Immunological functions of the proteasome

Current Topics in Microbiology and Immunology

Volumn 268, Issue , 2002, Pages 91-136

  Niedermann, G ^a  

^a MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; EPITOPE; GAMMA INTERFERON; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; POLYPEPTIDE; PROTEASOME; PROTEINASE; UBIQUITIN;

ANTIGEN PRESENTATION; CANCER CELL; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; IMMUNE SYSTEM; KNOCKOUT MOUSE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVIEW; T LYMPHOCYTE; VIRUS INFECTION;

EUKARYOTA;

EID: 0036092622     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-59414-4_5     Document Type: Review

References (187)

1. In vivo characterization of the proteasome regulator PA28
2. Interferon-gamma induces different subunit organizations and functional diversity of proteasomes
3. Processive degradation of proteins and other catalytic properties of the proteasome from Thermoplasma acidophilum
4. Sequence signals for generation of antigenic peptides by the proteasome: Implications for proteasomal cleavage mechanism
5. Identification of the yeast 20S proteasome catalytic centers and subunit interactions required for active-site formation
6. Proteasome subunits encoded in the MHC are not generally required for the processing of peptides bound by MHC class I molecules
7. The effect of the proteasome inhibitor lactacystin on the presentation of transporter associated with antigen processing (TAP)-dependent and TAP-independent peptide epitopes by class I molecules
8. Dendritic cells and the control of immunity
9. The proteasome: Paradigm of a self-compartmentalizing protease
10. Abrogation of CTL epitope processing by single amino acid substitution flanking the C-terminal proteasome cleavage site
11. Production of a specific major histocompatibility complex class I-restricted epitope by ubiquitin-dependent degradation of modified ovalbumin in lymphocyte lysate
12. Allelic differences in the relationship between proteasome activity and MHC class I peptide loading
13. Interferon-gamma can stimulate post-proteasomal trimming of the N terminus of an antigenic peptide by inducing leucine aminopeptidase
14. The proteasome
15. Nomenclature for factors of the HLA system, 1996
16. Cellular responses to interferon-gamma
17. Interferon gamma stimulation modulates the proteolytic activity and cleavage site preference of 20S mouse proteasomes
18. Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors
19. Substrate binding and sequence preference of the proteasome revealed by active-site-directed affinity probes
20. T cell-recognized antigenic peptides derived from the cellular genome are not protein degradation products but can be generated directly by transcription and translation of short subgenic regions. A hypothesis
21. Isolation of processed, H-2Kb-binding ovalbumin-derived peptides associated with the stress proteins HSP70 and gp96
22. Evidence that the nature of amino acid residues in the P3 position directs substrates to distinct catalytic sites of the pituitary multicatalytic proteinase complex (proteasome)
23. Cleavage of Pro-X and Glu-X bonds catalyzed by the branched chain amino acid preferring activity of the bovine pituitary multicatalytic proteinase complex (20S proteasome)
24. Altered properties of the branched chain amino acid-preferring activity contribute to increased cleavages after branched chain residues by the 'immunoproteasome'
25. Genes encoded in the major histocompatibility complex affecting the generation of peptides for TAP transport
26. The proteasome-specific inhibitor lactacystin blocks presentation of cytotoxic T lymphocyte epitopes in human and murine cells
27. Hepatitis B virus immunopathogenesis
28. Ubiquitin-mediated proteolysis: Biological regulation via destruction
29. Structure and functions of the 20S and 26S proteasomes
30. Two distinct proteolytic processes in the generation of a major histocompatibility complex class I-presented peptide
31. Lactacystin and clasto-lactacystin beta-lactone modify multiple proteasome beta-subunits and inhibit intracellular protein degradation and major histocompatibility complex class I antigen presentation
32. Relationship between peptide selectivities of human transporters associated with antigen processing and HLA class I molecules
33. Degradation of oxidized insulin B chain by the multiproteinase complex macropain (proteasome)
34. Proteolytic processing of ovalbumin and beta-galactosidase by the proteasome to a yield antigenic peptides
35. Coordinated dual cleavages induced by the proteasome regulator PA28 lead to dominant MHC ligands
36. Contribution of proteasomal beta-subunits to the cleavage of peptide substrates analyzed with yeast mutants
37. The making of the dominant MHC class I ligand SYFPEITHI
38. Conformational constraints for protein self-cleavage in the proteasome
39. Structural investigation of proteasome inhibition
40. Decelerated degradation of short peptides by the 20S proteasome
41. MHC-linked LMP gene products specifically alter peptidase activities of the proteasome
42. Purification of an 11S regulator of the multicatalytic protease
