Prognostic value of α6β4 integrin expression in breast carcinomas is affected by laminin production from tumor cells

Clinical Cancer Research

Volumn 4, Issue 2, 1998, Pages 407-410

  Tagliabue, Elda ^a   Ghirelli, Cristina ^a   Squicciarini, Paolo ^a   Aiello, Pierangela ^a   Colnaghi, Maria Ines ^a   Ménard, Sylvie ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN; LAMININ;

ARTICLE; BASEMENT MEMBRANE; BREAST CARCINOMA; CANCER SURVIVAL; DIAGNOSTIC VALUE; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; OUTCOMES RESEARCH; PRIORITY JOURNAL; PROGNOSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ANTIGENS, SURFACE; BREAST NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; INTEGRIN ALPHA6BETA4; INTEGRINS; LAMININ; NEOPLASM STAGING; PROGNOSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 0031914189     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Kennel, S. J., Foote, L. J., Falcioni, R., Sonnenberg, A., Stringer, C. D., Crouse, C., and Hemler, M. E. Analysis of the tumor-associated antigen TSP-180: identity with α6/β4 in the integrin superfamily. J. Biol. Chem., 264: 15515-15521, 1989.
2. Hemler, M. E., Crouse, C., and Sonnenberg, A. Association of the VLA α6 subunit with a novel protein: a possible alternative to the common VLA b1 subunit on certain cell lines. J. Biol. Chem., 264: 6529-6535, 1989.
3. Sonnenberg, A. F., Hogervorst, F., Osterop, A., and Veltman, F. E. M. Identification and characterization of a novel antigen complex on mouse mammary tumor cells using a monoclonal antibody against platelet glycoprotein lc. J. Biol. Chem., 263: 14030-14038, 1988.
4. Lee, E. C., Lotz, M. M., Steele, G. D., Jr., and Mercurio, A. M. The integrin α6β4 is a laminin receptor. J. Cell Biol., 117: 671-678, 1992.
5. Niessen, C. M., Hogervorst, F., Jaspars, L. H., De Melker, A. A., Delwel, G. O., Hulsman, E. H. M., Kuikman, I., and Sonnenberg, A. The α6β4 integrin is a receptor for both laminin and kalinin. Exp. Cell Res., 211: 360-367, 1994.
6. Kajiji, S., Tamura, R. N., and Quaranta, V. A novel integrin (αEβ4) from human epithelial cells suggests a fourth family of integrin adhesion receptors. EMBO J., 8: 673-680, 1989.
7. Kennel, S. J., Godfrey, V., Chang, L. Y., Lankfork, T. K., Foote, L. J., and Makkinje, A. The integrin β4 subunit is displayed on a restricted subset of endothelium im mice. J. Cell Sci., 101: 145-150, 1992.
8. Klein, S., Giancotti, F. G., Presta, M., Alberta, S. M., Buck, C. A., and Rifkin, D. B. Basic fibroblast growth factor modulates integrin expression in microvascular endothelial cells. Mol. Biol. Cell, 4: 973-982, 1993.
9. Sonnenberg, A., and Linders, C. J. T. The α6β1 (VLA-6) and α6β4 protein complexes: tissue distribution and biochemical properties. J. Cell Sci., 96: 207-217, 1990.
10. Mainiero, F., Pepe, A., Wary, K. K., Spinardi, L., Mohammadi, M., Schlessinger, J., and Giancotti, F. G. Signal transduction by the α6β4 integrin: distinct β4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes. EMBO J., 14: 4470-4481, 1995.
11. Legan, P. K., Collins, J. E., and Garrod, D. R. The molecular biology of desmosomes and hemidesmosomes: "what's in a name?". BioEssays, 14: 385-393, 1992.
12. Bottini, C., Miotti, S., Fiorucci, S., Facheris, P., Ménard, S., and Colnaghi, M. I. Polarization of the α6β4 integrin in ovarian carcinomas. Int. J. Cancer, 54: 261-267, 1993.
13. Natali, P. G., Nicotra, M. R., Bigotti, A., and De Martino, C. Localization of the α6 and β4 integrin subunits in normal human non-lymphoid tissues. J. Cell Sci., 103: 1243-1247, 1992.
14. Mariani-Costantini, R., Falcioni, R., Battista, P., Zupi, G., Kennel, S. J., Colasante, A., Venturo, I., Curcio, C. G., and Sacchi, A. Integrin (α-6, β-4) expression in human lung cancer as monitored by specific monoclonal antibodies. Cancer Res., 50: 6107-6112, 1990.
