Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals

Nature Genetics

Volumn 28, Issue 4, 2001, Pages 355-360

  Matikainen, Tiina ^a   Perez, Gloria I ^a   Jurisicova, Andrea ^a,b   Pru, James K ^a   Schlezinger, Jennifer J ^c   Ryu, Heui Young ^c   Laine, Jarmo ^d   Sakai, Toshiyuki ^e   Korsmeyer, Stanley J ^f   Casper, Robert F ^b   Sherr, David H ^c   Tilly, Jonathan L ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MOUNT SINAI HOSPITAL   (Canada)

^c BOSTON UNIVERSITY   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e KYOTO PREFECTURAL UNIVERSITY   (Japan)

^f HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

POLYCYCLIC AROMATIC HYDROCARBON; PROTEIN BAX;

ARTICLE; ENVIRONMENTAL EXPOSURE; FEMALE; GENE ACTIVATION; GENE EXPRESSION; GENE INACTIVATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; OVARY DISEASE; PATHOGENESIS; PRIORITY JOURNAL;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ADULT; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; ENVIRONMENTAL POLLUTION; FEMALE; GENE EXPRESSION; GENES, REPORTER; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, SCID; MICROINJECTIONS; OOCYTES; OVARIAN FAILURE, PREMATURE; OVARY; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, ARYL HYDROCARBON; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION; TRANSPLANTATION, HETEROLOGOUS;

EID: 0034928843     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng575     Document Type: Article

References (30)

1. The effect of smoking on oogenesis, fertilization and implantation
2. Modeling adverse environmental impacts on the reproductive system
3. Relation between smoking and age of natural menopause
4. The aryl hydrocarbon receptor complex
5. Mechanisms of ligand-induced aryl hydrocarbon receptor-mediated biochemical and toxic responses
6. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
7. Oocyte apoptosis: Like sand through an hourglass
8. Apoptosis-associated signaling pathways are required for chemotherapy-mediated female germ cell destruction
9. Prolongation of ovarian lifespan into advanced chronological age by Bax-deficiency
10. Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy
11. Programmed cell death in the ovary: Insights and future prospects using genetic technologies
12. The aryl hydrocarbon receptor, a basic helix-loop-helix transcription factor of the PAS gene family, is required for normal ovarian germ cell dynamics in the mouse
13. The biochemical and genetic characteristics of murine ovarian aryl hydrocarbon (benzo[a]pyrene) hydroxylase activity and its relationship to primordial oocyte destruction by polycyclic aromatic hydrocarbons
14. Bone marrow stromal cells constitutively express high levels of cytochrome P4501B1 that metabolize 7,12-dimethylbenz[a]anthracene
15. α-naphthoflavone antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced murine lymphocyte ethoxyresorufin-O-deethylase activity and immunosuppression
16. The role of polycyclic aromatic hydrocarbon metabolism in dimethylbenz[a]anthracene-induced pre-B lymphocyte apoptosis
17. Experimental and clinical studies on the reproductive toxicology of 2,3,7,8-tetrachlorodibenzo-p-dioxin
18. Protein-DNA interactions at a dioxin-responsive enhancer. Mutational analysis of the DNA-binding site for the liganded Ah receptor
19. Protein-DNA interactions at a dioxin-responsive enhancer. Analysis of six bona fide DNA-binding sites for the liganded Ah receptor
20. Bax-deficient mice with lymphoid hyperplasia and male germ cell death
21. Development in vitro of mouse oocytes from primordial follicles
22. Targeted expression of Bcl-2 in mouse oocytes inhibits ovarian follicle atresia and prevents spontaneous and chemotherapy-induced oocyte apoptosis in vitro
23. long messenger RNA levels
24. 2α secretion independently of the mitogen-activated protein kinase and nuclear factor-κB pathways
25. Antigen retrieval immunohistochemistry: Past, present, and future
26. Expression and regulation of genes associated with cell death during murine preimplantation embryo development
27. Molecular cloning and functional analysis of the murine bax gene promoter
28. Development of mouse ovarian follicles from primary to preovulatory stages in vitro
29. Preliminary experience with subcutaneous human ovarian cortex transplantation in the NOD-SCID mouse
30. Ovarian aryl hydrocarbon hydroxylase activity and primordial oocyte toxicity of polycyclic aromatic hydrocarbons in mice