Understanding the human health effects of chemical mixtures

Environmental Health Perspectives

Volumn 110, Issue SUPPL. 1, 2002, Pages 25-42

  Carpenter, David O ^a   Arcaro, Kathleen ^a   Spink, David C ^a  

^a UNIVERSITY AT ALBANY   (United States)

Author keywords

Aromatic hydrocarbon receptor; Cancer; Cardiovascular disease; Endocrine disruptors; Metals; Neurobehavioral abnormalities; Neurodegenerative diseases; PAHs; PCBs; Synergy

Indexed keywords

DIOXIN; DNA; ENVIRONMENTAL CHEMICAL; FURAN DERIVATIVE; HEAVY METAL; POLYCHLORINATED BIPHENYL; POLYCHLORINATED DIBENZODIOXIN; POLYCYCLIC AROMATIC HYDROCARBON; SEX HORMONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOVASCULAR DISEASE; CHEMICAL CARCINOGENESIS; CHEMICAL COMPOSITION; CHEMICAL INTERACTION; COGNITION; CONTROLLED STUDY; DEGENERATIVE DISEASE; DNA DAMAGE; ENDOCRINE FUNCTION; ENVIRONMENTAL EXPOSURE; GENETIC SUSCEPTIBILITY; HEALTH HAZARD; HORMONE ACTION; HUMAN; MALE INFERTILITY; MOLECULAR BIOLOGY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SPERM;

ANIMALIA;

EID: 0036175228     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.02110s125     Document Type: Article

