Endoplasmic reticulum-associated protein degradation

Seminars in Cell and Developmental Biology

Volumn 11, Issue 3, 2000, Pages 159-164

  Michael Lord, J ^a   Davey, John ^a   Frigerio, Lorenzo ^a   Roberts, Lynne M ^a  

^a UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

Endoplasmic reticulum; Proteasome; Protein degradation

Indexed keywords

CELL PROTEIN; OLIGOMER; TOXIN;

ANIMAL CELL; ARTICLE; CYTOSOL; ENDOPLASMIC RETICULUM; EUKARYOTIC CELL; NONHUMAN; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN SYNTHESIS; VIRUS;

EUKARYOTA;

EID: 0034500530     PISSN: 10849521     EISSN: None     Source Type: Journal    
DOI: 10.1006/scdb.2000.0160     Document Type: Article

References (50)

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8. Multiple proteolytic systems, including the proteasome, contribute to CFTR
9. The alpha chain of the T cell antigen receptor is degraded in the cytosol
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13. ER degradation of a misfolded lumenal protein by the cytosolic ubiquitin-proteasome pathway
14. Protein transport across the eukaryotic endoplasmic reticulum and bacterial inner membranes
15. The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol
16. Sec6I-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction
17. A protein translocation defect linked to ubiquitin conjugation at the endoplasmic reticulum
18. Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation
19. Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation
20. The requirement for molecular chaperones during endoplasmic reticulum-associated protein degradation demonstrates that protein export and import are mechanistically distinct
21. Derl, a novel protein specifically required for endoplasmic reticulum degradation in yeast
22. Role of Cuelp in ubiquitination and degradation at the ER surface
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27. Accumulating evidence suggests that several AB-toxins subvert the endoplasmic reticulum-associated protein degradation pathway to enter target cells
28. Free ricin A chain, proricin, and native toxin have different cellular fates when expressed in tobacco protoplasts
29. Ricin A chain utilises the endoplasmic reticulum-associated protein degradation pathway to enter the cytosol of yeast
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31. BiP acts as a molecular ratchet during posttranslational transport of preproalpha-factor across the ER membrane
32. The protein import motor of mitochondria: Unfolding and trapping of preproteins are distinct and separable functions of matrix Hsp70
33. BiP maintains the permeability barrier of the ER membrane by sealing the lumenal end of the translocation pore before and early in translocation
34. Protein folding in the cell
35. Endoplasmic reticulum degradation of a mutated ATP-binding cassette transporter Pdr5 proceeds in a concerted action of Sec61 and the proteasome
36. Glucose trimming and reglucosylation determine glycoprotein association with calnexin in the endoplasmic reticulum
37. Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex
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46. Involvement of heat shock protein 90 in the degradation of mutant insulin receptors by the proteasome
47. RAP, a specialized chaperone prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors
48. Regulation of the mevalonate pathway
49. Degradation of 3-hydroxy-3-methylglutaryl-CoA reductase in endoplasmic reticulum membranes is accelerated as a result of increased susceptibility to proteolysis
50. Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin