Generation of reactive oxygen species by tyrosine hydroxylase: A possible contribution to the degeneration of dopaminergic neurons?

Journal of Neurochemistry

Volumn 68, Issue 1, 1997, Pages 328-332

  Haavik, Jan ^a   Almås, Bjørg ^a   Flatmark, Torgeir ^a  

^a UNIVERSITY OF BERGEN   (Norway)

Author keywords

Dopaminergic neurons; Neurodegeneration; Oxidative stress; Parkinson's disease; Reactive oxygen species; Tyrosine hydroxylase

Indexed keywords

HYDROGEN PEROXIDE; HYDROXYL RADICAL; REACTIVE OXYGEN METABOLITE; TYROSINE; TYROSINE 3 MONOOXYGENASE;

ARTICLE; DOPAMINERGIC NERVE CELL; ENZYME ACTIVITY; HUMAN; NERVE CELL DEGENERATION; OXIDATIVE STRESS; PARKINSONISM; PRIORITY JOURNAL;

EID: 0031017290     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.68010328.x     Document Type: Article

References (32)

1. Beal M. F. (1995) Mitochondrial Dysfunction and Oxidative Damage in Neurodegenerative Diseases, Springer-Verlag, New York.
2. Blair J. A. and Pearson A. J. (1974) Kinetics and mechanism of the autoxidation of the 2-amino-4-hydroxy-5,6,7,8-tetrahydropteridines. J. Chem. Soc. Perkin Trans. II, 80-88.
3. Burkitt M. J. and Gilbert B. C. (1991) The autoxidation of iron(II) in aqueous systems: the effects of iron chelation by physiological, non-physiological and therapeutic chelators on the generation of reactive oxygen species and the inducement of biomolecular damage. Free Radic. Res. Commun. 14, 107-123.
4. Davis M. D. and Kaufman S. (1991) Studies on the partially uncoupled oxidation of tetrahydropterins by phenylalanine hydroxylase. Neurochem. Res. 16, 813-819.
5. Davis M. D. and Kaufman S. (1993) Products of the tyrosine-dependent oxidation of tetrahydrobiopterin by rat liver phenylalanine hydroxylase. Arch. Biochem. Biophys. 304, 9-16.
6. Davis M. D., Ribeiro P., Tipper J., and Kaufman S. (1992) "7-Tetrahydrobiopterin," a naturally occurring cofactor analogue of tetrahydrobiopterin, is a cofactor for and a potential inhibitor of the aromatic amino acid hydroxylases. Proc. Natl. Acad. Sci. USA 89, 10109-10113.
7. Dumas S., Le Hir H., Bodeau-Péan S., Hirsch E., Thermes C., and Mallet J. (1996) New species of human tyrosine hydroxylase mRNA are produced in variable amounts in adrenal medulla and are overexpressed in progressive supranuclear palsy. J. Neurochem. 67, 19-25.
8. Fahn S. and Cohen G. (1992) The oxidant stress hypothesis in Parkinson's disease: evidence supporting it. Ann. Neurol. 32, 804-812.
9. Floyd R. A., Lewis C. A., and Wong P. K. (1984) High-pressure liquid chromatography-electrochemical detection of oxygen free radicals. Methods Enzymol. 105, 231-237.
10. Fulton A. B. (1982) How crowded is the cytoplasm? Cell 30, 345-347.
11. Gutteridge J. M. C., Nagy I., Maidt L., and Floyd R. A. (1990) ADP-iron as a Fenton reactant: radical reactions detected by spin trapping, hydrogen abstraction and aromatic hydroxylation. Arch. Biochem. Biophys. 277, 422-428.
12. Haavik J. and Flatmark T. (1980) Rapid and sensitive assay of tyrosine 3-monooxygenase activity by high-performance liquid chromatography using the native fluorescence of DOPA. J. Chromatogr. 198, 511-515.
13. Haavik J., Døskeland A. P., and Flatmark T. (1986) Stereoselective effects in the interactions of pterin cofactors with rat-liver phenylalanine hydroxylase. Eur. J. Biochem. 160, 1-8.
14. Haavik J., Andersson K. K., Petersson L., and Flatmark T. (1988) Soluble tyrosine hydroxylase (tyrosine 3-monooxygenase) from bovine adrenal medulla: large scale purification and physicochemical properties. Biochim. Biophys. Acta 953, 142-156.
