Ras signaling in tumor necrosis factor-induced apoptosis

EMBO Journal

Volumn 15, Issue 17, 1996, Pages 4497-4505

  Trent II, Jonathan C ^a   McConkey, David J ^a   Loughlin, Susan M ^a   Harbison, Matthew T ^a   Fernandez, Antonio ^a   Ananthaswamy, Honnavara N ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Apoptosis; Endogenous endonuclease; Ras activation; Tumor necrosis factor

Indexed keywords

TUMOR NECROSIS FACTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL STRAIN L 929; CONTROLLED STUDY; CYTOTOXICITY; FIBROBLAST; MOUSE; NONHUMAN; ONCOGENE H RAS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

EID: 9544254849     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00827.x     Document Type: Article

References (43)

1. Adari, H., Lowy, D.R., Willumsen, B.M., Der, C.J. and McCormick, F. (1988) Guanosine triphosphatase activating protein (GAP) interacts with p21 ras effector binding domain. Science, 250, 518-521.
2. Arends, M.J., McGregor, A.H., Toft, N.J., Brown, E.J.H. and Wyllie, A.H. (1993) Susceptibility to apoptosis is differentially regulated by c-myc and mutated H-ras oncogenes and is associated with endonuclease availability. Br. J. Cancer, 68, 1127-1133.
3. Beutler, B. and Cerami, A. (1986) Cachectin and tumour necrosis factor as two sides of the same biological coin. Nature, 320, 584-588.
4. Beyaert, R. and Fiers, W. (1994) Molecular Mechanisms of tumor necrosis factor-induced cytotoxicity: what we do understand and what we do not. FEBS Lett., 340, 9-16.
5. Burton, K. (1956) A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem. J., 62, 315-323.
6. Chen, M.J., Holskin, B., Stickler, J., Gorniak, J., Clark, M.A., Johnson, P.J., Mitcho, M. and Shalloway, D. (1987) Induction by E1A oncogene expression of cellular susceptibility to lysis by TNF. Nature, 330, 581-583.
7. Cohen, G.M., Sun, X.M., Fearnhead, H., MacFarlane, M., Brown, D.G., Showden, R.T. and Dinsdale, D. (1994) Formation of large molecular weight fragments of DNA is a key committed step of apoptosis in thymocytes. J. Immunol., 153, 507-516.
8. Cook, S.J., Rubinfeld, B., Albert, I., and McCormick, F. (1993) RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts. EMBO J., 12, 3475-3485.
9. Dbaibo, G., Obeid, L. and Hannun, Y. (1993) Tumor necrosis factor-alpha (TNF-alpha) signal transduction through ceramide. J. Biol. Chem., 268, 17762-17766.
10. Feig, L.A. and Cooper, G.M. (1988) Inhibition of 3T3 cell proliferation by a mutant Ras protein with preferential affinity for GDP. Mol. Cell. Biol., 8, 3235-3243.
11. Fernandez, A. and Ananthaswamy, H.N. (1994) Molecular basis for tumor necrosis factor-induced apoptosis. Cancer Bull., 46, 153-160.
12. Fernandez, A., Marin, M., McDonnell, T. and Ananthaswamy, H.N. (1994a) Differential sensitivity of normal and Ha-ras-transformed C3H mouse embryo fibroblasts to tumor necrosis factor: induction of bcl-2, c-myc, and manganese Superoxide dismutase in resistant cells. Oncogene, 9, 2009-2017.
13. Fernandez, A., Chen, P.W. and Ananthaswamy, H.N. (1994b) ras-induced neoplastic transformation and sensitivity to tumor necrosis factor. Anticancer Res., 14, 2649-2652.
14. Fernandez, A., Fosdick, L.J., Marin, M.C., Diaz, C., McDonnell, T.J., Ananthaswamy, H.N. and McConkey, D. (1995) Differential regulation of endogenous endonuclease activation in isolated murine fibroblast nuclei by ras and bcl-2. Oncogene, 10, 769-774.
15. Filipski, J., Leblanc, J., Youdale, T., Sikorska, M. and Walker, P.R. (1990) Periodicity of DNA folding in higher order chromatin structures. EMBO J., 9, 1319-1327.
16. Goossens, V., Grooten, J., De Vos, K. and Fiers, W. (1995) Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity. Proc. Natl Acad. Sci. USA, 92, 8115-8119.
17. Green, L.M., Reade, J.L. and Ware, C.F. (1984) Rapid colorimetric assay: application to the quantitation of cytotoxic and growth inhibitory lymphokines. J. Immunol. Methods, 70, 257-268.
18. Gulbins, E. et al. (1995) FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway. Immunity, 2, 341-351.
19. Hudziak, R.M., Lewis, G.D., Shalaby, M.R., Eessalu, T.E., Aggarwal, B.B., Ullrich, A. and Shepard, H.M. (1988) Amplified expression of the HER2/ERBB2 oncogene induces resistance to tumor necrosis factor-α in NIH3T3 cells. Proc. Natl Acad. Sci. USA, 85, 5102-5106.
20. Jaatela, M. (1991) Biology of disease: biological activities and mechanism of action of tumor necrosis factor-α/cachectin. Lab. Invest., 64, 724-742.
