The requirement for proteasome activity in class I major histocompatibility complex antigen presentation is dictated by the length of preprocessed antigen

Journal of Experimental Medicine

Volumn 183, Issue 4, 1996, Pages 1545-1552

  Yang, Bing ^a   Hahn, Young S ^a   Hahn, Chang S ^a   Braciale, Thomas J ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PEPTIDE; PROTEASOME; VIRUS HEMAGGLUTININ;

ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FLUORESCENCE ACTIVATED CELL SORTER; INFLUENZA VIRUS; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; VIRUS INFECTION;

AMINO ACID SEQUENCE; ANTIGEN PRESENTATION; ANTIGENS, VIRAL; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; EPITOPES; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HEMAGGLUTININS, VIRAL; HISTOCOMPATIBILITY ANTIGENS CLASS I; LEUPEPTINS; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECOMBINANT PROTEINS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0029966286     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.4.1545     Document Type: Article

References (32)

1. Gotch, R., J. Rothbard, K. Howland, A. Townsend, and A. McMichael. 1987. Cytotoxic T lymphocytes recognize a fragment of influenza virus matrix protein in association with HLS-A2. Nature (Lond.). 326:881-882.
2. Braciale, T. J. 1992. Antigen processing for presentation by MHC class I molecules. Curr. Opin. Immunol. 4:59-62.
3. Rammensee, H.G., K. Falk, and O. Rotzschke. 1993. Peptides naturally presented by MHC class I molecules. Annu. Rev. Immunol. 11:213-244.
4. Monaco, J.J. 1992. Major histocompatibility complex-linked transport proteins and antigen processing. Immunol. Res. 11: 125-132.
5. Kelly, A., S.H. Powis, L.A. Kerr, I. Mockridge, T. Elliott, J. Bastin, Z.B. Uchanska, A. Ziegler, J. Trowsdale, and A. Town-send. 1992. Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex. Nature (Lond.). 355:641-644.
6. Spies, T., and R. DeMars. 1991. Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter. Nature (Lond.). 351:323-324.
7. Attaya, M., S. Jameson, C.K. Martinez, E. Hermel, C. Aldrich, J. Forman, K.F. Lindahl, M.J. Bevan, and J.J. Monaco. 1992. Ham-2 corrects the class I antigen-processing defect in RMA-S cells. Nature (Lond.). 355:647-649.
8. Shepherd, J.C., T.N. Schumacher, R.P. Ashton, S. Imaeda, H.L. Ploegh, C.J. Jancway, and S. Tonegawa, 1993. TAP1-dependent peptide translocation in vitro in ATP dependent and peptide selective. Cell. 74:577-584. Erratum: Cell. 75(4).
9. Schumacher, T.N., D.V. Kantesaria, M.T. Hcemels, R.P. Ashton, J.C. Shepherd, K. Fruh, Y. Yang, P.A. Peterson, S. Tonegawa, and H.L. Ploegh. 1994. Peptide length and sequence specificity of the mouse TAP1/TAP2 translocator. J. Exp. Med. 179:533-540.
10. Momburg, F., J. Roelse, J.C. Howard, G.W. Butcher, G.J. Hammerling, and J.J. Neefjes. 1994. Selectivity of MHC-encoded peptide transporters from human, mouse and rat. Nature (Lond.). 367:648-651.
11. Yang, B., and T.J. Braciale. 1995. Characteristics of ATP-dependent peptide transport in isolated microsome. J. Immunol. 155:3889-3896.
12. Driscoll, J., M.G. Brown, D. Finley, and J.J. Monaco. 1993. MHC-linked LMP gene products specifically alter peptidase activities of the proteasome. Nature (Lond.). 365:262-264.
13. Michalek, M.T., E.P. Grant, C. Gramm, A.L. Goldberg, and K.L. Rock. 1993. A role for the ubiquitm-dependent proteolytic pathway in MHC class I-restricted antigen presentation. Nature (Lond.). 363:552-554.
14. Gaczynska, M., K.L. Rock, and A.L. Goldberg. 1993. γ-interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes. Nature (Lond.). 365:264-267.