15. Haavik J., Le Bourdelles B., Martinez A., Flatmark T., and Mallet J. (1991) Recombinant human tyrosine hydroxylase isozymes. Reconstitution with iron and inhibitory effect of other metal ions. Eur. J. Biochem. 199, 371-378.
16. Hirsch E. C. (1993) Does oxidative stress participate in nerve cell death in Parkinson's disease? Eur. Neurol. 33 (Suppl. 1), 52-59.
17. Hirsch E. C., Graybiel A. M., and Agid Y. (1988) Melanized dopaminergic neurons are differentially affected in Parkinson's disease. Nature 334, 345-348.
18. Kastner A., Hirsch E. C., Agid Y., and Javoy-Agid F. (1993) Tyrosine hydroxylase protein and messenger RNA in the dopaminergic nigral neurons of patients with Parkinson's disease. Brain Res. 606, 341-345.
19. Kaufman S. (1995) Tyrosine hydroxylase, in Advances in Enzymology and Related Areas of Molecular Biology, Vol. 70 (Meister A., ed), pp. 103-220. John Wiley, New York.
20. Le Bourdelles B., Horellou P., Le Caer J. P., Denèfle P., Latta M., Haavik J., Guibert B., Mayaux J. F., and Mallet J. (1991) Phosphorylation of human recombinant tyrosine hydroxylase isoforms 1 and 2. An additional phosphorylated residue in TH2 isoform, generated through alternative splicing. J. Biol. Chem. 266, 17124-17130.
21. Loida P. J. and Sligar S. G. (1993) Molecular recognition in cytochrome P-450: mechanism for the control of uncoupling reactions. Biochemistry 32, 11530-11538.
22. Mallet J. (1996) Catecholamines: from gene regulation to neuropsychiatric disorders. Trends Neurosci. 19, 191-196.
23. Martinez A., Abeygunawardana C., Haavik J., Flatmark T., and Mildvan A. S. (1993) Conformation and interaction of phenylalanine with the divalent cation at the active site of human recombinant tyrosine hydroxylase as determined by proton NMR. Biochemistry 32, 6381-6390.
24. Matsubara C., Nishikawa Y., Yoshida Y., and Takamura K. (1983) Spectrophotometric determination of hydrogen peroxide with titanium 2-((5-bromopyridyl) azo)-5-(N-propyl-N-sulfopropylamino) phenol reagent and its application to the determination of serum glucose oxidase. Anal. Biochem. 130, 128-133.
25. Meyer W., Schünemann V., Winkler H., Trautwein A. X., Bill E., Haavik J., Martinez A., Flatmark T., and Nolting H.-F. (1996) Characterization of the iron environment in human tyrosine hydroxylase using Mössbauer, EPR and EXAFS-spectroscopy. Conf. Proc. Ital. Phys. Soc. 50, 819-822.
26. Ordway G. A., Smith K. S., and Haycock J. W. (1994) Elevated tyrosine hydroxylase in the locus ceruleus of suicide victims. J. Neurochem. 62, 680-685.
27. 3H]tyrosine by charcoal. Life Sci. 39, 2185-2189.
28. Richmond R., Halliwell B., Chauhan J., and Darbre A. (1981) Superoxide-dependent formation of hydroxyl radicals: detection of hydroxyl radicals by the hydroxylation of aromatic compounds. Anal. Biochem. 118, 328-335.
29. Roskoski R. Jr., Gahn L. G., and Roskoski L. M. (1993) Inactivation of phosphorylated rat tyrosine hydroxylase by ascorbate in vitro. Eur. J. Biochem. 218, 363-370.
30. Sibille J.-C., Doi K., and Aisen P. (1987) Hydroxyl radical formation and iron-binding proteins. Stimulation by the purple acid phosphatases. J. Biol. Chem. 262, 59-62.
31. Towell J. and Kalyanaraman B. (1991) Detection of radical adducts of 5,5-dimethyl-1-pyrroline N-oxide by the combined use of high-performance liquid chromatography with electrochemical detection and electron spin resonance. Anal. Biochem. 196, 111-119.
32. Vrana S. L., Azzaro A. J., and Vrana K. E. (1992) Chronic selegiline administration transiently decreases tyrosine hydroxylase activity and mRNA in the rat nigrostriatal pathway. Mol. Pharmacol. 51, 839-844.