Exposure to dioxin and nonneoplastic mortality in the expanded IARC international cohort study of phenoxy herbicide and chlorophenol production workers and sprayers

Environmental Health Perspectives

Volumn 106, Issue SUPPL. 2, 1998, Pages 645-653

  Vena, John ^a   Boffetta, Paolo ^b   Becher, Heiko ^c   Benn, Trevor ^d   Bas Bueno de Mesquita, H ^e   Coggon, David ^f   Colin, Didier ^b   Flesch Janys, Dieter ^g   Green, Lois ^h   Kauppinen, Timo ⁱ   Littorin, Margareta ^j   Lynge, Elsebeth ^k   Mathews, John D ^l   Neuberger, Manfred ^m   Pearce, Neil ⁿ   Pesatori, Angela C ^o   Saracci, Rodolfo ^p   Steenland, Kyle ^q   Kogevinas, Manolis ^r  

^a UNIVERSITY AT BUFFALO   (United States)

^b INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^d HEALTH AND SAFETY EXECUTIVE   (United Kingdom)

^e NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^f Med Res Cncl Environ E   (United Kingdom)

^g Med Ctr for Chem Workers' Health   (Germany)

^h ONTARIO HYDRO TECHNOLOGIES   (Canada)

ⁱ FINNISH INSTITUTE OF OCCUPATIONAL HEALTH   (Finland)

^j LUND UNIVERSITY   (Sweden)

^k DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^l MENZIES SCHOOL OF HEALTH RESEARCH   (Australia)

^m UNIVERSITY OF VIENNA   (Austria)

ⁿ UNIVERSITY OF OTAGO   (New Zealand)

^o UNIVERSITY OF MILAN   (Italy)

^p CNR   (Italy)

^q NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

^r INST MUNIC D INVESTIGACIO MEDICA   (Spain)

more..

Author keywords

Cardiovascular diseases; Diabetes; Dioxin; Epidemiology; Herbicides; Mortality

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; CHLOROPHENOL; HERBICIDE;

CARDIOVASCULAR DISEASE; COHORT ANALYSIS; CONFERENCE PAPER; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MORTALITY; OCCUPATIONAL EXPOSURE; PRIORITY JOURNAL;

EID: 0031803777     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.98106645     Document Type: Conference Paper

References (65)