15. Kimmel, K. A., and Carey, T. E. Altered expression in squamous carcinoma cells of an orientation restricted epithelial antigen detected by monoclonal antibody A9. Cancer Res., 46: 3614-3623, 1986.
16. Van Waes, C., Kozarsky, K. F., Warren, A. B., Kidd, L., Paugh, D., Liebert, M., and Carey, T. E. The A9 antigen associated with aggressive human squamous carcinoma is structurally and functionally similar to the newly defined integrin α6β4. Cancer Res., 51: 2395-2402, 1991.
17. Carico, E., French, D., Bucci, B., Falcioni, R., Vecchione, A., and Mariani-Costantini, R. Integrin β4 expression in the neoplastic progression of cervical epithelium. Gynecol. Oncol., 49: 61-66, 1993.
18. Wolf, G. T., Carey, T. E., Schmaltz, S. P., McClatchey, K. D., Poor Glaser, L., Hayashida, D. J. S., and Hsu, S. Altered antigen expression predicts outcome in squamous cell carcinomas of the head and neck. J. Natl. Cancer Inst. (Bethesda), 82: 1566-1572, 1990.
19. 6-integrins in the normal and neoplastic prostate. Am. J. Pathol., 145: 167-174, 1994.
20. Koukoulis, G. K., Virtanen, I., Korhonen, M., Laitinen, L., Quaranta, V., and Gould, V. E. Immunohistochemical localization of integrins in the normal, hyperplastic, and neoplastic breast: correlations with their functions as receptors and cell adhesion molecules. Am. J. Pathol., 139: 787-799, 1991.
21. Natali, P. G., Nicotra, M. R., Botti, C., Mottolese, M., Bigotti, A., and Segatto, O. Changes in expression of α6β4 integrin heterodimer in primary and metastatic breast cancer. Br. J. Cancer, 66: 318-322, 1992.
22. Weiss, A., and Littman, D. R. Signal transduction by lymphocyte antigen receptors. Cell, 76: 263-274, 1994.
23. Cowley, S., Paterson, H., Kemp, P., and Marshall, C. J. Activation of MAP kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell, 77: 841-852, 1994.
24. Clark, E. A., and Brugge, J. S. Integrins and signal transduction pathways: the road taken. Science (Washington DC), 265: 233-239, 1995.
25. Pellegrini, R., Centis, F., Martignone, S., Mastroianni, A., Tagliabue, E., Tosi, E., Ménard, S., and Colnaghi, M. I. Characterization of a monoclonal antibody directed against the epidermal growth factor receptor binding site. Cancer Immunol. Immunother., 34: 37-42, 1991.
26. HER2 and growth inhibition of cells with HER2/neu gene amplification. Int. J. Cancer, 47: 933-937, 1991.
27. Pyke, C., Romer, J., Kallunki, P., Lund, L. R., Ralfkiær, E., Dano, K., and Tryggvason, K. The γ2 chain of kalinin/laminin 5 is preferentially expressed in invading malignant cells in human cancers. Am. J. Pathol., 145: 782-791, 1994.
28. Pyke, C., Sale, S., Ralfkiaer, E., Romer, J., Dano, K., and Tryggvason, K. Laminin-5 is a marker of invading cancer cells in some human carcinomas and is coexpressed with the receptor for urokinase plasminogen activator in budding cancer cells in colon adenocarcinomas. Cancer Res., 55: 4132-4139, 1995.
29. Chao, C., Lotz, M. M., Clarke, A. C., and Mercurio, A. M. A function for the integrin α6β4 in the invasive properties of colorectal carcinoma cells. Cancer Res., 56: 4811-4819, 1996.
30. Kemperman, H., Wijnands, Y., De Rijk, D., and Roos, E. The integrin α6β4 on TA3/Ha mammary carcinoma cells is involved in adhesion to hepatocytes. Cancer Res., 53: 3611-3617, 1993.
31. Giancotti, F. G. Signal transduction by the α6β4 integrin: charting the path between laminin binding and nuclear events. J. Cell Sci., 109: 1165-1172, 1996.
32. Friedrichs, K., Ruiz, P., Franke, F., Gille, I., Terpe, H-J., and Imhof, B. A. High expression level of α6 integrin in human breast carcinoma is correlated with reduced survival. Cancer Res., 55: 901-906, 1995.