43. The 20S proteasome activator PA28 or 11S regulator
44. The cleavage preference of the proteasome governs the yield of antigenic peptides
45. Effects of major-histocompatibility-complex-encoded subunits on the peptidase and proteolytic activities of human 20S proteasomes. Cleavage of proteins and antigenic peptides
46. Expression of a membrane protease enhances presentation of endogenous antigens to MHC class I-restricted T lymphocytes
47. Bovine spleen multicatalytic proteinase complex (proteasome). Replacement of X, Y, and Z subunits by LMP7, LMP2, and MECL1 and changes in properties and specificity
48. Processing of major histocompatibility class I-restricted antigens in the endoplasmic reticulum
49. The human 26S and 20S proteasomes generate overlapping but different sets of peptide fragments from a model protein substrate
50. PRE3, highly homologous to the human major histocompatibility complex-linked LMP2 (RING12) gene, codes for a yeast proteasome subunit necessary for the peptidylglutamyl-peptide hydrolyzing activity
51. Subcellular distribution of proteasomes implicates a major location of protein degradation in the nuclear envelope-ER network in yeast
52. MHC class I expression in mice lacking the proteasome subunit LMP-7
53. Phenotype-dependent differences in proteasome subunit composition and cleavage specificity in B cell lines
54. Gamma-interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes
55. Proteasome subunits X and Y alter peptidase activities in opposite ways to the interferon-gamma-induced subunits LMP2 and LMP7
56. A giant protease with potential to substitute for some functions of the proteasome
57. Generation of an immunodominant CTL epitope is affected by proteasome subunit composition and stability of the antigenic protein
58. HLA-B27, a dominant restricting element in antiviral responses?
59. Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS
60. PA28 activator protein forms regulatory caps on proteasome stacked rings
61. Immunoproteasome assembly: Cooperative incorporation of interferon gamma (IFN-gamma)-inducible subunits
62. The interferon-gamma-inducible 11S regulator (PA28) and the LMP2/LMP7 subunits govern the peptide production by the 20S proteasome in vitro
63. A role for the proteasome regulator PA28alpha in antigen presentation
64. Peptide antigen production by the proteasome: Complexity provides efficiency
65. The subunits MECL-1 and LMP2 are mutually required for incorporation into the 20S proteasome
66. Structure of 20S proteasome from yeast at 2.4A resolution
67. Degradation of oxidized proteins in mammalian cells
68. Recognition of two overlapping CTL epitopes in HIV-1 p17 by CTL from a long-term nonprogressing HIV-1-infected individual
69. Induction of leucine aminopeptidase by interferon-gamma. Identification by protein microsequencing after purification by preparative two-dimensional gel electrophoresis
70. PRE2, highly homologous to the human major histocompatibility complex-linked RING10 gene, codes for a yeast proteasome subunit necessary for chrymotryptic activity and degradation of ubiquitinated proteins
71. The active sites of the eukaryotic 20S proteasome and their involvement in subunit precursor processing
72. Simultaneous binding of PA28 and PA700 activators to 20S proteasomes
73. Intracellular targeting of the proteasome
74. Supply and transport of peptides presented by class I MHC molecules
75. Characteristics of endogenous peptides eluted from the class I MHC molecule HLA-B7 determined by mass spectrometry and computer modeling
76. Isolation of MHC class I-restricted tumor antigen peptide and its precursors associated with heat shock proteins hsp70, hsp90, and gp96
77. NK cells, MHC class I antigens and missing self
78. What do the paralogous regions in the genome tell us about the origin of the adaptive immune system?
79. Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection
80. Chicken MHC molecules, disease resistance and the evolutionary origin of birds
81. The sizes of peptides generated from protein by mammalian 26 and 20S proteasomes. Implications for understanding the degradative mechanism and antigen presentation
82. Self-antigen presentation by thymic stromal cells: A subtle division of labor
83. Structure of the proteasome activator REGalpha (PA28alpha)
84. Translocation of long peptides by transporters associated with antigen processing (TAP)
85. ER quality control: The cytoplasmic connection
86. Incorporation of major histocompatibility complex-encoded subunits LMP2 and LMP7 changes the quality of the 20S proteasome polypeptide processing products independent of interferon-gamma
87. Self-nonself-discrimination revisited
88. Human transporters associated with antigen processing (TAPs) select epitope precursor peptides for processing in the endoplasmic reticulum and presentation to T cells
89. Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen 1
90. A glycine-rich region in NF-κB p105 functions as a processing signal for the generation of the p50 subunit
91. Recognition of vaccinia virus-encoded major histocompatibility complex class I antigens by virus immune cytotoxic T cells is independent of the polymorphism of the peptide transporters