15. Martinez, C.K., and J.J. Monaco. 1991. Homology of proteasome subunits to a major histocompatibility complex-linked LMP gene. Nature (Lond.). 353:664-667.
16. Kelly, A., S.H. Powis, R. Glynne, E. Radley, S. Beck, and J. Trowsdale. 1991. Second proteasome-related gene in the human MHC class II region. Nature (Lond.). 353:667-668.
17. Rock, K.L., C. Gramm, L. Rothstein, K. Clark, R. Stein, L. Dick, D. Hwang, and A.L. Goldberg. 1994. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell. 78:761-771.
18. Fenteany, G., R.F. Standaert, W.S. Lane, S. Choi, E.J. Corey, and S.L. Schreiber. 1995. Inhibition of proteasome activities and subumt-specific animo-terminal threonine modification by lactacystin. Science (Wash. DC). 268:726-731.
19. Hahn, C.S., Y.S. Hahn, T.J. Braciale, and C.M. Rice. 1992. Infectious Sindbis virus transient expression vectors for studying antigen processing and presentation. Proc. Natl. Acad. Sci. USA. 89:2679-2683.
20. Sweetser, M.T., V.L. Braciale, and T.J. Braciale. 1988. Class I MHC-restricted recognition of cells expressing a gene encoding a 41 amino acid product of the influenza hemagglutinin. J. Immunol. 141:3324-3328.
21. Yewdell, J.W., and J.R. Bennink. 1989. Brefeldin A specifically inhibits presentation of protein antigens to cytotoxic T lymphocytes. Science (Wash. DC). 244:1072-1075.
22. Palombella, V.J., O.J. Rando, A.L. Goldberg, and T. Mamatis. 1994. The ubiquitm-proteasome pathway is required for processing the NF-κ B1 precursor protein and the activation of NFκB. Cell. 78:773-785.
23. Elliott, T., A. Willis, V. Cerundolo, and A. Townscnd. 1995. Processing of major histocompatibility class I-restricted antigens in the endoplasmic reticulum. J. Exp. Med. 181:1481-1491.
24. Braciale, T.J., M.T. Sweetser, L.A. Morrison, D.J. Kittlesen, and V.L. Braciale. 1989. Class I major histocompatibility complex-restricted cytolytic T lymphocytes recognize a limited number of sites on the influenza hemagglutinin. Proc. Natl. Acad. Sci. USA. 86:277-281.
25. + T cell recognition of an endogenously processed epitope is regulated primarily by residues within the epitope. J. Exp. Med. 176:1335-1341.
26. Arnold, D., J. Driscoll, M. Androlewicz, E. Hughes, P. Cresswell, and T. Spies. 1992. Proteasome subunits encoded in the MHC are not generally required for the processing of peptides bound by MHC class I molecules. Nature (Lond.). 360:171-174.
27. Momburg, F., N.V. Ortiz, J. Neefjes, E. Goulmy, Y. van de Wal, H. Spits, S.J. Powis, G.W. Butcher, J.C. Howard, P. Walden et al. 1992. Proteasome subunits encoded by the major histocompatibility complex are not essential for antigen presentation. Nature (Lond.). 360:174-177.
28. Fehling, H.J., W. Swat, C. Laplace, R. Kuhn, K. Rajewsky, U. Muller, and H.V. Boehmer. 1994. MHC class I expression in mice lacking the proteasome subunit LMP-7. Science (Wash. DC). 265:1234-1237.
29. Kaer, L.V., P.G. Ashton-Rickardt, M.E. Eichelberger, M. Gaczynska, K. Nagashima, K.L. Rock, A.L. Goldberg, P.C. Doherty, and S. Tonegawa. 1994. Altered peptidase and viral-specific T cell response in LMP2 mutant mice. Immunity 1:533-541.
30. Falk, K., O. Rotzschke, S. Stevanovic, G. Jung, and H.G. Rammensee. 1991. Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature (Lond.). 351:290-296.
31. Falk, K., O. Rotzschke, and H.G. Rammensee. 1990. Cellular peptide composition governed by major histocompatibility complex class I molecules. Nature (Lond.). 348:248-251.
32. Dick, L.R., C. Aldrich, S.C. Jameson, C.R. Moomaw, B.C. Pramanik, C.K. Doyle, G.N. DeMartino, M.J. Bevan, J M. Forman, and C.A. Slaughter. 1994. Proteolytic processing of ovalbumin and ß-galactosidase by the proteasome to yield antigenic peptides. J. Immunol. 152:3884-3894.