A dose-response analysis of the reproductive effects of a single gestational dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin in male Long Evans hooded rat offspring

Toxicology and Applied Pharmacology

Volumn 146, Issue 1, 1997, Pages 11-20

  Gray Jr , L E ^a   Ostby, J S ^a   Kelce, W R ^a  

^a Reproductive Toxicology Branch   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DELAYED PUBERTY; DOSE RESPONSE; EYE TOXICITY; FEMALE; MALE; NONHUMAN; RAT; REPRODUCTIVE TOXICITY; SPERMATOZOON COUNT; TESTIS;

ANIMALIA; CAPUT; GLANS;

EID: 0342601484     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1997.8223     Document Type: Article

References (34)

1. Bjerke D. L., Peterson R. E. Reproductive toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in male rats: Different effects of in utero versus lactational exposure. Toxicol. Appl. Pharmacol. 127:1994a;241-249.
2. Bjerke D. L., Sommer R. J., Moore R. W., Peterson R. E. Effects of in utero and lactational exposure on responsiveness of the male rat reproductive system to testosterone stimulation in adulthood. Toxicol. Appl. Pharmacol. 127:1994b;250-257.
3. Bjerke D. L., Brown T. J., MacLusky N. J., Hochberg R. B., Peterson R. E. Partial demasculinization and feminization of sex behavior in male rats by in utero and lactational exposure of male rats to 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) is not associated with alterations in estrogen receptor binding or volumes of sexually dimorphic brain nuclei. Toxicol. Appl. Pharmacol. 127:1994c;258-267.
4. Chen S. W., Roman B. L., Saroya S., Shinomiya K., Moore R. W., Peterson R. E. In utero exposure to 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) does not impair testosterone production by fetal rat testes. Toxicologist. 13:1993;104.
5. Cochran R. C., Ewing L. L., Niswender G. D. Serum levels of follicle stimulating hormone, prolactin, testosterone, 5α-dihydrotestosterone, 5α-androstan-3α,17β-diol, 5α-androstan-3β,17β-diol and 17β-estradiol from male beagle dogs with spontaneous or induced benign prostatic hyperplasia. Invest. Urol. 19:1981;142-147.
6. DeVito M., Birnbaum L., Farland W., Gasiewicz T. Comparison of estimated human body burdens of dioxin-like chemicals and TCDD body burdens in experimentally exposed animals. Environ. Health Perspect. 103:1995;820-831.
7. Goldey E. S., Kehn L. S., Lau C., Rehnberg G. L., Crofton K. M. Developmental Exposure to polychlorinated biphenyls (Aroclor 1254) reduces circulating thyroid hormone concentrations and causes hearing deficits in rats. Toxicol. Appl. Pharmacol. 135:1995;77-88.
8. Gray L. E. Chemical-induced alterations of sexual differentiation: A review of effects in humans and rodents. Advances in Modern Environmental Toxicology: Chemically-Induced Alterations in Sexual and Functional Development: The Wildlife/Human Connection. 1992;Princeton Scientific. p. 203-230.
9. Gray L. E. Jr., Ostby J., Ferrell J., Rehnberg G., Linder R., Cooper R., Goldman J., Slott V., Laskey J. A dose-response analysis of methoxychlor-induced alterations of reproductive development and function in the rat. Fundam. Appl. Toxicol. 12:1989;92-108.
10. Gray L. E., Ostby J. S., Kelce W. R. Developmental effects of an environmental antiandrogen: The fungicide vinclozolin alters sex differentiation of the male rats. Toxicol. Appl. Pharmacol. 129:1994;46-52.
11. Gray L. E. Jr., Kelce W. R., Monosson E., Ostby J. S., Birnbaum L. S. Exposure to TCDD during development permanently alters reproductive function in male LE rats and hamsters: Reduced ejaculated and epididymal sperm numbers and sex accessory gland weights in offspring with normal androgenic status. Toxicol. Appl. Pharmacol. 131:1995a;108-118.
12. Gray L. E. Jr., Ostby J. S. In utero 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters reproductive morphology and function in female rat offspring. Toxicol. Appl. Pharmacol. 133:1995b;285-294.
13. Gray L. E. Jr., Kelce W. R. Latent effects of pesticides and toxic substances on sexual differentiation of rodents. Toxicol. Indust. Health. 12:1996;515-531.
14. Gray L. E. Jr., Wolf C., Mann P., Ostby J. S. In utero. Toxicol. Appl. Pharmacol. 145:1997.
15. Guo Y., Lai T., Ju S., Chen Y., Hsu C. Sexual developments and biological findings in Yu-Cheng Children. Organohalogen Compounds. 14:1993;235-238.
16. Hurst C., DeVito M., Abbott B., Birnbaum L. 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) in pregnant rats: Distribution to maternal and fetal tissues. Toxicologist. 30:1996;198.
17. Hurst C., DeVito M., Abbott B., Birnbaum L. Dose-response of (TCDD) distribution in pregnant Long Evans rats. Toxicologist. 36:1997;257.
18. Johnson L., Dickerson R., Safe S. H., Nyberg C. L., Lewis R. P., Welsh T. H. Reduced Leydig cell volume and function in adult rats exposed to 2,3,7,8-TCDD without a significant effect on spermatogenesis. Toxicology. 76:1992;103-118.
19. Kelce W. R., Monosson E., Gamcsik M. P., Laws S. C., Gray L. E. Jr. Environmental hormone disruptors: Evidence that vinclozolin developmental toxicity is mediated by antiandrogenic metabolites. Toxicol. Appl. Pharmacol. 126:1994;275-285.
20. Khera K. S., Ruddick J. A. Polychlorodibenzo-p-dioxins: Perinatal effects and the dominant lethal test in Wistar rats. Blair E. H. Chlorodioxins - Origin and Fate. 1973;70-84 American Chemical Society, Washington.
21. Klinefelter G. R., Roman B. L., Peterson R. E. A single gestational TCDD exposure alters protein expression in the adult rat epididymis. Toxicologist. 15:1995;233-234.
22. G. R. Klinefelter, R. A. Hess, Toxicology of the male excurrent ducts and accessory glands, Reproductive and Developmental Toxicology, Korach, Dekker, New York.
23. Mably T., Moore R. W., Peterson R. E. In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin. 1. Effects on Androgenic status. Toxicol. Appl. Pharmacol. 114:1992a;97-107.
24. Mably T., Moore R. W., Goy R. W., Peterson R. E. In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin. 2. Effects on sexual behavior and the regulation of luteinizing hormone secretion in adulthood. Toxicol. Appl. Pharmacol. 114:1992b;108-117.
25. Mably T., Bjerke D. L., Moore R. W., Gendron-Fitzpatrick A., Peterson R. E. In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin. 3. Effects on spermatogenesis and reproductive capability. Toxicol. Appl. Pharmacol. 114:1992c;118-126.
26. Moore R. W., Potter C. L., Theobald H. M., Robinson J. A., Peterson R. E. Androgenic deficiency in male rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol. Appl. Pharmacol. 79:1985;99-111.
27. Murray F. J., Smith F. A., Nitschke K. D., Humiston C. G., Kociba R. J., Schwetz B. A. Three-generation reproduction study in rats given 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the diet. Toxicol. Appl. Pharmacol. 50:1979;241-252.
28. Schardein J. L. Hormones and hormonal antagonists. Chemically Induced Birth Defects. 1993;Dekker, New York. p. 271-339.
29. Schecter A., Startin J., Wright C., Papke O., Ball M., Lis A. Concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans in human placental and fetal tissues from the U.S. and Placentas from Yu-Cheng Exposed mothers. Chemosphere. 32:1996;551-557.
30. Schnabacher B. D., Ewing L. L. Simultaneous determination of testosterone, 5α-androstan-17β-ol-3-one, 5α-androstan-3α,17β-diol, and 5α-androstan-3β,17β-diol in plasma of adult male rabbits by radioimmunoassay. Endocrinology. 97:1975;787-792.
31. Shinomiya K., Bjerke D. L., Moore R. W., Hess R. A., Cooke P. S., Zucker R. W., Peterson R. E. Effects of in utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on spermatogenesis in rats. Toxicologist. 14:1994;382.
32. Sommer R., Ippolito D., Peterson R. In utero and lactational exposure of the male Holtzman rat to 2,3,7,8-tetrachlorodibenzo-p-dioxin: Decreased epididymal and ejaculated sperm numbers without alterations in sperm transit rate. Toxicol. Appl. Pharmacol. 140:1996;146-153.
33. Wilker C. E., Welsh T. H. Jr., Johnson L. Effects of perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on sertoli cell number and testicular function. Toxicologist. 15:1995;293.
34. Wilker C., Johnson L., Safe S. Effects of developmental exposure to indole-3-carbinol or 2,3,7,8-tetrachlorodibenzo-p-dioxin on reproductive potential of male rat offspring. Toxicol. Appl. Pharmacol. 141:1996;68-75.