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197. In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin. 3: Effects on spermatogenesis and reproductive capability
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201. Exposure to TCDD during development permanently alters reproductive function in male Long Evans rats and hamsters: Reduced ejaculated and epididmymal sperm numbers and sex accessory gland weights in offspring status
202. A dose-response analysis of the reproductive effects of a single gestational dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin in male Long Evans hooded rat offspring
203. Androgen catabolism and excretion in 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated rats
204. Prenatal lead exposure in the rat during the third week of gestation: Long-term behavioral, physiological, and anatomical effects associated with reproduction
205. Endocrine mechanisms underlying reproductive toxicity in the developing rat chronically exposed to dietary lead
206. Lead toxicity and the hypothalamic-pituitary-testicular axis
207. Lead affects steroidogenesis in rat Leydig cells in vivo and in vitro
208. Lead-induced changes in spermatozoa function and metabolism
209. Neonatal polychlorinated biphenyl treatment increases adult testis size and sperm production in the rat
210. Effects of chronic exposure to PCBs on cytochrome P450 systems and steroidogenesis in liver and testis of bulls (Bos taurus)
211. Neonatal exposure to Aroclor 1254: Effects on adult hapatic testosterone hydroxylase activities
212. Biosynthesis of lipids by human fish spermatozoa
213. Peroxidative breakdown of phospholipids in human spermatozoa, spermicidal properties of fatty acid peroxidases, and protective action of seminal plasma
214. Increased oxidative deoxyribonucleic acid damage in the spermatozoa of infertile male patients
215. Does the increase of 8-hydroxydeoxyguanosine lead to poor sperm quality?
216. Nonenzymatic antioxidant activity of human seminal plasma
217. The effect of antioxidant on human spermatozoa and fertilization rate in an in vitro fertilization program
218. Ascorbic acid protects against endogenous oxidative DNA damage in human sperm
219. Smoking and low antioxidant levels increase oxidative damage
220. Detection of oxidative DNA damage in human sperm and the association with cigarette smoking
221. Increased oxidative damage to mitochondrial DNA following chronic ethanol consumption
222. Lead exposure causes generation of reactive oxygen species and functional impairment in rat sperm
223. Effect of long-term exposure to lead on testis and epididymis in rats
224. Metabolic activation of PCBs to quinones: Reactivity toward nitrogen and sulfur nucleophiles and influence of superoxide dismutase
225. Oxidative DNA damage induced by activation of polychlorinated biphenyls (PCBs): Implications for PCB-induced oxidative stress in breast cancer
226. Effects of phenobarbital, dexamethasone, and 3-methylcholanthrene administration on the metabolism of 17-beta-estradiol by liver microsomes from female rats
227. Stepping backward to improve assessment of PCB congener toxicities
228. Purification and characterization of liver microsomal cytochromes P-450: Electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with beta-naphthoflavone
229. Enzyme induction and acute endocrine effects in prepubertal female rats receiving environmental PCB/PCDF/PCDD mixtures
230. Determination of PCB metabolic, excretion, and accumulation rates for use as indicators of biological response and relative risk
231. cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt)
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233. Regulation of cytochrome P450 (CYP) genes by nuclear receptors
234. The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism
235. Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR
236. Localization of a phenobarbital-responsive element (PBRE) In the 5′-flanking region of the rat CYP2B2 gene
237. The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene
238. Phenobarbital response elements of cytochrome P450 genes and nuclear receptors
239. Nuclear receptor CAR as a regulatory factor for the sexually dimorphic induction of CYP2B1 gene by phenobarbital in rat livers
240. Orphan receptor promiscuity in the induction of P450 by xenobiotics
241. Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element
242. Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands
243. P450 gene induction by structurally diverse xenochemicals: Central role of nuclear receptors CAR, PXR, and PPAR
244. Activation of cytochrome P450 gene expression in the rat brain by phenobarbital-like inducers
245. Emissions of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans from the open burning of household waste in barrels
246. Cytochromes P450 5: Induction of cytochrome P4501A1: A model for analyzing mammalian gene transcription
247. Aryl hydrocarbon receptor-mediated signal transduction
248. Dioxin-inducible transactivation in an chromosomal setting
249. Dioxin induces localized, graded changes in chromatin structure-implications for CYP1A1 gene transcription
250. Differential recruitment of coactivator RIP140 by Ah and estrogen receptors - Absence of a role for LXXL motifs
251. A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin
252. Characterization of the Ah receptor-associated protein, ARA9
253. Maximal arylhydrocarbon receptor activity depends on an interaction with the retinoblastoma protein
254. Short heterodimer partner (SHP) orphan nuclear receptor inhibits the transcriptional activity of aryl hydrocarbon receptor (AHR)/AHR nuclear translocator (ARNT)
255. Ah receptor and NF-κB interactions, a potential mechanism for dioxin toxicity
256. Aryl hydrocarbon receptor imported into the nucleus following ligand binding is rapidly degraded via cytoplasmic proteasome following nuclear export
257. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced degradation of aryl hydrocarbon receptor (AhR) by the ubiquitin-proteasome pathway-role of the transcription activation and DNA binding of AhR
258. Structure and expression of the Ah receptor repressor gene
259. The aromatic hydrocarbon receptor modulates the Hepa 1c1c7 cell cycle and differentiated state independently of dioxin
260. Constitutive activation of the aromatic hydrocarbon receptor
261. Markedly increased constitutive CYP1A1 mRNA levels in the fertilized ovum of the mouse
262. Indirubin and indigo are potent aryl hydrocarbon receptor ligands present in human urine
263. The molecular epidemiology of lung cancer
264. Metabolism of benzo(a)pyrene and benzo(a)pyrene derivatives to mutagenic products by highly purified hepatic microsomal enzymes