1. IARC. Polychlorinated dibenzo-para-dioxins. In: IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol 69: Polychlorinated Dibenzo-para-dioxins and Polychlorinated Dibenzofurans. Lyon:International Agency for Research on Cancer, 1997;33-343.
2. U.S. Environmental Protection Agency. Health Assessment Document for 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and Related Compounds, Vols I-III. Rpt No EPA/600/BP-92/001. Washington:U.S. Government Printing Office, 1994.
3. Birnbaum LS. Evidence for the role of the Ah receptor in response to dioxin. In: Receptor Mediated Biological Processes: Implications for Evaluating Carcinogens. Progress in Clinical and Biological Research. Vol 387 (Spitzer HL, Slaga TL, Greenlee WF, McClain M, eds). New York:Wiley-Liss, 1994;139-154.
4. Swanson HF, Bradfield CA. The Ah receptor: genetics, structure and function. Pharmacogenetics 3:213-230 (1993).
5. Denison MS, Whitlock JP Jr. Xenobiotic-inducible transcription of cytochrome p450 genes. J Biol Chem 270:18175-18178 (1995).
6. Fuji-Kuriyama Y, Imataka H, Sogawa K, Yasumoto KI, Kiguchi Y. Regulation of CYP1A1 expression. FASEB J 6:706-710 (1992).
7. Lee DC, Barlow KD, Gaido KW. The actions of 2,3,7,8-tetrachlorodibenzo-p-dioxin on transforming growth factor-β2 promoter activity are localized to the TATA box binding region and controlled through a tyrosine kinase-dependent pathway, Toxicol Appl Pharmacol 137:90-99 (1996).
8. Lans MC, Spierty C, Brouwer A, Koeman JH. Different competition of thyroprine binding to transthyretin and thyroprine-binding globulin by hydroxy-PCBs, PCDDs, and PCDFs. Eur J Pharmacol 270:29-36 (1994).
9. Evan E, Matsumura F. Significance of TCDD-induced changes in protein phosphorylation in the adipocyte of male guinea pigs. J Biochem Toxicol 9:159-170 (1994).
10. Liu PC, Matsumura F. Differential effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the "adipose-type" and "brain-type" glucose transporter in mice. Mol Pharmacol 47:65-73 (1995).
11. Ryu BW, Roy S, Sparrow BR, Selivonchick DP, Schaup HW. Ah receptor involvement in mediation of pyruvate carboxylase levels and activity in mice given 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Biochem Toxicol 10:103-109 (1995).
12. Safe S. Modulation of gene expression and endocrine response pathways by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds. Pharmacol Ther 67:247-281 (1995).
13. Lathrop GD, Wolfe WH, Albanese RA, Moynihan PM. An epidemiologic investigation of health effects in Air Force personnel following exposure to herbicides. Baseline morbidity study results. Rpt No NTIS AD-A-138-340. Springfield., VA:National Technical Information Service, 1984.
14. Lathrop GD, Machado SG, Karrison TG, Grubs WE, Thomas WF, Wolfe WH, Michalek JE, Miner JC, Peterson MR. An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides; First Follow-up Examination Results, January 1985-September 1987. USAF-SAM-TR-87-27. Brooks Air Force Base, TX:U.S. Air Force School of Aerospace Medicine, Aerospace Medical Division, 1987.
15. U.S. Centers for Disease Control. Centers for Disease Control Vietnam Experience Study: health status of Vietnam veterans. II: Physical health. JAMA 259:2708-2714 (1988).
16. Roegner RH, Grubbs WD, Lustik MB, Brockman AS, Henderson AC, Williams DE, Wolfe WH, Michalek JE, Miner JC. Air Force Health Study: An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides: Serum Dioxin Analysis of 1987 Examination Results. Rpts NTIS AD-A-237-516-AD-A-237-524. Springfield, VA:National Technical Information Service, 1991.
17. Fingerhut MA, Halperin WE, Marlow DA, Piacitelli LA, Honchar PA, Sweeney MH, Greife AL, Dill PA, Steenland K, Suruda AJ. Cancer mortality in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. N Engl J Med 324:212-218 (1991).
18. Fingerhut MA, Halperin WE, Marlow DA, Piacitelli LA, Honchar PA, Sweeney MH, Greife AL, Dill PA, Steenland K, Suruda AJ. Mortality Among U.S. Workers Employed in the Production of Chemicals Contaminated with 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD). NIOSH Final Rpt PB91125971. Springfield, VA:National Technical Information Service, 1991.
19. Saracci R, Kogevinas M, Bertazzi P-A, Bueno de Mesquita BH, Coggon D, Green LM, Kauppinen T, L'Abbé KA, Littorin M, Lynge E et al. Cancer mortality in workers exposed to chlorophenoxy herbicides and chlorophenols. Lancet 338:1027-1032 (1991).
