MT1-MMP correlates with MMP-2 activation potential seen after epithelial to mesenchymal transition in human breast carcinoma cells

Clinical and Experimental Metastasis

Volumn 15, Issue 2, 1997, Pages 111-120

  Pulyaeva, Helena ^a,b   Bueno, Jorge ^a   Polette, Myriam ^d   Birembaut, Philippe ^d   Sato, Hiroshi ^e   Seiki, Motoharu ^e   Thompson, Erik W ^a,b,c  

^a GEORGETOWN UNIVERSITY   (United States)

^b GEORGETOWN UNIVERSITY   (United States)

^c GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^d REIMS UNIVERSITY HOSPITAL   (France)

^e KANAZAWA UNIVERSITY   (Japan)

Author keywords

EMT; human breast cancer; invasion; MMP 2 activation; MT1 MMP; vimentin

Indexed keywords

CONCANAVALIN A; GELATINASE A; MATRIX METALLOPROTEINASE 14; UNCLASSIFIED DRUG; VIMENTIN;

ARTICLE; BREAST CARCINOMA; CELL TRANSFORMATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN SITU HYBRIDIZATION; MESENCHYME;

ANIMALS; BLOTTING, WESTERN; BREAST NEOPLASMS; CONCANAVALIN A; ENZYME ACTIVATION; GELATINASES; HUMANS; IN SITU HYBRIDIZATION; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASES, MEMBRANE-ASSOCIATED; METALLOENDOPEPTIDASES; MICE; MICE, NUDE; NEOPLASM INVASIVENESS; RNA, MESSENGER; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL; VIMENTIN;

EID: 0030966970     PISSN: 02620898     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018444609098     Document Type: Article

References (48)