92. Endoplasmic reticulum-associated protein degradation
93. CTL-epitopes of HIV-1-Nef: Generation of multiple definitive epitopes by proteasomes
94. Identification, purification, and characterization of a protein activator (PA28) of the 20S proteasome (macropain)
95. Dendritic cells up-regulate immunoproteasomes and the proteasome regulator PA28 during maturation
96. The three-dimensional structure of peptide-MHC complexes
97. Presentation of out-of-frame peptide/MHC class I complexes by a novel translation initiation mechanism
98. Non-traditionally derived CTL epitopes: Exceptions that prove the rules?
99. Kinetic studies of the branched chain amino acid preferring peptidase activity of the 20S proteasome: Development of a continuous assay and inhibition by tripeptide aldehydes and clasto-lactacystin beta-lactone
100. Organization of the genes encoding the human proteasome activators PA28 alpha and beta
101. A critical role for the proteasome activator PA28 in the Hsp90-dependent protein refolding
102. Sequences that flank subdominant and cryptic epitopes influence the proteolytic generation of MHC class I-presented peptides
103. Distinct proteolytic processes generate the C and N termini of MHC class I-binding peptides
104. Proteasome subunits encoded by the major histocompatibility complex are not essential for antigen presentation
105. Selectivity of MHC-encoded peptide transporters from human, mouse and rat
106. Generation and TAP-mediated transport of peptides for major histocompatibility complex class I molecules
107. A molecular model of MHC class-I-restricted antigen processing
108. The LMP antigens: A stable MHC-controlled multisubunit protein complex
109. Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells
110. Growth retardation in mice lacking the proteasome activator PA28gamma
111. Identification of MECL-1 (LMP-10) as the third IFN-gamma-inducible proteasome subunit
112. How do endogenous proteins become peptides and reach the endoplasmic reticulum
113. Analysis of the fine specificity of rat, mouse and human TAP peptide transporters
114. Major differences in transporter associated with antigen presentation (TAP)-dependent translocation of MHC class I-presentable peptides and the effect of flanking sequences
115. Contribution of proteasome-mediated proteolysis to the hierarchy of epitopes presented by major histocompatibility complex class I molecules
116. The proteolytic fragments generated by vertebrate proteasomes: Structural relationships to major histocompatibility complex class I binding peptides
117. Potential immunocompetence of proteolytic fragments produced by proteasomes before evolution of the vertebrate immune system
118. The specificity of proteasomes: Impact on processing and presentation of antigens
119. Isolation of an immunodominant viral peptide that is endogenously bound to the stress protein GP96/GRP94
120. Cleavage motifs of the yeast 20S proteasome beta subunits deduced from digests of enolase 1
121. Pituitary multicatalytic proteinase complex. Specificity of components and aspects of proteolytic activity
122. Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids
123. A single residue exchange within a viral CTL epitope alters proteasome-mediated degradation resulting in lack of antigen presentation
124. Subpopulations of proteasomes in rat liver nuclei, microsomes and cytosol
125. Mechanisms of MHC class I-restricted antigen processing
126. Discrete proteolytic intermediates in the MHC class I antigen processing pathway and MHC I-dependent peptide trimming in the ER
127. MHC class II-restricted antigen processing and presentation
128. Impaired immunoproteasome assembly and immune responses in PA28-/- mice
129. The function
130. KEKE motifs. Proposed roles in protein-protein association and presentation of peptides by MHC class I receptors
131. The proteasome activator 11S REG (PA28) and class I antigen presentation
132. Dynamics of proteasome distribution in living cells
133. The major substrates for TAP in vivo are derived from newly synthesized proteins
134. Purification of a liver alkaline protease which degrades oxidatively modified glutamine synthetase. Characterization as a high molecular weight cysteine proteinase
135. Electron microscopic localization of the multicatalytic proteinase complex in rat liver and in cultured cells
136. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules
137. Degradation of cell proteins and the generation of MHC class I-presented peptides
138. Role of cellular immunity in protection against HIV infection
139. Rapid degradation of a large fraction of newly synthesized proteins by proteasomes
140. The selective proteasome inhibitors lactacystin and epoxomicin can be used to either up- or down-regulate antigen presentation at nontoxic doses
141. Overexpression of the proteasome subunits LMP2, LMP7, and MECL-1, but not PA28 alpha/beta, enhances the presentation of an immunodominant lymphocytic choriomeningitis virus T cell epitope
142. Proteasome from Thermoplasma acidophilum: A threonine protease
