Cellular N-Ras promotes cell survival by downregulation of Jun N-terminal protein kinase and p38

Molecular and Cellular Biology

Volumn 22, Issue 5, 2002, Pages 1589-1606

  Wolfman, Janice C ^a   Palmby, Todd ^a   Der, Channing J ^a   Wolfman, Alan ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN BAD; PROTEIN KINASE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL POPULATION; CELL STIMULATION; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; FIBROBLAST; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN N RAS; PROTEIN PHOSPHORYLATION; REDUCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STEADY STATE;

3T3 CELLS; ANIMALS; APOPTOSIS; CELL SURVIVAL; DOWN-REGULATION; ENZYME ACTIVATION; GENES, RAS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE 4; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS P21(RAS); SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0036174516     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.5.1589-1606.2002     Document Type: Article

References (138)

1. Death receptors: Signaling and modulation
2. Jun is phosphorylated by several protein kinases at the same sites that are modified in serum-stimulated fibroblasts
3. Ras genes
4. A specific function for phosphatidylinositol 3-kinase alpha (p85alpha-p110alpha) in cell survival and for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in de novo DNA synthesis of human colon carcinoma cells
5. The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Aktmediated phosphorylation of Bad on Ser136
6. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
7. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
8. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
9. Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation
10. Increasing complexity of Ras signaling
11. Regulation of cell death protease caspase-9 by phosphorylation
12. Construction and applications of a highly transmissible murine retrovirus shuttle vector
13. Selective activation of Ha-ras(val12) oncogene increases susceptibility of NIH/3T3 cells to TNF-alpha
14. Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in gamma radiation-induced apoptosis
15. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation
16. cAMP signaling selectively influences Ras effectors pathways
17. Biological assays for Ras transformation
18. Contenders in FasL/TNF death signaling
19. Ras effectors: Buying shares in Ras plc
20. Cellular survival: A play in three Akts
21. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
22. Signal transduction by the c-Jun N-terminal kinase
23. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
24. JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
25. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms
26. Insulin-mediated cell proliferation and survival involve inhibition of c-Jun N-terminal kinases through a phosphatidylinositol 3-kinase- and mitogen-activated protein kinase phosphatase-l-dependent pathway
27. Cell cycle: Routine role for Ras
28. How BAD phosphorylation is good for survival
29. Ras signalling and apoptosis
30. Role of phosphoinositide-3-OH kinase in Ras signaling
31. Signal transduction pathways that regulate cell survival and cell death
32. Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway
33. Synergy between the Mos/mitogen-activated protein kinase pathway and loss of p53 function in transformation and chromosome instability
34. p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons
35. Insulin-like growth factor-1-mediated protection from neuronal apoptosis is linked to phosphorylation of the pro-apoptotic protein BAD but not to inhibition of cytochrome c translocation in rat cerebellar neurons
36. Correlation between sustained c-Jun N-terminal protein kinase activation and apoptosis induced by tumor necrosis factor-alpha in rat mesangial cells
37. Selective interaction of JNK protein kinase isoforms with transcription factors
38. Ha-ras and N-ras regulate MAPK activity by distinct mechanisms in vivo
39. Characterization of the structure and function of a novel MAP kinase kinase (MKK6)
40. Characterization of the structure and function of a novel MAP kinase kinase (MKK6)
41. JNK/SAPK activity contributes to TRAIL-induced apoptosis
42. Quantitative analysis of the complex between p21ras and the Ras-binding domain of the human Raf-1 protein kinase
43. Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase
44. TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent. Smad4-independent pathway
45. Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator
46. MKK7 is a stress-activated mitogen-activated protein kinase kinase functionally related to hemipterous
47. Sustained JNK activation induces endothelial apoptosis: Studies with colchicine and shear stress
48. MEK kinase activity is not necessary for Raf-1 function
49. From receptors to stress-activated MAP kinases
50. Signal transduction by the c-Jun N-terminal kinase (JNK)-from inflammation to development
51. A direct interaction between oncogenic Ha-Ras and phosphatidylinositol 3-kinase is not required for the Ha-Ras-dependent transformation of epithelial cells
52. The regulation of AP-1 activity by mitogen-activated protein kinases
53. Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB
54. Activation and involvement of p38 mitogen-activated protein kinase in glutamate-induced apoptosis in rat cerebellar granule cells
55. Oncogenic K-Ras and basic fibroblast growth factor prevent Fas-mediated apoptosis in fibroblasts through activation of mitogen-activated protein kinase
56. Phospholipase C(epsilon): A novel Ras effector
57. Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage
58. Akt is more than just a Bad kinase
59. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
60. ralGDS family members interact with the effector loop of ras p21
61. BMP2-induced apoptosis is mediated by activation of the TAK1-38 kinase pathway that is negatively regulated by Smad6
62. Distinct mechanisms of alpha 5beta 1 integrin activation by Ha-Ras and R-Ras
63. Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GMCSF receptors
64. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase
65. Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death
66. Diverse functions of JNK signaling and c-Jun in stress response and apoptosis
67. Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2
68. Oncogenic ras mediates apoptosis in response to protein kinase C inhibition through the generation of reactive oxygen species
69. Selective activation of oncogenic Ha-ras-induced apoptosis in NlH/3T3 cells
70. Molecular switch in signal transduction: Reaction paths of the conformational changes in ras p21
71. RAS pathways to cell cycle control and cell transformation
72. Oncogenic ras causes resistance to the growth inhibitor insulin-like growth factor binding protein-3 (IGFBP-3) in breast cancer cells
73. Changes in the mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signaling associated with the induction of apoptosis
74. + T cells
75. Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene
76. Activation of cJun NH2-terminal kinase/stressactivated protein kinase by insulin
77. Regulation and function of the JNK subgroup of MAP kinases
78. Autocrine signaling through Ras prevents apoptosis in vascular smooth muscle cells in vitro
79. ras GMPPNP is dependent on B-Raf
80. Complexes of Ras · GTP with Raf-1 and mitogen-activated protein kinase kinase
81. 2
82. A novel SAPK/JNK kinase, MKK7, stimulated by TNFα and cellular stresses
83. Oncogenic Ras sensitizes cells to apoptosis by Par-4
84. Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun N-terminal protein kinase 3 and p38 mitogenactivated protein kinase
85. Activated Ha-ras induces apoptosis by association with phosphorylated Bcl-2 in a mitogen-activated protein kinase-independent manner
86. Axin-induced apoptosis depends on the extent of its JNK activation and its ability to down-regulate beta-catenin levels
87. Ras protein signalling
88. Akt-dependent antiapoptotic action of insulin is sensitive to farnesyltransferase inhibitor
89. Ordering the cell death pathway. Differential effects of BCL2, an interleukin-1-converting enzyme family protease inhibitor, and other survival agents on JNK activation in serum/nerve growth factor-deprived PC12 cells
90. Tumor necrosis factor induces phosphorylation and translocation of BAD through a phosphatidylinositide-3-OH kinase-dependent pathway
91. Oncogenic Ras inhibits Fas ligand-mediated apoptosis by downregulating the expression of Fas
92. Activation of AP-1 by okadaic acid in mouse keratinocytes associated with hyperphosphorylation of c-jun
93. Pancreatic cancer cell proliferation is phosphatidylinositol 3-kinase dependent
94. Loss of oncogenic ras expression does not correlate with loss of tumorigenicity in human cells
95. Translational control of the antiapoptotic function of Ras
96. Phosphorylation of c-jun mediated by MAP kinases
97. MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway
98. Phosphatidylinositol-3-OH kinase as a direct target of Ras
99. Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation
100. Activated Ras prevents downregulation of Bcl-X(L) triggered by detachment from the extracellular matrix. A mechanism of Ras-induced resistance to anoikis in intestinal epithelial cells
101. Matrix detachment induces caspase-dependent cytochrome c release from mitochondria: Inhibition by PKB/Akt but not Raf signalling
102. Phosphoinositide 3-OH kinase (P13K) and PKB/Akt delay the onset of p53- mediated, transcriptionally dependent apoptosis
103. Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun
104. CL100/MKP-1 modulates JNK activation and apoptosis in response to cisplatin
105. Argos induces programmed cell death in the developing Drosophila eye by inhibition of the Ras pathway
106. Two CD95 (APO- 1/Fas) signalling pathways
107. Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase
108. Understanding Ras: "it ain't over 'til it's over'
109. Signal transduction by tumor necrosis factor mediated by JNK protein kinases
110. Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73
111. Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap
112. Cloning and characterization of MEK6, a novel member of the mitogenactivatedprotein kinase kinase cascade
113. Apoptosis signaling
114. Analysis of Ras-dependent signals that prevent caspase-3 activation and apoptosis induced by cytokine deprivation in hematopoietic cells
115. ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis
116. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway
117. 2-terminal kinase
118. Ras signaling in tumor necrosis factor-induced apoptosis
119. The murine N-Ras gene is not essential for growth and development
120. Complex formation between RAS and RAF and other protein kinases
121. Fas ligand-induced c-Jun kinase activation in lymphoid cells requires extensive receptor aggregation but is independent of DAXX, and Fas- mediated cell death does not involve DAXX, RIP, or RAIDD
122. Mammalian Ras interacts directly with the serine/threonine kinase Raf
123. HSP72 can protect cells from heat-induced apoptosis by accelerating the inactivation of stress kinase JNK
124. Apoptosis suppression by Raf-1 and MEK1 requires MEK- and phosphatidylinositol 3-kinase-dependent signals
125. The CD95 (APO-1/Fas) and the TRAIL (APO-2L) apoptosis systems
126. Direct interaction of ras and the amino-terminal region of Raf-1 in vitro
127. Multiple Ras functions can contribute to mammalian cell transformation
128. A role for the Ral guanine nucleotide dissociation stimulator in mediating Ras-induced transformation
129. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways
130. The structure of ras protein: A model for a universal molecular switch
131. Endogenous c-N-Ras provides a steady-state anti-apoptotic signal
132. Ra1GDS-like factor (Rlf) is a novel Ras and Rap 1A -associating protein
133. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
134. The Ras/phosphatidylinositol 3-kinase and Ras/ERK pathways function as independent survival modules each of which inhibits a distinct apoptotic signaling pathway in sympathetic neurons
135. Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase
136. Daxx, a novel Fas-binding protein that activates JNK and apoptosis
137. Activation of the p38 mitogenactivated protein kinase pathway by estrogen or by 4-hydroxytamoxifen is coupled to estrogen receptor-induced apoptosis
138. Normal and oncogenic p21ras proteins bind to the amino-terminal domain of c-Raf-1