1. Woessner JF Jr, 1991, Matrix metalloproteinases and their inhibitors in connective tissue remodelling. FASEB J, 5, 2145-54.
2. Birkedal-Hansen H, Moore WG, Bodden MK, et al., 1993, Matrix metalloproteinases: a review. Crit Rev Oral Biol Med, 4(2), 197-250.
3. Stetler-Stevenson WG, Aznavoorian S and Liotta LA, 1993, Tumor cell interactions with the extracellular matrix during invasion and metastasis. Ann Rev Cell Biol, 9, 541-73.
4. Goldberg GA and Eisen AZ, 1991, Extracellular matrix metalloproteinases in tumor invasion and metastasis. In: Lippman ME and Dickson RB, eds. Regulatory Mechanisms in Breast Cancer. Kluwer Academic Publishers, pp. 421-40.
5. Springman EB, Angleton EL, Birkedahl-Hansen H and Van Wart HE, 1990, Multiple modes of activation of latent human fibroblast collagenase - Evidence for the role of a cys-73 active site zinc complex in latency and a cysteine switch mechanism for activation. Proc Natl Acad Sci, USA, 87, 364-8.
6. Stetler-Stevenson W, Krutzsch HC, Wacher M, Margulies IM and Liotta LA, 1989, The activation of human type IV collagenase proenzyme: sequence identification of the major conversion product following organomercurial activation. J Biol Chem, 264, 1353-6.
7. Murphy G, McAlpine CG, Poll CT and Reynolds JJ, 1985, Purification and characterization of a bone metalloproteinase that degrades gelatin and type IV and V collagen. Biochim Biophys Acta, 831, 49-58.
8. Brown PD, Levy AT, Margulies IM, Liotta LA and Stetler-Stevenson WG, 1990, Independent expression and cellular processing of Mr 72,000 type IV collagenase and interstitial collagenase in human tumorigenic cell lines. Cancer Res, 50, 6184-91.
9. Overall CM and Sodek J, 1990, Concanavalin A produces a matrix-degradative phenotype in human fibroblasts. J Biol Chem, 265, 21141-51.
10. Ward RV, Atkinson SJ, Slocombe PM, Docherty AJ, Reynolds JJ and Murphy G, 1991, Tissue inhibitor of metalloproteinases-2 inhibits the activation of 72 kDa progelatinase by fibroblast membranes. Biochim Biophys Acta, 1079, 242-6.
11. Azzam HS and Thompson EW, 1992, Collagen-induced activation of the 72 kDa type IV collagenase in human fibroblasts and a carcinosarcoma-derived human breast cancer cell line. Cancer Res, 52, 4540-4.
12. Azzam HS, Arand GA, Lippman ME and Thompson EW, 1993, MMP-2 activation potential associates with metastatic progression in human breast cancer cell lines, and is independent of MMP-2 production. J Natl Cancer Inst, 85, 1758-64.
13. Brown PD, Kleiner DE, Unsworth EJ and Stetler-Stevenson WG, 1993, Cellular activation of the 72 kDa type IV procollagenase/TIMP-2 complex. Kidney Int, 43, 163-70.
14. Murphy G, Willenbrock F, Ward RV, Cockett MI, Eaton D and Docherty AJ, 1992, The C-terminal domain of the 72 kDa gelatinase A is not required for catalysis but is essential for membrane activation and modulates interactions with tissue inhibitor of metalloproteinases. Biochem J, 283, 637-41.
15. Strongin AY, Marmer BL, Grant GA and Goldberg GI, 1993, Plasma membrane dependent activation of the 72 kDa type IV collagenase is prevented by complex formation with TIMP-2. J Biol Chem, 268, 14033-9.
16. Sato H, Takino T, Okada Y, et al., 1994, A matrix metalloproteinase expressed on the surface of invasive tumor cells. Nature, 370, 61-5.
17. Cao J, Sato H, Takino T and Seiki M, 1995, The C-terminal region of membrane type Matrix metalloproteinase (MT-MMP) is a functional transmembrane domain required for progelatinase activation. J Biol Chem, 270, 801-5.
18. Strongin AY, Collier IE, Bannikov GA, Marmer BL, Grant GA and Goldberg GI, 1995, Mechanism of cell surface activation of 72 kDa type IV collagenase: isolation of the activated form of the membrane metalloprotease. J Biol Chem, 270, 5331-8.
19. Will H and Hinzmann B, 1995, cDNA sequence and mRNA tissue distribution of a novel matrix metalloproteinase with a potential transmembrane segment. Eur J Biochem, 231, 602-8.
20. Takino T, Sato H, Shinagawa A and Seiki M, 1995, Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) from a human placental cDNA library: MTMMP's form a unique membrane-type subclass in the MMP family. J Biol Chem, 230, 23013-20.
21. Puente XS, Pendas AM, Llano E, Velasco G and Lopez-Otin C, 1996, Molecular cloning of novel membrane-type matrix metalloproteinase from a human breast carcinoma. Cancer Res, 56, 944-9.
22. Pei D and Weiss S, 1995, Furin-dependent intracellular activation of the human stromelysin-3 zymogen. Nature, 375, 244-7.
23. Pei D and Weiss S, 1996, Transmembrane-deletion mutants of the membrane-type matrix metalloproteinase-1 process progelatinase A and express intrinsic matrix-degrading activity. J Biol Chem, 271, 9135-40.
