IFN-γ exposes a cryptic cytotoxic T lymphocyte epitope in HIV-1 reverse transcriptase

Journal of Immunology

Volumn 162, Issue 12, 1999, Pages 7075-7079

  Sewell, Andrew K ^a   Price, David A ^a   Teisserenc, Helene ^a   Booth Jr , Bruce L ^a   Gileadi, Uzi ^a   Flavin, Fiona M ^a   Trowsdale, John ^b   Phillips, Rodney E ^a   Cerundolo, Vincenzo ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b Immunology Division   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; RNA DIRECTED DNA POLYMERASE;

ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CYTOTOXIC T LYMPHOCYTE; ENZYME SUBUNIT; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOREGULATION; MELANOMA CELL; PRIORITY JOURNAL;

ACETYLCYSTEINE; ANTIGEN PRESENTATION; ATP-BINDING CASSETTE TRANSPORTERS; CELL LINE; CYSTEINE ENDOPEPTIDASES; ENZYME INHIBITORS; EPITOPES, T-LYMPHOCYTE; GENE DELETION; HISTOCOMPATIBILITY ANTIGENS CLASS II; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; INTERFERON TYPE II; MULTIENZYME COMPLEXES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEINS; T-LYMPHOCYTES, CYTOTOXIC; TUMOR CELLS, CULTURED; VIRAL MATRIX PROTEINS;