265. Tumorigenicity studies with diol-epoxides of benzo(α)pyrene which indicate that (+/-)-trans-7β,8α-dihydroxy-9 α, 10 α-epoxy-7,8,9,10-tetrahydrobenzo(α)-pyrene is an ultimate carcinogen in newborn mice
266. Activation of chemically diverse procarcinogens by human cytochrome P450 1B1
267. CYP1B1 expression in human lung
268. Metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-diol by human cytochrome P450 1B1
269. Metabolism of benzo[α]pyrene to trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene by recombinant human cytochrome P4501B1 and purified liver epoxide hydrolase
270. The pregnane X receptor: A promiscuous xenobiotic receptor that has diverged during evolution
271. Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53
272. Inhibition of CYP1A1-dependent activity by the polynuclear aromatic hydrocarbon (PAH) fluoranthene
273. Effect of a complex environmental mixture from coal tar containing polycyclic aromatic hydrocarbons (PAH) on the tumor initiation, PAH-DNA binding and metabolic activation of carcinogenic PAH in mouse epidermis
274. Benzo[g,h,i]perylene synergistically transactivates benzo[a]pyrene-induced CYP1A1 gene expression by aryl hydrocarbon receptor pathway
275. The effects of a binary mixture of benzo(a)pyrene and 7H-dibenzo(c,g)carbazole on lung tumors and K-ras oncogene mutations in strain A/J mice
276. Antagonistic interactions among nephrotoxic polycyclic aromatic hydrocarbons
277. Genotoxic polycyclic aromatic hydrocarbon ortho-quinones generated by aldoketo reductases induce CYP1A1 via nuclear translocation of the aryl hydrocarbon receptor
278. Role of quinones in toxicology
279. NAD(P)H: Quinone oxidoreductase 1 deficiency and increased susceptibility to 7,12-dimethylbenz[a]-anthracene-induced carcinogenesis in mouse skin
280. NAD(P)H: Quinone oxidoreductase 1 deficiency increases susceptibility to benzo(a)pyrene-induced mouse skin carcinogenesis
281. Characterization of a murine Ahr null allele: Involvement of the Ah receptor in hepatic growth and development
282. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
283. Conditional disruption of the aryl hydrocarbon receptor nuclear translocator (Arnt) gene leads to loss of target gene induction by the aryl hydrocarbon receptor and hypoxia-inducible factor 1α
284. Functional interference between hypoxia and dioxin signal transduction pathways-competition for recruitment of the ARNT transcription factor
285. Cross-talk between the aryl hydrocarbon receptor and hypoxia inducible factor signaling pathways-demonstration of competition and compensation
286. Interactions between aryl hydrocarbon receptor (AhR) and hypoxia signaling pathways
287. Differential effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the adipose-type and brain-type glucose transporters in mice
288. A direct interaction between the aryl hydrocarbon receptor and retinoblastoma protein - Linking dioxin signaling to the cell cycle
289. Aromatic hydrocarbon receptor interaction with the retinoblastoma protein potentiates repression of E2F-dependent transcription and cell cycle arrest
290. Kip1 induction and inhibition of proliferation by intracellular Ah receptor in developing thymus and hepatoma cells
291. Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals
292. Disruption of dioxin-inducible phase I and phase II gene expression patterns by cadmium, chromium, and arsenic
293. Induction of oxyradicals by arsenic: Implication for mechanism of genotoxicity
294. Depletion of glutathione by benzo(a)pyrene metabolites, ionomycin, thapsigargin, and phorbol myristate in human peripheral blood mononuclear cells
295. Dioxin causes a sustained oxidative stress response in the mouse
296. Effects of selected polychlorinated biphenyl (PCB) congeners on hepatic glutathione, glutathione-related enzymes, and selenium status: Implications for oxidative stress
297. Regulation of gene expression by reactive oxygen
298. Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages
299. Nrf2 and c-Jun regulation of antioxidant response element (ARE)-mediated expression and induction of gamma-glutamylcysteine synthetase heavy subunit gene
300. Activation of mitogen-activated protein kinase pathways induces antioxidant response element-mediated gene expression via a Nrf2-dependent mechanism
301. Nrf2, a cap'n'collar transcription factor, regulates induction of the heme oxygenase-1 gene
302. Induction of 8-hydroxydeoxyguanosine in Ah-responsive mouse liver by iron and Aroclor 1254
303. Induction of cytochrome P4501A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin or indolo(3,2-b)carbazole is associated with oxidative DNA damage
304. Effect of arsenite on induction of CYP1A, CYP2B, and CYP3A in primary cultures of rat hepatocytes
305. Effect of metals on polycyclic aromatic hydrocarbon induction of CYP1A1 and CYP1A2 in human hepatocyte cultures
306. Down-regulation of P4501A1 and P450 1A2 in isolated hepatocytes by oxidative stress
307. Down-regulation of cytochrome P4501A1 gene promoter by oxidative stress-critical contribution of nuclear factor 1
308. Nuclear factor-kappaB: A pivotal transcription factor in chronic inflammatory diseases
309. Is NF-kappa B the sensor of oxidative stress?
310. Opposite effect of NF-B and C-Jun N-terminal kinase on p53-independent GADD45 induction by arsenite
311. Sodium arsenite enhances AP-1 and NF kappa B DNA binding and induces stress protein expression in precision-cut rat lung slices
312. Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase
313. Interleukin-1 beta suppresses the induction of P4501A1 and P4501A2 mRNAs in isolated hepatocytes
314. Mechanism of suppression of cytochrome P4501A1 expression by TNF-alpha and lipopolysaccharide
315. Toxicological interactions among arsenic, cadmium, chromium, and lead in human keratinocytes
316. Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: Relevance to xenobiotic metabolism and toxicity
317. Polymorphisms of xenobiotic-metabolizing enzymes and susceptibility to cancer
318. Genetic epidemiology of environmental toxicity and cancer susceptibility: Human allelic polymorphisms in drug-metabolizing enzyme genes, their functional importance, and nomenclature issues
319. Cigarette smoking, N-acetyltransferase 2 genetic polymorphisms, and breast cancer risk
320. Unique gene expression patterns in liver and kidney associated with exposure to chemical toxicants
321. Applications of gene arrays in environmental toxicology: Fingerprints of gene regulation associated with cadmium chloride, benzo(a)pyrene, and trichloroethylene
322. Application of genomics to the definition of the molecular basis for toxicity
323. Consent and privacy in pharmacogenetic testing