Phosphoinositide 3-OH kinase (PI3K) and PKB/Akt delay the onset of p53- mediated, transcriptionally dependent apoptosis

Journal of Biological Chemistry

Volumn 274, Issue 34, 1999, Pages 24263-24269

  Sabbatini, Peter ^a   McCormick, Frank ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DNA; CYTOKINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL X; PROTEIN KINASE B; PROTEIN P53; RAS PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL DEATH; CELL PROTECTION; CONTROLLED STUDY; DNA DEGRADATION; ENZYME ASSAY; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; STRAIN DIFFERENCE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; CASPASE 9; CASPASES; CELL LINE; DNA; MICE; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA;

EID: 0033588217     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.34.24263     Document Type: Article

References (82)

1. Staal, S. P. (1987) Proc. Natl. Acad. Sci. U. S. A, 84, 5034-5037
2. Coffer, P. J., Jin, J., and Woodgett, J. R. (1998) Biochem. J. 335, 1-13
3. Bellacosa, A., Franke, T. F., Gonzalez-Portal, M. E., Datta, K., Taguchi, T., Gardner, J., Cheng, J. Q., Testa, J. R., and Tsichlis, P. N. (1993) Oncogene 8, 745-754
4. Alessi, D. R., Andjelkovic, M., Caudwell, B., Cron, P., Morrice, N., Cohen, P., and Hemmings, B. A. (1996) EMBO J. 15, 6541-6551
5. Stokoe, D., Stephens, L. R., Copeland, T., Gaffney, P. R., Reese, C. B., Painter, G. F., Holmes, A. B., McCormick, F., and Hawkins, P. T. (1997) Science 277, 567-570
6. Stephens, L., Anderson, K., Stokoe, D., Erdjument-Bromage, H., Painter, G. F., Holmes, A. B., Gaffney, P. R., Reese, C. B., McCormick, F., Tempst, P., Coadwell, J., and Hawkins, P. T. (1998) Science 279, 710-714
7. Alessi, D. R., Deak, M., Casamayor, A., Caudwell, F. B., Morrice, N., Norman, D. G., Gaffney, P., Reese, C. B., MacDougall, C. N., Harbison, D., Ashworth, A., and Bownes, M. (1997) Curr. Biol. 7, 776-789
8. Kohn, A. D., Takeuchi, F., and Roth, R. A. (1996) J. Biol. Chem. 271, 21920-21926
9. Delcommenne, M., Tan, C., Gray, V., Rue, L., Woodgett, J., and Dedhar, S. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 11211-11216
10. Kohn, A. D., Kovacina, K. S., and Roth, R. A. (1995) EMBO J. 14, 4288-4295
11. Franke, T. F., Yang, S. I., Chan, T. O., Datta, K., Kazlauskas, A., Morrison, D. K., Kaplan, D. R., and Tsichlis, P. N. (1995) Cell 81, 727-736
12. Burgering, B. M., and Coffer, P. J. (1995) Nature 376, 599-602
13. Anderson, K. E., Coadwell, J., Stephens, L. R., and Hawkins, P. T. (1998) Curr. Biol. 8, 684-691
14. Vanhaesebroeck, B., Leevers, S. J., Panayotou, G., and Waterfield, M. D. (1997) Trends Biochem. Sci. 22, 267-272
15. Toker, A., and Cantley, L. C. (1997) Nature 387, 673-676
16. Rodriguez-Viciana, P., Warne, P. H., Khwaja, A., Marte, B. M., Pappin, D., Das, P., Waterfield, M. D., Ridley, A., and Downward, J. (1997) Cell 89, 457-467
17. Heldin, C. H. (1995) Cell 80, 213-223
18. Yao, R., and Cooper, G. M. (1995) Science 267, 2003-2006
19. Songyang, Z., Baltimore, D., Cantley, L. C., Kaplan, D. R., and Franke, T. F. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 11345-11350
20. Ahmed, N. N., Grimes, H. L., Bellacosa, A., Chan, T. O., and Tsichlis, P. N. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 3627-3632
