Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: A new model for metastasis

Nature Medicine

Volumn 6, Issue 1, 2000, Pages 100-102

  Al Mehdi, A B ^a   Tozawa, K ^a   Fisher, A B ^a   Shientag, L ^b   Lee, A ^b   Muschel, R J ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CELL ADHESION; CELL FATE; CONTROLLED STUDY; FLUORESCENCE; LUNG CIRCULATION; LUNG METASTASIS; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM;

ANIMALS; CELL ADHESION; ENDOTHELIUM, VASCULAR; FEMALE; FIBROSARCOMA; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HUMANS; LUMINESCENT PROTEINS; LUNG NEOPLASMS; MICE; MICE, NUDE; MICROCIRCULATION; NEOPLASM METASTASIS; PULMONARY CIRCULATION; RATS; RATS, SPRAGUE-DAWLEY; TRANSFECTION; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0033972059     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/71429     Document Type: Article

References (20)

1. Luzzi, K.J. et al. Multistep nature of metastatic inefficiency: dormancy of solitary cells after successful extravasation and limited survival of early micrometastases. Am. J. Pathol. 153, 865-873 (1998).
2. +. Circ. Res. 83, 730-737 (1998).
3. Voyta, J.C., Via, D.P., Butterfield, C.E. & Zetter, B.R. Identification and isolation of endothelial cells based on their increased uptake of acetylated-low density lipoprotein. J. Cell Biol. 99, 2034-2040 (1984).
4. Bernhard, E.J., Gruber, S.B. & Muschel, R.J. Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells. Proc. Natl. Acad. Sci. USA 91, 4293-4297 (1994).
5. Hua, J. & Muschel, R.J. Inhibition of matrix metalloproteinase 9 expression by a ribozyme blocks metastasis in a rat sarcoma model system. Cancer Res. 56, 5279-5284 (1996).
6. Frisch, S.M. et al. Adenovirus E1A represses protease gene expression and inhibits metastasis of human tumor cells. Oncogene 5, 75-83 (1990).
7. Liotta, LA., Steeg, P.S. & Stetler-Stevenson, W.G. Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 64, 327-336 (1991).
8. 1251-5-iodo-2′-deoxyuridine. J. Natl. Cancer Inst. 45, 773-782 (1970).
9. Fidler, I.J. & Nicolson, G.L., Brief communication: Organ selectivity for implantation survival and growth of B16 melanoma variant tumor lines. J. Natl. Cancer Inst. 57, 1199-1202 (1976).
10. Chen, W.T. Proteolytic activity of specialized surface protrusions formed at rosette contact sites of transformed cells. J. Exp. Zool. 251, 167-185 (1989).
11. Crissman, J.D., Hatfield, J., Schaldenbrand, M., Sloane, B.F. & Honn, K.V. Arrest and extravasation of B16 amelanotic melanoma in murine lungs. A light and electron microscopic study. Lab. Invest. 53, 470-478 (1985).
12. Roos, E., Dingemans, K.P. Mechanisms of metastasis. Biochim. Biophys. Acta. 560, 135-166 (1979).
13. Dingemans, K.P. Behavior of intravenously injected malignant lymphoma cells. A morphologic study. J. Natl. Cancer Inst. 51, 1883-1895 (1973).
14. Lapis, K., Paku, S., Liotta, LA. Endothelialization of embolized tumor cells during metastasis formation. Clin. Exp. Metastasis 6, 73-89 (1988).
15. 1) function in postextravasation movement of human rhabdomyosarcoma RD cells in the liver. Cancer Res. 56, 3142-3149 (1996).
16. Scherbarth, S. & Orr, F.W. Intravital videomicroscopic evidence for regulation of metastasis by the hepatic microvasculature: effects of interleukin-1 alpha on metastasis and the location of B16F1 melanoma cell arrest. Cancer Res. 57, 4105-4110 (1997).
17. Boudreau, N., Sympson, C.J. & Werb, Z., Bissell, M.J. Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science 267, 891-893 (1995).
18. Frisch, S.M. & Francis, H. Disruption of epithelial cell-matrix interactions induces apoptosis. J. Cell Biol. 124, 619-626 (1994).
19. Nikiforov M.A. et al. p53 modulation of anchorage independent growth and experimental metastasis. Oncogene 13, 1709-1719 (1996).
20. Hauser, P.J., Agrawal, D. & Pledger, W.J. Primary keratinocytes have an adhesion dependent S phase checkpoint that is absent in immortalized cell lines. Oncogene 17, 3083-3092 (1998).