EID: 0033564707     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Fenteany, G., R. F. Standaert, W. S. Lane, S. Choi, E. J. Corey, and S. L. Schreiber. 1995. Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science 268:726.
2. Rock, K. L., C. Gramm, L. Rothstein, K. Clark, R. Stein, L. Dick, D. Hwang, and A. L. Goldberg. 1994. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78:761.
3. Cerundolo, V., A. Benham, V. Braud, S. Mukherjee, K. Gould, B. Macino, J. Neefjes, and A. Townsend. 1997. The proteasome-specific inhibitor lactacystin blocks presentation of cytotoxic T lymphocyte epitopes in human and murine cells. Eur. J. Immunol. 27:336.
4. Belich, M. P., R. J. Glynne, G. Senger, D. Sheer, and J. Trowsdale. 1994. Proteasome components with reciprocal expression to that of the MHC-encoded LMP proteins. Curr. Biol. 4:769.
5. Hisamatsu, H., N. Shimbara, Y. Saito, P. Kristensen, K. B. Hendil, T. Fujiwara, E. Takahashi, N. Tanahashi, T. Tamura, A. Ichihara, and K. Tanaka. 1996. Newly identified pair of proteasomal subunits regulated reciprocally by interferon γ. J. Exp. Med. 183:1807.
6. Van, K. L., R. P. Ashton, M. Eichelberger, M. Gaczynska, K. Nagashima, K. L. Rock, A. L. Goldberg, P. C. Doherty, and S. Tonegawa. 1994. Altered peptidase and viral-specific T cell response in LMP2 mutant mice. Immunity 1:533.
7. Fehling, H. J., W. Swat, C. Laplace, R. Kuhn, K. Rajewsky, U. Muller, and B. H. von. 1994. MHC class I expression in mice lacking the proteasome subunit LMP-7. Science 265:1234.
8. Griffin, T. A., D. Nandi, M. Cruz, H. J. Fehling, L. V. Kaer, J. J. Monaco, and R. A. Colbert. 1998. Immunoproteasome assembly: cooperative incorporation of interferon γ (IFN-γ)-inducible subunits. J. Exp. Med. 187:97.
9. Driscoll, J., M. G. Brown, D. Finley, and J. J. Monaco. 1993. MHC-linked LMP gene products specifically alter peptidase activities of the proteasome. Nature 365:262.
10. Eleuteri, A. M., R. A. Kohanski, C. Cardozo, and M. Orlowski. 1997. Bovine spleen multicatalytic proteinase complex (proteasome): replacement of X, Y, and Z subunits by LMP7, LMP2, and MECL1 and changes in properties and specificity. J. Biol. Chem. 272:11824.
11. Kuckelkorn, U., S. Frentzel, R. Kraft, S. Kostka, M. Groettrup, and P. M. Kloetzel. 1995. Incorporation of major histocompatibilily complex-encoded subunits LMP2 and LMP7 changes the quality of the 20S proteasome polypeptide processing products independent of interferon-γ Eur. J. Immmol. 25:2605.
12. Imanishi, T., T. Akaza, A. Kimura, K. Tokunaga, and T. Gojobori. 1992. Allele and haplotype frequencies for HLA and complement loci in various ethnic groups. In HLA 1991: Proceedings of the Eleventh International Histocompatibility Workshop and Conference. K. Tsuji, M. Aizawa, and T. Sasazuki, eds. Oxford University Press, Oxford, U.K., pp. 1065-1220.
13. Sewell, A. K., G. C. Harcourt, P. J. Goulder, D. A. Price, and R. E. Phillips. 1997. Antagonism of cytotoxic T lymphocyte-mediated lysis by natural HIV-1 altered peptide ligands requires simultaneous presentation of agonist and antagonist peptides. Eur. J. Immunol. 27:2323.
14. Goulder, P. J., A. K. Sewell, D. G. Lalloo, D. A. Price, J. A. Whelan, J. Evans, G. P. Taylor, G. Luzzi, P. Giangrande, R. E. Phillips, and A. J. McMichael. 1997. Patterns of immunodominance in HIV-1-specific cytotoxic T lymphocyte responses in two human histocompatibility leukocyte antigens (HLA)-identical siblings with HLA-A*0201 are influenced by epitope mutation. J. Exp. Med 185:1423.
15. Tsomides, T. J., A. Aldovini, R. P. Johnson, B.D. Walker, R. A. Young, and H. N. Eisen. 1994. Naturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by human immunodeficiency virus type 1. J. Exp. Med. 180:1283.
16. Boyer, P. L., A. L. Ferris, and S. H. Hughes. 1992. Cassette mutagenesis of the reverse transcriptase of human immunodeficiency virus type 1. J. Virol. 66:1031.
17. Myers, G., et al., eds. 1995. Human Retroviruses and AIDS: A Compilation and Analysis of Nucleic Acid and Amino Acid Sequences. Los Alamos National Laboratory, Los Alamos, NM.
18. Harrer, E., T. Harrer, P. Barbosa, M. Feinberg, R. P. Johnson, S. Buchbinder, and B. D. Walker. 1996. Recognition of the highly conserved YMDD region in the human immunodeficiency virus type 1 reverse transcriptase by HLA-A2-restricted cytotoxic T lymphocytes from an asymptomatic long-term nonprogressor. J. Infect. Dis. 173:476.
19. DeMars, R., C. C. Chang, S. Shaw, P. J. Reitnauer, and P. M. Sondel. 1984. Homozygous deletions that simultaneously eliminate expressions of class I and class II antigens of EBV-transformed B-lymphoblastoid cells. I. Reduced proliferative responses of autologous and allogeneic T cells to mutant cells that have decreased expression of class II antigens. Hum. Immunol. 11:77.
20. Cerundolo, V., A. Kelly, T. Elliott, J. Trowsdale, and A. Townsend. 1995. Genes encoded in the major histocompatibilily complex affecting the generation of peptides for TAP transport. Eur. J. Immunol. 25:554.
21. Price, D. A., A. K. Sewell, T. Dong, R. Tan, P. J. R. Goulder, S. L. Rowland-Jones, and R. E. Phillips. 1998. Antigen-specific release of beta-chemokines by anti-HIV-1 cytotoxic T lymphocytes. Curr. Biol. 8:355.
22. Flexner, C., S. S. Broyles, P. Earl, S. Chakrabarti, and B. Moss. 1988. Characterization of human immunodeficiency virus gaglpol gene products expressed by recombinant vaccinia viruses. Virology 166:339.
23. Nixon, D. F., A. R. Townsend, J. G. Elvin, C. R. Rizza, J. Gallwey, and A.J. McMichael. 1988. HIV-1 gag-specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptides. Nature 336:484.
24. Craiu, A., M. Gaczynska, T. Akopian, C. F. Gramm, G. Fenteany, A. L. Goldberg, and K. L. Rock. 1997. Lactacystin and clasto-lactacystin β-lactone modify multiple proteasome β-subunits and inhibit intracellular protein degradation and major histocompatibility complex class I antigen presentation. J. Biol. Chem. 272:13437.
25. Schmidtke, G., M. Eggers, T. Ruppert, M. Groettrup, U. H. Kosinowski, and P.M. Kloetzel. 1998. Inactivation of a defined active site in the mouse 20S proteasome complex enhances major histocompatibility complex class I antigen presentation of a murine cytomegalovirus protein. J. Exp. Med. 187:1641.
26. Glas, R., M. Bogyo, J. S. McMaster, M. Gaczynska, and H. Ploegh. 1998. A proteolytic system that compensates for loss of proteasome function. Nature 392:618.
27. Andre, P., M. Groettrup, P. Klenerman, DeGuili R., B. Booth, V. Cerundolo, M. Bonneville, F. Jotereau, R. Zinkernagel, and V. Lotteau. 1998. An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell responses. Proc. Natl. Acad. Sci. USA 95:13120.
28. Luckey, C. J., G. M. King, J. A. Marto, S. Venketeswaran, B. F. Maier, V. L. Crotzer, T. A. Colella, J. Shabanowitz, D. F. Hunt, and V. H. Engelhard. 1998. Proteasomes can either generate or destroy MHC class I epitopes: evidence for nonproteasomal epitope generation in the cytosol. J. Immunol. 161:112.
29. Vinitsky, A., L. C. Anton, H. L. Snyder, M. Orlowski, J. R. Bennink, and J. W. Yewdell. 1997. The generation of MHC class I-associated peptides is only partially inhibited by proteasome inhibitors: involvement of nonproteasomal cytosolic proteases in antigen processing? J. Immunol. 159:554.
30. Antón, L. C., H. L. Snyder, J. R. Bennink, A. Vinitisky, M. Orlowski, A. Porgador, and J. W. Yewdell. 1998. Dissociation of proteasomal degradation of biosynthesized viral proteins from generation of MHC class I-associated antigenic peptides. J. Immunol. 160:4859.
31. Fenteany, G., R. F. Standaert, G. A. Reichard, E. J. Corey, and S. L. Schreiber. 1994. A β-lactone related to lactacystin induces neunte outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line. Proc. Natl. Acad. Sci. USA 91:3358.
32. Niedermann, G., S. Butz, H. G. Ihlenfeldt, R. Grimm, M. Lucchiari, H. Hoschutzky, G. Jung, B. Maier, and K. Eichmann. 1995. Contribution of proteasome-mediated proteolysis to the hierarchy of epitopes presented by major histocompatibility complex class I molecules. Immunity 2:289.