24. Thompson EW, Paik S, Brünner N, et al., 1992, Association of increased basement membrane-invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines. J Cell Physiol, 150, 534-44.
25. Bae SG, Arand G, Pavasant P, Azzam H and Thompson EW, 1992, Molecular and cellular analysis of basement membrane invasion by human breast cancer cells in Matrigel-based in vitro assays. Breast Cancer Res Treatm, 24, 241-55.
26. Gilles C and Thompson EW, 1996, The epithelial to mesenchymal transition and metastatic progression in carcinoma. The Breast J, 2, 83-96.
27. Thompson EW, Yoon J, Burgess MB, et al., 1991, Matrix metallo-proteinase family analysis in human breast cancer cell lines of differential in vivo and in vitro invasiveness. Proc Am Assoc Can Res, 32, 71 (abstract).
28. Maiti SN, Yu M, Bueno J, et al., 1994, Differential regulation of Matrix Metalloproteinase-2 (MMP-2) activation in human breast cancer cell lines. Ann NY Acad Sci, 732, 456-9.
29. Heussen C and Dowdle EB, 1980, Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates. Analyt Biochem, 102, 196-202.
30. Polette M, Clavel Ch, Cockett M, Girod de Bentzmann S, Murphy G and Birembaut Ph, 1993, Detection and localization of mRNA's encoding matrix metalloproteinases and their tissue inhibitor in human breast pathology. Invasion Metastasis, 13, 31-7.
31. Monteagudo C, Merino M, San-Juan J, Liotta L and Stetler-Stevenson W, 1990, Immunohistochemical distribution of type IV collagenase in normal, benign and malignant breast tissue. Am J Pathol, 136, 585-92.
32. Daidone MG, Silvestrini R, D'Errico A, et al., 1991, Laminin receptors, collagenase IV and prognosis in node-negative breast cancers. Int J Cancer, 48, 529-32.
33. D'Errico A, Garbisa S, Liotta LA, Castronovo V, Stetler-Stevenson WG and Grigioni WF, 1991, Augmentation of type IV collagenase, laminin receptor, and Ki67 proliferation antigen associated with human colon, gastric, and breast carcinoma progression. Modern Pathol, 4, 239-46.
34. Hoyhtya M, Fridman R, Komarek D, et al., 1994, Immunohistochemical localization of matrix metalloproteinase 2 and its specific inhibitor TIMP-2 in neoplastic tissues with monoclonal antibodies. Int J Cancer, 56, 500-5.
35. Tryggvason K, 1993, Type IV collagenase in invasive tumors. Breast Cancer Res Treatm, 24, 209-18.
36. Clavel C, Polette M, Doco M, Binninger I and Birembaut P, 1992, Immunolocalization of matrix metallo-proteinases and their tissue inhibitor in human mammary pathology. Bull Cancer (Paris), 79, 261-70.
37. Basset P, Bellocq JP, Wolf C, et al., 1990, A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas. Nature, 348, 699-704.
38. Polette M, Gilbert N, Stas I, et al., 1994, Gelatinase A expression and localization in human breast cancers. An in situ hybridization study and immunohistochemical detection using confocal microscopy. Virchows Arch, 424, 641-5.
39. Brown PD, Bloxidge RE, Anderson E and Howell A, 1993, Expression of activated gelatinase in human invasive breast carcinoma. Clin Exp Metastases, 11, 183-9.
40. Yamagata S, Yoshii Y, Suh JG, Tanaka R and Shimizu S, 1991, Occurrence of an active form of gelatinase in human gastric and colorectal carcinoma tissues. Cancer Lett, 59, 51-5.
41. Davies B, Miles DW, Hepperfield LC, et al., 1993, Activity of type IV collagenases in benign and malignant breast disease. Br J Cancer, 67, 1126-31.
42. Davies B, Waxman J, Wasan H, et al., 1993, Levels of matrix metalloproteases in bladder cancer correlate with tumor grade and invasion. Cancer Res, 53, 5365-9.
43. Rha SY, Cho JY, Ahn JB, et al., Sequential steps in matrix metalloproteinase-2 activation and expression during breast cancer progression. Proc Am Assoc Cancer Res, 36, 96.
44. Okada A, Bellocq JP, Rouyer N, et al., 1995, Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas. Proc Natl Acad Sci, USA, 92, 2730-4.
45. Freije JMP, Diez-Itza I, Balbin M, et al., 1994, Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinoma. J Biol Chem, 269, 16766-73.
46. Himelstein BP. Canete-Soler R, Bernhard E. Dilks DW and Muschel R, 1995, Metalloproteinases in tumor progression: the contribution of MMP-9. Invasion and Metastasis, 14, 246-58.
47. Polette M, Nowrochi B, Gilles C, et al., 1995, MT-MMP expression and localization in human breast and lung cancers. Virchows Arch, in press.
48. Yu M. Sato H, Seiki M and Thompson EW, 1995, Complex regulation of MT-MMP expression and MMP-2 activation by Concanavalin A in MDA-MB-231 human breast cancer cells. Cancer Res, 55, 3272-7.