Induction of cytochrome P4501A1: A model for analyzing mammalian gene transcription

FASEB Journal

Volumn 10, Issue 8, 1996, Pages 809-818

  Whitlock Jr , James P ^a   Okino, Steven T ^a   Dong, Liqun ^a   Ko, Hyunsung P ^a   Clarke Katzenberg, Regina ^a   Ma, Qiang ^a   Li, Hui ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Ah receptor; basic helix loop helix proteins; chromatin structure; dioxin; protein DNA interactions

Indexed keywords

AROMATIC HYDROCARBON; CYTOCHROME P450; TRANSCRIPTION FACTOR;

ANIMAL CELL; CHROMATIN STRUCTURE; ENHANCER REGION; ENZYME INDUCTION; ENZYME MECHANISM; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REVIEW; TRANSCRIPTION REGULATION; ANIMAL; BIOLOGICAL MODEL; BIOSYNTHESIS; FORECASTING; GENETICS; MAMMAL;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; FORECASTING; MAMMALS; MODELS, BIOLOGICAL; TRANSCRIPTION, GENETIC;

EID: 0030163010     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.10.8.8666157     Document Type: Review

References (44)

1. Conney, A. H. (1982) Induction of microsomal enzymes by foreign compounds and carcinogenesis by polycyclic aromatic hydrocarbons. Cancer Res. 42, 4875-4917
2. Jerina, D. M., and Daly, J. W. (1974) Arene oxides: A new aspect of drug metabolism. Science 185, 573-582
3. Gelboin, H. V. (1980) Benzo(a)pyrene metabolism, activation, and carcinogenesis: Role and regulation of mixed-function oxidases and related enzymes. Physiol. Rev. 60, 1107-1166
4. Okey, A. B. (1990) Enzyme induction in the cytochrome P450 system. Pharmacol. Ther. 45, 241-298
5. Poland, A., and Knudson, J. C. (1982) 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related aromatic hydrocarbons: examination of the mechanism of toxicity. Annu. Rev. Pharmacol. Toxicol. 22, 517-554
6. Okey, A. B., Riddick, D. S., and Harper, P. A. (1994) Molecular biology of the aromatic hydrocarbon (dioxin) receptor. Trends Pharrnacol. Sci. 15, 226-232
7. Swanson, H. I., and Bradfield, C. A. (1993) The AH-receptor: genetics, structure and function. Pharmacogenetics 3, 213-230
8. Hankinson, O. (1995) The aryl hydrocarbon receptor complex. Annu. Rev. Pharmacol. Toxicol. 35, 307-340
9. Safe, S. H. (1986) Comparative toxicology and mechanism of action of polychlorinated dibenzo-p-dioxins and dibenzofurans. Annu. Rev. Pharmacol. Toxicol. 26, 371-399
10. Huff, J., Lucier, G., and Tritsher, A. (1994) Carcinogenicity of TCDD: experimental, mechanistic, and epidemiological evidence. Annu. Rev. Pharmacol. Toxicol. 34, 343-372
11. Gonzalez, F. J., and Nebert, D. W. (1990) Evolution of the P450 gene superfamily. Trends Genet. 6, 182-186
12. Fernandez-Salguero, P., Pineau, T., Hilbert, D. M., McPhail, T., Lee, S. S. T., Kimura, S., Nebert, D. W., Rudikoff, S., Ward, J. M., and F. J. Gonzalez. (1995) Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor. Science 268, 722-726
13. Fujii-Kuriyama, Y., Imatakaa, H., Sogawa, K., Yasumoto, K., and Kikuchi, Y. (1992) Regulation of CKP1A1 expression. FASEB J. 6, 706-710
14. Whitlock, J. P., Jr. (1993) Mechanistic aspects of dioxin action. Chem. Res. Toxicol. 6, 754-763
15. Shen, E. S., and Whitlock, J. P., Jr. (1992) Protein-DNA interactions at a dioxin-responsive enhancer: mutational analysis of the DNA-binding site for the liganded Ah receptor. J. Biol. Chem. 267, 6815-6819
16. Kadesch, T. (1993) Consequences of heteromeric interactions among helix-loop-helix proteins. Cell Growth Differ. 4, 49-55
17. Jones, K. W., and Whitlock, J. P., Jr. (1990) Functional analysis of the transcriptional promoter for the CYP1A1 gene. Mol. Cell. Biol. 10, 5098-5105
18. Pollenz, R. S., Sattler, C. A., Poland, A. (1993) The aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein show distinct subcellular localizations in Hepa lclc7 cells by immunfluorescence microscopy. Mol. Pharmacol. 45, 428-438
19. Pongratz, I., Mason, G. G. F., and Poellinger, L. (1992) Dual roles of the 90 kDA heat shock protein hsp90 in modulating functional activities of the dioxin receptor. J. Biol. Chem. 267, 13728-13734
20. Carver, L.A., Jackiw, V., and Bradfield, C. A. (1994) The 90-kDa heat shock protein is essential for Ah receptor signaling in a yeast expression system. J. Biol. Chem. 269, 30109-30112
21. Whitelaw, M.L., McGuire, J., Picard, D., Gustafsson, J.-A., and Poellinger, L. (1995) Heat shock protein hsp90 regulates dioxin receptor function in vivo. Proc. Natl. Acad. Sci. 92, 4437-4441
22. Henry, E. C., and Gasciewicz, T. A. (1993) Transformation of the aryl hydrocarbon receptor to a DNA-binding form is accompanied by release of the 90kDa heat-shock protein and increased affinity for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochem. J. 294, 95-101