143. IFN-gamma exposes a cryptic cytotoxic T lymphocyte epitope in HIV-1 reverse transcriptase
144. Double-cleavage production of the CTL epitope by proteasomes and PA28: Role of the flanking region
145. Contribution of proline residue for efficient production of MHC class I ligands by proteasomes
146. + proteasomes are required for the presentation of specific antigens to cytotoxic T lymphocytes
147. Efficient generation of a hepatitis B virus cytotoxic T lymphocyte epitope requires the structural features of immunoproteasomes
148. MHC class I antigen processing of an adenovirus CTL epitope is linked to the levels of immunoproteasomes in infected cells
149. Trimming of antigenic peptides in an early secretory compartiment
150. A model for the quaternary structure of the proteasome activator PA28
151. Kinetic characterization of the chymotryptic activity of the 20S proteasome
152. Quantitative aspects of T cell activation-peptide generation and editing by MHC class I molecules
153. Generation of the vesicular stomatitis virus nucleoprotein cytotoxic T lymphocyte epitope requires proteasome-dependent and -independent proteolytic activities
154. Proteasomes generate in vitro a natural peptide of influenza-A nucleoprotein functional in HLA-B27 antigen assembly
155. The MHC class I ligand-generating system: Roles of immunoproteasomes and the interferon-gamma-inducible proteasome activator PA28
156. The sequence alteration associated with a mutational hotspot in p53 protects cells from lysis by cytotoxic T lymphocytes specific for a flanking peptide epitope
157. Processive degradation of proteins by the ATP-dependent Clp protease from Escherichia coli. Requirement for the multiple array of active sites in ClpP but not ATP hydrolysis
158. ATP- and antizyme-dependent endoproteolysis of ornithine decarboxylase to oligopeptides by the 26S proteasome
159. Purification and characterization of an endogenous inhibitor specific to the Z-Leu-Leu-Leu-MCA degrading activity in proteasome and its identification as heatshock protein 90
160. + T-cell clone
161. Recognition principle of the TAP transporter disclosed by combinatorial peptide libraries
162. Identification of a unique antigen peptide pRL1 on BALB/c RL male 1 leukemia recognized by cytotoxic T lymphocytes and its relation to the Akt oncogene
163. Effects of interferon gamma and major histocompatibility complex-encoded subunits on peptidase activities of human multicatalytic proteases
164. Modulation of proteasomal activity required for the generation of a cytotoxic T lymphocyte-defined peptide derived from the tumor antigen MAGE-3
165. Peptide selection for presentation by HLA class I: A role for the human transporter associated with antigen processing?
166. The peptide-binding motif for the human transporter associated with antigen processing
167. Differential influence on cytotoxic T lymphocyte epitope presentation by controlled expression of either proteasome immunosubunits or PA28
168. Altered peptidase and viral-specific T cell response in LMP2 mutant mice
169. Proteolysis in MHC class II antigen presentation: Who's in charge?
170. Inhibition of the proteolytic activity of the multicatalytic proteinase complex (proteasome) by substrate-related peptidyl aldehydes
171. The generation of MHC class I-associated peptides is only partially inhibited by proteasome inhibitors: Involvement of nonproteasomal cytosolic proteases in antigen processing?
172. Existence of a molecular ruler in proteasomes suggested by analysis of degradation products
173. Cation-sensitive neutral endopeptidase: Isolation and specificity of the bovine pituitary enzyme
174. An N-acetylated natural ligand of human histocompatibility leukocyte antigen (HLA)-B39. Classical major histocompatibility complex class I proteins bind peptides with a blocked NH(2) terminus in vivo
175. The requirement for proteasome activity class I major histocompatibility complex antigen presentation is dictated by the length of preprocessed antigen
176. Proteasomes are regulated by interferon gamma: Implications for antigen processing
177. Point mutation flanking a CTL epitope ablates in vitro and in vivo recognition of a full-length viral protein
178. Presentation of numerous viral peptides to mouse major histocompatibility complex (MHC) class I-restricted T lymphocytes is mediated by the human MHC-encoded transporter or by a hybrid mouse-human transporter
179. MHC-encoded proteasome subunits LMP2 and LMP7 are not required for efficient antigen presentation
180. Defective ribosomal products (DRiPs): A major source of antigenic peptides for MHC class I molecules?
181. Immunodominance in major histocompatibility complex class I-restricted T lymphocyte responses
182. Generating MHC class I ligands from viral gene products
183. Proteasome and its novel endogeneous activator in human platelets
184. Presentation of viral antigens restricted by H-2Kb, Db or Kd in proteasome subunit LMP2- and LMP7-deficient cells
185. Antigen localisation regulates immune responses in a dose- and time-dependent fashion: A geographical view of immune reactivity
186. AAA-ATPases at the crossroads of protein life and death