NAD(P)H:Quinone oxidoreductase 1 deficiency increases susceptibility to benzo(a)pyrene-induced mouse skin carcinogenesis

Cancer Research

Volumn 60, Issue 21, 2000, Pages 5913-5915

  Long II, D J ^a   Waikel, R L ^a   Wang, X J ^a   Perlaky, L ^a   Roop, D R ^a   Jaiswal, A K ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZO[A]PYRENE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (QUINONE); RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER SUSCEPTIBILITY; CELL PROLIFERATION; CELL PROTECTION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEFICIENCY; FEMALE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN CARCINOGENESIS;

ANIMALS; BENZO(A)PYRENE; BIOTRANSFORMATION; CARCINOGENS; COCARCINOGENESIS; DISEASE SUSCEPTIBILITY; FEMALE; MALE; MICE; MICE, INBRED A; MODELS, ANIMAL; NAD(P)H DEHYDROGENASE (QUINONE); SKIN; SKIN NEOPLASMS; TETRADECANOYLPHORBOL ACETATE;

EID: 0034326245     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Benzo[a]pyrene metabolism, activation and carcinogenesis: Role and regulation of mixed-function oxidases and related enzymes
2. Roles of cytochromes P-450 enzymes in chemical carcinogenesis and cancer chemotherapy
3. Chemoprotection against cancer by phase 2 enzyme induction
4. DT-diaphorase and cancer chemotherapy
5. Gene expression of DT-diaphorase (NQO1) in cancer cells
6. Glutathione-S-transferases, structure, regulation and therapeutic implications
7. Regulation of γ-glutamylcysteine synthetase subunit gene expression: Insights into transcriptional control of antioxidant defenses
8. Chemoprevention of cancer
9. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates
10. Disruption of the DT diaphorase (NQO1) in mice leads to increased menadione toxicity
11. Covalent binding of benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxides to DNA: Molecular structures, induced mutations and biological consequences
12. Toxicity of metabolic benzo[a]pyrenediones to cultured cells and the dependence upon molecular oxygen
13. NAD(P)H:quinone oxidoreductase 1 (DT diaphorase) specifically prevents the formation of benzo[a]pyrene quinone-DNA adducts generated by cytochrome P4501AI and P450 reductase
14. Mutagenicity of quinones: Pathways of metabolic activation and detoxification
15. Tumor initiating and promoting activities of various benzo[a]pyrene metabolites in mouse skin
16. NAD(P)H:quinone oxidoreductase 1 (NQO1) reduces the mutagenicity of DNA caused by NAD(P)H:P450 reductase activated metabolites of benzo[a]pyrene quinones
17. Characterization of skin tumor promotion by mirex: Structure-activity relationships, sexual dimorphism and presence of Ha-ras mutation
18. Localization of human NQO1 gene to chromosome 16q22 and NQO2-6p25 and associated polymorphism
19. DT-diaphorase: Possible roles in cancer chemotherapy and carcinogenesis
20. Benzene poisoning, a risk factor for hematological malignancy, is associated with the NQO1 609C→T mutation and rapid fractional excretion of chlorzoxazone
21. Prevalence of the inactivating 609 C→T polymorphism in the NAD(P)H:quinone oxidoreductase 1 (NQO1) gene in patients with primary and therapy-related myeloid leukemia