20. Kogevinas M, Becher H, Benn T, Bertazzi PA, Boffetta P, Bueno-de-Mesquita HB, Coggon D, Colin D, Flesch-Janys D, Fingerhut M et al. Cancer mortality in workers exposed to phenoxy herbicides, chlorophenols and dioxins: an expanded and updated international cohort study. Am J Epidemiol 145:1061-1075 (1997).
21. Flesch-Janys D, Berger J, Konietzko J, Gurn P, Manz A, Nagel S, Waltsgott H, Dwyer JH. Exposure to polychlorinated dioxins and furans (PCDD/F) and mortality in a cohort of workers from a herbicide producing plant in Hamburg, FRG. Am J Epidemiol 142:1165-1175 (1995).
22. Becher H, Flesch-Janys D, Kauppinen T, Kogevinas M, Steindorf K, Manz A, Wahrendorf J. Cancer mortality in German male workers exposed to phenoxy herbicides and dioxins. Cancer Causes Control 7:312-321 (1996).
23. Zober A, Ott MG, Messerer P. Morbidity followup study of BASF employees exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) after a 1953 chemical reactor incident. Occup Environ Med 51:479-486 (1994).
24. Ott MG, Zober A. Cause-specific mortality and cancer incidence among employees exposed to 2,3,7,8-TCDD after a 1953 reactor accident. Occup Environ Med 53:606-612 (1996).
25. Collins JJ, Strauss ME, Levinkas GJ, Conner PR. The mortality experience of workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin in a trichlorophenol process accident. Epidemiology 4:7-13 (1993).
26. Ramlow J, Spadacene N, Hoag C, Stafford B, Cartmill J, Lerner. Mortality in a cohort of pentachlorophenol workers, 1940-1989. Am J Ind Med 30:180-194 (1996).
27. Suskind RR, Hertzberg VS. Human health effects of 2,4,5-T and its toxic contaminants. JAMA 251:2372-2380 (1984).
28. Mocarelli P, Marocchi A, Brambilla P, Gerthoux P, Young DS, Mantel N. Clinical laboratory manifestations of exposure to dioxin in children. A six year study of the effects of an environmental disaster near Seveso, Italy. JAMA 256:2687-2695 (1986).
29. Bertazzi PA, Pesatori AC, Consonni D, Tironi A, Landi MT, Zocchetti C. Cancer incidence in a population accidentally exposed to 2,3,7,8-tetrachlorodibenzo-para-dioxin. Epidemiology 4:398-406 (1993).
30. Moses M, Lills R, Crow KD, Thornton J, Fischbein A, Anderson HA, Selikoff IJ. Health status of workers with past exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in the manufacture of 2,4,5-trichlorophenoxyacetic acid: comparison of findings with and without chloracne. Am J Ind Med 5:161-182 (1984).
31. Coggon D, Pannett B, Winter P. Mortality and incidence of cancer at four factories making phenoxy herbicides. Br J Ind Med 48:173-178 (1991).
32. Kauppinen T, Kogevinas M, Johnson E, Becher H, Bertazzi PA, Bueno de Mesquita HB, Coggon D, Green L, Littorin M, Lynge E et al. Chemical exposure in manufacture of phenoxy herbicides and chlorophenols and in spraying of phenoxy herbicides. Am J Ind Med 23:903-920 (1993).
33. Coleman M, Douglas A, Hermon C, Peto J. Cohort study analysis with a FORTRAN computer programme. Int J Epidemiol 15:134-137 (1986).
34. Payne CD. The GLIM System, Release 3.77. Oxford:Numerical Algorithms Group, 1985.
35. Boxer PA, Burnett C, Swanson M. Suicide and occupation: a review of the literature. J Occup Environ Med 37:442-452 (1995).
36. Violonti JM, Vena JE, Marshall Jr, Petralia S. A comparative evaluation of police suicide rate validity. Suicide Life Threat Behav 26:79-85 (1996).
37. Schiller CM, Adcock CM, Moore RA, Waiden R. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin and fasting on body weight and lipid parameters in rats. Toxicol Appl Pharmacol 81:356-361 (1985).
38. Kelline CK, Menahan LA, Peterson RE. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment on chemical function of the rat heart. Toxicol Appl Pharmacol 91:497-501 (1987).
39. Canga L, Rifkind R. Heart as a target organ in 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity: decreased beta-adrenergic responsiveness and evidence of increased intracellular calcium. Proc Natl Acad Sci USA 85:905-909 (1988).
40. Hermansky SJ, Holcslaw TL, Murray WJ, Markin RS, Stohs SJ. Biochemical and functional effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the heart of female rats. Toxicol Appl Pharmacof 95:175-184 (1988).
41. Kociba RJ, Keyes DG, Beyer JE, Carreon RM, Wade CE, Dittenber DA, Kalniza PP, Frowson LE, Park CN, Barnard SD et al. Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats. Toxicol Appl Pharmacol 46:279-303 (1978).