21. Kulik, G., Klippel, A., and Weber, M. J. (1997) Mol. Cell. Biol. 17, 1595-1606
22. Kennedy, S. G., Wagner, A. J., Conzen, S. D., Jordan, J., Bellacosa, A., Tsichlis, P. N., and Hay, N. (1997) Genes Dev. 11, 701-713
23. Dudek, H., Datta, S. R., Franke, T. F., Birnbaum, M. J., Yao, R., Cooper, G. M., Segal, R. A., Kaplan, D. R., and Greenberg, M. E. (1997) Science 275, 661-665
24. Mendez, R., Myers, M.G., Jr., White, M. F., and Rhoads, R. E. (1996) Mol. Cell. Biol. 16, 2857-2864
25. Kauffmann-Zeh, A., Rodriguez-Viciana, P., Ulrich, E., Gilbert, C., Coffer, P., Downward, J., and Evan, G. (1997) Nature 385, 544-548
26. Khwaja, A., Rodriguez-Viciana, P., Wennstrom, S., Warne, P. H., and Downward, J. (1997) EMBO J. 16, 2783-2793
27. Gottlieb, T. M., and Oren, M. (1996) Biochim. Biophys. Acta 1287, 77-102
28. Levine, A. J. (1997) Cell 88, 323-331
29. Lane, D. P. (1992) Nature 368, 15-16
30. el-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., and Vogelstein, B. (1993) Cell 75, 817-825
31. Hartwell, L. H., and Kastan, M. B. (1994) Science 266, 1821-1828
32. Lin, Y., and Benchimol, S. (1995) Mol. Cell. Biol. 15, 6045-6054
33. Quelle, F. W., Wang, J., Feng, J., Wang, D., Cleveland, J. L., Ihle, J. N., and Zambetti, G. P. (1998) Genes Dev. 12, 1099-1107
34. Lin, H. J., Eviner, V., Prendergast, G. C., and White, E. (1995) Mol. Cell. Biol. 15, 4536-4544
35. Sabbatini, P., Lin, J., Levine, A. J., and White, E. (1995) Genes Dev. 9, 2184-2192
36. Sakamuro, D., Sabbatini, P., White, E., and Prendergast, G. C. (1997) Oncogene 15, 887-898
37. Chiou, S. K., Rao, L., and White, E. (1994) Mol. Cell. Biol. 14, 2556-2563
38. Debbas, M., and White, E. (1993) Genes Dev. 7, 546-554
39. Wyllie, A. H., Kerr, J. F., and Currie, A. R. (1980) Int. Rev. Cytol. 68, 251-306
40. Han, J., Sabbatini, P., Perez, D., Rao, L., Modha, D., and White, E. (1996) Genes Dev. 10, 461-477
41. Skorski, T., Bellacosa, A., Nieborowska-Skorska, M., Majewski, M., Martinez, R., Choi, J. K., Trotta, R., Wlodarski, P., Perrotti, D., Chan, T. O., Wasik, M. A., Tsichlis, P. N., and Calabretta, B. (1997) EMBO J. 16, 6151-6161
42. Reed, J. C. (1998) Oncogene 17, 3225-3236
43. Schott, A. F., Apel, I. J., Nunez, G., and Clarke, M. F. (1995) Oncogene 11, 1389-1394
44. Sabbatini, P., Han, J., Chiou, S. K., Nicholson, D. W., and White, E. (1997) Cell Growth Differ. 8, 643-653
45. Thomas, A., and White, E. (1998) Genes Dev. 12, 1975-1985
46. Rao, L., Perez, D., and White, E. (1996) J. Cell Biol. 136, 1441-1455
47. Nicholson, D. W. (1996) Nat. Biotechnol. 14, 297-301
48. Cryns, V., and Yuan, J. (1998) Genes Dev. 12, 1551-1570
49. Thornberry, N. A., and Lazebnik, Y. (1998) Science 281, 1312-1316
50. Nunez, G., Benedict, M. A., Hu, Y., and Inohara, N. (1998) Oncogene 17, 3237-3245
51. Cardone, M. H., Roy, N., Stennicke, H. R., Salvesen, G. S., Franke, T. F., Stanbridge, E., Frisch, S., and Reed, J. C. (1998) Science 282, 1318-1321
52. Seol, D.-W., and Billiar, T. R. (1999) J. Biol. Chem. 274, 2072-2076
53. Fearnhead, H. O., Rodriguez, J., Govek, E. E., Guo, W., Kobayashi, R., Hannon, G., and Lazebnik, Y. A. (1998) Proc. Natl. Acad. Sci. U. S. A 95, 13664-13669
54. Soengas, M. S., Alarćon, R. M., Yoshida, H., Giaccia, A. J., Hakem, R., Mak, T. W., and Lowe, S. W. (1999) Science 284, 156-159
