Building a multigenic model of breast cancer susceptibility: CYP17 and HSD17B1 are two important candidates

Cancer Research

Volumn 61, Issue 2, 2001, Pages 785-789

  Feigelson, Heather Spencer ^a,b   McKean Cowdin, Roberta ^b   Coetzee, Gerhard A ^b,c   Stram, Daniel O ^b   Kolonel, Laurence N ^d   Henderson, Brian E ^b  

^a AMERICAN CANCER SOCIETY   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d UNIVERSITY OF HAWAII CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 17; CYTOCHROME P450 ISOENZYME; UNCLASSIFIED DRUG;

AGE; ALLELE; ARTICLE; BODY WEIGHT; BREAST CANCER; CANCER INCIDENCE; CANCER RISK; CANCER SUSCEPTIBILITY; CONTROLLED STUDY; DNA POLYMORPHISM; ESTROGEN METABOLISM; ETHNOLOGY; FEMALE; GENOTYPE; HIGH RISK POPULATION; HORMONE SUBSTITUTION; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL;

17-HYDROXYSTEROID DEHYDROGENASES; AGED; ALLELES; BREAST NEOPLASMS; CASE-CONTROL STUDIES; COHORT STUDIES; DNA, NEOPLASM; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; NEOPLASM STAGING; RISK FACTORS; STEROID 17-ALPHA-HYDROXYLASE;

EID: 0035863524     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Genetic dissection of complex traits
2. Genetic susceptibility to cancer from exogenous and endogenous exposures
3. Tissue-specific, cyclic adenosine 3′,5′-monophosphate-induced, and phorbol esterrepressed transcription from the human P450c17 promoter in mouse cells
4. Cytochrome P450c17α gene (CYP17) polymorphism is associated with serum estrogen and progesterone concentrations
5. The relationship between a polymorphism in CYP17 with plasma hormone levels and breast cancer
6. A polymorphism in the CYP17 gene increases the risk of breast cancer
7. No association between a polymorphism in the steroid metabolism gene CYP17 and risk of breast cancer
8. Association between CYP17 polymorphisms and the development of breast cancer
9. CYP17 genotype and breast cancer risk
10. Breast cancer risk associated with genotype polymorphisms of the estrogen-metabolizing genes CYPI7, CYP1A1, and COMT: A multigenic study on cancer susceptibility
11. CYP17 and breast cancer risk: The polymorphism in the 5′ flanking area of the gene does not influence binding to Sp-1
12. Association between CYP17 gene polymorphism and risk of breast cancer in young women
13. Cytochrome P450c17α gene (CYP17) polymorphism predicts use of hormone replacement therapy
14. Human familial and sporadic breast cancer: Analysis of the coding regions of the 17β-hydroxysteroid dehydrogenase 2 gene (EDH17B2) using a single-strand conformation polymorphism assay
15. Detection of polymorphisms in the estradiol 17β-hydroxysteroiddehydrogenase 2 gene at the EDHl7B2 locus on 17q11q21
16. Site-directed mutagenesis of the putative active site of human 17β-hydroxysteroid dehydrogenase type 1
17. A multiethnic cohort in Hawaii and Los Angeles: Baseline characteristics
18. Ethnic differences in postmenopausal plasma estrogen levels: High estrone levels in Japanese-American women despite low weight
19. Polycystic ovaries and premature male pattern baldness are associated with one allele of the steroid metabolism gene CYP17
20. Hormonal risk factors, breast-tissue age, and age-incidence of breast cancer