23. McGuire, J., Whitelaw, M. L., Pongratz, I., Gustafsson, J.-A., and Poellinger, L. (1994) A cellular factor stimulates ligand-dependent release of hsp90 from the basic helix-loop-helix dioxin receptor. Mol. Cell. Biol. 14, 2438-2446
24. Reyes, H., Reisz-Porszasz, S., and Hankinson, O. (1992) Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor. Science 256, 1193-1195
25. Matsushita, N., Sogawa, K., Ema, M., Yoshida, A., and Fujii-Kuriyama, Y. (1993) A factor binding to the xenobiotic responsive element (XRE) of P-450IA1 gene consists of at least two helix-loop-helix proteins, Ah receptor and Arnt. J. Biol. Chem. 268, 21002-21006.
26. Probst, M. R., Reisz-Porszasz, S., Agbunag, V., Ong, M. S., and Hankinson, O. (1993) Role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon (dioxin) receptor action. Mol. Pharmacol. 44, 511-518
27. Whitelaw, M., Pongratz, I., Wilhelmsson, A., Gustafsson, J.-Å., and Poellinger, L. (1993) Ligand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptor. Mol. Cell. Biol. 13, 2504-2514
28. Dolwick, K. M., Swanson, H. I., and Bradfield, C. A. (1993) In vitro analysis of Ah receptor domains involved in ligand-activated DNA recognition. Proc. Natl. Acad. Sci. USA 90, 8566-8570
29. Bacsi, S. C., Reisz-Porszasz, S., and Hankinson, O. (1995) Orientation of the heterodimeric aryl hydrocarbon (dioxin) receptor complex on its asymmetric DNA recognition sequence. Mol Pharmacol. 47, 432-438
30. Lindebro, M. C., Poellinger, L., and Whitelaw, M. L. (1995) Protein-protein interaction via PAS domains: role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex. EMBO J. 14, 3528-3539
31. Jain, S., Dolwick, K. M., Schmidt, J. V., and Bradfield, C. A. (1994) Potent transactivation domains of the Ah receptor and the Ah receptor nuclear translocator map to their carboxyl termini. J. Biol. Chem. 269, 31518-31524
32. Li, H., Dong, L., and Whitlock, J. P., Jr. (1994) Transcriptional activation function of the mouse Ah receptor nuclear translocator. J. Biol. Chem. 269, 28098-28105
33. Reisz-Porszasz, S., Probst, M. R., Fukunaga, B. N., and Hankinson, O. (1994) Identification of functional domains of the aryl hydrocarbon receptor nuclear translocator protein (ARNT). Mol. Cell. Biol 14, 6075-6086
34. Whitelaw, M., Gustafsson, J.-Å., and Poellinger, L. (1994) Identification of transactivation and repressive functions of the dioxin receptor and its basic helix-loop-helix/PAS partner factor Arnt: inducible versus constitutive modes of regulation. Mol. Cell. Biol. 14, 8343-8355
35. Ma, Q., Dong, L., and Whitlock, J. P., Jr. (1995) Transcriptional activation by the mouse Ah receptor, Interplay between multiple stimulatory and inhibitory functions. J. Biol. Chem. 270, 12697-12703
36. Berghard, A., Gradin, K., Pongratz, I., Whitelaw, M., and Poellinger, L. (1993) Cross-coupling of signal transduction pathways: the dioxin receptor mediates induction of cytochrome P4501A1 expression via a protein kinase C mechanism. Mol. Cell. Biol. 13, 677-689
37. Paranjape, S. M., Kamakaka, R. T., and Kadonaga, J. T. (1994) Role of chromatin structure in the regulation of transcription by RNA polymerase II. Annu. Rev. Biochem. 63, 265-297
38. Morgan, J. E., and Whitlock, J. P., Jr. (1992) Transcription-dependent and transcription-independent nucleosome disruption induced by dioxin. Proc. Natl. Acad. Sci. USA 89, 11622-11626
39. Wu, L., and Whitlock, J. P., Jr. (1992) Mechanism of dioxin action: Ah receptor-mediated increase in promoter accessibility in vivo. Proc. Natl. Acad. Sci. USA 89, 4811-4815
40. Wu, L., and Whitlock, J. P., Jr. (1993) Mechanism of dioxin action: receptor-enhancer interactions in intact cells. Nucleic Acids Res. 21, 119-125
41. Okino, S. T., and Whitlock, J. P., Jr. (1995) Dioxin induces localized, graded changes in chromatin structure: implications for CYP1A1 gene transcription. Mol. Cell. Biol. 15, 3714-3721
42. Ko, H. P., Okino, S. T., Ma, Q., and Whitlock, J. P., Jr. (1996) Dioxin-induced CYP1A1 transcription in vivo: Ah receptor mediates transactivation, enhancer-promoter communication, and changes in chromatin structure. Mol. Cell. Biol. 16, 430-436
43. 2 tension. Proc. Natl. Acad. Sci. USA 92, 5510-5514
44. Nebert, D. W. (1991) Proposed role of drug-metabolizing enzymes: regulation of steady-state levels of the ligands that effect growth, homeostasis, differentiation, and neuroendocrine functions. Mol Endocrinol. 5, 1203-1214