55. Zha, J., Harada, H., Yang, E., Jockel, J., and Korsmeyer, S. J. (1996) Cell 87, 619-628
56. del Peso, L., Gonzalez-Garcia, M., Page, C., Herrera, R., and Nunez, G. (1997) Science 278, 687-689
57. Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., and Greenberg, M. E. (1997) Cell 91, 231-241
58. Kitada, S., Krajewska, M., Zhang, X., Scudiero, D., Zapata, J. M., Wang, H. G., Shabaik, A., Tudor, G., Krajewski, S., Myers, T. G., Johnson, G. S., Sausville, E. A., and Reed, J. C. (1998) Am. J. Pathol. 152, 51-61
59. Scheid, M. P., and Duronio, V. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 7439-7444
60. Lowe, S. W., Ruley, H. E., Jacks, T., and Housman, D. E. (1993) Cell 74, 957-967
61. Clarke, A. R., Purdie, C. A., Harrison, D. J., Morris, R. G., Bird, C. C., Hooper, M. L., and Wyllie, A. H. (1993) Nature 362, 849-852
62. O'Connor, P. M., Jackman, J., Jondle, D., Bhatia, K., Magrath, I., and Kohn, K. W. (1993) Cancer Res. 53, 4776-4780
63. Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., and Jacks, T. (1993) Nature 362, 847-849
64. Lotem, J., and Sachs, L. (1993) Cell Growth Differ. 4, 41-47
65. Cheng, J. Q., Godwin, A. K., Bellacosa, A., Taguchi, T., Franke, T. F., Hamilton, T. C., Tsichlis, P. N., and Testa, J. R. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 9267-9271
66. Shayesteh, L., Lu, Y., Kuo, W. L., Baldocchi, R., Godfrey, T., Collins, C., Pinkel, D., Powell, B., Mills, G. B., and Gray, J. W. (1999) Nat. Genet. 21, 99-102
67. Iwabuchi, H., Sakamoto, M., Sakunaga, H., Ma, Y. Y., Carcangiu, M. L., Pinkel, D., Yang-Feng, T. L., and Gray, J. W. (1995) Cancer Res. 55, 6172-6180
68. Howes, K. A., Ransom, N., Papermaster, D. S., Lasudry, J. G., Albert, D. M., and Windle, J. J. (1994) Genes Dev. 8, 1300-1310
69. Pan, H., and Griep, A. E. (1994) Genes Dev. 8, 1285-1299
70. Lowe, S. W., Jacks, T., Housman, D. E., and Ruley, H. E. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 2026-2030
71. Canman, C. E., and Kastan, M. B. (1997) Adv. Pharmacol. 41, 429-460
72. Bedi, A., Pasricha, P. J., Akhtar, A. J., Barber, J. P., Bedi, G. C., Giardiello, F. M., Zehnbauer, B. A., Hamilton, S. R., and Jones, R. J. (1995) Cancer Res. 55, 1811-1816
73. Fearon, E. R., and Vogelstein, B. (1990) Cell 61, 759-767
74. Rodriguez-Viciana, P., Warne, P. H., Dhand, R., Vanhaesebroeck, B., Gout, I., Fry, M. J., Waterfield, M. D., and Downward, J. (1994) Nature 370, 527-532
75. Warne, P. H., Viciana, P. R., and Downward, J. (1993) Nature 364, 352-355
76. Zhang, X. F., Settleman, J., Kyriakis, J. M., Takeuchi-Suzuki, E., Elledge, S. J., Marshall, M. S., Bruder, J. T., Rapp, U. R., and Avruch, J. (1993) Nature 364, 308-313
77. Vojtek, A. B., Hollenberg, S. M., and Cooper, J. A. (1993) Cell 74, 205-214
78. Kikuchi, A., Demo, S. D., Ye, Z. H., Chen, Y. W., and Williams, L. T. (1994) Mol. Cell. Biol. 14, 7483-7491
79. Spaargaren, M., and Bischoff, J. R. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 12609-12613
80. Ahmed, N. N., Franke, T. F., Bellacosa, A., Datta, K., Gonzalez-Portal, M. E., Taguchi, T., Testa, J. R., and Tsichlis, P. N. (1993) Oncogene 8, 1957-1963
81. Hirt, B. (1967) J. Mol. Biol. 26, 365-369
82. Kastan, M. B., Onyekwere, O., Sidransky, D., Vogelstein, B., and Craig, R. W. (1991) Cancer Res. 51, 6304-6311