Interactions between aryl hydrocarbon receptor (AhR) and hypoxia signaling pathways

Environmental Toxicology and Pharmacology

Volumn 10, Issue 1-2, 2001, Pages 17-27

  Nie, Minghua ^a   Blankenship, Alan L ^a,b   Giesy, John P ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b ENTRIX INC   (United States)

Author keywords

Ah Receptor; ARNT; HIF 1 ; Hypoxia; In vitro; PAS

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; COBALT CHLORIDE; CYTOCHROME P450 1A1; DEFEROXAMINE; DIOXIN; LUCIFERASE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DNA BINDING; GENE EXPRESSION; HUMAN; HUMAN CELL; HYPOXIA; MOUSE; NONHUMAN; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN BINDING; RAT; REPORTER GENE;

EID: 0034992644     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1382-6689(01)00065-5     Document Type: Article

References (81)

1. Effects of TCDD on embryonic ureteric epithelial EGF receptor expression and cell proliferation
2. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced changes in activities of nuclear protein kinases and phosphatases affecting DNA binding activity of c-MYC and AP-1 in the livers of guinea pigs
3. Organization and characterization of the rat class 3 aldehyde dehydrogenase gene
4. DNA binding of the transformed guinea pig hepatic Ah receptor complex: Identification and partial characterization of two high-affinity DNA binding forms
5. TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) causes increases in protein kinases, particularly protein kinase C, in the hepatic plasma membrane of the rat and the guinea pig
6. Erythropoietin: A model system for studying oxygen-dependent gene regulation
7. Regulatory squelching
8. Embryotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): The embryonic vasculature is a physiological target for TCDD-induced DNA damage and apoptotic cell death in Medaka (Orizias latipes
9. Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivo
10. Cross-talk between the aryl hydrocarbon receptor and hypoxia inducible factor signaling pathways-Demonstration of competition and compensation
11. Dioxin induces transforming growth factor-a in human keratinocytes
12. Tumor necrosis factor involvement in 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated endotoxin hypersensitivity in C57BL/6J mice congenic at the Ah locus
13. Aryl hydrocarbon receptor imported into the nucleus following ligand binding is rapidly degraded via the cytoplasmic proteasome following nuclear export
14. Protein-DNA interactions at recognition sites for the dioxin-Ah receptor complex
15. Characterization of the interaction of transformed rat hepatic cytosolic Ah receptor with a dioxin responsive transcriptional enhancer
16. DNA binding by the heterodimeric Ah receptor: Relationship to dioxin-induced CYP1A1 transcription in vivo
17. Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct cis-acting sequences
18. Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein
19. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced alterations in protein phosphorylation in guinea pig adipose tissue
20. Transcriptional regulation of the rat NAD(P)H: Quinone reductase gene. Identification of regulatory elements controlling basal level expression and inducible expression by planar aromatic compounds and phenolic antioxidants
21. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
22. Species-specific recombinant cell lines as bioassay systems for the detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals
23. Oxygen- and dioxin-regulated gene expression in mouse hepatoma cells
24. Dioxins, dibenzofurans, PCBs and colonial, fish-eating water birds
25. Deformities in birds of the Great Lakes region: Assigning causality
26. Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin
27. Functional interference between hypoxia and dioxin signal transduction pathways: Competition for recruitment of the Arnt transcription factor
28. The hypoxic response: Huffing and hifing
29. The aryl hydrocarbon receptor: A comparative perspective
30. The aryl hydrocarbon receptor complex
31. Characterization of a subset of the basci-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway
32. Determination of aryl hydrocarbon receptor nuclear translocator protein concentration and subcellular localization in hepatic and nonhepatic cell culture lines: Development of quantitative western blotting protocols for caculation of aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein in total cell lysates
33. Regulation of hypoxia-inducible factor 1a is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway
34. PER protein interactions and temperature compensation of a circadian clock in Drosophila
35. Tubulogenesis in Drosophila: A requirement for the trachealess gene product
36. Cellular and developmental control of O2 homostasis by hypoxia-inducible factor 1a
37. Dimerization, DNA binding, and transaction properties of hypoxia-inducible factor 1
38. Signal transduction in hypoxic cells: Inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1a
39. Activation of hypoxia-inducible factor 1a: Posttranscriptional regulation and conformational change by recruitment of the Arnt trancription factor
40. Simultaneous measurement of cytochrome P4501A catalytic activity and total protein concentration with a fluorescence plate reader
41. Positional cloning of the mouse circadian clock gene
42. CBP/p300 functions as a possible transcriptional coactivator of Ah receptor nuclear translocator (Arnt)
43. ARNT-deficient mice and placental differentiation
44. Deformities, PCBs, and TCDD-equivalents in double-crested cormorants (Phalacrocorax auritus) and Caspian terns (Hydroprogne caspia) of the Upper Great Lakes 1986-1991: Testing a cause-effect hypothesis
45. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced degradation of aryl hydrocarbon receptor (AhR) by the ubiquitin-proteasome pathway
46. A novel cytoplasmic protein that interacts with the Ah receptor, contains tetraicopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin
47. Anormal angiogenesis and response to glucose and oxygen deprivation in mice lacking the protein ARNT
48. Mechanism of action of dioxin-type chemicals, pesticides, and other xenobiotics affecting nutritional indexes
49. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
50. The murine Sim-2 gene product inhibits transcription by active repression and functional interference
51. The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development
52. Role of the Ah receptor and the dioxin-inducible [Ah] gene battery in toxicity, cancer, and signal transduction
53. MyoD family: A paradigm for development?
54. Molecular biology of the aromatic hydrocarbon (dioxin) receptor
55. Analysis of the upstream elements of the xenobiotic compound-inducible and positionally regulated glutathione S-transferase Ya gene
56. Short-term toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in laboratory animals: Effects, mechanisms, and animal models
57. Stereospecific high affinity binding of 2,3,6,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol
58. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: Examination of the mechanism of toxicity
59. Role of the PAS domain in regulation of dimerization and DNA binding specificity of the dioxin receptor
60. Role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon (dioxin) receptor action
61. The human cytochrome Cyp1A2 gene contains regulatory elements responsive to 3-methylcholanthrene
62. Comparative toxicology and mechanism of action of polychlorinated dibenzo-p-dioxins and dibenzofurans
63. Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: Environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs)
64. Absolute requirement of aryl hydrocarbon receptor nuclear translocator protein for gene activation by hypoxia
65. Hypoxia-induced factor 1a (HIF-1a) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions
66. Comparison of Ah receptor-mediated luciferase and ethoxyresorufin-o-deethylase induction in H4IIE cells: Implications for their use as bioanalytical tools for the detection of polyhalogenated aromatic hydrocarbons
67. Ah receptor signaling pathways
68. Regulation of erythropoietin production
69. Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene
70. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
71. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
72. Possible function of Ah receptor nuclear translocator (Arnt) homodimer in transcriptional regulation
73. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
74. Expression of the aryl hycarbon receptor (AhR) and AhR nuclear translocator during chick cardiogenesis is consistent with 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced heart defects
75. Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia
76. Oxygen(es) and the hypoxia-inducible factor-1
77. The regulation of gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin
78. Genetic and molecular aspects of 2,3,7,8-tetrachlorodibenzo-p-dioxin action
79. Mechanistic aspects of dioxin action
80. The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression
81. The nuclear hormone receptor co-activator SRC-1 is a specific target of p300