21. Kim, M.Y., Linardic, C., Obeid, L. and Hannun, Y. (1991) TNF-alpha and interferon-gamma signaling through ceramide. J. Biol. Chem., 266, 484-489.
22. Kitayama, H., Sugimoto, Y., Matsuzaki, T., Ikawa, Y. and Noda, M. (1989) A ras-related gene with transformation suppressor activity. Cell, 56, 77-84.
23. Kitayama, H., Matsuzaki, T., Ikawa, Y. and Noda, M. (1990) Genetic analysis of the Kirsten-ras-revertant-1 gene: potentiation of its tumor suppressor activity by specific point mutations. Proc. Natl Acad. Sci. USA, 87, 4284-4288.
24. McConkey, D.J., Hartzell, P., Jondal, M. and Orrenius, S. (1989) Inhibition of DNA fragmentation in thymocytes and isolated thymocyte nuclei by agents that stimulate protein kinase C. J. Biol. Chem., 264, 13399-13402.
25. Obeid, L., Linardic, C., Karolak, L. and Hannun, Y. (1993) Programmed cell death induced by ceramide. Science, 259, 1769-1771.
26. Pizon, V., Chardin, P., Lerosey, I., Oloffsson, B. and Tavitian, A. (1988) Human cDNAs rap1 and rap2 homologues to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region. Oncogene, 3, 201-204.
27. Quilliam, L.A., Der, C.J., Clark, R., O'Rourke, E.C., Zhang, K., McCormick, F. and Bokoch, G.M. (1990) Biochemical characterization of baculovirus-expressed rap 1 A/K-rev-1 and its regulation by GTPase-activating proteins. Mol. Cell. Biol., 10, 2901-2908.
28. Rafiee, P., Lee, J., Leung, C.-C. and Raffin, T. (1995) TNF-alpha induces tyrosine phosphorylation of mitogen-activated protein kinase in adherent human neutrophils. J. Immunol., 154, 4785-4792.
29. Reznikoff, C.A., Brankow, D.W. and Heidelberger, C. (1973) Establishment and characteristics of a cloned line of C3H mouse embryo cells sensitive to post confluence inhibition of division. Cancer Res., 33, 3231-3238.
30. Sidhu, R. and Bollon, A. (1993) Tumor necrosis factor activities and cancer therapy - a perspective. Pharmacol. Ther., 57, 79-128.
31. Sluss, H.K., Barrett, T., Derijard, B. and Davis, R. (1994) Signal transduction by tumor necrosis factor mediated by JNK protein kinases. Mol. Cell Biol., 14, 8376-8384.
32. Stacey, D.W., Feig, L.A. and Gibbs, J.B. (1991) Dominant inhibitory Ras mutants selectively inhibit the activity of either cellular or oncogenic Ras. Mol. Cell. Biol., 11, 4053-4064.
33. Suen, T.C., Rodriguez, R.U., Hung, M.C. and Klostergaard, J. (1990) V-abl confers resistance and growth advantage to TNF-α in NIH3T3 cells. Lymphokine Res., 9, 15-25.
34. Sugarman, B.J., Aggarwal, B.B., Hass, P.E., Figari, I.S., Palladino, M.A. and Shepard, H.M. (1985) Recombinant human tumor necrosis factor alpha: effects on proliferation of normal and transformed cells in vitro. Science, 230, 943-945.
35. Tanaka, N., Ishihara, M., Kitagawa, M., Harada, H., Kimura, T., Matsuyama, T., Lamphier, M.S., Mak, T.W. and Taniguchi, T. (1994) Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1. Cell, 77, 829-839.
36. Tartaglia, L., Weber, R., Figari, I., Reynolds, C., Palladino, M. and Goeddel, D. (1991) The two different receptors for tumor necrosis factor mediate distinct cellular responses. Proc. Natl Acad. Sci. USA, 88, 9292-9296.
37. Tartaglia, L., Ayres, T., Wong, G. and Goeddel, D. (1993) A novel domain within the 55 kDa TNF receptor signals cell death. Cell, 74, 845-853.
38. Van Lint, J., Agostinis, P., Vandevoorde, V., Haegeman, G., Fiers, W., Merlevede, W. and Vandenheede, J. (1992) Tumor necrosis factor stimulates multiple serine/threonine protein kinases in Swiss 3T3 and L929 cells. J. Biol. Chem., 267, 25916-25921.
39. Victor, I., Schwenger, P., Li, W., Schlessinger, J. and Vilcek, J. (1993) Tumor necrosis factor-induced activation and increased tyrosine phosphorylation of mitogen-activated protein kinase in human fibroblasts. J. Biol. Chem., 268, 18994-18999.
40. Wyllie, A.H. (1980) Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature, 284, 555-556.
41. Wyllie, A.H., Rose, K.A., Morris, R.G., Steel, C.M., Foster, E. and Spandidos, D.A. (1987) Rodent fibroblast tumors expressing human myc and ras genes: growth, metastasis and endogenous oncogene expression. Br. J. Cancer, 56, 251-259.
42. Xie, K., Huang, S., Dong, Z. and Fidler, I.J. (1993) Cytokine-induced apoptosis in transformed murine fibroblasts involves synthesis of endogenous nitric oxide. Int. J. Oncol., 3, 1043-1048.
43. Yao, B., Zhang, Y., Delikat, S., Mathias, S., Basu, S. and Kolesnick, R. (1995) Phosphorylation of Raf by ceramide-activated protein kinase. Nature, 378, 307-310.