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Because of journal-imposed space limitations, it was not possible to include a comprehensive list of references to all work cited; many of these references can be found in (1). I thank my colleagues at Columbia University and other institutions who contributed to the research cited, A. Rundle for graphics, and C. Rodriguez for help in preparation of the manuscript. Supported in part by grants from NIH, the National Institute of Environmental Health Sciences, and the U.S. Departments of Energy and Defense.
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