherin in human arachnoid villi and meningiomas. Cancer Res 52: 1981-1987
313. Turpeenniemi-Hujanen T, Thorgeirsson UP, Rao CN, Liotta LA (1986) Laminin increases the release of type IV collagenase from malignant cells J Biol Chem 261: 1883-1889
314. Uchida N, Shimamura K, Miyatani S, Copeland NG, Gilbert DJ, Jenkins NA, Takeichi M (1994) Mouse alphaN-catenin: two isoforms, specific expression in the nervous system, and chromosomal localization of the gene. Dev Biol 163: 75-85
315. Umbas R, Schalken, Aalders TW, Carter BS, Karthaus HFM, Schaafsma HE, Debruyne FMJ, Isaacs WB (1992) Expression of the cellular adhesion molecule E-cadherin is reduced or absent in high-grade prostate cancer. Cancer Res 52: 5104-5109
316. Umbas R, Isaacs WB, Bringuier PP, Schaafsma HE, Karthaus HFM, Oosterhof GON, Debruyne FMJ, Schalken JA (1994) Decreased E-cadherin expression is associated with poor prognosis in patients with prostate cancer. Cancer Res 54: 3929-3933
317. Van Aken J, Cuvelier CA, De Wever N, Gao Y, Mareel MM, Roels HJ (1993) Immunohistochemical analysis of E-cadherin expression in human colorectal tumours. Pathol Res Pract 189: 975-978
318. Van der Wurff AAM, Ten Kate J, Van der Linden EPM, Dinjens WNM, Arends J-W, Bosman FT (1992) L-Cam expression in normal, premalignant, and malignant colon mucosa. J Pathol 168: 287-291
319. Vandenbossche GMR, De Bruyne GK, Bruyneel EA, Clemminck G, Vleminckx K, Van Roy FM, Mareel MM (1994) Microencapsulation of MDCK-ras-e cells prevents loss of the E-cadherin invasion suppressor function in vivo. Int J Cancer 57: 73-80
320. Van Hengel J, Nollet F, Berx G, Van Roy N, Speleman F, Van Roy F (1995) Assignment of the human β-catenin gene (CTNNB1) to 3p22→ p21 3 by fluorescence in situ hybridization, cytogenet Cell Genet (in press)
321. Veatch AL, Carson LF, Ramakrishnan S (1994) Differential expression of the cell-cell adhesion molecule E-cadherin in ascites and solid human ovarian tumor cell Int J Cancer 58: 393-399
322. Vestweber D, Kemler R (1985) Identification of a putatiave cell adhesion domain of uvomorulin. EMBO J 4 3393-3398
323. Vet JA, Debruyne FM, Schalken JA (1994) Molecular prognostic factor in bladder cancer World J Urol 12: 84-88
324. Vleminckx K, Vakaet L Jr, Mareel M, Fiers W, Van Roy F (1991) Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell 66: 107-119
325. Vleminckx KL, Deman JJ, Bruyneel EA, Vandenbossche GMR, Keirseblick AA, Mareel MM, Van Roy FM (1994) Enlarged cell-associated proteoglycans abolish E-cadherin functionally in invasive tumor cells. Cancer Res 54: 873-877
326. Vlodavsky I, Svahn CM, Mohsen M, Ishai-Michaeli R, Eldor A, Fuks Z (1991) Heparan sulfate degradation in tumor cell invasion and neovascularization. TIGG 3. 82-90
327. Volk T, Cohen O, Geiger B (1987) Formation of heterotypic adherens-type junctions between L-CAM-containing liver cells and A-CAM containing lens cells. Cell 50: 987-994
328. Wagner HE, Toth CA, Steele GD Jr, Thomas P (1992) Metastatic potential of human colon cancer cell lines: relationship to cellular differentiation and carcinoembryonic antigen production. Clin Exp Metastasis 10 25-31
329. Walsh FS, Barton CH, Putt W, Moore SE, Kelsell D, Spurr N, Goodfellow PN (1990) N-cadherin gene maps to human chromosome 18 and is not linked to the E-cadherin gene J Neurochem 55: 805-812
330. Wang AZ, Ojakian GK, Nelson WJ (1990) Steps in the morphogenesis of a polarized epithelium I. Uncoupling the roles of cell-cell and cell-substratum contact in establishing plasma membrane polarity in multicellular epithelial (MDCK) cysts J Cell Sci 95: 137-151
331. Watabe M, Nagafuchi A, Tsukita S, Takeichi M (1994) Induction of polarized cell-cell association and retardation of growth by activation of the E-cadherin-catenin adhesion system in a dispersed carcinoma line J Cell Biol 127: 247-256
332. Watanabe H, Nabi IR, Raz A (1991) The relationship between motility factor receptor internalization and the lung colonization capacity of murine melanoma cells. Cancer Res 51 2699-2705
333. Weidner KM, Behrens J, Vandekerckhove J, Birchmeier W (1990) Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells. J Cell Biol 111: 2097-2108
334. Wheelock MJ, Knudsen (1991) Cadherins and associated proteins In Vivo 5: 505-514
335. Whitlon DS (1993) E-cadherin in the mature and developing organ of Corti of the mouse. J Neurocytol 22: 1030-1038
336. Willems J, Zwtjsen A, Siegers H, Nicolai S, Bettadapura J, Raymackers J, Scarcez T (1993) Purification and sequence of rat extracellular superoxide dismutase B secretede by C6 glioma J Biol Chem 268: 24614-24621
337. Williams E, Furness J, Walsh FS, Doherty P (1994) Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, NCAM and N-cadherin Neuron 13. 583-594
338. Wollner DA, Krzeminiski KA, Nelson WJ (1992) Remodeling the cell surface distribution of membrane proteins during the development of epithelial cell polarity. J Cell Biol 116: 889-899
339. Xiang Y-Y, Tanaka M, Suzuki M, Igarashi H, Kiyokawa E, Naito Y, Ohtawara Y, Shen Q, Sugimura H, Kino I (1994) Isolation of complementary DNA encoding K-cadherm, a novel rat cadherin preferentially expressed in fetal kidney and kidney carcinoma. Cancer Res 54: 3034-3041
340. Yamashima T, Tohma Y, Yamashita J (1992) Expression of cell adhesion molecule E-cadherin in human arachnoid villi J Neurosurg 77: 749-756
341. Zou Z, Anisowicz A, Hendrix MJ, Thor A, Neveu M, Sheng S, Rafidi K, Seftor E, Sager R (1994) Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells. Science 263: 526-529