42. Kociba RJ, Keyes DG, Beyer JE, Carreon RM, Gehring PJ. Long-term toxicology studies of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in laboratory animals. Ann NY Acad Sci 320:397-404 (1979).
43. Sweeney MH, Hornung RW, Wall DK, Fingerhut MA, Halperin WE. Prevalence of diabetes and elevated serum glucose levels in workers exposed 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Organohalogen Compounds 10:225-226 (1992).
44. Wolfe WH, Michalek JE, Miner JC, Needham L, Patterson, D. Diabetes versus dioxin body burden in veterans of Operation Ranch Hand. Organohalogen Compounds 10:279-282 (1992).
45. Martin JV. Lipid abnormalities in workers exposed to dioxin. Br J Ind Med 41:254-256 (1984).
46. Cavert GM, Wille KK, Sweeney MH, Fingerhut MA, Halperin WE. Evaluation of serum lipid concentrations among U.S. workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Arch Environ Health 51:100-107 (1996).
47. Pesatori AC, Zocchetti C, Guercilena S, Consonni D, Turrini D, Bertazzi PA. Dioxin exposure and non-malignant health effects: a mortality study. Occup Environ Med (in press).
48. Grubbs WD, Lustik MB, Brockman AS, Henderson AC, Burnett FR, Land RG, Osborne DJ, Rocconi VK, Schrieber ME, Willliams DE et al. Air Force Health Study. An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. Vol III: 1992 Followup Examination Results, May 2, 1995. Springfield, VA:National Technical Information Service, 1995.
49. Henriksen GL, Ketchum NS, Michalek JE, Swaby JA. Serum dioxin and diabetes mellitus in veterans of Operation Ranch Hand. Epidemiology 8:252-258 (1997).
50. Ridker PM, Cushman M, Stampfer MJ, Tracy PP, Hennekens CH. Inflammation, aspirin and the risk of cardiovascular disease in apparently healthy men. New Engl J Med 336:973-979 (1997).
51. Bataille R, Klein B. C-reactive protein levels as a direct indicator of interleukin-6 levels in humans in vivo. Arthritis Rheum 35:982-984 (1992).
52. Sutter TR, Guzman K, Dold KM, Greenlee WF. Targets for dioxin: genes for plasminogen activator inhibitor-2 and interleukin 1β. Science 254:415-418 (1991).
53. Zober A, Messerer P, Huber P. Thirty-four-year mortality follow-up of BASF employees exposed to 2,3,7,8-TCDD after the 1953 accident. Int Arch Occup Environ Health 62:139-157 (1990).
54. Bond GG, McLaren EA, Brenner FE, Cook RR. Incidence of chloracne among chemical workers potentially exposed to chlorinated dioxins, J Occup Med 31:771-774 (1989).
55. Zack JA, Gaffey WR. A mortality study of workers employed at the Monsanto Company plant in Nitro, West Virginia. In: Human and Environmental Risks of Chlorinated Dioxins and Related Compounds (Tuckes RE, Young AL, eds). New York:Plenum Press, 1983:575-591.
56. Ott MG, Oison RA, Cook RR, Bond GG. Cohort mortality study of chemical workers with potential exposure to higher chlorinated dioxins. J Occup Med 29:422-429 (1987).
57. Bond GG, McLaren EA, Lipps TE, Cook RR. Update of mortality among chemical workers with potential exposure to higher chlorinated dioxins. J Occup Med 31:121-123 (1989).
58. Green LM. A cohort mortality study of forestry workers exposed to phenoxyacid herbicides. Br J Ind Med 48:234-238 (1991).
59. Bueno de Mesquita HB, Doornbos G, van der Kuip DAM, Kogevinas M, winkelmann R. Occupational exposure to phenoxy herbicides and chlorophenols and cancer mortality in the Netherlands. Am J Ind Med 23:289-300 (1993).
60. Ketchum N, Akhtar F, Air Force Health Study: An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides: Mortality Update 1996. Rpt AL/AO-TR-1996-0068. Brooks Air Force Base, TX:U.S. Air Force School of Aerospace Medicine, Aerospace Medical Division, 1996.
61. Pesatori AC, Landi MT, Bernucci I, Bertazzi PA, Zochetti C, Tironi A, Mascagni P. Fifteen-year follow up for nonmalignant health outcomes after dioxin exposure. Organohalogen Compounds 30:298-301 (1996).
62. Green LM. Suicide and exposure to phenoxy acid herbicides. Scand J Work Environ Health 13:460 (1987).[Letter].
63. IARC. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Volume 41: Some Halogenated Hydrocarbons and Pesticide Exposures. Lyon:International Agency for Research on Cancer, 1986.
64. Oliver RM. Toxic effects of 2,3,7,8-tetrachlorodibenzo-1,4-dioxin in laboratory workers. Br J Ind Med 32:49-53 (1975).
65. Poland AP, Smith D, Metter G, Possick P. A health survey of workers in a 2,4-D and 2,4,5-T plant. Arch Environ Health 22:316-327 (1971).